Dexter Fowler hit a three-run homer and drove in four runs, Paul DeJong and Paul Goldschmidt added two-run shots and the St. Louis Cardinals rocked Luis Castillo on the way to a 13-4 romp over the Cincinnati Reds on Friday night.

Kolten Wong had a solo homer among his four hits and Fowler, Marcell Ozuna and Tommy Edman each had three as the Cardinals piled up a season-high 18 hits and moved into sole possession of first place in the NL Central.

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St. Louis Cardinals' Paul Goldschmidt, right, is congratulated on a two-run home run off Cincinnati Reds starting pitcher Luis Castillo by Marcell Ozuna (23) during the fifth inning of a baseball game, Friday, Aug. 16, 2019, in Cincinnati. (AP PhotoGary Landers)

Dexter Fowler hit a three-run homer and drove in four runs, Paul DeJong and Paul Goldschmidt added two-run shots and the St. Louis Cardinals rocked Luis Castillo on the way to a 13-4 romp over the Cincinnati Reds on Friday night.

St. Louis Cardinals' Paul Goldschmidt (46) rounds the bases with a two-run home run off Cincinnati Reds starting pitcher Luis Castillo during the fifth inning of a baseball game, Friday, Aug. 16, 2019, in Cincinnati. (AP PhotoGary Landers)

Castillo (11-5) tied his career highs with nine hits and three homers allowed, and set a career worst by yielding eight runs in 4 1/3 innings. The All-Star right-hander had three strikeouts.

St. Louis Cardinals' Tommy Edman (19) is congratulated in the dugout after scoring on a double by Marcell Ozuna off Cincinnati Reds starting pitcher Luis Castillo during the first inning of a baseball game, Friday, Aug. 16, 2019, in Cincinnati. (AP PhotoGary Landers)

Castillo retired the first two batters in the second before Wong and Wainwright singled on back-to-back pitches, setting up Fowler's three-run shot into the right-center seats.

Cincinnati Reds starting pitcher Luis Castillo (58) reacts after being pulled by manager David Bell, right, during the fifth inning of a baseball game against the St. Louis Cardinals, Friday, Aug. 16, 2019, in Cincinnati. Reds catcher Tucker Barnhart, center, looks on. (AP PhotoGary Landers)

Cardinals: OF José Martinez decided against receiving a cortisone shot in his right shoulder and hopes to resume baseball activities this weekend.

Cincinnati Reds' Aristides Aquino reacts as he rounds third base with a two-run home run off St. Louis Cardinals starting pitcher Adam Wainwright during the sixth inning of a baseball game, Friday, Aug. 16, 2019, in Cincinnati. (AP PhotoGary Landers)

Cardinals: RHP Miles Mikolas (7-12) avoided a loss despite getting roughed up for seven hits and six runs in five innings of St. Louis's 11-9 win over Pittsburgh on Sunday.

Rookie sensation Aristides Aquino, who was the first player since 1900 to hit at least nine home runs in his first 14 games, made it a record 10 in 16 with a two-run shot deep into the left-field seats in Cincinnati's three-run sixth. Rhys Hoskins previously held the record with nine in 2017 for Philadelphia.

St. Louis Cardinals' Paul Goldschmidt, right, is congratulated on a two-run home run off Cincinnati Reds starting pitcher Luis Castillo by Marcell Ozuna (23) during the fifth inning of a baseball game, Friday, Aug. 16, 2019, in Cincinnati. (AP PhotoGary Landers)

St. Louis Cardinals' Paul Goldschmidt, right, is congratulated on a two-run home run off Cincinnati Reds starting pitcher Luis Castillo by Marcell Ozuna (23) during the fifth inning of a baseball game, Friday, Aug. 16, 2019, in Cincinnati. (AP PhotoGary Landers)

Castillo (11-5) tied his career highs with nine hits and three homers allowed, and set a career worst by yielding eight runs in 4 1/3 innings. The All-Star right-hander had three strikeouts.

Adam Wainwright (9-8) improved to 4-1 over his last seven starts. He allowed eight hits and four runs with one walk and six strikeouts in 6 2/3 innings.

Ozuna drove in Edman from first base with a two-out double in the first inning, giving the Cardinals as many hits and runs in their first four batters as they collected in nine innings on Thursday.

St. Louis Cardinals' Paul Goldschmidt (46) rounds the bases with a two-run home run off Cincinnati Reds starting pitcher Luis Castillo during the fifth inning of a baseball game, Friday, Aug. 16, 2019, in Cincinnati. (AP PhotoGary Landers)

St. Louis Cardinals' Paul Goldschmidt (46) rounds the bases with a two-run home run off Cincinnati Reds starting pitcher Luis Castillo during the fifth inning of a baseball game, Friday, Aug. 16, 2019, in Cincinnati. (AP PhotoGary Landers)

Castillo retired the first two batters in the second before Wong and Wainwright singled on back-to-back pitches, setting up Fowler's three-run shot into the right-center seats.

Goldschmidt broke the game open with his two-run, opposite-field shot to right-center in the fifth.

TRAINER'S ROOM

St. Louis Cardinals' Tommy Edman (19) is congratulated in the dugout after scoring on a double by Marcell Ozuna off Cincinnati Reds starting pitcher Luis Castillo during the first inning of a baseball game, Friday, Aug. 16, 2019, in Cincinnati. (AP PhotoGary Landers)

St. Louis Cardinals' Tommy Edman (19) is congratulated in the dugout after scoring on a double by Marcell Ozuna off Cincinnati Reds starting pitcher Luis Castillo during the first inning of a baseball game, Friday, Aug. 16, 2019, in Cincinnati. (AP PhotoGary Landers)

Cardinals: OF José Martinez decided against receiving a cortisone shot in his right shoulder and hopes to resume baseball activities this weekend.

Reds: 3B Eugenio Suaréz left the game in the top of the sixth with a hand injury. . 1B Joey Votto missed his second straight start with lower back tightness . OF Jesse Winker was experiencing upper back tightness.

UP NEXT

Cincinnati Reds starting pitcher Luis Castillo (58) reacts after being pulled by manager David Bell, right, during the fifth inning of a baseball game against the St. Louis Cardinals, Friday, Aug. 16, 2019, in Cincinnati. Reds catcher Tucker Barnhart, center, looks on. (AP PhotoGary Landers)

Cincinnati Reds starting pitcher Luis Castillo (58) reacts after being pulled by manager David Bell, right, during the fifth inning of a baseball game against the St. Louis Cardinals, Friday, Aug. 16, 2019, in Cincinnati. Reds catcher Tucker Barnhart, center, looks on. (AP PhotoGary Landers)

Cardinals: RHP Miles Mikolas (7-12) avoided a loss despite getting roughed up for seven hits and six runs in five innings of St. Louis's 11-9 win over Pittsburgh on Sunday.

Reds: RHP Anthony DeSclafani (7-7) gave up four hits and two runs, one earned, with no walks and 11 strikeouts in his last start against St. Louis, a 3-1 loss on July 21.

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Cincinnati Reds' Aristides Aquino reacts as he rounds third base with a two-run home run off St. Louis Cardinals starting pitcher Adam Wainwright during the sixth inning of a baseball game, Friday, Aug. 16, 2019, in Cincinnati. (AP PhotoGary Landers)

Cincinnati Reds' Aristides Aquino reacts as he rounds third base with a two-run home run off St. Louis Cardinals starting pitcher Adam Wainwright during the sixth inning of a baseball game, Friday, Aug. 16, 2019, in Cincinnati. (AP PhotoGary Landers)