Yoan Moncada homered, José Abreu hit a three-run double and the playoff-bound Chicago White Sox beat the NL Central champion Chicago Cubs 9-5 at Guaranteed Rate Field to snap a season-high six-game losing streak Saturday.

The Cubs clinched their third division title in five years when the St. Louis Cardinals lost 3-0 to Milwaukee.

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Chicago Cubs starting pitcher Jon Lester heads to the dugout after being pulled by manager David Ross during the fourth inning of the team's baseball game against the Chicago White Sox in Chicago, Saturday, Sept. 26, 2020. (AP PhotoNam Y. Huh)

Yoan Moncada homered, José Abreu hit a three-run double and the playoff-bound Chicago White Sox beat the NL Central champion Chicago Cubs 9-5 at Guaranteed Rate Field to snap a season-high six-game losing streak Saturday.

Chicago Cubs starting pitcher Jon Lester, center, catcher Willson Contreras, left, and third baseman Kris Bryant wait for pitching coach Tommy Hottovy during the fourth inning of the team's baseball game against the Chicago White Sox in Chicago, Saturday, Sept. 26, 2020. (AP PhotoNam Y. Huh)

The White Sox need another victory Sunday over the Cubs and a Minnesota loss at home to Cincinnati to win the division title by virtue of the tiebreaker Chicago holds over the Twins.

Chicago White Sox's Jose Abreu, right, is congratulated by third base coach Nick Capra after his three-run double during the fourth inning of a baseball game against the Chicago Cubs in Chicago, Saturday, Sept. 26, 2020. Abreu had advanced to third on an error on the play. (AP PhotoNam Y. Huh)

Moncada bumped the lead to four with his two-run drive against Jason Adam in the sixth. James McCann hit a solo homer in a two-run second, and five relievers combined to hold the Cubs to two hits after Dunning lasted just three innings.

Chicago Cubs relief pitcher Jason Adam tosses a ball after Chicago White Sox's Yoan Moncada hit a two-run home run during the sixth inning of a baseball game in Chicago, Saturday, Sept. 26, 2020. (AP PhotoNam Y. Huh)

Lester got tagged for seven runs in 3 2/3 innings and gave up six hits in another rough outing against the White Sox. The five-time All-Star gave up a season-high eight runs against them in a 10-1 loss at Wrigley Field on Aug. 21. And with his six-year, $155 million contract expiring, this could be his final regular-season start with the Cubs.

Chicago White Sox's Yoan Moncada runs the bases after hitting a two-run home run during the sixth inning of the team's baseball game against the Chicago Cubs in Chicago, Saturday, Sept. 26, 2020. (AP PhotoNam Y. Huh)

White Sox: OF Eloy Jiménez (sprained right foot) is “progressing positively” and the White Sox “remain optimistic” he will be ready for the start of the playoffs, manager Rick Renteria said. Jiménez, batting .296 with 14 homers and 41 RBIs, was out of the lineup for the second straight game after he was hurt sliding across home plate at Cleveland on Thursday.

Chicago White Sox relief pitcher Garrett Crochet throws to a Chicago Cubs batter during the fifth inning of a baseball game in Chicago, Saturday, Sept. 26, 2020. (AP PhotoNam Y. Huh)

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Chicago White Sox's Yoan Moncada, left, scores on a three-run double by Jose Abreu as Chicago Cubs catcher Willson Contreras misses the throws during the fourth inning of a baseball game in Chicago, Saturday, Sept. 26, 2020. (AP PhotoNam Y. Huh)

Chicago White Sox's Yoan Moncada, left, scores on a three-run double by Jose Abreu as Chicago Cubs catcher Willson Contreras misses the throws during the fourth inning of a baseball game in Chicago, Saturday, Sept. 26, 2020. (AP PhotoNam Y. Huh)

Chicago Cubs relief pitcher Ryan Tepera pauses after Chicago White Sox's Jose Abreu, right rear, hit a three-run double and advanced to third on an error during the fourth inning of a baseball game in Chicago, Saturday, Sept. 26, 2020. (AP PhotoNam Y. Huh)

Chicago Cubs relief pitcher Ryan Tepera pauses after Chicago White Sox's Jose Abreu, right rear, hit a three-run double and advanced to third on an error during the fourth inning of a baseball game in Chicago, Saturday, Sept. 26, 2020. (AP PhotoNam Y. Huh)

Chicago White Sox's Yoan Moncada scores on a three-run double by Jose Abreu as Chicago Cubs catcher Willson Contreras misses the throw during the fourth inning of a baseball game in Chicago, Saturday, Sept. 26, 2020. (AP PhotoNam Y. Huh)

Chicago White Sox's Yoan Moncada scores on a three-run double by Jose Abreu as Chicago Cubs catcher Willson Contreras misses the throw during the fourth inning of a baseball game in Chicago, Saturday, Sept. 26, 2020. (AP PhotoNam Y. Huh)

The White Sox were on their way to a win they sorely needed by then and remained a game behind AL Central leader Minnesota, with the Twins beating Cincinnati. Chicago also took sole possession of second place, with Cleveland losing to Pittsburgh.

Chicago Cubs starting pitcher Jon Lester heads to the dugout after being pulled by manager David Ross during the fourth inning of the team's baseball game against the Chicago White Sox in Chicago, Saturday, Sept. 26, 2020. (AP PhotoNam Y. Huh)

Chicago Cubs starting pitcher Jon Lester heads to the dugout after being pulled by manager David Ross during the fourth inning of the team's baseball game against the Chicago White Sox in Chicago, Saturday, Sept. 26, 2020. (AP PhotoNam Y. Huh)

The White Sox need another victory Sunday over the Cubs and a Minnesota loss at home to Cincinnati to win the division title by virtue of the tiebreaker Chicago holds over the Twins.

Kris Bryant propelled the Cubs to a 5-2 lead, hitting a single and scoring in the second inning and launching his fifth career grand slam in the third — a long drive down the left-field line against rookie Dane Dunning.

But the South Siders took advantage of some shaky defense while chasing Jon Lester (3-3) in a five-run fourth. Abreu made it 7-5 when he greeted Ryan Tepera with a three-run double to left.

Chicago Cubs starting pitcher Jon Lester, center, catcher Willson Contreras, left, and third baseman Kris Bryant wait for pitching coach Tommy Hottovy during the fourth inning of the team's baseball game against the Chicago White Sox in Chicago, Saturday, Sept. 26, 2020. (AP PhotoNam Y. Huh)

Chicago Cubs starting pitcher Jon Lester, center, catcher Willson Contreras, left, and third baseman Kris Bryant wait for pitching coach Tommy Hottovy during the fourth inning of the team's baseball game against the Chicago White Sox in Chicago, Saturday, Sept. 26, 2020. (AP PhotoNam Y. Huh)

Moncada bumped the lead to four with his two-run drive against Jason Adam in the sixth. James McCann hit a solo homer in a two-run second, and five relievers combined to hold the Cubs to two hits after Dunning lasted just three innings.

The 25-year-old right-hander gave up five runs — four earned — and three hits. He walked three and hit a batter with a pitch.

Matt Foster (6-1) worked a perfect fourth and got the win.

Chicago White Sox's Jose Abreu, right, is congratulated by third base coach Nick Capra after his three-run double during the fourth inning of a baseball game against the Chicago Cubs in Chicago, Saturday, Sept. 26, 2020. Abreu had advanced to third on an error on the play. (AP PhotoNam Y. Huh)

Chicago White Sox's Jose Abreu, right, is congratulated by third base coach Nick Capra after his three-run double during the fourth inning of a baseball game against the Chicago Cubs in Chicago, Saturday, Sept. 26, 2020. Abreu had advanced to third on an error on the play. (AP PhotoNam Y. Huh)

Lester got tagged for seven runs in 3 2/3 innings and gave up six hits in another rough outing against the White Sox. The five-time All-Star gave up a season-high eight runs against them in a 10-1 loss at Wrigley Field on Aug. 21. And with his six-year, $155 million contract expiring, this could be his final regular-season start with the Cubs.

TRAINER'S ROOM

Cubs: Bryant (lower right oblique tightness) was back in the lineup after missing four games. ... Manager David Ross said INF David Bote was available after missing Friday's game with an undisclosed injury.

Chicago Cubs relief pitcher Jason Adam tosses a ball after Chicago White Sox's Yoan Moncada hit a two-run home run during the sixth inning of a baseball game in Chicago, Saturday, Sept. 26, 2020. (AP PhotoNam Y. Huh)

Chicago Cubs relief pitcher Jason Adam tosses a ball after Chicago White Sox's Yoan Moncada hit a two-run home run during the sixth inning of a baseball game in Chicago, Saturday, Sept. 26, 2020. (AP PhotoNam Y. Huh)

White Sox: OF Eloy Jiménez (sprained right foot) is “progressing positively” and the White Sox “remain optimistic” he will be ready for the start of the playoffs, manager Rick Renteria said. Jiménez, batting .296 with 14 homers and 41 RBIs, was out of the lineup for the second straight game after he was hurt sliding across home plate at Cleveland on Thursday.

UP NEXT

The two teams close out the regular season, with RHP Adbert Alzolay (0-1, 3.31 ERA) starting for the Cubs and RHP Reynaldo Lopez (1-2, 4.68) for the White Sox. Alzolay has 21 strikeouts in 16 1/3 innings over five appearances — three starts. Lopez has a 2.35 ERA in his past three starts.

Chicago White Sox's Yoan Moncada runs the bases after hitting a two-run home run during the sixth inning of the team's baseball game against the Chicago Cubs in Chicago, Saturday, Sept. 26, 2020. (AP PhotoNam Y. Huh)

Chicago White Sox's Yoan Moncada runs the bases after hitting a two-run home run during the sixth inning of the team's baseball game against the Chicago Cubs in Chicago, Saturday, Sept. 26, 2020. (AP PhotoNam Y. Huh)

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Chicago White Sox relief pitcher Garrett Crochet throws to a Chicago Cubs batter during the fifth inning of a baseball game in Chicago, Saturday, Sept. 26, 2020. (AP PhotoNam Y. Huh)

Chicago White Sox relief pitcher Garrett Crochet throws to a Chicago Cubs batter during the fifth inning of a baseball game in Chicago, Saturday, Sept. 26, 2020. (AP PhotoNam Y. Huh)

Chicago White Sox's Yoan Moncada, left, scores on a three-run double by Jose Abreu as Chicago Cubs catcher Willson Contreras misses the throws during the fourth inning of a baseball game in Chicago, Saturday, Sept. 26, 2020. (AP PhotoNam Y. Huh)

Chicago White Sox's Yoan Moncada, left, scores on a three-run double by Jose Abreu as Chicago Cubs catcher Willson Contreras misses the throws during the fourth inning of a baseball game in Chicago, Saturday, Sept. 26, 2020. (AP PhotoNam Y. Huh)

Chicago Cubs relief pitcher Ryan Tepera pauses after Chicago White Sox's Jose Abreu, right rear, hit a three-run double and advanced to third on an error during the fourth inning of a baseball game in Chicago, Saturday, Sept. 26, 2020. (AP PhotoNam Y. Huh)

Chicago Cubs relief pitcher Ryan Tepera pauses after Chicago White Sox's Jose Abreu, right rear, hit a three-run double and advanced to third on an error during the fourth inning of a baseball game in Chicago, Saturday, Sept. 26, 2020. (AP PhotoNam Y. Huh)

Chicago White Sox's Yoan Moncada scores on a three-run double by Jose Abreu as Chicago Cubs catcher Willson Contreras misses the throw during the fourth inning of a baseball game in Chicago, Saturday, Sept. 26, 2020. (AP PhotoNam Y. Huh)

Chicago White Sox's Yoan Moncada scores on a three-run double by Jose Abreu as Chicago Cubs catcher Willson Contreras misses the throw during the fourth inning of a baseball game in Chicago, Saturday, Sept. 26, 2020. (AP PhotoNam Y. Huh)