Mike Zunino, Brandon Lowe and Willy Adames had two-out, run-scoring singles in the fifth inning as the AL East champion Tampa Bay Rays beat Philadelphia 4-3 Saturday night and damaged the Phillies' postseason hopes.

Andrew McCutchen had four hits for Philadelphia, which has lost six of seven. The Phillies started the day a game behind San Francisco for the second NL wild card. The Giants faced San Diego later Saturday.

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Tampa Bay Rays relief pitcher Diego Castillo reacys after pitching out of trouble against the Philadelphia Phillies during the sixth inning of a baseball game Saturday, Sept. 26, 2020, in St. Petersburg, Fla. (AP PhotoChris O'Meara)

Mike Zunino, Brandon Lowe and Willy Adames had two-out, run-scoring singles in the fifth inning as the AL East champion Tampa Bay Rays beat Philadelphia 4-3 Saturday night and damaged the Phillies' postseason hopes.

Philadelphia Phillies' Andrew McCutchen (22) celebrates his solo home run off Tampa Bay Rays relief pitcher Peter Fairbanks during the fifth inning of a baseball game Saturday, Sept. 26, 2020, in St. Petersburg, Fla. (AP PhotoChris O'Meara)

The Rays have an AL-best 20 come-from-behind wins this season. The Phillies have lost a major league-leading 21 games after holding a lead.

Tampa Bay Rays left fielder Manuel Margot goes up but can't make the catch on a solo home run by Philadelphia Phillies' Andrew McCutchen during the fifth inning of a baseball game Saturday, Sept. 26, 2020, in St. Petersburg, Fla. (AP PhotoChris O'Meara)

Bryce Harper had a run-scoring single in the seventh that got the Phillies within 4-3.

Philadelphia Phillies' Andrew McCutchen (22) follows the flight of his solo home run off Tampa Bay Rays relief pitcher Peter Fairbanks during the fifth inning of a baseball game Saturday, Sept. 26, 2020, in St. Petersburg, Fla. (AP PhotoChris O'Meara)

McCutchen appeared to have a leadoff triple in the third, but was sent back to second after a video review determined the ball got stuck under the center field fence. It eventually cost Philadelphia a run when McCutchen was thrown out at the plate by center field Kevin Kiermaier on a two-out single by J.T. Realmuto.

Tampa Bay Rays shortstop Willy Adames throws out Philadelphia Phillies' Roman Quinn at first base during the fifth inning of a baseball game Saturday, Sept. 26, 2020, in St. Petersburg, Fla. (AP PhotoChris O'Meara)

POSTSEASON PLANS

Philadelphia Phillies' Alec Bohm, left, and Andrew McCutchen remain in the dugout after the team lost to the Tampa Bay Rays during a baseball game Saturday, Sept. 26, 2020, in St. Petersburg, Fla. (AP PhotoChris O'Meara)

Phillies: Harper (back) was the DH for the third straight game. ... Realmuto (left hip flexor) started at catcher after playing first base in the previous two games. ... 1B Rhys Hoskins (left elbow strain) could take batting practice Sunday.

Tampa Bay Rays' Brandon Lowe, right, scores in front of Philadelphia Phillies catcher J.T. Realmuto on an RBI single by Yoshi Tsutsugo during the fourth inning of a baseball game Saturday, Sept. 26, 2020, in St. Petersburg, Fla. (AP PhotoChris O'Meara)

Phillies RHP Aaron Nola (5-4) will start Sunday’s regular-season finale against Tampa Bay. The Rays have not announced a starter.

Tampa Bay clinched the AL No. 1 seed about 30 minutes before game time, when Oakland lost 5-1 to Seattle in the first game of a doubleheader.

Tampa Bay Rays relief pitcher Diego Castillo reacys after pitching out of trouble against the Philadelphia Phillies during the sixth inning of a baseball game Saturday, Sept. 26, 2020, in St. Petersburg, Fla. (AP PhotoChris O'Meara)

Tampa Bay Rays relief pitcher Diego Castillo reacys after pitching out of trouble against the Philadelphia Phillies during the sixth inning of a baseball game Saturday, Sept. 26, 2020, in St. Petersburg, Fla. (AP PhotoChris O'Meara)

The Rays have an AL-best 20 come-from-behind wins this season. The Phillies have lost a major league-leading 21 games after holding a lead.

The Rays' three-run fifth came against Zack Wheeler (4-2) and gave Tampa Bay a 4-2 lead.

Wheeler gave up four runs and seven hits over seven-plus innings, and had his streak of starting the season with 10 starts of at least 5 2/3 innings and three or fewer runs end. Only Curt Schilling, who began the 1998 season with 11 straight, had a longer run for the Phillies since 1900.

Philadelphia Phillies' Andrew McCutchen (22) celebrates his solo home run off Tampa Bay Rays relief pitcher Peter Fairbanks during the fifth inning of a baseball game Saturday, Sept. 26, 2020, in St. Petersburg, Fla. (AP PhotoChris O'Meara)

Philadelphia Phillies' Andrew McCutchen (22) celebrates his solo home run off Tampa Bay Rays relief pitcher Peter Fairbanks during the fifth inning of a baseball game Saturday, Sept. 26, 2020, in St. Petersburg, Fla. (AP PhotoChris O'Meara)

Bryce Harper had a run-scoring single in the seventh that got the Phillies within 4-3.

McCutchen put the Phillies up 2-1 on a solo shot during the fifth off reliever Pete Fairbanks (6-3).

Aaron Slegers went the final three innings and earned his second save.

Tampa Bay Rays left fielder Manuel Margot goes up but can't make the catch on a solo home run by Philadelphia Phillies' Andrew McCutchen during the fifth inning of a baseball game Saturday, Sept. 26, 2020, in St. Petersburg, Fla. (AP PhotoChris O'Meara)

Tampa Bay Rays left fielder Manuel Margot goes up but can't make the catch on a solo home run by Philadelphia Phillies' Andrew McCutchen during the fifth inning of a baseball game Saturday, Sept. 26, 2020, in St. Petersburg, Fla. (AP PhotoChris O'Meara)

McCutchen appeared to have a leadoff triple in the third, but was sent back to second after a video review determined the ball got stuck under the center field fence. It eventually cost Philadelphia a run when McCutchen was thrown out at the plate by center field Kevin Kiermaier on a two-out single by J.T. Realmuto.

Rays opener John Curtiss allowed a run and three hits in two-thirds of an inning. He became the eighth pitcher since saves became an official stat in 1969 to record a save and then start the team’s next game.

Philadelphia rookie Alec Bohm went 2 for 4 and has a hit in 17 of his last 19 games, including 11 multi-hit games. He has 39 hits this month.

Philadelphia Phillies' Andrew McCutchen (22) follows the flight of his solo home run off Tampa Bay Rays relief pitcher Peter Fairbanks during the fifth inning of a baseball game Saturday, Sept. 26, 2020, in St. Petersburg, Fla. (AP PhotoChris O'Meara)

Philadelphia Phillies' Andrew McCutchen (22) follows the flight of his solo home run off Tampa Bay Rays relief pitcher Peter Fairbanks during the fifth inning of a baseball game Saturday, Sept. 26, 2020, in St. Petersburg, Fla. (AP PhotoChris O'Meara)

POSTSEASON PLANS

Rays manager Kevin Cash made it official that LHP Blake Snell will start Game 1 on Tuesday in a first-round playoff series. RHPs Tyler Glasnow and RHP Charlie Morton round out the rotation.

TRAINER’S ROOM

Tampa Bay Rays shortstop Willy Adames throws out Philadelphia Phillies' Roman Quinn at first base during the fifth inning of a baseball game Saturday, Sept. 26, 2020, in St. Petersburg, Fla. (AP PhotoChris O'Meara)

Tampa Bay Rays shortstop Willy Adames throws out Philadelphia Phillies' Roman Quinn at first base during the fifth inning of a baseball game Saturday, Sept. 26, 2020, in St. Petersburg, Fla. (AP PhotoChris O'Meara)

Phillies: Harper (back) was the DH for the third straight game. ... Realmuto (left hip flexor) started at catcher after playing first base in the previous two games. ... 1B Rhys Hoskins (left elbow strain) could take batting practice Sunday.

Rays: LHP José Alvarado (left shoulder inflammation) threw to 1B Ji-Man Choi (left hamstring strain) and INF Yandy Díaz (right hamstring strain).

UP NEXT

Philadelphia Phillies' Alec Bohm, left, and Andrew McCutchen remain in the dugout after the team lost to the Tampa Bay Rays during a baseball game Saturday, Sept. 26, 2020, in St. Petersburg, Fla. (AP PhotoChris O'Meara)

Philadelphia Phillies' Alec Bohm, left, and Andrew McCutchen remain in the dugout after the team lost to the Tampa Bay Rays during a baseball game Saturday, Sept. 26, 2020, in St. Petersburg, Fla. (AP PhotoChris O'Meara)

Phillies RHP Aaron Nola (5-4) will start Sunday’s regular-season finale against Tampa Bay. The Rays have not announced a starter.

More AP MLB: https://apnews.com/MLB and https://twitter.com/AP_Sports

Tampa Bay Rays' Brandon Lowe, right, scores in front of Philadelphia Phillies catcher J.T. Realmuto on an RBI single by Yoshi Tsutsugo during the fourth inning of a baseball game Saturday, Sept. 26, 2020, in St. Petersburg, Fla. (AP PhotoChris O'Meara)

Tampa Bay Rays' Brandon Lowe, right, scores in front of Philadelphia Phillies catcher J.T. Realmuto on an RBI single by Yoshi Tsutsugo during the fourth inning of a baseball game Saturday, Sept. 26, 2020, in St. Petersburg, Fla. (AP PhotoChris O'Meara)