Adam Plutko pitched six effective innings, rookie Oscar Mercado homered and the Cleveland Indians beat Detroit 7-2 on Tuesday night for their 15th straight victory against the Tigers.

Cleveland has won 16 of 17 in the season series, with Detroit's only win coming on April 10 at Comerica Park. They play two more games against each other this year, Wednesday and Thursday at Progressive Field.

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Cleveland Indians' Oscar Mercado looks up after hitting a solo home run during the first inning of the team's baseball game against the Detroit Tigers, Tuesday, Sept. 17, 2019, in Cleveland. (AP PhotoTony Dejak)

Adam Plutko pitched six effective innings, rookie Oscar Mercado homered and the Cleveland Indians beat Detroit 7-2 on Tuesday night for their 15th straight victory against the Tigers.

Detroit Tigers' Dawel Lugo throws out Cleveland Indians' Greg Allen at first base during the third inning of a baseball game Tuesday, Sept. 17, 2019, in Cleveland. (AP PhotoTony Dejak)

The Indians entered play trailing Minnesota by five games in the AL Central and were 1½ games behind Tampa Bay for the second AL wild card.

Detroit Tigers' Ronny Rodriguez throws his bat after striking out during the fourth inning of the team's baseball game against the Cleveland Indians, Tuesday, Sept. 17, 2019, in Cleveland. (AP PhotoTony Dejak)

Reininger started in place of Matthew Boyd, who is away from the team for personal reasons. Reininger was charged with four runs in two-plus innings,

Cleveland Indians relief pitcher Carlos Carrasco, right, is congratulated by catcher Roberto Perez after the Indians defeated the Detroit Tigers 7-2 in a baseball game Tuesday, Sept. 17, 2019, in Cleveland. (AP PhotoTony Dejak)

Indians second baseman Jason Kipnis will miss the rest of the season with a broken right hand. He is expected to have surgery in the next few days.

Cleveland Indians' Mike Freeman scores on a double by Roberto Perez during the second inning in the team's baseball game against the Detroit Tigers, Tuesday, Sept. 17, 2019, in Cleveland. Tigers catcher Grayson Greiner is at left. (AP PhotoTony Dejak)

SCRATCHED

The Indians' longest single-season win streak over one team was when they beat the Baltimore Orioles 17 consecutive times from May 21-Sept. 6, 1954.

Cleveland Indians' Oscar Mercado looks up after hitting a solo home run during the first inning of the team's baseball game against the Detroit Tigers, Tuesday, Sept. 17, 2019, in Cleveland. (AP PhotoTony Dejak)

Cleveland Indians' Oscar Mercado looks up after hitting a solo home run during the first inning of the team's baseball game against the Detroit Tigers, Tuesday, Sept. 17, 2019, in Cleveland. (AP PhotoTony Dejak)

The Indians entered play trailing Minnesota by five games in the AL Central and were 1½ games behind Tampa Bay for the second AL wild card.

Plutko (7-4) allowed two runs and four hits in his first win since he beat Detroit on Aug. 27. The right-hander is 4-0 in his career against the Tigers, including three victories this season.

Mercado hit a solo drive off Zac Reininger (0-3) in the second for his 12th homer. Jordan Luplow's pinch-hit triple in the third drove in two runs, and Roberto Pérez also had two hits and two RBIs.

Detroit Tigers' Dawel Lugo throws out Cleveland Indians' Greg Allen at first base during the third inning of a baseball game Tuesday, Sept. 17, 2019, in Cleveland. (AP PhotoTony Dejak)

Detroit Tigers' Dawel Lugo throws out Cleveland Indians' Greg Allen at first base during the third inning of a baseball game Tuesday, Sept. 17, 2019, in Cleveland. (AP PhotoTony Dejak)

Reininger started in place of Matthew Boyd, who is away from the team for personal reasons. Reininger was charged with four runs in two-plus innings,

Dawel Lugo homered in the fifth for Detroit. Víctor Reyes singled in a run in the third.

OUT

Detroit Tigers' Ronny Rodriguez throws his bat after striking out during the fourth inning of the team's baseball game against the Cleveland Indians, Tuesday, Sept. 17, 2019, in Cleveland. (AP PhotoTony Dejak)

Detroit Tigers' Ronny Rodriguez throws his bat after striking out during the fourth inning of the team's baseball game against the Cleveland Indians, Tuesday, Sept. 17, 2019, in Cleveland. (AP PhotoTony Dejak)

Indians second baseman Jason Kipnis will miss the rest of the season with a broken right hand. He is expected to have surgery in the next few days.

Andrew Velazquez, called up from the minors to replace Kipnis, made a long run to catch Lugo's foul popup in the second. Velazquez hung on to the ball after banging into the stands. Kipnis, wearing a brace on his hand, clapped in the dugout following the play.

Velazquez, recalled from Triple-A Columbus before the game, struck out in all four at-bats. The 25-year-old was acquired from the Tampa Bay Rays on July 3.

Cleveland Indians relief pitcher Carlos Carrasco, right, is congratulated by catcher Roberto Perez after the Indians defeated the Detroit Tigers 7-2 in a baseball game Tuesday, Sept. 17, 2019, in Cleveland. (AP PhotoTony Dejak)

Cleveland Indians relief pitcher Carlos Carrasco, right, is congratulated by catcher Roberto Perez after the Indians defeated the Detroit Tigers 7-2 in a baseball game Tuesday, Sept. 17, 2019, in Cleveland. (AP PhotoTony Dejak)

SCRATCHED

Franmil Reyes was scratched as Cleveland's designated hitter because he's dealing with a family matter.

TRAINER'S ROOM

Tigers: 3B Jeimer Candelario (bruised triceps) was scratched, one day after being hit by a pitch.

Cleveland Indians' Mike Freeman scores on a double by Roberto Perez during the second inning in the team's baseball game against the Detroit Tigers, Tuesday, Sept. 17, 2019, in Cleveland. Tigers catcher Grayson Greiner is at left. (AP PhotoTony Dejak)

Cleveland Indians' Mike Freeman scores on a double by Roberto Perez during the second inning in the team's baseball game against the Detroit Tigers, Tuesday, Sept. 17, 2019, in Cleveland. Tigers catcher Grayson Greiner is at left. (AP PhotoTony Dejak)

Indians: LHP Brad Hand is scheduled to throw a bullpen session Wednesday. He hasn't pitched since Sept. 8 with what the team says is a tired arm.

UP NEXT

Tigers: RHP Spencer Turnbull (3-15, 4.77 ERA) gets the ball Wednesday. He leads the majors in losses. The rookie is 0-11 over 15 starts since beating Atlanta on May 31.

Indians: Rookie RHP Aaron Civale (3-3, 1.93 ERA) is 2-0 with a 1.38 ERA in two starts against Detroit.