Asian shares were mostly lower Friday after a slide on Wall Street as nervous investors eyed U.S.-China trade talks in Washington.

Japan's benchmark Nikkei 225 slipped 0.3 percent to 21,402.57 in morning trading. Australia's S&P/ASX 200 gained 0.4 percent to 6,165.00. South Korea's Kospi fell 0.4 percent to 2,220.23, while Hong Kong's Hang Seng shed 0.3 percent to 28,545.23. The Shanghai Composite was flat at 2,752.62.

Health care and energy companies led U.S. stocks lower. The S&P 500, which has risen for the past three weeks, fell 0.4 percent to 2,774.88. The Dow Jones Industrial Average also lost 0.4 percent, to 25,850.63. The Nasdaq composite declined 0.4 percent to 7,459.71 while the Russell 2000 index of smaller companies gave up 0.4 percent to 1,575.55.

A visitor sits in front of private stock trading boards at a private stock market gallery in Kuala Lumpur, Malaysia, Friday, Feb. 22, 2019. Asian shares were mostly lower Friday after a slide on Wall Street as investors nervously watched the U.S.-China trade talks in Washington. (AP PhotoYam G-Jun)

A visitor sits in front of private stock trading boards at a private stock market gallery in Kuala Lumpur, Malaysia, Friday, Feb. 22, 2019. Asian shares were mostly lower Friday after a slide on Wall Street as investors nervously watched the U.S.-China trade talks in Washington. (AP PhotoYam G-Jun)

A hodge-podge of recent economic data is fueling concerns over risks to global growth. The U.S. Labor Department said fewer workers applied for unemployment benefits last week than economists expected, an encouraging sign. But investors are cautious about business conditions going forward as signs of weakness in the global economy emerge. The long-running, costly trade dispute between the U.S. and China has also clouded the outlook.

The world's two biggest economies are locked in a trade war spurred by U.S. contentions that China uses predatory tactics in a quest to overtake U.S. technological dominance, including pressuring American companies to hand over trade secrets and in some cases stealing them outright.

The Trump administration has warned it will increase its import taxes on $200 billion in Chinese goods from 10 percent to 25 percent if the two sides haven't reached a resolution by March 2. But Trump in recent days has signaled a willingness to extend the deadline if negotiators are making progress.

Visitors sit in front of private stock trading boards at a private stock market gallery in Kuala Lumpur, Malaysia, Friday, Feb. 22, 2019. Asian shares were mostly lower Friday after a slide on Wall Street as investors nervously watched the U.S.-China trade talks in Washington. (AP PhotoYam G-Jun)

Visitors sit in front of private stock trading boards at a private stock market gallery in Kuala Lumpur, Malaysia, Friday, Feb. 22, 2019. Asian shares were mostly lower Friday after a slide on Wall Street as investors nervously watched the U.S.-China trade talks in Washington. (AP PhotoYam G-Jun)

"The trade talks do appear to have made some progress, however, but a run of weak data from Japan, Europe and the U.S. yesterday took the wind out of the equity market sails," said Jeffrey Halley, senior market analyst at OANDA.

ENERGY: Benchmark U.S. crude fell 10 cents to $56.86 a barrel in electronic trading on the New York Mercantile Exchange. It slid 0.3 percent to settle at $56.96 a barrel in New York. Brent crude, used to price international oils, slid 18 cents to $66.89 a barrel.

CURRENCIES: The dollar rose to 110.78 yen from 110.70 yen on Thursday. The euro weakened to $1.1335 from $1.1338.

Yuri Kageyama is on Twitter at https://twitter.com/yurikageyama

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