A U.S.-Russian space crew blasted off Thursday to the International Space Station following a tight quarantine amid the coronavirus pandemic.

NASA astronaut Chris Cassidy and Roscosmos’ Anatoly Ivanishin and Ivan Vagner lifted off as scheduled at 1:05 p.m. (0805 GMT, 4:05 a.m. EDT) from the Russian-operated Baikonur cosmodrome in Kazakhstan. Their Soyuz MS-16 spacecraft is set to dock at the station six hours later.

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In this handout photo released by Roscosmos U.S. astronaut Chris Cassidy, left, Russian cosmonauts Anatoly Ivanishin, centre, and Ivan Vagner, members of the main crew to the International Space Station (ISS), attend a news conference at the Baikonur Cosmodrome, Kazakhstan, Wednesday, April 8, 2020. The new Soyuz mission to the International Space Station is scheduled on Thursday, April 9. (Roscosmos Space Agency Press Service via AP)

A U.S.-Russian space crew blasted off Thursday to the International Space Station following a tight quarantine amid the coronavirus pandemic.

In this handout photo released by Roscosmos Russian cosmonauts Ivan Vagner, member of the main crew to the International Space Station (ISS), seen through glass as he attends a State Committee meeting at the Baikonur Cosmodrome, Kazakhstan, Wednesday, April 8, 2020. The new Soyuz mission to the International Space Station is scheduled on Thursday, April 9. (Roscosmos Space Agency Press Service via AP)

Speaking to journalists Wednesday in a video link from Baikonur, Cassidy said the crew had been in “a very strict quarantine” for the past month and is in good health.

In this handout photo released by Roscosmos Russian cosmonauts Anatoly Ivanishin, member of the main crew to the International Space Station (ISS), seen through glass as he attends a State Committee meeting at the Baikonur Cosmodrome, Kazakhstan, Wednesday, April 8, 2020. The new Soyuz mission to the International Space Station is scheduled on Thursday, April 9. (Roscosmos Space Agency Press Service via AP)

“We’ve been completely isolated at this final stage of training,” Ivanishin said.

In this handout photo released by Roscosmos U.S. astronaut Chris Cassidy, member of the main crew to the International Space Station (ISS), seen through glass as he attends a State Committee meeting at the Baikonur Cosmodrome, Kazakhstan, Wednesday, April 8, 2020. The new Soyuz mission to the International Space Station is scheduled on Thursday, April 9. (Roscosmos Space Agency Press Service via AP)

Ivanishin and Vagner had trained as back-ups for the other two Russians and were picked for the flight only in February after a member of the original Russian crew suffered an eye injury.

In this grab taken from video footage released by Roscosmos Space Agency,  the Soyuz-2.1a rocket booster with Soyuz MS-16 space ship carrying a new crew to the International Space Station, ISS, blasts off at the Russian leased Baikonur cosmodrome, Kazakhstan, Thursday, April 9, 2020. The Russian rocket carries U.S. astronaut Chris Cassidy, Russian cosmonauts Anatoly Ivanishin and Ivan Vagner. (Roscosmos Space Agency via AP)

In this grab taken from video footage released by Roscosmos Space Agency, the Soyuz-2.1a rocket booster with Soyuz MS-16 space ship carrying a new crew to the International Space Station, ISS, blasts off at the Russian leased Baikonur cosmodrome, Kazakhstan, Thursday, April 9, 2020. The Russian rocket carries U.S. astronaut Chris Cassidy, Russian cosmonauts Anatoly Ivanishin and Ivan Vagner. (Roscosmos Space Agency via AP)

In this grab taken from video footage released by Roscosmos Space Agency the Soyuz-2.1a rocket booster with Soyuz MS-16 space ship carrying a new crew to the International Space Station, ISS, blasts off at the Russian leased Baikonur cosmodrome, Kazakhstan, Thursday, April 9, 2020. The Russian rocket carries U.S. astronaut Chris Cassidy, Russian cosmonauts Anatoly Ivanishin and Ivan Vagner. (Roscosmos Space Agency via AP)

In this grab taken from video footage released by Roscosmos Space Agency the Soyuz-2.1a rocket booster with Soyuz MS-16 space ship carrying a new crew to the International Space Station, ISS, blasts off at the Russian leased Baikonur cosmodrome, Kazakhstan, Thursday, April 9, 2020. The Russian rocket carries U.S. astronaut Chris Cassidy, Russian cosmonauts Anatoly Ivanishin and Ivan Vagner. (Roscosmos Space Agency via AP)

In this handout photo released by Roscosmos U.S. astronaut Chris Cassidy, left, Russian cosmonauts Anatoly Ivanishin, centre, and Ivan Vagner, members of the main crew to the International Space Station (ISS), pose during a news conference at the Baikonur Cosmodrome, Kazakhstan, Wednesday, April 8, 2020. The new Soyuz mission to the International Space Station is scheduled on Thursday, April 9. (Roscosmos Space Agency Press Service via AP)

In this handout photo released by Roscosmos U.S. astronaut Chris Cassidy, left, Russian cosmonauts Anatoly Ivanishin, centre, and Ivan Vagner, members of the main crew to the International Space Station (ISS), pose during a news conference at the Baikonur Cosmodrome, Kazakhstan, Wednesday, April 8, 2020. The new Soyuz mission to the International Space Station is scheduled on Thursday, April 9. (Roscosmos Space Agency Press Service via AP)

Russian space officials have taken extra precautions to protect the crew during training and pre-flight preparations as the coronavirus outbreak has swept the world.

In this handout photo released by Roscosmos U.S. astronaut Chris Cassidy, left, Russian cosmonauts Anatoly Ivanishin, centre, and Ivan Vagner, members of the main crew to the International Space Station (ISS), attend a news conference at the Baikonur Cosmodrome, Kazakhstan, Wednesday, April 8, 2020. The new Soyuz mission to the International Space Station is scheduled on Thursday, April 9. (Roscosmos Space Agency Press Service via AP)

In this handout photo released by Roscosmos U.S. astronaut Chris Cassidy, left, Russian cosmonauts Anatoly Ivanishin, centre, and Ivan Vagner, members of the main crew to the International Space Station (ISS), attend a news conference at the Baikonur Cosmodrome, Kazakhstan, Wednesday, April 8, 2020. The new Soyuz mission to the International Space Station is scheduled on Thursday, April 9. (Roscosmos Space Agency Press Service via AP)

Speaking to journalists Wednesday in a video link from Baikonur, Cassidy said the crew had been in “a very strict quarantine” for the past month and is in good health.

"We all feel fantastic,” he said.

Commander Anatoly Ivanishin also noted that extra measures have been taken to keep the crew healthy and safe before launch, adding that none of the crew has had any guests — no family or friends.

In this handout photo released by Roscosmos Russian cosmonauts Ivan Vagner, member of the main crew to the International Space Station (ISS), seen through glass as he attends a State Committee meeting at the Baikonur Cosmodrome, Kazakhstan, Wednesday, April 8, 2020. The new Soyuz mission to the International Space Station is scheduled on Thursday, April 9. (Roscosmos Space Agency Press Service via AP)

In this handout photo released by Roscosmos Russian cosmonauts Ivan Vagner, member of the main crew to the International Space Station (ISS), seen through glass as he attends a State Committee meeting at the Baikonur Cosmodrome, Kazakhstan, Wednesday, April 8, 2020. The new Soyuz mission to the International Space Station is scheduled on Thursday, April 9. (Roscosmos Space Agency Press Service via AP)

“We’ve been completely isolated at this final stage of training,” Ivanishin said.

Roscosmos director Dmitry Rogozin said earlier this week that nine employees of the state corporation have tested positive for coronavirus. Roscosmos, which controls a sprawling network of production plants and launch facilities, has about 200,000 employees, Rogozin said.

As part of additional precautions, Roscosmos has barred reporters from covering the launch contrary to usual practice.

In this handout photo released by Roscosmos Russian cosmonauts Anatoly Ivanishin, member of the main crew to the International Space Station (ISS), seen through glass as he attends a State Committee meeting at the Baikonur Cosmodrome, Kazakhstan, Wednesday, April 8, 2020. The new Soyuz mission to the International Space Station is scheduled on Thursday, April 9. (Roscosmos Space Agency Press Service via AP)

In this handout photo released by Roscosmos Russian cosmonauts Anatoly Ivanishin, member of the main crew to the International Space Station (ISS), seen through glass as he attends a State Committee meeting at the Baikonur Cosmodrome, Kazakhstan, Wednesday, April 8, 2020. The new Soyuz mission to the International Space Station is scheduled on Thursday, April 9. (Roscosmos Space Agency Press Service via AP)

Ivanishin and Vagner had trained as back-ups for the other two Russians and were picked for the flight only in February after a member of the original Russian crew suffered an eye injury.

The International Space Station is currently operated by Russian Oleg Skripochka and NASA astronauts Jessica Meir and Andrew Morgan, who are due to return to Earth on April 17.

In this handout photo released by Roscosmos U.S. astronaut Chris Cassidy, member of the main crew to the International Space Station (ISS), seen through glass as he attends a State Committee meeting at the Baikonur Cosmodrome, Kazakhstan, Wednesday, April 8, 2020. The new Soyuz mission to the International Space Station is scheduled on Thursday, April 9. (Roscosmos Space Agency Press Service via AP)

In this handout photo released by Roscosmos U.S. astronaut Chris Cassidy, member of the main crew to the International Space Station (ISS), seen through glass as he attends a State Committee meeting at the Baikonur Cosmodrome, Kazakhstan, Wednesday, April 8, 2020. The new Soyuz mission to the International Space Station is scheduled on Thursday, April 9. (Roscosmos Space Agency Press Service via AP)

In this grab taken from video footage released by Roscosmos Space Agency,  the Soyuz-2.1a rocket booster with Soyuz MS-16 space ship carrying a new crew to the International Space Station, ISS, blasts off at the Russian leased Baikonur cosmodrome, Kazakhstan, Thursday, April 9, 2020. The Russian rocket carries U.S. astronaut Chris Cassidy, Russian cosmonauts Anatoly Ivanishin and Ivan Vagner. (Roscosmos Space Agency via AP)

In this grab taken from video footage released by Roscosmos Space Agency, the Soyuz-2.1a rocket booster with Soyuz MS-16 space ship carrying a new crew to the International Space Station, ISS, blasts off at the Russian leased Baikonur cosmodrome, Kazakhstan, Thursday, April 9, 2020. The Russian rocket carries U.S. astronaut Chris Cassidy, Russian cosmonauts Anatoly Ivanishin and Ivan Vagner. (Roscosmos Space Agency via AP)

In this grab taken from video footage released by Roscosmos Space Agency the Soyuz-2.1a rocket booster with Soyuz MS-16 space ship carrying a new crew to the International Space Station, ISS, blasts off at the Russian leased Baikonur cosmodrome, Kazakhstan, Thursday, April 9, 2020. The Russian rocket carries U.S. astronaut Chris Cassidy, Russian cosmonauts Anatoly Ivanishin and Ivan Vagner. (Roscosmos Space Agency via AP)

In this grab taken from video footage released by Roscosmos Space Agency the Soyuz-2.1a rocket booster with Soyuz MS-16 space ship carrying a new crew to the International Space Station, ISS, blasts off at the Russian leased Baikonur cosmodrome, Kazakhstan, Thursday, April 9, 2020. The Russian rocket carries U.S. astronaut Chris Cassidy, Russian cosmonauts Anatoly Ivanishin and Ivan Vagner. (Roscosmos Space Agency via AP)

In this handout photo released by Roscosmos U.S. astronaut Chris Cassidy, left, Russian cosmonauts Anatoly Ivanishin, centre, and Ivan Vagner, members of the main crew to the International Space Station (ISS), pose during a news conference at the Baikonur Cosmodrome, Kazakhstan, Wednesday, April 8, 2020. The new Soyuz mission to the International Space Station is scheduled on Thursday, April 9. (Roscosmos Space Agency Press Service via AP)

In this handout photo released by Roscosmos U.S. astronaut Chris Cassidy, left, Russian cosmonauts Anatoly Ivanishin, centre, and Ivan Vagner, members of the main crew to the International Space Station (ISS), pose during a news conference at the Baikonur Cosmodrome, Kazakhstan, Wednesday, April 8, 2020. The new Soyuz mission to the International Space Station is scheduled on Thursday, April 9. (Roscosmos Space Agency Press Service via AP)