Former champion Sevilla became the first team to reach the round of 16 in the Europa League with a 2-0 victory over Lazio on Wednesday in a game that saw both sides have a player sent off.

Sevilla advanced 3-0 on aggregate following a 1-0 victory in the first leg in Rome last week.

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Sevilla's Wissam Ben Yedder celebrates after scoring his side's opening goal during the Europa League round of 32 second leg soccer match between Sevilla and Lazio at the Sanchez Pizjuan stadium, in Seville, Spain, Wednesday, Feb. 20, 2019. (AP PhotoMiguel Morenatti)

Former champion Sevilla became the first team to reach the round of 16 in the Europa League with a 2-0 victory over Lazio on Wednesday in a game that saw both sides have a player sent off.

Sevilla's Wissam Ben Yedder, left, duels for the ball with Lazio's Francesco Acerbi during the Europa League round of 32 second leg soccer match between Sevilla and Lazio at the Sanchez Pizjuan stadium, in Seville, Spain, Wednesday, Feb. 20, 2019. (AP PhotoMiguel Morenatti)

Sevilla striker Wissam Ben Yedder struck 20 minutes into the match on a rebound after Lazio goalkeeper Thomas Strakosha parried a low shot from Pablo Sarabia. Ben Yedder also scored in the first leg.

Sevilla's Wissam Ben Yedder, third left, celebrates with teammates after scoring his side's opening goal during the Europa League round of 32 second leg soccer match between Sevilla and Lazio at the Sanchez Pizjuan stadium, in Seville, Spain, Wednesday, Feb. 20, 2019. (AP PhotoMiguel Morenatti)

Lazio fell to a third straight loss in all competitions.

Sevilla fans support their team during the Europa League round of 32 second leg soccer match between Sevilla and Lazio at the Sanchez Pizjuan stadium, in Seville, Spain, Wednesday, Feb. 20, 2019. (AP PhotoMiguel Morenatti)

Sevilla fans support their team during the Europa League round of 32 second leg soccer match between Sevilla and Lazio at the Sanchez Pizjuan stadium, in Seville, Spain, Wednesday, Feb. 20, 2019. (AP PhotoMiguel Morenatti)

Lazio players pose for a team picture before the Europa League round of 32 second leg soccer match between Sevilla and Lazio at the Sanchez Pizjuan stadium, in Seville, Spain, Wednesday, Feb. 20, 2019. (AP PhotoMiguel Morenatti)

Lazio players pose for a team picture before the Europa League round of 32 second leg soccer match between Sevilla and Lazio at the Sanchez Pizjuan stadium, in Seville, Spain, Wednesday, Feb. 20, 2019. (AP PhotoMiguel Morenatti)

Sevilla coach Pablo Machin, left, speaks with Lazio coach Simone Inzaghi prior the Europa League round of 32 second leg soccer match between Sevilla and Lazio at the Sanchez Pizjuan stadium, in Seville, Spain, Wednesday, Feb. 20, 2019. (AP PhotoMiguel Morenatti)

Sevilla coach Pablo Machin, left, speaks with Lazio coach Simone Inzaghi prior the Europa League round of 32 second leg soccer match between Sevilla and Lazio at the Sanchez Pizjuan stadium, in Seville, Spain, Wednesday, Feb. 20, 2019. (AP PhotoMiguel Morenatti)

Referee Anthony Taylor, right, shows a red card to Sevilla's Franco Vazquez, second right, during the Europa League round of 32 second leg soccer match between Sevilla and Lazio at the Sanchez Pizjuan stadium, in Seville, Spain, Wednesday, Feb. 20, 2019. (AP PhotoMiguel Morenatti)

Referee Anthony Taylor, right, shows a red card to Sevilla's Franco Vazquez, second right, during the Europa League round of 32 second leg soccer match between Sevilla and Lazio at the Sanchez Pizjuan stadium, in Seville, Spain, Wednesday, Feb. 20, 2019. (AP PhotoMiguel Morenatti)

Lazio's Ciro Immobile reacts after missing a chance to score during the Europa League round of 32 second leg soccer match between Sevilla and Lazio at the Sanchez Pizjuan stadium, in Seville, Spain, Wednesday, Feb. 20, 2019. (AP PhotoMiguel Morenatti)

Lazio's Ciro Immobile reacts after missing a chance to score during the Europa League round of 32 second leg soccer match between Sevilla and Lazio at the Sanchez Pizjuan stadium, in Seville, Spain, Wednesday, Feb. 20, 2019. (AP PhotoMiguel Morenatti)

Sevilla's Franco Vazquez leaves the field during the Europa League round of 32 second leg soccer match between Sevilla and Lazio at the Sanchez Pizjuan stadium, in Seville, Spain, Wednesday, Feb. 20, 2019. (AP PhotoMiguel Morenatti)

Sevilla's Franco Vazquez leaves the field during the Europa League round of 32 second leg soccer match between Sevilla and Lazio at the Sanchez Pizjuan stadium, in Seville, Spain, Wednesday, Feb. 20, 2019. (AP PhotoMiguel Morenatti)

The home side was reduced to 10 men when Franco Vazquez received his second yellow card on the hour-mark but Lazio followed suit 11 minutes later when Adam Marusic got a straight red.

Sevilla's Wissam Ben Yedder celebrates after scoring his side's opening goal during the Europa League round of 32 second leg soccer match between Sevilla and Lazio at the Sanchez Pizjuan stadium, in Seville, Spain, Wednesday, Feb. 20, 2019. (AP PhotoMiguel Morenatti)

Sevilla's Wissam Ben Yedder celebrates after scoring his side's opening goal during the Europa League round of 32 second leg soccer match between Sevilla and Lazio at the Sanchez Pizjuan stadium, in Seville, Spain, Wednesday, Feb. 20, 2019. (AP PhotoMiguel Morenatti)

Sevilla striker Wissam Ben Yedder struck 20 minutes into the match on a rebound after Lazio goalkeeper Thomas Strakosha parried a low shot from Pablo Sarabia. Ben Yedder also scored in the first leg.

Sarabia doubled the advantage in the 78th.

Sevilla has a perfect home record in the Europa League this season with seven wins, including the qualifying phase. It has three Europa League titles and also won the tournament twice when it was known as the UEFA Cup.

Sevilla's Wissam Ben Yedder, left, duels for the ball with Lazio's Francesco Acerbi during the Europa League round of 32 second leg soccer match between Sevilla and Lazio at the Sanchez Pizjuan stadium, in Seville, Spain, Wednesday, Feb. 20, 2019. (AP PhotoMiguel Morenatti)

Sevilla's Wissam Ben Yedder, left, duels for the ball with Lazio's Francesco Acerbi during the Europa League round of 32 second leg soccer match between Sevilla and Lazio at the Sanchez Pizjuan stadium, in Seville, Spain, Wednesday, Feb. 20, 2019. (AP PhotoMiguel Morenatti)

Lazio fell to a third straight loss in all competitions.

The remaining 15 second-leg games in the round of 32 are scheduled for Thursday.

More AP soccer: https://apnews.com/apf-Soccer and https://twitter.com/AP_Sports

Sevilla's Wissam Ben Yedder, third left, celebrates with teammates after scoring his side's opening goal during the Europa League round of 32 second leg soccer match between Sevilla and Lazio at the Sanchez Pizjuan stadium, in Seville, Spain, Wednesday, Feb. 20, 2019. (AP PhotoMiguel Morenatti)

Sevilla's Wissam Ben Yedder, third left, celebrates with teammates after scoring his side's opening goal during the Europa League round of 32 second leg soccer match between Sevilla and Lazio at the Sanchez Pizjuan stadium, in Seville, Spain, Wednesday, Feb. 20, 2019. (AP PhotoMiguel Morenatti)

Sevilla fans support their team during the Europa League round of 32 second leg soccer match between Sevilla and Lazio at the Sanchez Pizjuan stadium, in Seville, Spain, Wednesday, Feb. 20, 2019. (AP PhotoMiguel Morenatti)

Sevilla fans support their team during the Europa League round of 32 second leg soccer match between Sevilla and Lazio at the Sanchez Pizjuan stadium, in Seville, Spain, Wednesday, Feb. 20, 2019. (AP PhotoMiguel Morenatti)

Lazio players pose for a team picture before the Europa League round of 32 second leg soccer match between Sevilla and Lazio at the Sanchez Pizjuan stadium, in Seville, Spain, Wednesday, Feb. 20, 2019. (AP PhotoMiguel Morenatti)

Lazio players pose for a team picture before the Europa League round of 32 second leg soccer match between Sevilla and Lazio at the Sanchez Pizjuan stadium, in Seville, Spain, Wednesday, Feb. 20, 2019. (AP PhotoMiguel Morenatti)

Sevilla coach Pablo Machin, left, speaks with Lazio coach Simone Inzaghi prior the Europa League round of 32 second leg soccer match between Sevilla and Lazio at the Sanchez Pizjuan stadium, in Seville, Spain, Wednesday, Feb. 20, 2019. (AP PhotoMiguel Morenatti)

Sevilla coach Pablo Machin, left, speaks with Lazio coach Simone Inzaghi prior the Europa League round of 32 second leg soccer match between Sevilla and Lazio at the Sanchez Pizjuan stadium, in Seville, Spain, Wednesday, Feb. 20, 2019. (AP PhotoMiguel Morenatti)

Referee Anthony Taylor, right, shows a red card to Sevilla's Franco Vazquez, second right, during the Europa League round of 32 second leg soccer match between Sevilla and Lazio at the Sanchez Pizjuan stadium, in Seville, Spain, Wednesday, Feb. 20, 2019. (AP PhotoMiguel Morenatti)

Referee Anthony Taylor, right, shows a red card to Sevilla's Franco Vazquez, second right, during the Europa League round of 32 second leg soccer match between Sevilla and Lazio at the Sanchez Pizjuan stadium, in Seville, Spain, Wednesday, Feb. 20, 2019. (AP PhotoMiguel Morenatti)

Lazio's Ciro Immobile reacts after missing a chance to score during the Europa League round of 32 second leg soccer match between Sevilla and Lazio at the Sanchez Pizjuan stadium, in Seville, Spain, Wednesday, Feb. 20, 2019. (AP PhotoMiguel Morenatti)

Lazio's Ciro Immobile reacts after missing a chance to score during the Europa League round of 32 second leg soccer match between Sevilla and Lazio at the Sanchez Pizjuan stadium, in Seville, Spain, Wednesday, Feb. 20, 2019. (AP PhotoMiguel Morenatti)

Sevilla's Franco Vazquez leaves the field during the Europa League round of 32 second leg soccer match between Sevilla and Lazio at the Sanchez Pizjuan stadium, in Seville, Spain, Wednesday, Feb. 20, 2019. (AP PhotoMiguel Morenatti)

Sevilla's Franco Vazquez leaves the field during the Europa League round of 32 second leg soccer match between Sevilla and Lazio at the Sanchez Pizjuan stadium, in Seville, Spain, Wednesday, Feb. 20, 2019. (AP PhotoMiguel Morenatti)