Paul Goldschmidt hit a two-run home run, Steven Souza Jr. drove in three and the Arizona Diamondbacks beat the San Diego Padres 9-4 on Friday night.

Goldschmidt drove the first pitch he saw from left-hander Joey Lucchesi out to left-center field for his 28th of the season. That got Arizona going en route to its sixth straight win over San Diego at Petco Park.

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The San Diego Padres' Eric Hosmer, right, reacts as umpire James Hoye calls a strike during the first inning of the team's baseball game against the Arizona Diamondbacks on Friday, Aug. 17, 2018, in San Diego. (AP PhotoGregory Bull)

Paul Goldschmidt hit a two-run home run, Steven Souza Jr. drove in three and the Arizona Diamondbacks beat the San Diego Padres 9-4 on Friday night.

Arizona Diamondbacks starting pitcher Robbie Ray works against a San Diego Padres batter during the first inning of a baseball game Friday, Aug. 17, 2018, in San Diego. (AP PhotoGregory Bull)

Robbie Ray started for Arizona and walked his first two batters. While Ray held San Diego to two hits, both by Eric Hosmer, he allowed three runs over 4 2/3 innings. Ray walked five and struck out three.

Arizona Diamondbacks' Jon Jay (9) is greeted by Steven Souza Jr. after scoring during the fourth inning of a baseball game against the San Diego Padres on Friday, Aug. 17, 2018, in San Diego. (AP PhotoGregory Bull)

Lucchesi (6-7) allowed five runs and nine hits over four innings. He struck out six and walked three.

Arizona Diamondbacks' Nick Ahmed, right, is held back by third base coach Tony Perezchica as manager Torey Lovullo (17) speaks with umpire James Hoye, left, during the third inning of the team's baseball game against the San Diego Padres on Friday, Aug. 17, 2018, in San Diego. Ahmed was ejected by Hoye for arguing after striking out during his at-bat. (AP PhotoGregory Bull)

TRAINER'S ROOM

San Diego Padres' Eric Hosmer reacts after hitting a home run during the fifth inning against the Arizona Diamondbacks in a baseball game Friday, Aug. 17, 2018, in San Diego. (AP PhotoGregory Bull)

Padres: LHP Clayton Richard gets the call and looks to continue a stretch of pitching five innings or more in his last four starts.

A fan reacts after catching a home run ball hit by the San Diego Padres' Manuel Margot as Arizona Diamondbacks center fielder Jon Jay, below, looks on during the eighth inning of a baseball game Friday, Aug. 17, 2018, in San Diego. (AP PhotoGregory Bull)

A fan reacts after catching a home run ball hit by the San Diego Padres' Manuel Margot as Arizona Diamondbacks center fielder Jon Jay, below, looks on during the eighth inning of a baseball game Friday, Aug. 17, 2018, in San Diego. (AP PhotoGregory Bull)

Arizona Diamondbacks' Eduardo Escobar reacts after hitting a home run during the eighth inning against the San Diego Padres in a baseball game Friday, Aug. 17, 2018, in San Diego. (AP PhotoGregory Bull)

Arizona Diamondbacks' Eduardo Escobar reacts after hitting a home run during the eighth inning against the San Diego Padres in a baseball game Friday, Aug. 17, 2018, in San Diego. (AP PhotoGregory Bull)

Souza doubled into the right-center gap with the bases loaded to bring home three runs in the sixth and extend the lead to 8-3.

The San Diego Padres' Eric Hosmer, right, reacts as umpire James Hoye calls a strike during the first inning of the team's baseball game against the Arizona Diamondbacks on Friday, Aug. 17, 2018, in San Diego. (AP PhotoGregory Bull)

The San Diego Padres' Eric Hosmer, right, reacts as umpire James Hoye calls a strike during the first inning of the team's baseball game against the Arizona Diamondbacks on Friday, Aug. 17, 2018, in San Diego. (AP PhotoGregory Bull)

Robbie Ray started for Arizona and walked his first two batters. While Ray held San Diego to two hits, both by Eric Hosmer, he allowed three runs over 4 2/3 innings. Ray walked five and struck out three.

Hosmer homered in the fifth on a ball that just cleared the left field fence beyond Jon Jay's glove. Arizona challenged the call as it appeared a fan interfered with Jay, but the call was upheld after replay review.

Eduardo Escobar added a solo home run in the eighth against Jose Castillo.

Arizona Diamondbacks starting pitcher Robbie Ray works against a San Diego Padres batter during the first inning of a baseball game Friday, Aug. 17, 2018, in San Diego. (AP PhotoGregory Bull)

Arizona Diamondbacks starting pitcher Robbie Ray works against a San Diego Padres batter during the first inning of a baseball game Friday, Aug. 17, 2018, in San Diego. (AP PhotoGregory Bull)

Lucchesi (6-7) allowed five runs and nine hits over four innings. He struck out six and walked three.

Manuel Margot hit a solo homer to left in the eighth to cut the lead to 9-4.

YOU'RE OUTTA HERE

Diamondbacks shortstop Nick Ahmed was ejected in the third by home plate umpire James Hoye after striking out looking. Daniel Descalsco replaced Ahmed in the lineup. It was Ahmed's second career ejection.

Arizona Diamondbacks' Jon Jay (9) is greeted by Steven Souza Jr. after scoring during the fourth inning of a baseball game against the San Diego Padres on Friday, Aug. 17, 2018, in San Diego. (AP PhotoGregory Bull)

Arizona Diamondbacks' Jon Jay (9) is greeted by Steven Souza Jr. after scoring during the fourth inning of a baseball game against the San Diego Padres on Friday, Aug. 17, 2018, in San Diego. (AP PhotoGregory Bull)

TRAINER'S ROOM

Padres: LHP Eric Lauer made a rehab start at Class A Lake Elsinore on Friday night. Lauer has been sidelined since July 31 with a left forearm strain.

UP NEXT

Diamondbacks: RHP Zack Godley (13-6, 4.20) takes the mound in the third game of the series. Godley is 4-0 in his last eight starts.

Arizona Diamondbacks' Nick Ahmed, right, is held back by third base coach Tony Perezchica as manager Torey Lovullo (17) speaks with umpire James Hoye, left, during the third inning of the team's baseball game against the San Diego Padres on Friday, Aug. 17, 2018, in San Diego. Ahmed was ejected by Hoye for arguing after striking out during his at-bat. (AP PhotoGregory Bull)

Arizona Diamondbacks' Nick Ahmed, right, is held back by third base coach Tony Perezchica as manager Torey Lovullo (17) speaks with umpire James Hoye, left, during the third inning of the team's baseball game against the San Diego Padres on Friday, Aug. 17, 2018, in San Diego. Ahmed was ejected by Hoye for arguing after striking out during his at-bat. (AP PhotoGregory Bull)

Padres: LHP Clayton Richard gets the call and looks to continue a stretch of pitching five innings or more in his last four starts.

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San Diego Padres' Eric Hosmer reacts after hitting a home run during the fifth inning against the Arizona Diamondbacks in a baseball game Friday, Aug. 17, 2018, in San Diego. (AP PhotoGregory Bull)

San Diego Padres' Eric Hosmer reacts after hitting a home run during the fifth inning against the Arizona Diamondbacks in a baseball game Friday, Aug. 17, 2018, in San Diego. (AP PhotoGregory Bull)

A fan reacts after catching a home run ball hit by the San Diego Padres' Manuel Margot as Arizona Diamondbacks center fielder Jon Jay, below, looks on during the eighth inning of a baseball game Friday, Aug. 17, 2018, in San Diego. (AP PhotoGregory Bull)

A fan reacts after catching a home run ball hit by the San Diego Padres' Manuel Margot as Arizona Diamondbacks center fielder Jon Jay, below, looks on during the eighth inning of a baseball game Friday, Aug. 17, 2018, in San Diego. (AP PhotoGregory Bull)

Arizona Diamondbacks' Eduardo Escobar reacts after hitting a home run during the eighth inning against the San Diego Padres in a baseball game Friday, Aug. 17, 2018, in San Diego. (AP PhotoGregory Bull)

Arizona Diamondbacks' Eduardo Escobar reacts after hitting a home run during the eighth inning against the San Diego Padres in a baseball game Friday, Aug. 17, 2018, in San Diego. (AP PhotoGregory Bull)