Cristiano Ronaldo scored his 750th career goal. Olivier Giroud put on a four-goal masterclass. Neymar got the goals that mattered most to leave Manchester United facing a possible Champions League exit.

Neymar scored early and late at Old Trafford as Paris Saint-Germain won 3-1 in the latest bout of a fierce Champions League rivalry to take control of its destiny in Group H.

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PSG's Marquinhos scores his side's second goal during a Group H Champions League soccer match between Manchester United and Paris Saint Germain at the Old Trafford stadium in Manchester, England, Wednesday, Dec. 2, 2020. (AP PhotoDave Thompson)

Cristiano Ronaldo scored his 750th career goal. Olivier Giroud put on a four-goal masterclass. Neymar got the goals that mattered most to leave Manchester United facing a possible Champions League exit.

Manchester United's Fred, left, challenges for the ball with PSG's Leandro Paredes during a Group H Champions League soccer match between Manchester United and Paris Saint Germain at the Old Trafford stadium in Manchester, England, Wednesday, Dec. 2, 2020. (AP PhotoDave Thompson)

Fred finally saw a red card in the 70th minute just as United tried to come back from PSG taking a 2-1 lead through another Brazilian, Marquinhos.

Leipzig's Alexander Sorloth, second right, celebrates with teammates his side's fourth goal during the Champions League group H soccer match between Istanbul Basaksehir and RB Leipzig at Fatih Terim Stadium in Istanbul, Wednesday, Dec. 2, 2020. Leipzig won 4-3. (AP Photo)

Borussia Dortmund was the only team to advance Wednesday, drawing 1-1 at home against Lazio to become the ninth team in the round of 16.

Brugge's Odilon Kossounou, left, vies for the ball with Zenit's Sebastian Driussi during a Champions league Group F soccer match between Brugge and Zenit at the Jan Breydel stadium in Bruges, Belgium, Wednesday, Dec. 2, 2020. (AP PhotoFrancisco Seco)

THREE-WAY BATTLE

PSG's Neymar, right, shoots to score the opening goal during a Group H Champions League soccer match between Manchester United and Paris Saint Germain at the Old Trafford stadium in Manchester, England, Wednesday, Dec. 2, 2020. (AP PhotoDave Thompson)

But a chipped shot by Edinson Cavani, PSG’s record goalscorer who joined United this season, came back off the crossbar and Anthony Martial skied a clear chance minutes later.

A technical staff sits on empty stands ahead of the Champions League group G soccer match between Ferencvaros and Barcelona at the Ferenc Puskas stadium in Budapest, Hungary, Wednesday, Dec. 2, 2020. (AP PhotoLaszlo Balogh)

It was tough on Başakşehir’s İrfan Can Kahveci who completed an impressive hat trick in the 85th minute to cancel Leipzig’s lead for a second time.

Dortmund's Raphael Guerreiro, right, celebrates after scoring his side's opening goal during the Champions League, Group F, soccer match between Borussia Dortmund and Lazio at the Signal Iduna Park stadium in Dortmund, Germany, Wednesday, Dec. 2, 2020. (AP PhotoMartin Meissner, Pool)

The most significant detail of Juve’s routine 3-0 win over Dynamo Kviv was the history made by the referee.

PSG's Neymar, right, celebrates with Kylian Mbappe after scoring his side's third goal during a Group H Champions League soccer match between Manchester United and Paris Saint Germain at the Old Trafford stadium in Manchester, England, Wednesday, Dec. 2, 2020. (AP PhotoDave Thompson)

If Messi and Ronaldo both play, it will be the veterans’ first meeting in the group stage.

United was left to regret not substituting midfielder Fred who seemed lucky not to be sent off in the first half when head-butting PSG’s Leandro Paredes.

PSG's Marquinhos scores his side's second goal during a Group H Champions League soccer match between Manchester United and Paris Saint Germain at the Old Trafford stadium in Manchester, England, Wednesday, Dec. 2, 2020. (AP PhotoDave Thompson)

PSG's Marquinhos scores his side's second goal during a Group H Champions League soccer match between Manchester United and Paris Saint Germain at the Old Trafford stadium in Manchester, England, Wednesday, Dec. 2, 2020. (AP PhotoDave Thompson)

Fred finally saw a red card in the 70th minute just as United tried to come back from PSG taking a 2-1 lead through another Brazilian, Marquinhos.

PSG and United are joined on nine points by Leipzig, which got a stoppage-time winning goal to beat İstanbul Başakşehir 4-3 in a thrilling game.

United has perhaps the toughest task in the final games next Tuesday, traveling to Leipzig while PSG hosts Başakşehir.

Manchester United's Fred, left, challenges for the ball with PSG's Leandro Paredes during a Group H Champions League soccer match between Manchester United and Paris Saint Germain at the Old Trafford stadium in Manchester, England, Wednesday, Dec. 2, 2020. (AP PhotoDave Thompson)

Manchester United's Fred, left, challenges for the ball with PSG's Leandro Paredes during a Group H Champions League soccer match between Manchester United and Paris Saint Germain at the Old Trafford stadium in Manchester, England, Wednesday, Dec. 2, 2020. (AP PhotoDave Thompson)

Borussia Dortmund was the only team to advance Wednesday, drawing 1-1 at home against Lazio to become the ninth team in the round of 16.

Juventus was already safely into the next round before Ronaldo marked his 750th goal for his clubs and Portugal. It was a simple tap-in at the far post in a 3-0 win over Dynamo Kyiv.

Chelsea and Sevilla had also advanced before Giroud tore apart the Spanish side on its home turf. The France forward’s perfectly balanced quadruple came from shots with his right and left feet, a header, and then from the penalty spot.

Leipzig's Alexander Sorloth, second right, celebrates with teammates his side's fourth goal during the Champions League group H soccer match between Istanbul Basaksehir and RB Leipzig at Fatih Terim Stadium in Istanbul, Wednesday, Dec. 2, 2020. Leipzig won 4-3. (AP Photo)

Leipzig's Alexander Sorloth, second right, celebrates with teammates his side's fourth goal during the Champions League group H soccer match between Istanbul Basaksehir and RB Leipzig at Fatih Terim Stadium in Istanbul, Wednesday, Dec. 2, 2020. Leipzig won 4-3. (AP Photo)

THREE-WAY BATTLE

Like Real Madrid on Tuesday, Man United lost to leave itself a tense last-round challenge just to qualify for the knockout stage in February.

United recovered well from Neymar’s sixth-minute opener and leveled before halftime from Marcus Rashfiord’s deflected shot before coming out strong in the second half.

Brugge's Odilon Kossounou, left, vies for the ball with Zenit's Sebastian Driussi during a Champions league Group F soccer match between Brugge and Zenit at the Jan Breydel stadium in Bruges, Belgium, Wednesday, Dec. 2, 2020. (AP PhotoFrancisco Seco)

Brugge's Odilon Kossounou, left, vies for the ball with Zenit's Sebastian Driussi during a Champions league Group F soccer match between Brugge and Zenit at the Jan Breydel stadium in Bruges, Belgium, Wednesday, Dec. 2, 2020. (AP PhotoFrancisco Seco)

But a chipped shot by Edinson Cavani, PSG’s record goalscorer who joined United this season, came back off the crossbar and Anthony Martial skied a clear chance minutes later.

PSG then deservedly retook the lead and after Fred’s dismissal, a third goal looked likely even before Neymar rolled the ball into an unguarded goal in stoppage time.

Leipzig’s late goal in Istanbul changed the calculations. Substitute Alexander Sörloth struck just minutes after the ball had rebounded off his face to hit the crossbar of Başakşehir’s goal.

PSG's Neymar, right, shoots to score the opening goal during a Group H Champions League soccer match between Manchester United and Paris Saint Germain at the Old Trafford stadium in Manchester, England, Wednesday, Dec. 2, 2020. (AP PhotoDave Thompson)

PSG's Neymar, right, shoots to score the opening goal during a Group H Champions League soccer match between Manchester United and Paris Saint Germain at the Old Trafford stadium in Manchester, England, Wednesday, Dec. 2, 2020. (AP PhotoDave Thompson)

It was tough on Başakşehir’s İrfan Can Kahveci who completed an impressive hat trick in the 85th minute to cancel Leipzig’s lead for a second time.

BARCA, JUVE CRUISING

In the most lopsided group, Barcelona was able to rest Lionel Messi against Ferencvaros and still score all its goals in the first half hour in a 3-0 win.

A technical staff sits on empty stands ahead of the Champions League group G soccer match between Ferencvaros and Barcelona at the Ferenc Puskas stadium in Budapest, Hungary, Wednesday, Dec. 2, 2020. (AP PhotoLaszlo Balogh)

A technical staff sits on empty stands ahead of the Champions League group G soccer match between Ferencvaros and Barcelona at the Ferenc Puskas stadium in Budapest, Hungary, Wednesday, Dec. 2, 2020. (AP PhotoLaszlo Balogh)

The most significant detail of Juve’s routine 3-0 win over Dynamo Kviv was the history made by the referee.

Stéphanie Frappart of France became the first woman to referee a men’s Champions League match.

Barcelona has five straight wins and leads Juve by three points before they meet in Spain next Tuesday to decide who tops the group. Group winners are seeded in the last-16 draw and play the second leg at home.

Dortmund's Raphael Guerreiro, right, celebrates after scoring his side's opening goal during the Champions League, Group F, soccer match between Borussia Dortmund and Lazio at the Signal Iduna Park stadium in Dortmund, Germany, Wednesday, Dec. 2, 2020. (AP PhotoMartin Meissner, Pool)

Dortmund's Raphael Guerreiro, right, celebrates after scoring his side's opening goal during the Champions League, Group F, soccer match between Borussia Dortmund and Lazio at the Signal Iduna Park stadium in Dortmund, Germany, Wednesday, Dec. 2, 2020. (AP PhotoMartin Meissner, Pool)

If Messi and Ronaldo both play, it will be the veterans’ first meeting in the group stage.

A RUSSIAN WIN

Krasnodar’s 1-0 win at home to Rennes was the Russian club's first in its debut Champions League campaign. It assured Krasnodar of third place in the group behind Chelsea and Sevilla, and means it will enter the Europa League's last 32.

PSG's Neymar, right, celebrates with Kylian Mbappe after scoring his side's third goal during a Group H Champions League soccer match between Manchester United and Paris Saint Germain at the Old Trafford stadium in Manchester, England, Wednesday, Dec. 2, 2020. (AP PhotoDave Thompson)

PSG's Neymar, right, celebrates with Kylian Mbappe after scoring his side's third goal during a Group H Champions League soccer match between Manchester United and Paris Saint Germain at the Old Trafford stadium in Manchester, England, Wednesday, Dec. 2, 2020. (AP PhotoDave Thompson)

It was also a first victory this season for any of the six Russian clubs that entered the two European competitions.

Later, Russian champion Zenit St. Petersburg lost 3-0 at Club Brugge to stay rooted to the bottom of Group F despite being the top-seeded team. Zenit cannot qualify for the Europa League.

Brugge can join Dortmund in advancing from Group F, if it beats Lazio in Rome next Tuesday.

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