Shane Bieber kept up his record strikeout run, fanning 13 and pitching the Cleveland Indians past the Cincinnati Reds 6-3 on Sunday.

Bieber (2-1) become the first pitcher in big league history to begin the season with four straight starts with at least 10 strikeouts.

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Cleveland Indians' Amed Rosario, left, reaches first base safely as Cincinnati Reds' Joey Votto, right, fields the ball during the fourth inning of a baseball game in Cincinnati, Sunday, April 18, 2021. (AP PhotoAaron Doster)

Shane Bieber kept up his record strikeout run, fanning 13 and pitching the Cleveland Indians past the Cincinnati Reds 6-3 on Sunday.

Cleveland Indians' Yu Chang hits the ball for a single during the third inning of a baseball game against the Cincinnati Reds in Cincinnati, Sunday, April 18, 2021. (AP PhotoAaron Doster)

Bieber went eight innings, allowing three runs and six hits with two walks.

Cleveland Indians' Roberto Perez hits a three-run home run during the fourth inning of a baseball game against the Cincinnati Reds in Cincinnati, Sunday, April 18, 2021. (AP PhotoAaron Doster)

Roberto Pérez hit a three-run homer off Wade Miley (2-1) over the center field wall with two on in the fourth inning for a 4-0 lead.

Cleveland Indians' Eddie Rosario makes a catch for an out during the fifth inning of a baseball game in Cincinnati, Sunday, April 18, 2021. (AP PhotoAaron Doster)

Joey Votto had three hits, including a two-run double in the Reds fifth. Tyler Naquin homered off Bieber in the eighth.

Cincinnati Reds' Joey Votto hits a two-run RBI double during the fifth inning of a baseball game against the Cleveland Indians in Cincinnati, Sunday, April 18, 2021. (AP PhotoAaron Doster)

UP NEXT

A view of the field during the fourth inning of a baseball game between the Cleveland Indians and the Cincinnati Reds in Cincinnati, Sunday, April 18, 2021. (AP PhotoAaron Doster)

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Cleveland Indians' Jordan Luplow reacts with teammate Yu Chang after hitting a two-run home run during the seventh inning of a baseball game against the Cincinnati Reds in Cincinnati, Sunday, April 18, 2021. (AP PhotoAaron Doster)

Cleveland Indians' Jordan Luplow reacts with teammate Yu Chang after hitting a two-run home run during the seventh inning of a baseball game against the Cincinnati Reds in Cincinnati, Sunday, April 18, 2021. (AP PhotoAaron Doster)

The AL Cy Young Award winner has 48 strikeouts this year, matching Hall of Famer Nolan Ryan for the most through the first four start of a season. Bieber has fanned at least eight in a 16 straight starts, one short of Randy Johnson’s major league mark.

Cleveland Indians' Amed Rosario, left, reaches first base safely as Cincinnati Reds' Joey Votto, right, fields the ball during the fourth inning of a baseball game in Cincinnati, Sunday, April 18, 2021. (AP PhotoAaron Doster)

Cleveland Indians' Amed Rosario, left, reaches first base safely as Cincinnati Reds' Joey Votto, right, fields the ball during the fourth inning of a baseball game in Cincinnati, Sunday, April 18, 2021. (AP PhotoAaron Doster)

Bieber went eight innings, allowing three runs and six hits with two walks.

Emmanuel Clase struck out the side in the ninth, again hitting 100 mph with his heater.

The Indians hit three home runs, all with two outs, to salvage a win in the all-Ohio series.

Cleveland Indians' Yu Chang hits the ball for a single during the third inning of a baseball game against the Cincinnati Reds in Cincinnati, Sunday, April 18, 2021. (AP PhotoAaron Doster)

Cleveland Indians' Yu Chang hits the ball for a single during the third inning of a baseball game against the Cincinnati Reds in Cincinnati, Sunday, April 18, 2021. (AP PhotoAaron Doster)

Roberto Pérez hit a three-run homer off Wade Miley (2-1) over the center field wall with two on in the fourth inning for a 4-0 lead.

José Ramírez launched a solo drive into the upper deck in the first. Jordan Luplow had a two-run homer in the seventh.

Wade Miley (2-1) took the loss for the Reds, lasting five innings and striking out five.

Cleveland Indians' Roberto Perez hits a three-run home run during the fourth inning of a baseball game against the Cincinnati Reds in Cincinnati, Sunday, April 18, 2021. (AP PhotoAaron Doster)

Cleveland Indians' Roberto Perez hits a three-run home run during the fourth inning of a baseball game against the Cincinnati Reds in Cincinnati, Sunday, April 18, 2021. (AP PhotoAaron Doster)

Joey Votto had three hits, including a two-run double in the Reds fifth. Tyler Naquin homered off Bieber in the eighth.

TRAINER'S ROOM

Reds 3B Mike Moustakas missed his third straight game with a non-COVID illness. Kyle Farmer started in his place. OF Shogo Akiyama (hamstring) is back with the team, but it not expected to play until at least May.

Cleveland Indians' Eddie Rosario makes a catch for an out during the fifth inning of a baseball game in Cincinnati, Sunday, April 18, 2021. (AP PhotoAaron Doster)

Cleveland Indians' Eddie Rosario makes a catch for an out during the fifth inning of a baseball game in Cincinnati, Sunday, April 18, 2021. (AP PhotoAaron Doster)

UP NEXT

Indians: After an off day, open a nine-game homestand Tuesday with a pair against the White Sox. The teams split a four-game series last week in Chicago. Cleveland sends RHP Zach Plesac against LHP Carlos Rodón, who threw a no-hitter against them in an 8-0 White Sox win Wednesday.

Reds: After an off day, RHP Luis Castillo (1-1) will be on the mound Tuesday night to open a three-game home series with Arizona. RHP Zac Gallen (0-0) starts for the Diamondbacks, who took two out of three from the Reds in a series earlier this month in Phoenix. Castillo struck out seven in a no-decision on Tuesday. Coming off the disabled list, Gallen struck out eight over four innings in Tuesday's loss to the A's.

Cincinnati Reds' Joey Votto hits a two-run RBI double during the fifth inning of a baseball game against the Cleveland Indians in Cincinnati, Sunday, April 18, 2021. (AP PhotoAaron Doster)

Cincinnati Reds' Joey Votto hits a two-run RBI double during the fifth inning of a baseball game against the Cleveland Indians in Cincinnati, Sunday, April 18, 2021. (AP PhotoAaron Doster)

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A view of the field during the fourth inning of a baseball game between the Cleveland Indians and the Cincinnati Reds in Cincinnati, Sunday, April 18, 2021. (AP PhotoAaron Doster)

A view of the field during the fourth inning of a baseball game between the Cleveland Indians and the Cincinnati Reds in Cincinnati, Sunday, April 18, 2021. (AP PhotoAaron Doster)

Cleveland Indians' Jordan Luplow reacts with teammate Yu Chang after hitting a two-run home run during the seventh inning of a baseball game against the Cincinnati Reds in Cincinnati, Sunday, April 18, 2021. (AP PhotoAaron Doster)

Cleveland Indians' Jordan Luplow reacts with teammate Yu Chang after hitting a two-run home run during the seventh inning of a baseball game against the Cincinnati Reds in Cincinnati, Sunday, April 18, 2021. (AP PhotoAaron Doster)