Sevilla beat Roma 2-0 in the round of 16 on Thursday to stay in the hunt for a record sixth Europa League title, as Bayer Leverkusen also qualified for the quarterfinals.

Full-back Sergio Reguilon gave Sevilla the lead with a surging run through the Roma defense and a shot past keeper Pau Lopez in the 22nd minute. Youssef En-Nesyri added the second just before halftime, tapping in a low cross from Lucas Ocampos.

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Sevilla's Sergio Reguilon, 2nd right, celebrates after scoring his side's opening goal during the Europa League, round of 16 soccer match between Roma and Sevilla, at the Schauinsland-Reisen-Arena in Duisburg, Germany, Thursday, Aug. 6, 2020. (Friedemann VogelPool Photo via AP)

Sevilla beat Roma 2-0 in the round of 16 on Thursday to stay in the hunt for a record sixth Europa League title, as Bayer Leverkusen also qualified for the quarterfinals.

Roma's Henrikh Mkhitaryan, foreground, and teammate react after Sevilla's Sergio Reguilon scored his side's opening goal, during the Europa League, round of 16 soccer match between Roma and Sevilla, at the Schauinsland-Reisen-Arena in Duisburg, Germany, Thursday, Aug. 6, 2020. (Friedemann VogelPool Photo via AP)

It was a single game at a neutral venue in Germany because no first leg was played in March before the season was suspended amid the coronavirus pandemic.

Sevilla's head coach Julen Lopetegui talks to his players during the Europa League, round of 16 soccer match between Roma and Sevilla, at the Schauinsland-Reisen-Arena in Duisburg, Germany, Thursday, Aug. 6, 2020. (Friedemann VogelPool Photo via AP)

Later Thursday, Wolverhampton bids to reach its first European quarterfinal since 1972 against Olympiakos with the score level at 1-1 from the first leg. Basel tries to hold on to a 3-0 lead over Eintracht Frankfurt.

Leverkusen's Moussa Diaby scores the opening goal during the Europa League round of 16, second leg, soccer match between Bayer Leverkusen and Glasgow Rangers at the BayArena in Leverkusen, Germany, Thursday, Aug. 6, 2020. (Sascha Schuermann, Pool Photo via AP)

Leverkusen's Moussa Diaby scores the opening goal during the Europa League round of 16, second leg, soccer match between Bayer Leverkusen and Glasgow Rangers at the BayArena in Leverkusen, Germany, Thursday, Aug. 6, 2020. (Sascha Schuermann, Pool Photo via AP)

Leverkusen's Kai Havertz runs with the ball past Rangers' Filip Helander, right, during the Europa League round of 16, second leg, soccer match between Bayer Leverkusen and Glasgow Rangers at the BayArena in Leverkusen, Germany, Thursday, Aug. 6, 2020. (Sascha Schuermann, Pool Photo via AP)

Leverkusen's Kai Havertz runs with the ball past Rangers' Filip Helander, right, during the Europa League round of 16, second leg, soccer match between Bayer Leverkusen and Glasgow Rangers at the BayArena in Leverkusen, Germany, Thursday, Aug. 6, 2020. (Sascha Schuermann, Pool Photo via AP)

Leverkusen's Kai Havertz runs to control the ball during the Europa League round of 16, second leg, soccer match between Bayer Leverkusen and Glasgow Rangers at the BayArena in Leverkusen, Germany, Thursday, Aug. 6, 2020. (AP PhotoMartin Meissner)

Leverkusen's Kai Havertz runs to control the ball during the Europa League round of 16, second leg, soccer match between Bayer Leverkusen and Glasgow Rangers at the BayArena in Leverkusen, Germany, Thursday, Aug. 6, 2020. (AP PhotoMartin Meissner)

Sevilla could easily have scored more, with two shots hitting the crossbar and a goal overturned for offside on video review. Playing after a packed run of Serie A games, Roma didn't muster a single shot on target in the first half and just one in the second.

Sevilla's Sergio Reguilon, 2nd right, celebrates after scoring his side's opening goal during the Europa League, round of 16 soccer match between Roma and Sevilla, at the Schauinsland-Reisen-Arena in Duisburg, Germany, Thursday, Aug. 6, 2020. (Friedemann VogelPool Photo via AP)

Sevilla's Sergio Reguilon, 2nd right, celebrates after scoring his side's opening goal during the Europa League, round of 16 soccer match between Roma and Sevilla, at the Schauinsland-Reisen-Arena in Duisburg, Germany, Thursday, Aug. 6, 2020. (Friedemann VogelPool Photo via AP)

It was a single game at a neutral venue in Germany because no first leg was played in March before the season was suspended amid the coronavirus pandemic.

Sevilla next faces a quarterfinal against either Wolverhampton or Olympiakos on Tuesday.

Bayer Leverkusen cruised into the quarterfinals, beating Rangers 1-0 on Thursday thanks to a powerful shot from Moussa Diaby for a 4-1 aggregate win. Leverkusen takes on Inter Milan in the quarterfinals Monday.

Roma's Henrikh Mkhitaryan, foreground, and teammate react after Sevilla's Sergio Reguilon scored his side's opening goal, during the Europa League, round of 16 soccer match between Roma and Sevilla, at the Schauinsland-Reisen-Arena in Duisburg, Germany, Thursday, Aug. 6, 2020. (Friedemann VogelPool Photo via AP)

Roma's Henrikh Mkhitaryan, foreground, and teammate react after Sevilla's Sergio Reguilon scored his side's opening goal, during the Europa League, round of 16 soccer match between Roma and Sevilla, at the Schauinsland-Reisen-Arena in Duisburg, Germany, Thursday, Aug. 6, 2020. (Friedemann VogelPool Photo via AP)

Later Thursday, Wolverhampton bids to reach its first European quarterfinal since 1972 against Olympiakos with the score level at 1-1 from the first leg. Basel tries to hold on to a 3-0 lead over Eintracht Frankfurt.

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Sevilla's head coach Julen Lopetegui talks to his players during the Europa League, round of 16 soccer match between Roma and Sevilla, at the Schauinsland-Reisen-Arena in Duisburg, Germany, Thursday, Aug. 6, 2020. (Friedemann VogelPool Photo via AP)

Sevilla's head coach Julen Lopetegui talks to his players during the Europa League, round of 16 soccer match between Roma and Sevilla, at the Schauinsland-Reisen-Arena in Duisburg, Germany, Thursday, Aug. 6, 2020. (Friedemann VogelPool Photo via AP)

Leverkusen's Moussa Diaby scores the opening goal during the Europa League round of 16, second leg, soccer match between Bayer Leverkusen and Glasgow Rangers at the BayArena in Leverkusen, Germany, Thursday, Aug. 6, 2020. (Sascha Schuermann, Pool Photo via AP)

Leverkusen's Moussa Diaby scores the opening goal during the Europa League round of 16, second leg, soccer match between Bayer Leverkusen and Glasgow Rangers at the BayArena in Leverkusen, Germany, Thursday, Aug. 6, 2020. (Sascha Schuermann, Pool Photo via AP)

Leverkusen's Kai Havertz runs with the ball past Rangers' Filip Helander, right, during the Europa League round of 16, second leg, soccer match between Bayer Leverkusen and Glasgow Rangers at the BayArena in Leverkusen, Germany, Thursday, Aug. 6, 2020. (Sascha Schuermann, Pool Photo via AP)

Leverkusen's Kai Havertz runs with the ball past Rangers' Filip Helander, right, during the Europa League round of 16, second leg, soccer match between Bayer Leverkusen and Glasgow Rangers at the BayArena in Leverkusen, Germany, Thursday, Aug. 6, 2020. (Sascha Schuermann, Pool Photo via AP)

Leverkusen's Kai Havertz runs to control the ball during the Europa League round of 16, second leg, soccer match between Bayer Leverkusen and Glasgow Rangers at the BayArena in Leverkusen, Germany, Thursday, Aug. 6, 2020. (AP PhotoMartin Meissner)

Leverkusen's Kai Havertz runs to control the ball during the Europa League round of 16, second leg, soccer match between Bayer Leverkusen and Glasgow Rangers at the BayArena in Leverkusen, Germany, Thursday, Aug. 6, 2020. (AP PhotoMartin Meissner)