Jeff Wilson Jr. rushed for a career-high three touchdowns and 112 yards before leaving with an ankle injury and the San Francisco 49ers dominated in a 33-6 win over the New England Patriots on Sunday.

49ers quarterback Jimmy Garoppolo finished 20 of 25 for 277 yards with two interceptions in his first game against his former team. San Francisco (4-3) has followed back-to-back losses with two wins and is 3-0 on the road.

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San Francisco 49ers running back Jeff Wilson Jr. lies on the turf after an injury while scoring a touchdown in the second half of an NFL football game against the New England Patriots Sunday, Oct. 25, 2020, in Foxborough, Mass. (AP PhotoSteven Senne)

Jeff Wilson Jr. rushed for a career-high three touchdowns and 112 yards before leaving with an ankle injury and the San Francisco 49ers dominated in a 33-6 win over the New England Patriots on Sunday.
San Francisco 49ers running back Jeff Wilson Jr. gains yardage against the New England Patriots in the first half of an NFL football game, Sunday, Oct. 25, 2020, in Foxborough, Mass. (AP PhotoSteven Senne)

New England was outgained 467-241 in total yards.
San Francisco 49ers tight end George Kittle (85) eludes New England Patriots defensive back J.C. Jackson (27) after catching a pass in the first half of an NFL football game, Sunday, Oct. 25, 2020, in Foxborough, Mass. (AP PhotoSteven Senne)

Newton was out of sync from the outset, making poor reads and poorer throws. But Garoppolo was successful in spreading out New England’s defense with a steady diet of passes behind the line scrimmage and jet sweeps to get the ball in the hands of Wilson, Samuel and George Kittle.
San Francisco 49ers quarterback Jimmy Garoppolo passes against the New England Patriots in the first half of an NFL football game, Sunday, Oct. 25, 2020, in Foxborough, Mass. (AP PhotoSteven Senne)

Following a Patriots punt, San Francisco was pinned inside its 15. Long completions by Garoppolo helped erase some early penalty losses before he missed high on a pass for Kittle and was intercepted by Devin McCourty.
San Francisco 49ers quarterback Jimmy Garoppolo passes against the New England Patriots in the first half of an NFL football game, Sunday, Oct. 25, 2020, in Foxborough, Mass. (AP PhotoSteven Senne)

Trailing 10-3, Newton made a bad developing play worse when he tried to dump off the ball on the run to receiver Jakobi Meyers. It was picked off by linebacker Fred Warner. Five plays later the 49ers capitalized on a 4-yard touchdown run by Kyle Juszczyk.
New England Patriots quarterback Cam Newton drops back to pass under pressure from San Francisco 49ers defensive end Arik Armstead (91) in the first half of an NFL football game, Sunday, Oct. 25, 2020, in Foxborough, Mass. (AP PhotoCharles Krupa)

49ers: Wilson Had just crossed into the end zone following his third TD when his leg twisted as he was tackled. He stayed down on the field before being able to walk off under his own power.
San Francisco 49ers wide receiver Deebo Samuel (19) runs from New England Patriots linebacker Ja'Whaun Bentley after catching a pass in the first half of an NFL football game, Sunday, Oct. 25, 2020, in Foxborough, Mass. (AP PhotoSteven Senne)

The 49ers head to Seattle next Sunday. The Patriots visit Buffalo.
San Francisco 49ers linebacker Fred Warner, left, celebrates his interception with teammates in the first half of an NFL football game against the New England Patriots, Sunday, Oct. 25, 2020, in Foxborough, Mass. (AP PhotoSteven Senne)

San Francisco 49ers linebacker Fred Warner, left, celebrates his interception with teammates in the first half of an NFL football game against the New England Patriots, Sunday, Oct. 25, 2020, in Foxborough, Mass. (AP PhotoSteven Senne)
San Francisco 49ers fullback Kyle Juszczyk, center, celebrates his touchdown with teammates Jeff Wilson Jr., left, and George Kittle, right, in the first half of an NFL football game against the New England Patriots, Sunday, Oct. 25, 2020, in Foxborough, Mass. (AP PhotoSteven Senne)

San Francisco 49ers fullback Kyle Juszczyk, center, celebrates his touchdown with teammates Jeff Wilson Jr., left, and George Kittle, right, in the first half of an NFL football game against the New England Patriots, Sunday, Oct. 25, 2020, in Foxborough, Mass. (AP PhotoSteven Senne)
San Francisco 49ers running back Jeff Wilson Jr., left, celebrates his touchdown with George Kittle, right, in the first half of an NFL football game against the New England Patriots, Sunday, Oct. 25, 2020, in Foxborough, Mass. (AP PhotoSteven Senne)

San Francisco 49ers running back Jeff Wilson Jr., left, celebrates his touchdown with George Kittle, right, in the first half of an NFL football game against the New England Patriots, Sunday, Oct. 25, 2020, in Foxborough, Mass. (AP PhotoSteven Senne)
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San Francisco 49ers running back Jeff Wilson Jr. lies on the turf after an injury while scoring a touchdown in the second half of an NFL football game against the New England Patriots Sunday, Oct. 25, 2020, in Foxborough, Mass. (AP PhotoSteven Senne)

Jeff Wilson Jr. rushed for a career-high three touchdowns and 112 yards before leaving with an ankle injury and the San Francisco 49ers dominated in a 33-6 win over the New England Patriots on Sunday.

San Francisco 49ers running back Jeff Wilson Jr. gains yardage against the New England Patriots in the first half of an NFL football game, Sunday, Oct. 25, 2020, in Foxborough, Mass. (AP PhotoSteven Senne)

New England was outgained 467-241 in total yards.

San Francisco 49ers tight end George Kittle (85) eludes New England Patriots defensive back J.C. Jackson (27) after catching a pass in the first half of an NFL football game, Sunday, Oct. 25, 2020, in Foxborough, Mass. (AP PhotoSteven Senne)

Newton was out of sync from the outset, making poor reads and poorer throws. But Garoppolo was successful in spreading out New England’s defense with a steady diet of passes behind the line scrimmage and jet sweeps to get the ball in the hands of Wilson, Samuel and George Kittle.

San Francisco 49ers quarterback Jimmy Garoppolo passes against the New England Patriots in the first half of an NFL football game, Sunday, Oct. 25, 2020, in Foxborough, Mass. (AP PhotoSteven Senne)

Following a Patriots punt, San Francisco was pinned inside its 15. Long completions by Garoppolo helped erase some early penalty losses before he missed high on a pass for Kittle and was intercepted by Devin McCourty.

San Francisco 49ers quarterback Jimmy Garoppolo passes against the New England Patriots in the first half of an NFL football game, Sunday, Oct. 25, 2020, in Foxborough, Mass. (AP PhotoSteven Senne)

Trailing 10-3, Newton made a bad developing play worse when he tried to dump off the ball on the run to receiver Jakobi Meyers. It was picked off by linebacker Fred Warner. Five plays later the 49ers capitalized on a 4-yard touchdown run by Kyle Juszczyk.

New England Patriots quarterback Cam Newton drops back to pass under pressure from San Francisco 49ers defensive end Arik Armstead (91) in the first half of an NFL football game, Sunday, Oct. 25, 2020, in Foxborough, Mass. (AP PhotoCharles Krupa)

49ers: Wilson Had just crossed into the end zone following his third TD when his leg twisted as he was tackled. He stayed down on the field before being able to walk off under his own power.

San Francisco 49ers wide receiver Deebo Samuel (19) runs from New England Patriots linebacker Ja'Whaun Bentley after catching a pass in the first half of an NFL football game, Sunday, Oct. 25, 2020, in Foxborough, Mass. (AP PhotoSteven Senne)

The 49ers head to Seattle next Sunday. The Patriots visit Buffalo.

San Francisco 49ers linebacker Fred Warner, left, celebrates his interception with teammates in the first half of an NFL football game against the New England Patriots, Sunday, Oct. 25, 2020, in Foxborough, Mass. (AP PhotoSteven Senne)

San Francisco 49ers linebacker Fred Warner, left, celebrates his interception with teammates in the first half of an NFL football game against the New England Patriots, Sunday, Oct. 25, 2020, in Foxborough, Mass. (AP PhotoSteven Senne)

San Francisco 49ers fullback Kyle Juszczyk, center, celebrates his touchdown with teammates Jeff Wilson Jr., left, and George Kittle, right, in the first half of an NFL football game against the New England Patriots, Sunday, Oct. 25, 2020, in Foxborough, Mass. (AP PhotoSteven Senne)

San Francisco 49ers fullback Kyle Juszczyk, center, celebrates his touchdown with teammates Jeff Wilson Jr., left, and George Kittle, right, in the first half of an NFL football game against the New England Patriots, Sunday, Oct. 25, 2020, in Foxborough, Mass. (AP PhotoSteven Senne)

San Francisco 49ers running back Jeff Wilson Jr., left, celebrates his touchdown with George Kittle, right, in the first half of an NFL football game against the New England Patriots, Sunday, Oct. 25, 2020, in Foxborough, Mass. (AP PhotoSteven Senne)

San Francisco 49ers running back Jeff Wilson Jr., left, celebrates his touchdown with George Kittle, right, in the first half of an NFL football game against the New England Patriots, Sunday, Oct. 25, 2020, in Foxborough, Mass. (AP PhotoSteven Senne)

The Patriots' 27-point loss was their largest at home under Bill Belichick, according to Elias Sports Bureau. They had gone 286 games without a three-game losing streak, the longest span between three-game slides in NFL history. New England fell to 2-4 for the first since coach Belichick’s first season in 2000, when the Patriots went 5-11.

San Francisco 49ers running back Jeff Wilson Jr. lies on the turf after an injury while scoring a touchdown in the second half of an NFL football game against the New England Patriots Sunday, Oct. 25, 2020, in Foxborough, Mass. (AP PhotoSteven Senne)

San Francisco 49ers running back Jeff Wilson Jr. lies on the turf after an injury while scoring a touchdown in the second half of an NFL football game against the New England Patriots Sunday, Oct. 25, 2020, in Foxborough, Mass. (AP PhotoSteven Senne)

New England was outgained 467-241 in total yards.

San Francisco's Brandon Aiyuk had six catches for 115 yards and Deebo Samuel had five catches for 65 yards before leaving the game with a hamstring injury.

Patriots quarterback Cam Newton struggled throughout, completing 9 of 15 passes for 98 yards and three interceptions before being replaced by Jarrett Stidham in the fourth quarter. Stidham was 6 of 10 for 64 yards and an interception.

San Francisco 49ers running back Jeff Wilson Jr. gains yardage against the New England Patriots in the first half of an NFL football game, Sunday, Oct. 25, 2020, in Foxborough, Mass. (AP PhotoSteven Senne)

San Francisco 49ers running back Jeff Wilson Jr. gains yardage against the New England Patriots in the first half of an NFL football game, Sunday, Oct. 25, 2020, in Foxborough, Mass. (AP PhotoSteven Senne)

Newton was out of sync from the outset, making poor reads and poorer throws. But Garoppolo was successful in spreading out New England’s defense with a steady diet of passes behind the line scrimmage and jet sweeps to get the ball in the hands of Wilson, Samuel and George Kittle.

San Francisco dominated the first half, taking a 23-3 lead, holding the ball for 22:30, and racking up a 301-59 advantage in total yards. The Patriots also managed just four first downs to the 49ers’ 18.

The Niners took just over five minutes and nine plays to march 75 yards and take a 7-0 lead on 3-yard run by Wilson. It was the first time the Patriots have allowed a touchdown on an opponents’ opening drive at home since Week 4 of 2016 against Buffalo.

San Francisco 49ers tight end George Kittle (85) eludes New England Patriots defensive back J.C. Jackson (27) after catching a pass in the first half of an NFL football game, Sunday, Oct. 25, 2020, in Foxborough, Mass. (AP PhotoSteven Senne)

San Francisco 49ers tight end George Kittle (85) eludes New England Patriots defensive back J.C. Jackson (27) after catching a pass in the first half of an NFL football game, Sunday, Oct. 25, 2020, in Foxborough, Mass. (AP PhotoSteven Senne)

Following a Patriots punt, San Francisco was pinned inside its 15. Long completions by Garoppolo helped erase some early penalty losses before he missed high on a pass for Kittle and was intercepted by Devin McCourty.

San Francisco’s defense limited the damage, yielding a 40-yard field goal by Nick Folk.

That wasn’t the case for the Patriots’ defense later in the second quarter.

San Francisco 49ers quarterback Jimmy Garoppolo passes against the New England Patriots in the first half of an NFL football game, Sunday, Oct. 25, 2020, in Foxborough, Mass. (AP PhotoSteven Senne)

San Francisco 49ers quarterback Jimmy Garoppolo passes against the New England Patriots in the first half of an NFL football game, Sunday, Oct. 25, 2020, in Foxborough, Mass. (AP PhotoSteven Senne)

Trailing 10-3, Newton made a bad developing play worse when he tried to dump off the ball on the run to receiver Jakobi Meyers. It was picked off by linebacker Fred Warner. Five plays later the 49ers capitalized on a 4-yard touchdown run by Kyle Juszczyk.

The lead grew to 23-3 with just under a minute to go before halftime on a 16-yard run by Wilson.

INJURIES

San Francisco 49ers quarterback Jimmy Garoppolo passes against the New England Patriots in the first half of an NFL football game, Sunday, Oct. 25, 2020, in Foxborough, Mass. (AP PhotoSteven Senne)

San Francisco 49ers quarterback Jimmy Garoppolo passes against the New England Patriots in the first half of an NFL football game, Sunday, Oct. 25, 2020, in Foxborough, Mass. (AP PhotoSteven Senne)

49ers: Wilson Had just crossed into the end zone following his third TD when his leg twisted as he was tackled. He stayed down on the field before being able to walk off under his own power.

Patriots: WR N’Keal Harry left with a head injury and did not return. … LG Joe Thuney departed with an ankle injury. … RT Justin Herron also left with an ankle injury.

UP NEXT

New England Patriots quarterback Cam Newton drops back to pass under pressure from San Francisco 49ers defensive end Arik Armstead (91) in the first half of an NFL football game, Sunday, Oct. 25, 2020, in Foxborough, Mass. (AP PhotoCharles Krupa)

New England Patriots quarterback Cam Newton drops back to pass under pressure from San Francisco 49ers defensive end Arik Armstead (91) in the first half of an NFL football game, Sunday, Oct. 25, 2020, in Foxborough, Mass. (AP PhotoCharles Krupa)

The 49ers head to Seattle next Sunday. The Patriots visit Buffalo.

More AP NFL coverage: https://apnews.com/NFL and https://twitter.com/AP_NFL

San Francisco 49ers wide receiver Deebo Samuel (19) runs from New England Patriots linebacker Ja'Whaun Bentley after catching a pass in the first half of an NFL football game, Sunday, Oct. 25, 2020, in Foxborough, Mass. (AP PhotoSteven Senne)

San Francisco 49ers wide receiver Deebo Samuel (19) runs from New England Patriots linebacker Ja'Whaun Bentley after catching a pass in the first half of an NFL football game, Sunday, Oct. 25, 2020, in Foxborough, Mass. (AP PhotoSteven Senne)

 San Francisco 49ers linebacker Fred Warner, left, celebrates his interception with teammates in the first half of an NFL football game against the New England Patriots, Sunday, Oct. 25, 2020, in Foxborough, Mass. (AP PhotoSteven Senne)

San Francisco 49ers linebacker Fred Warner, left, celebrates his interception with teammates in the first half of an NFL football game against the New England Patriots, Sunday, Oct. 25, 2020, in Foxborough, Mass. (AP PhotoSteven Senne)

 San Francisco 49ers fullback Kyle Juszczyk, center, celebrates his touchdown with teammates Jeff Wilson Jr., left, and George Kittle, right, in the first half of an NFL football game against the New England Patriots, Sunday, Oct. 25, 2020, in Foxborough, Mass. (AP PhotoSteven Senne)

San Francisco 49ers fullback Kyle Juszczyk, center, celebrates his touchdown with teammates Jeff Wilson Jr., left, and George Kittle, right, in the first half of an NFL football game against the New England Patriots, Sunday, Oct. 25, 2020, in Foxborough, Mass. (AP PhotoSteven Senne)

 San Francisco 49ers running back Jeff Wilson Jr., left, celebrates his touchdown with George Kittle, right, in the first half of an NFL football game against the New England Patriots, Sunday, Oct. 25, 2020, in Foxborough, Mass. (AP PhotoSteven Senne)

San Francisco 49ers running back Jeff Wilson Jr., left, celebrates his touchdown with George Kittle, right, in the first half of an NFL football game against the New England Patriots, Sunday, Oct. 25, 2020, in Foxborough, Mass. (AP PhotoSteven Senne)