The Orioles fell to the Toronto Blue Jays 6-4 Tuesday night, dropping their 108th game, a team record for losses since they arrived in Baltimore in 1954.

The 1988 Orioles, who opened the season 0-21, held the previous team record for losses with a 54-107 finish. The overall franchise record for defeats is 111, set by the 1939 St. Louis Browns — a mark this year's team could still eclipse.

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Baltimore Orioles relief pitcher Paul Fry walks off the field after the seventh inning of a baseball game against the Toronto Blue Jays, Tuesday, Sept. 18, 2018, in Baltimore. Toronto scored four runs against Fry in the seventh, and went on to win 6-4. (AP PhotoPatrick Semansky)

The Orioles fell to the Toronto Blue Jays 6-4 Tuesday night, dropping their 108th game, a team record for losses since they arrived in Baltimore in 1954.

Toronto Blue Jays' Aledmys Diaz high-fives teammates in the dugout after hitting a solo home run in the ninth inning of a baseball game against the Baltimore Orioles, Monday, Sept. 17, 2018, in Baltimore. (AP PhotoPatrick Semansky)

Dylan Bundy (8-15) started strong for the Orioles before being lifted with two outs in the seventh as the game unraveled. He was charged with five runs (two earned), seven hits and six strikeouts. Bundy did not allow a home run for the first time since June 23, a span of 13 consecutive starts.

Toronto Blue Jays starting pitcher Aaron Sanchez throws to the Baltimore Orioles in the second inning of a baseball game, Tuesday, Sept. 18, 2018, in Baltimore. (AP PhotoPatrick Semansky)

The Orioles extended the lead ito 4-0 off Aaron Sanchez in the fourth. Trey Mancini led off with a triple and scored on a sacrifice fly by Breyvic Valera. Maninci was initially called out, but a review showed he touched the plate before catcher Reese McGuire applied the tag. DJ Stewart followed with his first career single and Chris Davis scored on a throwing error by right fielder Billy McKinney. Stewart scored on a throwing error by Sanchez.

Baltimore Orioles manager Buck Showalter stands in the dugout in the seventh inning of a baseball game against the Toronto Blue Jays, Tuesday, Sept. 18, 2018, in Baltimore. Toronto won 6-4. (AP PhotoPatrick Semansky)

Orioles: RHP Alex Cobb (blister) threw off a mound, but there is no timetable for his return. RHP Andrew Cashner is making progress with his injured knee, but manager Buck Showalter was uncertain if he will be pitch again this season. "Obviously, they're both going to be with us next year and that will take precedent, to make sure that it's in the best interest of their health," Showalter said. . Rookie RHP Luis Ortiz (hamstring) will not pitch over the final two weeks.

Toronto Blue Jays' Lourdes Gurriel Jr. singles in the seventh inning of a baseball game against the Baltimore Orioles, Tuesday, Sept. 18, 2018, in Baltimore. Reese McGuire and Teoscar Hernandez scored on the play. Toronto won 6-4. (AP PhotoPatrick Semansky)

Orioles: With several pitchers sidelined with injuries, Showalter is still mulling his options for a starter.

Toronto Blue Jays manager John Gibbons sits in the dugout before a baseball game against the Baltimore Orioles, Tuesday, Sept. 18, 2018, in Baltimore. (AP PhotoPatrick Semansky)

Toronto Blue Jays manager John Gibbons sits in the dugout before a baseball game against the Baltimore Orioles, Tuesday, Sept. 18, 2018, in Baltimore. (AP PhotoPatrick Semansky)

Baltimore Orioles' Cedric Mullins swings during an at-bat as he wears a jersey featuring his name in braille in the first inning of a baseball game against the Toronto Blue Jays, Tuesday, Sept. 18, 2018, in Baltimore. The Orioles wore first-of-their kind big league jerseys with their names spelled in braille, for its National Federation of the Blind Night. (AP PhotoPatrick Semansky)

Baltimore Orioles' Cedric Mullins swings during an at-bat as he wears a jersey featuring his name in braille in the first inning of a baseball game against the Toronto Blue Jays, Tuesday, Sept. 18, 2018, in Baltimore. The Orioles wore first-of-their kind big league jerseys with their names spelled in braille, for its National Federation of the Blind Night. (AP PhotoPatrick Semansky)

Toronto Blue Jays shortstop Lourdes Gurriel Jr., left, tags out Baltimore Orioles' Adam Jones as Jones attempts to steal second in the first inning of a baseball game, Tuesday, Sept. 18, 2018, in Baltimore. (AP PhotoPatrick Semansky)

Toronto Blue Jays shortstop Lourdes Gurriel Jr., left, tags out Baltimore Orioles' Adam Jones as Jones attempts to steal second in the first inning of a baseball game, Tuesday, Sept. 18, 2018, in Baltimore. (AP PhotoPatrick Semansky)

Baltimore Orioles' Adam Jones wears a jersey that reads "Orioles" in Braille during a baseball game against the Toronto Blue Jays, Tuesday, Sept. 18, 2018, in Baltimore. The Orioles wore first-of-their kind big league jerseys with their names spelled in Braille, for its National Federation of the Blind Night. (AP PhotoPatrick Semansky)

Baltimore Orioles' Adam Jones wears a jersey that reads "Orioles" in Braille during a baseball game against the Toronto Blue Jays, Tuesday, Sept. 18, 2018, in Baltimore. The Orioles wore first-of-their kind big league jerseys with their names spelled in Braille, for its National Federation of the Blind Night. (AP PhotoPatrick Semansky)

Baltimore Orioles' Cedric Mullins, right, rounds the bases after hitting a solo home run in the first inning of a baseball game against the Toronto Blue Jays, Tuesday, Sept. 18, 2018, in Baltimore. (AP PhotoPatrick Semansky)

Baltimore Orioles' Cedric Mullins, right, rounds the bases after hitting a solo home run in the first inning of a baseball game against the Toronto Blue Jays, Tuesday, Sept. 18, 2018, in Baltimore. (AP PhotoPatrick Semansky)

Baltimore Orioles starting pitcher Dylan Bundy throws to the Toronto Blue Jays in the first inning of a baseball game, Tuesday, Sept. 18, 2018, in Baltimore. (AP PhotoPatrick Semansky)

Baltimore Orioles starting pitcher Dylan Bundy throws to the Toronto Blue Jays in the first inning of a baseball game, Tuesday, Sept. 18, 2018, in Baltimore. (AP PhotoPatrick Semansky)

The Orioles led 4-2 in the seventh before a throwing error by third baseman Steve Wilkerson on a grounder by Teoscar Hernández allowed two runs to score. Lourdes Gurriel Jr. followed with a two-RBI single off reliever Paul Fry that that gave Toronto a 6-4 lead.

Baltimore Orioles relief pitcher Paul Fry walks off the field after the seventh inning of a baseball game against the Toronto Blue Jays, Tuesday, Sept. 18, 2018, in Baltimore. Toronto scored four runs against Fry in the seventh, and went on to win 6-4. (AP PhotoPatrick Semansky)

Baltimore Orioles relief pitcher Paul Fry walks off the field after the seventh inning of a baseball game against the Toronto Blue Jays, Tuesday, Sept. 18, 2018, in Baltimore. Toronto scored four runs against Fry in the seventh, and went on to win 6-4. (AP PhotoPatrick Semansky)

Dylan Bundy (8-15) started strong for the Orioles before being lifted with two outs in the seventh as the game unraveled. He was charged with five runs (two earned), seven hits and six strikeouts. Bundy did not allow a home run for the first time since June 23, a span of 13 consecutive starts.

Reliever Jake Petricka (3-1) pitched two scoreless innings. Tyler Clippard held the Orioles in the eighth, and Ken Giles earned his 23rd save.

Cedric Mullins led off the first inning with his fourth home run for Baltimore.

Toronto Blue Jays' Aledmys Diaz high-fives teammates in the dugout after hitting a solo home run in the ninth inning of a baseball game against the Baltimore Orioles, Monday, Sept. 17, 2018, in Baltimore. (AP PhotoPatrick Semansky)

Toronto Blue Jays' Aledmys Diaz high-fives teammates in the dugout after hitting a solo home run in the ninth inning of a baseball game against the Baltimore Orioles, Monday, Sept. 17, 2018, in Baltimore. (AP PhotoPatrick Semansky)

The Orioles extended the lead ito 4-0 off Aaron Sanchez in the fourth. Trey Mancini led off with a triple and scored on a sacrifice fly by Breyvic Valera. Maninci was initially called out, but a review showed he touched the plate before catcher Reese McGuire applied the tag. DJ Stewart followed with his first career single and Chris Davis scored on a throwing error by right fielder Billy McKinney. Stewart scored on a throwing error by Sanchez.

The Blue Jays got on the board in the fifth on an RBI single by Dwight Smith Jr. A fielder's choice by Justin Smoak an inning later cut the margin to 4-2.

TRAINER'S ROOM

Toronto Blue Jays starting pitcher Aaron Sanchez throws to the Baltimore Orioles in the second inning of a baseball game, Tuesday, Sept. 18, 2018, in Baltimore. (AP PhotoPatrick Semansky)

Toronto Blue Jays starting pitcher Aaron Sanchez throws to the Baltimore Orioles in the second inning of a baseball game, Tuesday, Sept. 18, 2018, in Baltimore. (AP PhotoPatrick Semansky)

Orioles: RHP Alex Cobb (blister) threw off a mound, but there is no timetable for his return. RHP Andrew Cashner is making progress with his injured knee, but manager Buck Showalter was uncertain if he will be pitch again this season. "Obviously, they're both going to be with us next year and that will take precedent, to make sure that it's in the best interest of their health," Showalter said. . Rookie RHP Luis Ortiz (hamstring) will not pitch over the final two weeks.

UP NEXT

Blue Jays: Marco Estrada (7-12, 5.75 ERA) wasn't scheduled to pitch until Thursday, but he threw only 55 pitches in his last outing against the Yankees, allowing eight runs and six hits.

Baltimore Orioles manager Buck Showalter stands in the dugout in the seventh inning of a baseball game against the Toronto Blue Jays, Tuesday, Sept. 18, 2018, in Baltimore. Toronto won 6-4. (AP PhotoPatrick Semansky)

Baltimore Orioles manager Buck Showalter stands in the dugout in the seventh inning of a baseball game against the Toronto Blue Jays, Tuesday, Sept. 18, 2018, in Baltimore. Toronto won 6-4. (AP PhotoPatrick Semansky)

Orioles: With several pitchers sidelined with injuries, Showalter is still mulling his options for a starter.

Toronto Blue Jays' Lourdes Gurriel Jr. singles in the seventh inning of a baseball game against the Baltimore Orioles, Tuesday, Sept. 18, 2018, in Baltimore. Reese McGuire and Teoscar Hernandez scored on the play. Toronto won 6-4. (AP PhotoPatrick Semansky)

Toronto Blue Jays' Lourdes Gurriel Jr. singles in the seventh inning of a baseball game against the Baltimore Orioles, Tuesday, Sept. 18, 2018, in Baltimore. Reese McGuire and Teoscar Hernandez scored on the play. Toronto won 6-4. (AP PhotoPatrick Semansky)

Toronto Blue Jays manager John Gibbons sits in the dugout before a baseball game against the Baltimore Orioles, Tuesday, Sept. 18, 2018, in Baltimore. (AP PhotoPatrick Semansky)

Toronto Blue Jays manager John Gibbons sits in the dugout before a baseball game against the Baltimore Orioles, Tuesday, Sept. 18, 2018, in Baltimore. (AP PhotoPatrick Semansky)

Baltimore Orioles' Cedric Mullins swings during an at-bat as he wears a jersey featuring his name in braille in the first inning of a baseball game against the Toronto Blue Jays, Tuesday, Sept. 18, 2018, in Baltimore. The Orioles wore first-of-their kind big league jerseys with their names spelled in braille, for its National Federation of the Blind Night. (AP PhotoPatrick Semansky)

Baltimore Orioles' Cedric Mullins swings during an at-bat as he wears a jersey featuring his name in braille in the first inning of a baseball game against the Toronto Blue Jays, Tuesday, Sept. 18, 2018, in Baltimore. The Orioles wore first-of-their kind big league jerseys with their names spelled in braille, for its National Federation of the Blind Night. (AP PhotoPatrick Semansky)

Toronto Blue Jays shortstop Lourdes Gurriel Jr., left, tags out Baltimore Orioles' Adam Jones as Jones attempts to steal second in the first inning of a baseball game, Tuesday, Sept. 18, 2018, in Baltimore. (AP PhotoPatrick Semansky)

Toronto Blue Jays shortstop Lourdes Gurriel Jr., left, tags out Baltimore Orioles' Adam Jones as Jones attempts to steal second in the first inning of a baseball game, Tuesday, Sept. 18, 2018, in Baltimore. (AP PhotoPatrick Semansky)

Baltimore Orioles' Adam Jones wears a jersey that reads "Orioles" in Braille during a baseball game against the Toronto Blue Jays, Tuesday, Sept. 18, 2018, in Baltimore. The Orioles wore first-of-their kind big league jerseys with their names spelled in Braille, for its National Federation of the Blind Night. (AP PhotoPatrick Semansky)

Baltimore Orioles' Adam Jones wears a jersey that reads "Orioles" in Braille during a baseball game against the Toronto Blue Jays, Tuesday, Sept. 18, 2018, in Baltimore. The Orioles wore first-of-their kind big league jerseys with their names spelled in Braille, for its National Federation of the Blind Night. (AP PhotoPatrick Semansky)

Baltimore Orioles' Cedric Mullins, right, rounds the bases after hitting a solo home run in the first inning of a baseball game against the Toronto Blue Jays, Tuesday, Sept. 18, 2018, in Baltimore. (AP PhotoPatrick Semansky)

Baltimore Orioles' Cedric Mullins, right, rounds the bases after hitting a solo home run in the first inning of a baseball game against the Toronto Blue Jays, Tuesday, Sept. 18, 2018, in Baltimore. (AP PhotoPatrick Semansky)

Baltimore Orioles starting pitcher Dylan Bundy throws to the Toronto Blue Jays in the first inning of a baseball game, Tuesday, Sept. 18, 2018, in Baltimore. (AP PhotoPatrick Semansky)

Baltimore Orioles starting pitcher Dylan Bundy throws to the Toronto Blue Jays in the first inning of a baseball game, Tuesday, Sept. 18, 2018, in Baltimore. (AP PhotoPatrick Semansky)