Juan Soto homered off Wrigley Field’s right-field scoreboard, helping Max Scherzer win his third straight decision in the Washington Nationals' 4-3 win over the Chicago Cubs on Wednesday night.

Soto became the 16th player to hit the scoreboard that was installed in 2012, hitting a 421-foot drive on a 3-2 slider in the fifth from Jake Arrieta (4-4) that gave Washington a 4-1 lead. Soto also singled twice.

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Washington Nationals' Juan Soto, left, celebrates after hitting a solo home run as Chicago Cubs catcher Willson Contreras looks to the field during the fifth inning of a baseball game in Chicago, Wednesday, May 19, 2021. (AP PhotoNam Y. Huh)

Juan Soto homered off Wrigley Field’s right-field scoreboard, helping Max Scherzer win his third straight decision in the Washington Nationals' 4-3 win over the Chicago Cubs on Wednesday night.

Washington Nationals manager Dave Martinez, left, congratulates Juan Soto after Juan Soto hit a solo home run during the fifth inning of a baseball game against the Chicago Cubs in Chicago, Wednesday, May 19, 2021. (AP PhotoNam Y. Huh)

Kyle Finnegan, Daniel Hudson and Brad Hand combined on three-hit relief. Hand struck out three in the ninth for his fifth save in seven chances despite allowing Javier Báez's solo homer.

Chicago Cubs starting pitcher Jake Arrieta, right, reacts as Washington Nationals' Juan Soto rounds the bases after hitting a solo home run during the fifth inning of a baseball game in Chicago, Wednesday, May 19, 2021. (AP PhotoNam Y. Huh)

Ian Happ and Nico Hoerner had RBIs for the Cubs, who slipped to .500 (21-21). Jake Arrieta (4-4) yielded four runs on seven hits in five innings in his second start since coming off the injured list.

Washington Nationals starting pitcher Max Scherzer adjusts his hat during the fifth inning of a baseball game against the Chicago Cubs in Chicago, Wednesday, May 19, 2021. (AP PhotoNam Y. Huh)

THAT’S HIS BAG

Washington Nationals starting pitcher Max Scherzer throws against the Chicago Cubs during the first inning of a baseball game in Chicago, Wednesday, May 19, 2021. (AP PhotoNam Y. Huh)

Martinez picked up the first base bag, slammed it to the ground and then kicked it.

Washington Nationals starting pitcher Max Scherzer, left, talks with catcher Yan Gomes during the fifth inning of a baseball game against the Chicago Cubs in Chicago, Wednesday, May 19, 2021. (AP PhotoNam Y. Huh)

ROSTER MOVE

Chicago Cubs' Javier Baez celebrates after hitting a solo home run during the ninth inning of a baseball game against the Washington Nationals in Chicago, Wednesday, May 19, 2021. The Nationals won 4-3. (AP PhotoNam Y. Huh)

Nationals: An unidentified player who is vaccinated and asymptomatic tested positive for COVID-19, Martinez said before the game. That player was deemed to have been in close contact with another Nationals player who is not vaccinated. The Nationals placed RHP Erick Fedde and RHP Tanner Rainey on the injured list before the first pitch. RHPs Kyle McGowin and Paolo Espina were activated from Washington’s taxi squad to fill the spots.

Chicago Cubs' Willson Contreras reacts after striking out swinging during the fifth inning of a baseball game against the Washington Nationals in Chicago, Wednesday, May 19, 2021. (AP PhotoNam Y. Huh)

Washington RHP Joe Ross (2-3, 5.80) faces Chicago RHP Trevor Williams (2-2, 6.27) in the series finale on Thursday.

Scherzer (4-2) allowed two runs and five hits in five innings with eight strikeouts and four walks. The three-time Cy Young Award winner labored at times against the Cubs but has given up just four runs over his last four starts.

Washington Nationals' Juan Soto, left, celebrates after hitting a solo home run as Chicago Cubs catcher Willson Contreras looks to the field during the fifth inning of a baseball game in Chicago, Wednesday, May 19, 2021. (AP PhotoNam Y. Huh)

Washington Nationals' Juan Soto, left, celebrates after hitting a solo home run as Chicago Cubs catcher Willson Contreras looks to the field during the fifth inning of a baseball game in Chicago, Wednesday, May 19, 2021. (AP PhotoNam Y. Huh)

Kyle Finnegan, Daniel Hudson and Brad Hand combined on three-hit relief. Hand struck out three in the ninth for his fifth save in seven chances despite allowing Javier Báez's solo homer.

Ian Happ's RBI single had pulled the Cubs to 4-2 in the fifth.

Arrieta allowed four runs and seven hits in five innings in his second start since coming off the injured list caused by a cut in his right thumb. Washington stopped the Cubs' three-game winning streak and dropped Chicago to 21-21.

Washington Nationals manager Dave Martinez, left, congratulates Juan Soto after Juan Soto hit a solo home run during the fifth inning of a baseball game against the Chicago Cubs in Chicago, Wednesday, May 19, 2021. (AP PhotoNam Y. Huh)

Washington Nationals manager Dave Martinez, left, congratulates Juan Soto after Juan Soto hit a solo home run during the fifth inning of a baseball game against the Chicago Cubs in Chicago, Wednesday, May 19, 2021. (AP PhotoNam Y. Huh)

Ian Happ and Nico Hoerner had RBIs for the Cubs, who slipped to .500 (21-21). Jake Arrieta (4-4) yielded four runs on seven hits in five innings in his second start since coming off the injured list.

Nico Hoerner’s bloop single in the second drove in the first run.

Trea Turner hit an RBI single in the third and scored on a wild pitch, and Victor Robles' run-scoring single gave Washington a 3-1 lead in the fourth. Robles would have reached second, but tripped over first base and stayed down for a few minutes while training staff checked an ankle.

Chicago Cubs starting pitcher Jake Arrieta, right, reacts as Washington Nationals' Juan Soto rounds the bases after hitting a solo home run during the fifth inning of a baseball game in Chicago, Wednesday, May 19, 2021. (AP PhotoNam Y. Huh)

Chicago Cubs starting pitcher Jake Arrieta, right, reacts as Washington Nationals' Juan Soto rounds the bases after hitting a solo home run during the fifth inning of a baseball game in Chicago, Wednesday, May 19, 2021. (AP PhotoNam Y. Huh)

THAT’S HIS BAG

Washington manager Dave Martinez was ejected in the seventh in an argument with first-base umpire Chris Conroy.

Turner struck out on a pitch that sailed over catcher Willson Contreras. Turner sprinted to first, but was called out for running outside the baseline and creating interference as Contreras’ throw went into right field.

Washington Nationals starting pitcher Max Scherzer adjusts his hat during the fifth inning of a baseball game against the Chicago Cubs in Chicago, Wednesday, May 19, 2021. (AP PhotoNam Y. Huh)

Washington Nationals starting pitcher Max Scherzer adjusts his hat during the fifth inning of a baseball game against the Chicago Cubs in Chicago, Wednesday, May 19, 2021. (AP PhotoNam Y. Huh)

Martinez picked up the first base bag, slammed it to the ground and then kicked it.

SPECIAL K

Scherzer passed Hall of Famer Jim Bunning for 19th place on the strikeout list. Scherzer has 2,860 strikeouts.

Washington Nationals starting pitcher Max Scherzer throws against the Chicago Cubs during the first inning of a baseball game in Chicago, Wednesday, May 19, 2021. (AP PhotoNam Y. Huh)

Washington Nationals starting pitcher Max Scherzer throws against the Chicago Cubs during the first inning of a baseball game in Chicago, Wednesday, May 19, 2021. (AP PhotoNam Y. Huh)

ROSTER MOVE

The Cubs selected P.J. Higgins from Triple-A Iowa before the game and designated C Tony Wolters for assignment. Higgins, listed as a catcher, made his major league debut when he pinch hit in the fourth, then stayed in the game to play first.

TRAINER’S ROOM

Washington Nationals starting pitcher Max Scherzer, left, talks with catcher Yan Gomes during the fifth inning of a baseball game against the Chicago Cubs in Chicago, Wednesday, May 19, 2021. (AP PhotoNam Y. Huh)

Washington Nationals starting pitcher Max Scherzer, left, talks with catcher Yan Gomes during the fifth inning of a baseball game against the Chicago Cubs in Chicago, Wednesday, May 19, 2021. (AP PhotoNam Y. Huh)

Nationals: An unidentified player who is vaccinated and asymptomatic tested positive for COVID-19, Martinez said before the game. That player was deemed to have been in close contact with another Nationals player who is not vaccinated. The Nationals placed RHP Erick Fedde and RHP Tanner Rainey on the injured list before the first pitch. RHPs Kyle McGowin and Paolo Espina were activated from Washington’s taxi squad to fill the spots.

Cubs: RF Jason Heyward left in the fourth inning with left hamstring tightness. ... 1B Anthony Rizzo was held out of the starting lineup with lower back tightness. ... SS Baez also didn’t start, put pinch hit in the seventh and stayed in the game.

UP NEXT

Chicago Cubs' Javier Baez celebrates after hitting a solo home run during the ninth inning of a baseball game against the Washington Nationals in Chicago, Wednesday, May 19, 2021. The Nationals won 4-3. (AP PhotoNam Y. Huh)

Chicago Cubs' Javier Baez celebrates after hitting a solo home run during the ninth inning of a baseball game against the Washington Nationals in Chicago, Wednesday, May 19, 2021. The Nationals won 4-3. (AP PhotoNam Y. Huh)

Washington RHP Joe Ross (2-3, 5.80) faces Chicago RHP Trevor Williams (2-2, 6.27) in the series finale on Thursday.

More AP MLB: https://apnews.com/MLB and https://twitter.com/AP_Sports

Chicago Cubs' Willson Contreras reacts after striking out swinging during the fifth inning of a baseball game against the Washington Nationals in Chicago, Wednesday, May 19, 2021. (AP PhotoNam Y. Huh)

Chicago Cubs' Willson Contreras reacts after striking out swinging during the fifth inning of a baseball game against the Washington Nationals in Chicago, Wednesday, May 19, 2021. (AP PhotoNam Y. Huh)