Khris Davis, Robbie Grossman and Stephen Piscotty homered in a 10-run sixth inning, and the Oakland Athletics hit six home runs overall in a 16-2 rout of the Baltimore Orioles on Tuesday night.

Ramón Laureano, Chad Pinder and Beau Taylor also homered as the A's set a season-high for home runs. It's the first time that Oakland has had six home runs in a game since June 17, 2008.

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Baltimore Orioles pitcher Dan Straily, front, reacts after allowing a three-run home run to Oakland Athletics' Stephen Piscotty during the sixth inning of a baseball game in Oakland, Calif., Tuesday, June 18, 2019. At rear is Athletics' Robbie Grossman. (AP PhotoJeff Chiu)

Khris Davis, Robbie Grossman and Stephen Piscotty homered in a 10-run sixth inning, and the Oakland Athletics hit six home runs overall in a 16-2 rout of the Baltimore Orioles on Tuesday night.

Oakland Athletics' Beau Taylor watches his solo home run against the Baltimore Orioles during the third inning of a baseball game in Oakland, Calif., Tuesday, June 18, 2019. (AP PhotoJeff Chiu)

Laureano finished with four hits and made a terrific running catch before crashing into the center field wall. Matt Olson added two hits and scored twice.

Baltimore Orioles pitcher Gabriel Ynoa throws to an Oakland Athletics batter during the first inning of a baseball game in Oakland, Calif., Tuesday, June 18, 2019. (AP PhotoJeff Chiu)

Laureano hit a three-run drive in the fourth, then the A's sent 13 men to the plate during a 24-minute sixth inning.

Oakland Athletics' Blake Treinen celebrates the 3-2 win over the Baltimore Orioles at the end of a baseball game, Monday, June 17, 2019, in Oakland, Calif. (AP PhotoBen Margot)

Pinder homered as a pinch-hitter in the seventh.

Oakland Athletics' Beau Taylor, right, is congratulated by third base coach Matt Williams after hitting a solo home run against the Baltimore Orioles during the third inning of a baseball game in Oakland, Calif., Tuesday, June 18, 2019. (AP PhotoJeff Chiu)

TRAINERS ROOM

Oakland Athletics' Ramon Laureano, center, celebrates after hitting a three-run home run that scored Khris Davis (2) and Matt Olson, right, during the fourth inning of the team's baseball game against the Baltimore Orioles in Oakland, Calif., Tuesday, June 18, 2019. (AP PhotoJeff Chiu)

Oakland RHP Chris Bassitt (3-3, 3.68 ERA) starts the series finale Wednesday afternoon. Bassitt has one win in two starts against Baltimore. The Orioles plan to use RHP Jimmy Yacabonis (1-1, 5.40) as an opener, with Josh Rogers to follow.

Baltimore Orioles' Jonathan Villar (2) is congratulated by teammates after hitting a solo home run against the Oakland Athletics during the fifth inning of a baseball game in Oakland, Calif., Tuesday, June 18, 2019. (AP PhotoJeff Chiu)

Baltimore Orioles' Jonathan Villar (2) is congratulated by teammates after hitting a solo home run against the Oakland Athletics during the fifth inning of a baseball game in Oakland, Calif., Tuesday, June 18, 2019. (AP PhotoJeff Chiu)

Oakland Athletics' Robbie Grossman (8) is congratulated for his two-run home run that scored Ramon Laureano (22) during the sixth inning of a baseball game against the Baltimore Orioles in Oakland, Calif., Tuesday, June 18, 2019. (AP PhotoJeff Chiu)

Oakland Athletics' Robbie Grossman (8) is congratulated for his two-run home run that scored Ramon Laureano (22) during the sixth inning of a baseball game against the Baltimore Orioles in Oakland, Calif., Tuesday, June 18, 2019. (AP PhotoJeff Chiu)

Baltimore Orioles' Keon Broxton, top, rounds runs toward home plate to score as Oakland Athletics third baseman Matt Chapman looks for the ball after a throwing error by shortstop Marcus Semien during the fifth inning of a baseball game in Oakland, Calif., Tuesday, June 18, 2019. (AP PhotoJeff Chiu)

Baltimore Orioles' Keon Broxton, top, rounds runs toward home plate to score as Oakland Athletics third baseman Matt Chapman looks for the ball after a throwing error by shortstop Marcus Semien during the fifth inning of a baseball game in Oakland, Calif., Tuesday, June 18, 2019. (AP PhotoJeff Chiu)

Baltimore Orioles third baseman Rio Ruiz, left, watches as Oakland Athletics' Khris Davis runs the bases after hitting a three-run home run during the sixth inning of a baseball game in Oakland, Calif., Tuesday, June 18, 2019. (AP PhotoJeff Chiu)

Baltimore Orioles third baseman Rio Ruiz, left, watches as Oakland Athletics' Khris Davis runs the bases after hitting a three-run home run during the sixth inning of a baseball game in Oakland, Calif., Tuesday, June 18, 2019. (AP PhotoJeff Chiu)

Brett Anderson (7-4) allowed one earned run and four hits in seven innings in beating the Orioles for the second time this season. Anderson retired 13 of the first 14 batters he faced and carried a shutout into the fifth inning before Jonathan Villar homered with one out. The victory was Anderson's first since May 26.

Baltimore Orioles pitcher Dan Straily, front, reacts after allowing a three-run home run to Oakland Athletics' Stephen Piscotty during the sixth inning of a baseball game in Oakland, Calif., Tuesday, June 18, 2019. At rear is Athletics' Robbie Grossman. (AP PhotoJeff Chiu)

Baltimore Orioles pitcher Dan Straily, front, reacts after allowing a three-run home run to Oakland Athletics' Stephen Piscotty during the sixth inning of a baseball game in Oakland, Calif., Tuesday, June 18, 2019. At rear is Athletics' Robbie Grossman. (AP PhotoJeff Chiu)

Laureano finished with four hits and made a terrific running catch before crashing into the center field wall. Matt Olson added two hits and scored twice.

Keon Broxton singled and scored for Baltimore.

The A's beat the Orioles on Monday without hitting a home run — just the second time they've done that this season. They got six home runs Tuesday, including the first of Taylor's career. It was the only solo shot of the six.

Oakland Athletics' Beau Taylor watches his solo home run against the Baltimore Orioles during the third inning of a baseball game in Oakland, Calif., Tuesday, June 18, 2019. (AP PhotoJeff Chiu)

Oakland Athletics' Beau Taylor watches his solo home run against the Baltimore Orioles during the third inning of a baseball game in Oakland, Calif., Tuesday, June 18, 2019. (AP PhotoJeff Chiu)

Laureano hit a three-run drive in the fourth, then the A's sent 13 men to the plate during a 24-minute sixth inning.

Grossman hit a 395-foot blast to right, a two-run home run. Davis' three-run shot went 382 feet, while Piscotty also had a three-run homer to center that traveled 418 feet.

Oakland hadn't scored 10 or more runs in an inning at the Coliseum since July 5, 1996.

Baltimore Orioles pitcher Gabriel Ynoa throws to an Oakland Athletics batter during the first inning of a baseball game in Oakland, Calif., Tuesday, June 18, 2019. (AP PhotoJeff Chiu)

Baltimore Orioles pitcher Gabriel Ynoa throws to an Oakland Athletics batter during the first inning of a baseball game in Oakland, Calif., Tuesday, June 18, 2019. (AP PhotoJeff Chiu)

Pinder homered as a pinch-hitter in the seventh.

Three of Oakland's home runs came off Baltimore starter Gabriel Ynoa (0-4). Ynoa allowed seven hits and a career-high six runs in 5 1/3 innings.

Marcus Semien added an RBI triple off Paul Fry to extend his career-high hitting streak to 15 games.

Oakland Athletics' Blake Treinen celebrates the 3-2 win over the Baltimore Orioles at the end of a baseball game, Monday, June 17, 2019, in Oakland, Calif. (AP PhotoBen Margot)

Oakland Athletics' Blake Treinen celebrates the 3-2 win over the Baltimore Orioles at the end of a baseball game, Monday, June 17, 2019, in Oakland, Calif. (AP PhotoBen Margot)

TRAINERS ROOM

Athletics: Nick Hundley will miss at least six weeks after undergoing arthroscopic surgery to repair a torn meniscus in his left knee. Hundley was already on the disabled list since June 8 due to back spasms. ... RHP Jharel Cotton has been playing catch but has yet to get back on a mound after undergoing hamstring surgery. Cotton had made three starts in the minors in his comeback from Tommy John surgery before injuring his hamstring. ... RHP Marco Estrada (lumbar strain) threw off flat ground before the game.

UP NEXT

Oakland Athletics' Beau Taylor, right, is congratulated by third base coach Matt Williams after hitting a solo home run against the Baltimore Orioles during the third inning of a baseball game in Oakland, Calif., Tuesday, June 18, 2019. (AP PhotoJeff Chiu)

Oakland Athletics' Beau Taylor, right, is congratulated by third base coach Matt Williams after hitting a solo home run against the Baltimore Orioles during the third inning of a baseball game in Oakland, Calif., Tuesday, June 18, 2019. (AP PhotoJeff Chiu)

Oakland RHP Chris Bassitt (3-3, 3.68 ERA) starts the series finale Wednesday afternoon. Bassitt has one win in two starts against Baltimore. The Orioles plan to use RHP Jimmy Yacabonis (1-1, 5.40) as an opener, with Josh Rogers to follow.

More AP MLB: https://apnews.com/tag/MLB and https://twitter.com/AP_Sports

Oakland Athletics' Ramon Laureano, center, celebrates after hitting a three-run home run that scored Khris Davis (2) and Matt Olson, right, during the fourth inning of the team's baseball game against the Baltimore Orioles in Oakland, Calif., Tuesday, June 18, 2019. (AP PhotoJeff Chiu)

Oakland Athletics' Ramon Laureano, center, celebrates after hitting a three-run home run that scored Khris Davis (2) and Matt Olson, right, during the fourth inning of the team's baseball game against the Baltimore Orioles in Oakland, Calif., Tuesday, June 18, 2019. (AP PhotoJeff Chiu)

Baltimore Orioles' Jonathan Villar (2) is congratulated by teammates after hitting a solo home run against the Oakland Athletics during the fifth inning of a baseball game in Oakland, Calif., Tuesday, June 18, 2019. (AP PhotoJeff Chiu)

Baltimore Orioles' Jonathan Villar (2) is congratulated by teammates after hitting a solo home run against the Oakland Athletics during the fifth inning of a baseball game in Oakland, Calif., Tuesday, June 18, 2019. (AP PhotoJeff Chiu)

Oakland Athletics' Robbie Grossman (8) is congratulated for his two-run home run that scored Ramon Laureano (22) during the sixth inning of a baseball game against the Baltimore Orioles in Oakland, Calif., Tuesday, June 18, 2019. (AP PhotoJeff Chiu)

Oakland Athletics' Robbie Grossman (8) is congratulated for his two-run home run that scored Ramon Laureano (22) during the sixth inning of a baseball game against the Baltimore Orioles in Oakland, Calif., Tuesday, June 18, 2019. (AP PhotoJeff Chiu)

Baltimore Orioles' Keon Broxton, top, rounds runs toward home plate to score as Oakland Athletics third baseman Matt Chapman looks for the ball after a throwing error by shortstop Marcus Semien during the fifth inning of a baseball game in Oakland, Calif., Tuesday, June 18, 2019. (AP PhotoJeff Chiu)

Baltimore Orioles' Keon Broxton, top, rounds runs toward home plate to score as Oakland Athletics third baseman Matt Chapman looks for the ball after a throwing error by shortstop Marcus Semien during the fifth inning of a baseball game in Oakland, Calif., Tuesday, June 18, 2019. (AP PhotoJeff Chiu)

Baltimore Orioles third baseman Rio Ruiz, left, watches as Oakland Athletics' Khris Davis runs the bases after hitting a three-run home run during the sixth inning of a baseball game in Oakland, Calif., Tuesday, June 18, 2019. (AP PhotoJeff Chiu)

Baltimore Orioles third baseman Rio Ruiz, left, watches as Oakland Athletics' Khris Davis runs the bases after hitting a three-run home run during the sixth inning of a baseball game in Oakland, Calif., Tuesday, June 18, 2019. (AP PhotoJeff Chiu)