Thunder guards Terrance Ferguson and Deonte Burton are out against the Minnesota Timberwolves on Friday night.
Thunder coach Billy Donovan made the announcements during his pregame media session.
Ferguson has soreness in his right hip. The starting shooting guard averages 5.7 points per game. Donovan did not say who would start in his place.
Burton has been suspended one game because of conduct detrimental to the team. The reserve averages 2.8 points per game.
The Thunder already were without guard Hamidou Diallo. He missed the previous five games with a hyperextended right elbow and remains a few weeks from being re-evaluated.