Austin Nola homered, doubled and drove in a career-high six runs, and Tommy Pham and rookie Kim Ha-seong also connected off Adam Wainwright to lead the San Diego Padres to a 13-3 laugher against the St. Louis Cardinals on Saturday night.

The Padres beat the Cardinals for the second straight night in their first matchup since San Diego eliminated St. Louis from the playoffs last season.

More Images
San Diego Padres' Austin Nola (26) hits a three-run home run during the third inning of a baseball game against the St. Louis Cardinals, Saturday, May 15, 2021, in San Diego. (AP PhotoDenis Poroy)

Austin Nola homered, doubled and drove in a career-high six runs, and Tommy Pham and rookie Kim Ha-seong also connected off Adam Wainwright to lead the San Diego Padres to a 13-3 laugher against the St. Louis Cardinals on Saturday night.

San Diego Padres' Tommy Pham (28) is congratulated by Jake Cronenworth, center, and Austin Nola, right, after hitting a two-run home run during the first inning of a baseball game against the St. Louis Cardinals, Saturday, May 15, 2021, in San Diego. (AP PhotoDenis Poroy)

Nola hit a three-run homer off Wainwright in the third, an RBI double off Tyler Webb in the sixth and a two-run single off infielder Matt Carpenter, who was summoned to pitch with the bases loaded and two outs in the seventh.

San Diego Padres' Ha-Seong Kim (7) points skyward after hitting a solo home run during the second inning of a baseball game against the St. Louis Cardinals, Saturday, May 15, 2021, in San Diego. (AP PhotoDenis Poroy)

Paddack's only big mistake was allowing a solo homer to Yadier Molina with one out in the fourth, his sixth.

St. Louis Cardinals center fielder Harrison Bader catches a ball hit by San Diego Padres' Manny Machado during the second inning of a baseball game Saturday, May 15, 2021, in San Diego. (AP PhotoDenis Poroy)

Kim homered to left with one out in the second, his second.

St. Louis Cardinals' Harrison Bader (48) celebrates after hitting a solo home run during the seventh inning of a baseball game against the San Diego Padres, Saturday, May 15, 2021, in San Diego. (AP PhotoDenis Poroy)

Nolan Arenano and Harrison Bader also homered for the Cardinals. It was Arenado's eighth and Bader's fourth.

St. Louis Cardinals' Yadier Molina (4) waves after hitting a solo home run during the fourth inning of a baseball game against the San Diego Padres, Saturday, May 15, 2021, in San Diego. (AP PhotoDenis Poroy)

St. Louis Cardinals' Yadier Molina (4) waves after hitting a solo home run during the fourth inning of a baseball game against the San Diego Padres, Saturday, May 15, 2021, in San Diego. (AP PhotoDenis Poroy)

San Diego is missing shortstop Fernando Tatis Jr. and right fielder Wil Myers due to COVID-19, and first baseman Eric Hosmer, infielder-outfielder Jurickson Profar and utilityman Jorge Mateo due to contact tracing.

San Diego Padres' Austin Nola (26) hits a three-run home run during the third inning of a baseball game against the St. Louis Cardinals, Saturday, May 15, 2021, in San Diego. (AP PhotoDenis Poroy)

San Diego Padres' Austin Nola (26) hits a three-run home run during the third inning of a baseball game against the St. Louis Cardinals, Saturday, May 15, 2021, in San Diego. (AP PhotoDenis Poroy)

Nola hit a three-run homer off Wainwright in the third, an RBI double off Tyler Webb in the sixth and a two-run single off infielder Matt Carpenter, who was summoned to pitch with the bases loaded and two outs in the seventh.

Carpenter also pitched the scoreless eighth, allowing a single and hitting a batter.

Padres right-hander Chris Paddack threw well but was on a pitch count and came out after throwing 84 pitches in four innings. He held the Cardinals to one run and three hits, struck out two and waked one. Four Cardinals batters worked Paddack for 29 pitches in the first inning. The tall Texan then needed just 12 pitches to get through a perfect second.

San Diego Padres' Tommy Pham (28) is congratulated by Jake Cronenworth, center, and Austin Nola, right, after hitting a two-run home run during the first inning of a baseball game against the St. Louis Cardinals, Saturday, May 15, 2021, in San Diego. (AP PhotoDenis Poroy)

San Diego Padres' Tommy Pham (28) is congratulated by Jake Cronenworth, center, and Austin Nola, right, after hitting a two-run home run during the first inning of a baseball game against the St. Louis Cardinals, Saturday, May 15, 2021, in San Diego. (AP PhotoDenis Poroy)

Paddack's only big mistake was allowing a solo homer to Yadier Molina with one out in the fourth, his sixth.

Miguel Diaz (2-0) pitched two innings in relief of Paddack for the win.

Pham, who has struggled offensively this season, hit a two-run homer to deep left field with two outs in the first, his first of the year.

San Diego Padres' Ha-Seong Kim (7) points skyward after hitting a solo home run during the second inning of a baseball game against the St. Louis Cardinals, Saturday, May 15, 2021, in San Diego. (AP PhotoDenis Poroy)

San Diego Padres' Ha-Seong Kim (7) points skyward after hitting a solo home run during the second inning of a baseball game against the St. Louis Cardinals, Saturday, May 15, 2021, in San Diego. (AP PhotoDenis Poroy)

Kim homered to left with one out in the second, his second.

Nola hit a three-run, opposite-field shot into the home run porch in right field with no outs in the third, his first. He missed the first 39 games after breaking a finger during spring training.

Wainwright (2-4) allowed six runs and eight hits in four innings, struck out two and walked three.

St. Louis Cardinals center fielder Harrison Bader catches a ball hit by San Diego Padres' Manny Machado during the second inning of a baseball game Saturday, May 15, 2021, in San Diego. (AP PhotoDenis Poroy)

St. Louis Cardinals center fielder Harrison Bader catches a ball hit by San Diego Padres' Manny Machado during the second inning of a baseball game Saturday, May 15, 2021, in San Diego. (AP PhotoDenis Poroy)

Nolan Arenano and Harrison Bader also homered for the Cardinals. It was Arenado's eighth and Bader's fourth.

UP NEXT:

Cardinals LHP Kwang Hyun Kim (1-0, 2.74) is scheduled to start the series finale Sunday night opposite Padres rookie LHP Ryan Weathers (2-1, 0.81).

St. Louis Cardinals' Harrison Bader (48) celebrates after hitting a solo home run during the seventh inning of a baseball game against the San Diego Padres, Saturday, May 15, 2021, in San Diego. (AP PhotoDenis Poroy)

St. Louis Cardinals' Harrison Bader (48) celebrates after hitting a solo home run during the seventh inning of a baseball game against the San Diego Padres, Saturday, May 15, 2021, in San Diego. (AP PhotoDenis Poroy)

St. Louis Cardinals' Yadier Molina (4) waves after hitting a solo home run during the fourth inning of a baseball game against the San Diego Padres, Saturday, May 15, 2021, in San Diego. (AP PhotoDenis Poroy)

St. Louis Cardinals' Yadier Molina (4) waves after hitting a solo home run during the fourth inning of a baseball game against the San Diego Padres, Saturday, May 15, 2021, in San Diego. (AP PhotoDenis Poroy)