Rafael Devers homered and the Boston Red Sox scored twice in the 10th inning on a wild pitch and an RBI single by Christian Vázquez to extend their winning streak to five games with a 6-4 victory over the Baltimore Orioles on Saturday night.

Baltimore outfielder Trey Mancini hit his first home run since his return from cancer surgery that caused him to miss the 2020 season. It was Mancini’s first homer since Sept. 28, 2019.

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Baltimore Orioles' Trey Mancini runs the bases after hitting a solo home run off Boston Red Sox starting pitcher Garrett Richards during the first inning of a baseball game, Saturday, April 10, 2021, in Baltimore. (AP PhotoJulio Cortez)

Rafael Devers homered and the Boston Red Sox scored twice in the 10th inning on a wild pitch and an RBI single by Christian Vázquez to extend their winning streak to five games with a 6-4 victory over the Baltimore Orioles on Saturday night.

Boston Red Sox outfielders, from left, Franchy Cordero, Enrique Hernandez and Alex Verdugo react after defeating the Baltimore Orioles 6-4 in ten innings during a baseball game, Saturday, April 10, 2021, in Baltimore. (AP PhotoJulio Cortez)

Michael Chavis, recalled from the alternate training site earlier in the day, entered as a pinch-runner in the 10th and scored on a low pitch by Dillon Tate (0-1) that rolled to the backstop. Vázquez added an insurance run with a single off Wade LeBlanc.

Baltimore Orioles' Trey Mancini smashes his helmet on the grass after grounding out with the bases loaded to end the eighth inning of a baseball game against the Boston Red Sox, Saturday, April 10, 2021, in Baltimore. The Red Sox won 6-4 in ten innings. (AP PhotoJulio Cortez)

The Orioles were 1 for 13 with runners in scoring position.

Baltimore Orioles' Maikel Franco breaks his bat while driving in Ryan Mountcastle with a run against the Boston Red Sox during the eighth inning of a baseball game, Saturday, April 10, 2021, in Baltimore. The Red Sox won 6-4 in ten innings. (AP PhotoJulio Cortez)

Devers broke the deadlock with a towering homer to right-center off rookie left-hander Bruce Zimmermann in the sixth.

Baltimore Orioles' Ryan Mountcastle, left, slides in ahead of the tag by Boston Red Sox catcher Kevin Plawecki on a fielders choice ground ball by Orioles' Maikel Franco during the eighth inning of a baseball game, Saturday, April 10, 2021, in Baltimore. The Red Sox won 6-4 in ten innings. (AP PhotoJulio Cortez)

Red Sox: DH/OF J.D. Martinez has cold symptoms and was placed on the COVID-19 injured list. Martinez underwent testing and the team is awaiting the results. “We do believe he will be back with us (Sunday),” manager Alex Cora said.

Boston Red Sox starting pitcher Garrett Richards throws a pitch to the Baltimore Orioles during the third inning of a baseball game, Saturday, April 10, 2021, in Baltimore. (AP PhotoJulio Cortez)

Red Sox: RHP Nick Pivetta (1-0, 0.00 ERA) will make his first career start at Camden Yards. He was solid in his season debut, throwing five scoreless innings of two-hit ball in an 11-2 win over the Rays on Monday.

Donnie Carroll, right, reacts after his childhood friend, Baltimore Orioles starting pitcher Bruce Zimmermann gave up a solo home run to Boston Red Sox's Rafael Devers to break a 2-2 tie during the sixth inning of a baseball game, Saturday, April 10, 2021, in Baltimore. (AP PhotoJulio Cortez)

Donnie Carroll, right, reacts after his childhood friend, Baltimore Orioles starting pitcher Bruce Zimmermann gave up a solo home run to Boston Red Sox's Rafael Devers to break a 2-2 tie during the sixth inning of a baseball game, Saturday, April 10, 2021, in Baltimore. (AP PhotoJulio Cortez)

Baltimore Orioles center fielder Cedric Mullins goes up to make a warning track catch on a ball hit by Boston Red Sox's Enrique Hernandez during the fifth inning of a baseball game, Saturday, April 10, 2021, in Baltimore. (AP PhotoJulio Cortez)

Baltimore Orioles center fielder Cedric Mullins goes up to make a warning track catch on a ball hit by Boston Red Sox's Enrique Hernandez during the fifth inning of a baseball game, Saturday, April 10, 2021, in Baltimore. (AP PhotoJulio Cortez)

Boston Red Sox's Alex Verdugo scores on a single by Christian Vazquez during the tenth inning of a baseball game against the Baltimore Orioles, Saturday, April 10, 2021, in Baltimore. The Red Sox won 6-4 in ten innings. (AP PhotoJulio Cortez)

Boston Red Sox's Alex Verdugo scores on a single by Christian Vazquez during the tenth inning of a baseball game against the Baltimore Orioles, Saturday, April 10, 2021, in Baltimore. The Red Sox won 6-4 in ten innings. (AP PhotoJulio Cortez)

Baltimore Orioles catcher Chance Sisco, right, prepares to tag out Boston Red Sox's Marwin Gonzalez at home during the fourth inning of a baseball game, Saturday, April 10, 2021, in Baltimore. Gonzalez was trying to score on a hit by Christian Arroyo. (AP PhotoJulio Cortez)

Baltimore Orioles catcher Chance Sisco, right, prepares to tag out Boston Red Sox's Marwin Gonzalez at home during the fourth inning of a baseball game, Saturday, April 10, 2021, in Baltimore. Gonzalez was trying to score on a hit by Christian Arroyo. (AP PhotoJulio Cortez)

Boston Red Sox third baseman Rafael Devers, center, makes a catch on a fly ball hit by Baltimore Orioles' Cedric Mullins, not visible, as Red Sox's Marwin Gonzalez, font left, Enrique Hernandez, back left, and Xander Bogaerts look on during the first inning of a baseball game, Saturday, April 10, 2021, in Baltimore. (AP PhotoJulio Cortez)

Boston Red Sox third baseman Rafael Devers, center, makes a catch on a fly ball hit by Baltimore Orioles' Cedric Mullins, not visible, as Red Sox's Marwin Gonzalez, font left, Enrique Hernandez, back left, and Xander Bogaerts look on during the first inning of a baseball game, Saturday, April 10, 2021, in Baltimore. (AP PhotoJulio Cortez)

Baltimore Orioles shortstop Freddy Galvis, right, runs to tag out Boston Red Sox's Enrique Hernandez, left, on a fielders choice ground ball by Red Sox's Alex Verdugo during the first inning of a baseball game, Saturday, April 10, 2021, in Baltimore. (AP PhotoJulio Cortez)

Baltimore Orioles shortstop Freddy Galvis, right, runs to tag out Boston Red Sox's Enrique Hernandez, left, on a fielders choice ground ball by Red Sox's Alex Verdugo during the first inning of a baseball game, Saturday, April 10, 2021, in Baltimore. (AP PhotoJulio Cortez)

A socially distanced crowd watches on as Baltimore Orioles starting pitcher Bruce Zimmermann throws a pitch to the Boston Red Sox during the first inning of a baseball game, Saturday, April 10, 2021, in Baltimore. (AP PhotoJulio Cortez)

A socially distanced crowd watches on as Baltimore Orioles starting pitcher Bruce Zimmermann throws a pitch to the Boston Red Sox during the first inning of a baseball game, Saturday, April 10, 2021, in Baltimore. (AP PhotoJulio Cortez)

Baltimore Orioles shortstop Freddy Galvis throws to first base while trying to put out Boston Red Sox's Alex Verdugo on a fielders choice ground ball during the first inning of a baseball game, Saturday, April 10, 2021, in Baltimore. (AP PhotoJulio Cortez)

Baltimore Orioles shortstop Freddy Galvis throws to first base while trying to put out Boston Red Sox's Alex Verdugo on a fielders choice ground ball during the first inning of a baseball game, Saturday, April 10, 2021, in Baltimore. (AP PhotoJulio Cortez)

Baltimore Orioles starting pitcher Bruce Zimmermann throws a pitch to the Boston Red Sox during the first inning of a baseball game, Saturday, April 10, 2021, in Baltimore. (AP PhotoJulio Cortez)

Baltimore Orioles starting pitcher Bruce Zimmermann throws a pitch to the Boston Red Sox during the first inning of a baseball game, Saturday, April 10, 2021, in Baltimore. (AP PhotoJulio Cortez)

The Orioles scored twice in the eighth to take a 4-3 lead on a fielder’s choice by Maikel Franco and an RBI single by Freddy Galvis off Adam Ottavino. Boston tied it in the ninth on a fielder's choice by Bobby Dalbec against César Valdez, who had converted his two previous save chances.

Baltimore Orioles' Trey Mancini runs the bases after hitting a solo home run off Boston Red Sox starting pitcher Garrett Richards during the first inning of a baseball game, Saturday, April 10, 2021, in Baltimore. (AP PhotoJulio Cortez)

Baltimore Orioles' Trey Mancini runs the bases after hitting a solo home run off Boston Red Sox starting pitcher Garrett Richards during the first inning of a baseball game, Saturday, April 10, 2021, in Baltimore. (AP PhotoJulio Cortez)

Michael Chavis, recalled from the alternate training site earlier in the day, entered as a pinch-runner in the 10th and scored on a low pitch by Dillon Tate (0-1) that rolled to the backstop. Vázquez added an insurance run with a single off Wade LeBlanc.

Matt Barnes (1-0) struck out two in the ninth and Matt Andriese earned Boston's first save of the season.

Devers had two RBIs for the Red Sox, who have won five consecutive games for the first time since August 2019.

Boston Red Sox outfielders, from left, Franchy Cordero, Enrique Hernandez and Alex Verdugo react after defeating the Baltimore Orioles 6-4 in ten innings during a baseball game, Saturday, April 10, 2021, in Baltimore. (AP PhotoJulio Cortez)

Boston Red Sox outfielders, from left, Franchy Cordero, Enrique Hernandez and Alex Verdugo react after defeating the Baltimore Orioles 6-4 in ten innings during a baseball game, Saturday, April 10, 2021, in Baltimore. (AP PhotoJulio Cortez)

The Orioles were 1 for 13 with runners in scoring position.

Boston took a 2-0 lead in the first. Devers hit an RBI single and then got picked off first, but stayed in a rundown long enough to allow Xander Bogaerts to score from second.

Mancini and Anthony Santander responded with back-to-back homers off Garrett Richards in the bottom half.

Baltimore Orioles' Trey Mancini smashes his helmet on the grass after grounding out with the bases loaded to end the eighth inning of a baseball game against the Boston Red Sox, Saturday, April 10, 2021, in Baltimore. The Red Sox won 6-4 in ten innings. (AP PhotoJulio Cortez)

Baltimore Orioles' Trey Mancini smashes his helmet on the grass after grounding out with the bases loaded to end the eighth inning of a baseball game against the Boston Red Sox, Saturday, April 10, 2021, in Baltimore. The Red Sox won 6-4 in ten innings. (AP PhotoJulio Cortez)

Devers broke the deadlock with a towering homer to right-center off rookie left-hander Bruce Zimmermann in the sixth.

Zimmermann, a Maryland native who grew up rooting for the Orioles, made his third career start, but it was his first game at Camden Yards with fans in attendance (9,307). Zimmermann allowed three runs and seven hits with four strikeouts and a walk over six innings.

TRAINER’S ROOM

Baltimore Orioles' Maikel Franco breaks his bat while driving in Ryan Mountcastle with a run against the Boston Red Sox during the eighth inning of a baseball game, Saturday, April 10, 2021, in Baltimore. The Red Sox won 6-4 in ten innings. (AP PhotoJulio Cortez)

Baltimore Orioles' Maikel Franco breaks his bat while driving in Ryan Mountcastle with a run against the Boston Red Sox during the eighth inning of a baseball game, Saturday, April 10, 2021, in Baltimore. The Red Sox won 6-4 in ten innings. (AP PhotoJulio Cortez)

Red Sox: DH/OF J.D. Martinez has cold symptoms and was placed on the COVID-19 injured list. Martinez underwent testing and the team is awaiting the results. “We do believe he will be back with us (Sunday),” manager Alex Cora said.

Orioles: OF DJ Stewart (left hamstring) was reinstated from the 10-day IL. He has not played since March 5. “I was worried it was going to be a lot longer,” Stewart said before the game.

UP NEXT

Baltimore Orioles' Ryan Mountcastle, left, slides in ahead of the tag by Boston Red Sox catcher Kevin Plawecki on a fielders choice ground ball by Orioles' Maikel Franco during the eighth inning of a baseball game, Saturday, April 10, 2021, in Baltimore. The Red Sox won 6-4 in ten innings. (AP PhotoJulio Cortez)

Baltimore Orioles' Ryan Mountcastle, left, slides in ahead of the tag by Boston Red Sox catcher Kevin Plawecki on a fielders choice ground ball by Orioles' Maikel Franco during the eighth inning of a baseball game, Saturday, April 10, 2021, in Baltimore. The Red Sox won 6-4 in ten innings. (AP PhotoJulio Cortez)

Red Sox: RHP Nick Pivetta (1-0, 0.00 ERA) will make his first career start at Camden Yards. He was solid in his season debut, throwing five scoreless innings of two-hit ball in an 11-2 win over the Rays on Monday.

Orioles: RHP Jorge Lopez (0-1) will look to avoid the sweep against Boston. He struggled in his last start, allowing four runs, three hits and three walks over 4 2/3 innings in a 7-0 loss to the Yankees.

More AP MLB: https://apnews.com/MLB and https://twitter.com/AP_Sports

Boston Red Sox starting pitcher Garrett Richards throws a pitch to the Baltimore Orioles during the third inning of a baseball game, Saturday, April 10, 2021, in Baltimore. (AP PhotoJulio Cortez)

Boston Red Sox starting pitcher Garrett Richards throws a pitch to the Baltimore Orioles during the third inning of a baseball game, Saturday, April 10, 2021, in Baltimore. (AP PhotoJulio Cortez)

Donnie Carroll, right, reacts after his childhood friend, Baltimore Orioles starting pitcher Bruce Zimmermann gave up a solo home run to Boston Red Sox's Rafael Devers to break a 2-2 tie during the sixth inning of a baseball game, Saturday, April 10, 2021, in Baltimore. (AP PhotoJulio Cortez)

Donnie Carroll, right, reacts after his childhood friend, Baltimore Orioles starting pitcher Bruce Zimmermann gave up a solo home run to Boston Red Sox's Rafael Devers to break a 2-2 tie during the sixth inning of a baseball game, Saturday, April 10, 2021, in Baltimore. (AP PhotoJulio Cortez)

Baltimore Orioles center fielder Cedric Mullins goes up to make a warning track catch on a ball hit by Boston Red Sox's Enrique Hernandez during the fifth inning of a baseball game, Saturday, April 10, 2021, in Baltimore. (AP PhotoJulio Cortez)

Baltimore Orioles center fielder Cedric Mullins goes up to make a warning track catch on a ball hit by Boston Red Sox's Enrique Hernandez during the fifth inning of a baseball game, Saturday, April 10, 2021, in Baltimore. (AP PhotoJulio Cortez)

Boston Red Sox's Alex Verdugo scores on a single by Christian Vazquez during the tenth inning of a baseball game against the Baltimore Orioles, Saturday, April 10, 2021, in Baltimore. The Red Sox won 6-4 in ten innings. (AP PhotoJulio Cortez)

Boston Red Sox's Alex Verdugo scores on a single by Christian Vazquez during the tenth inning of a baseball game against the Baltimore Orioles, Saturday, April 10, 2021, in Baltimore. The Red Sox won 6-4 in ten innings. (AP PhotoJulio Cortez)

Baltimore Orioles catcher Chance Sisco, right, prepares to tag out Boston Red Sox's Marwin Gonzalez at home during the fourth inning of a baseball game, Saturday, April 10, 2021, in Baltimore. Gonzalez was trying to score on a hit by Christian Arroyo. (AP PhotoJulio Cortez)

Baltimore Orioles catcher Chance Sisco, right, prepares to tag out Boston Red Sox's Marwin Gonzalez at home during the fourth inning of a baseball game, Saturday, April 10, 2021, in Baltimore. Gonzalez was trying to score on a hit by Christian Arroyo. (AP PhotoJulio Cortez)

Boston Red Sox third baseman Rafael Devers, center, makes a catch on a fly ball hit by Baltimore Orioles' Cedric Mullins, not visible, as Red Sox's Marwin Gonzalez, font left, Enrique Hernandez, back left, and Xander Bogaerts look on during the first inning of a baseball game, Saturday, April 10, 2021, in Baltimore. (AP PhotoJulio Cortez)

Boston Red Sox third baseman Rafael Devers, center, makes a catch on a fly ball hit by Baltimore Orioles' Cedric Mullins, not visible, as Red Sox's Marwin Gonzalez, font left, Enrique Hernandez, back left, and Xander Bogaerts look on during the first inning of a baseball game, Saturday, April 10, 2021, in Baltimore. (AP PhotoJulio Cortez)

Baltimore Orioles shortstop Freddy Galvis, right, runs to tag out Boston Red Sox's Enrique Hernandez, left, on a fielders choice ground ball by Red Sox's Alex Verdugo during the first inning of a baseball game, Saturday, April 10, 2021, in Baltimore. (AP PhotoJulio Cortez)

Baltimore Orioles shortstop Freddy Galvis, right, runs to tag out Boston Red Sox's Enrique Hernandez, left, on a fielders choice ground ball by Red Sox's Alex Verdugo during the first inning of a baseball game, Saturday, April 10, 2021, in Baltimore. (AP PhotoJulio Cortez)

A socially distanced crowd watches on as Baltimore Orioles starting pitcher Bruce Zimmermann throws a pitch to the Boston Red Sox during the first inning of a baseball game, Saturday, April 10, 2021, in Baltimore. (AP PhotoJulio Cortez)

A socially distanced crowd watches on as Baltimore Orioles starting pitcher Bruce Zimmermann throws a pitch to the Boston Red Sox during the first inning of a baseball game, Saturday, April 10, 2021, in Baltimore. (AP PhotoJulio Cortez)

Baltimore Orioles shortstop Freddy Galvis throws to first base while trying to put out Boston Red Sox's Alex Verdugo on a fielders choice ground ball during the first inning of a baseball game, Saturday, April 10, 2021, in Baltimore. (AP PhotoJulio Cortez)

Baltimore Orioles shortstop Freddy Galvis throws to first base while trying to put out Boston Red Sox's Alex Verdugo on a fielders choice ground ball during the first inning of a baseball game, Saturday, April 10, 2021, in Baltimore. (AP PhotoJulio Cortez)

Baltimore Orioles starting pitcher Bruce Zimmermann throws a pitch to the Boston Red Sox during the first inning of a baseball game, Saturday, April 10, 2021, in Baltimore. (AP PhotoJulio Cortez)

Baltimore Orioles starting pitcher Bruce Zimmermann throws a pitch to the Boston Red Sox during the first inning of a baseball game, Saturday, April 10, 2021, in Baltimore. (AP PhotoJulio Cortez)