Vladimir Guerrero Jr. homered and five Toronto pitchers combined on a six-hitter to beat Philadelphia 4-0 Saturday night in a game when Phillies star Bryce Harper exited early with right shoulder soreness.

Harper was replaced defensively in right field by Scott Kingery to start the bottom of the fourth. Harper struck out in both of his at-bats.

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Philadelphia Phillies starting pitcher Aaron Nola throws against the Toronto Blue Jays during the first inning of a baseball game Saturday, May 15, 2021, in Dunedin, Fla. (AP PhotoMike Carlson)

Vladimir Guerrero Jr. homered and five Toronto pitchers combined on a six-hitter to beat Philadelphia 4-0 Saturday night in a game when Phillies star Bryce Harper exited early with right shoulder soreness.

Toronto Blue Jays starting pitcher Anthony Kay throws against the Philadelphia Phillies during the first inning of a baseball game Saturday, May 15, 2021, in Dunedin, Fla. (AP PhotoMike Carlson)

Guerrero hit his 10th homer, a first-inning solo shot off Aaron Nola (3-3). The drive to right was Guerrero's sixth to the opposite field.

Toronto Blue Jays' Lourdes Gurriel Jr. celebrates after scoring against the Philadelphia Phillies during the second inning of a baseball game Saturday, May 15, 2021, in Dunedin, Fla. (AP PhotoMike Carlson)

Nola allowed three runs and nine hits over 6 2/3 innings. The right-hander struck out nine and walked three.

Toronto Blue Jays' Vladimir Guerrero Jr. celebrates as he rounds third base after hitting a solo home run against the Philadelphia Phillies during the first inning of a baseball game Saturday, May 15, 2021, in Dunedin, Fla. (AP PhotoMike Carlson)

TRAINER’S ROOM

Philadelphia Phillies starting pitcher Aaron Nola throws against the Toronto Blue Jays during the first inning of a baseball game Saturday, May 15, 2021, in Dunedin, Fla. (AP PhotoMike Carlson)

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The Phillies said Harper is day to day.

Philadelphia Phillies starting pitcher Aaron Nola throws against the Toronto Blue Jays during the first inning of a baseball game Saturday, May 15, 2021, in Dunedin, Fla. (AP PhotoMike Carlson)

Philadelphia Phillies starting pitcher Aaron Nola throws against the Toronto Blue Jays during the first inning of a baseball game Saturday, May 15, 2021, in Dunedin, Fla. (AP PhotoMike Carlson)

Guerrero hit his 10th homer, a first-inning solo shot off Aaron Nola (3-3). The drive to right was Guerrero's sixth to the opposite field.

Anthony Kay went four innings for the Blue Jays, giving up one hit, two walks and striking out six during a 79-pitch outing. Relievers Travis Bergen (2-0), A.J. Cole, Tyler Chatwood and Jordan Romano helped Toronto pitchers finish with 14 strikeouts.

Lourdes Gurriel Jr. had an RBI double and Reese McGuire added a run-scoring single as Toronto took a 3-0 lead in the second.

Toronto Blue Jays starting pitcher Anthony Kay throws against the Philadelphia Phillies during the first inning of a baseball game Saturday, May 15, 2021, in Dunedin, Fla. (AP PhotoMike Carlson)

Toronto Blue Jays starting pitcher Anthony Kay throws against the Philadelphia Phillies during the first inning of a baseball game Saturday, May 15, 2021, in Dunedin, Fla. (AP PhotoMike Carlson)

Nola allowed three runs and nine hits over 6 2/3 innings. The right-hander struck out nine and walked three.

Andrew Knapp pinch-hit for Phillies catcher J.T. Realmuto in the eighth. Manager Joe Girardi said Realmuto had a sore left wrist.

Realmuto left Tuesday's game against Washington after taking a foul ball off his left knee and felt ill with a fever Wednesday night. After not playing Thursday, he was the DH in Friday night's series opener with the Blue Jays.

Toronto Blue Jays' Lourdes Gurriel Jr. celebrates after scoring against the Philadelphia Phillies during the second inning of a baseball game Saturday, May 15, 2021, in Dunedin, Fla. (AP PhotoMike Carlson)

Toronto Blue Jays' Lourdes Gurriel Jr. celebrates after scoring against the Philadelphia Phillies during the second inning of a baseball game Saturday, May 15, 2021, in Dunedin, Fla. (AP PhotoMike Carlson)

TRAINER’S ROOM

Phillies: SS Didi Gregorius (right elbow stiffness) was out of the lineup for the third straight game and said he will undergo additional tests that will likely include a second MRI exam on Monday. Gregorius said there is swelling on the outside of the elbow that limits his swinging a bat. “I am worried because I haven’t been on the field,” said Gregorius, who isn’t sure if he can avoid going on the injured list. … RHP Archie Bradley (left oblique strain) allowed one run and two hits over one inning for Triple-A Lehigh Valley.

Blue Jays: CF George Springer (quadriceps) continues taking batting practice and is going through his rehab program but there is no date for when he will return. “It’s always tough to tell when it comes to quads,” manager Charlie Montoyo said.

Toronto Blue Jays' Vladimir Guerrero Jr. celebrates as he rounds third base after hitting a solo home run against the Philadelphia Phillies during the first inning of a baseball game Saturday, May 15, 2021, in Dunedin, Fla. (AP PhotoMike Carlson)

Toronto Blue Jays' Vladimir Guerrero Jr. celebrates as he rounds third base after hitting a solo home run against the Philadelphia Phillies during the first inning of a baseball game Saturday, May 15, 2021, in Dunedin, Fla. (AP PhotoMike Carlson)

UP NEXT

Phillies RHP Chase Anderson (2-3) and Toronto LHP Robbie Ray (1-1) are the scheduled starters in the series finale on Sunday.

More AP MLB: https://apnews.com/hub/MLB and https://twitter.com/AP_Sports

Philadelphia Phillies starting pitcher Aaron Nola throws against the Toronto Blue Jays during the first inning of a baseball game Saturday, May 15, 2021, in Dunedin, Fla. (AP PhotoMike Carlson)

Philadelphia Phillies starting pitcher Aaron Nola throws against the Toronto Blue Jays during the first inning of a baseball game Saturday, May 15, 2021, in Dunedin, Fla. (AP PhotoMike Carlson)