Tyler Glasnow struck out a career-high 13 over seven innings and the AL East-leading Tampa Bay Rays beat the Baltimore Orioles 4-2 on Tuesday night.

Glasnow (1-1) fanned nine of his final 10 batters. The 6-foot-8 right-hander allowed two runs, five hits and one walk.

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Tampa Bay Rays' Ji-Man Choi, of South Korea, watches his run-scoring sacrifice fly off Baltimore Orioles relief pitcher Travis Lakins Sr., during the sixth inning of a baseball game Tuesday, Aug. 25, 2020, in St. Petersburg, Fla. Rays' Hunter Renfroe scored on the play. (AP PhotoChris O'Meara)

Tyler Glasnow struck out a career-high 13 over seven innings and the AL East-leading Tampa Bay Rays beat the Baltimore Orioles 4-2 on Tuesday night.

Tampa Bay Rays' Hunter Renfroe celebrates with Manuel Margot (13) and Jose Martinez (40) after Renfroe hit a two-run home run off Baltimore Orioles starting pitcher Tommy Milone during the second inning of a baseball game Tuesday, Aug. 25, 2020, in St. Petersburg, Fla. (AP PhotoChris O'Meara)

Edgar García got the final two outs with a runner on second, claiming his first career save.

Baltimore Orioles' Renato Nunez (39) celebrates his solo home run off Tampa Bay Rays starting pitcher Tyler Glasnow with Anthony Santander (25) during the first inning of a baseball game Tuesday, Aug. 25, 2020, in St. Petersburg, Fla. (AP PhotoChris O'Meara)

After Renfroe hit a two-run drive, two pitches later Margot made it 3-1 in the second on his homer off Tommy Milone (1-4).

Tampa Bay Rays pitcher Edgar Garcia, right, celebrates with catcher Michael Perez after closing out the Baltimore Orioles during the ninth inning of a baseball game Tuesday, Aug. 25, 2020, in St. Petersburg, Fla. (AP PhotoChris O'Meara)

Ryan Mountcastle got the Orioles within 3-2 on a fourth-inning RBI single.

Tampa Bay Rays' Hunter Renfroe scores around Baltimore Orioles catcher Chance Sisco (15) on a sacrifice fly by Ji-Man Choi during the sixth inning of a baseball game Tuesday, Aug. 25, 2020, in St. Petersburg, Fla. (AP PhotoChris O'Meara)

TRAINER’S ROOM

Hunter Renfroe and Manuel Margot hit back-to-back homers for the Rays, who have won eight of 10.

Tampa Bay Rays' Ji-Man Choi, of South Korea, watches his run-scoring sacrifice fly off Baltimore Orioles relief pitcher Travis Lakins Sr., during the sixth inning of a baseball game Tuesday, Aug. 25, 2020, in St. Petersburg, Fla. Rays' Hunter Renfroe scored on the play. (AP PhotoChris O'Meara)

Tampa Bay Rays' Ji-Man Choi, of South Korea, watches his run-scoring sacrifice fly off Baltimore Orioles relief pitcher Travis Lakins Sr., during the sixth inning of a baseball game Tuesday, Aug. 25, 2020, in St. Petersburg, Fla. Rays' Hunter Renfroe scored on the play. (AP PhotoChris O'Meara)

Edgar García got the final two outs with a runner on second, claiming his first career save.

The Orioles, who lost for just the second time in 10 road games, got a homer from Renato Núñez.

Baltimore’s Anthony Santander had his 18-game hitting streak end after going 0 for 4. He hit .329 (25-for-76) with eight homer and 20 RBIs during the streak.

Tampa Bay Rays' Hunter Renfroe celebrates with Manuel Margot (13) and Jose Martinez (40) after Renfroe hit a two-run home run off Baltimore Orioles starting pitcher Tommy Milone during the second inning of a baseball game Tuesday, Aug. 25, 2020, in St. Petersburg, Fla. (AP PhotoChris O'Meara)

Tampa Bay Rays' Hunter Renfroe celebrates with Manuel Margot (13) and Jose Martinez (40) after Renfroe hit a two-run home run off Baltimore Orioles starting pitcher Tommy Milone during the second inning of a baseball game Tuesday, Aug. 25, 2020, in St. Petersburg, Fla. (AP PhotoChris O'Meara)

After Renfroe hit a two-run drive, two pitches later Margot made it 3-1 in the second on his homer off Tommy Milone (1-4).

Renfroe had been hitless in his previous 12 at-bats.

The Rays went up 4-2 on Ji-Man Choi’s sacrice fly in the sixth.

Baltimore Orioles' Renato Nunez (39) celebrates his solo home run off Tampa Bay Rays starting pitcher Tyler Glasnow with Anthony Santander (25) during the first inning of a baseball game Tuesday, Aug. 25, 2020, in St. Petersburg, Fla. (AP PhotoChris O'Meara)

Baltimore Orioles' Renato Nunez (39) celebrates his solo home run off Tampa Bay Rays starting pitcher Tyler Glasnow with Anthony Santander (25) during the first inning of a baseball game Tuesday, Aug. 25, 2020, in St. Petersburg, Fla. (AP PhotoChris O'Meara)

Ryan Mountcastle got the Orioles within 3-2 on a fourth-inning RBI single.

Núñez hit a solo shot in the first that stopped a 58 at-bat homer drought.

Milone gave up four runs and four hits in 5 1/3 innings.

Tampa Bay Rays pitcher Edgar Garcia, right, celebrates with catcher Michael Perez after closing out the Baltimore Orioles during the ninth inning of a baseball game Tuesday, Aug. 25, 2020, in St. Petersburg, Fla. (AP PhotoChris O'Meara)

Tampa Bay Rays pitcher Edgar Garcia, right, celebrates with catcher Michael Perez after closing out the Baltimore Orioles during the ninth inning of a baseball game Tuesday, Aug. 25, 2020, in St. Petersburg, Fla. (AP PhotoChris O'Meara)

TRAINER’S ROOM

Orioles: LHP Wade LeBlanc was placed on the 60-day injured list with a left elbow stress reaction, ending his season. LeBlanc left Sunday’s game against Boston in the first inning after feeling elbow discomfort. LeBlanc was 1-0 with an 8.06 ERA over six starts in his first season with Baltimore. ... C Pedro Severino was not in the starting lineup and is day-to-day with a hip flexor injury. “Hopefully he’ll be in there the next day or two,” manager Brandon Hyde said. ... SS José Iglesias (left quadriceps strain) and RH Hunter Harvey (right forearm strain) traveled with the team to continue their rehab assignments. Both could come off the IL during this road trip.

Rays: CF Kevin Kiermaier, who left Monday’s game one inning after getting on the right foot by a pitch, entered as defensive replacement in the seventh inning. ... RHP Charlie Morton (right shoulder inflammation) had a bullpen session and could soon throw to hitters.

Tampa Bay Rays' Hunter Renfroe scores around Baltimore Orioles catcher Chance Sisco (15) on a sacrifice fly by Ji-Man Choi during the sixth inning of a baseball game Tuesday, Aug. 25, 2020, in St. Petersburg, Fla. (AP PhotoChris O'Meara)

Tampa Bay Rays' Hunter Renfroe scores around Baltimore Orioles catcher Chance Sisco (15) on a sacrifice fly by Ji-Man Choi during the sixth inning of a baseball game Tuesday, Aug. 25, 2020, in St. Petersburg, Fla. (AP PhotoChris O'Meara)

UP NEXT

Orioles RHP Asher Wojciechowski (1-3) will start Wednesday night in the second game of the three-game set. The Rays have not announced their starter.

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