Lille won 2-1 at Angers to secure its first French league title in 10 years and beat defending champion Paris Saint-Germain by one point, preventing PSG from sealing a record-equaling 10th championship.
Neymar missed a penalty before Kylian Mbappe netted his league-leading 27th goal as PSG won 2-0 at Brest.
Canada forward Jonathan David opened the scoring early for Lille and then won a penalty converted by Turkey veteran Burak Yilmaz just before the break.
Lille's Burak Yilmaz, left, celebrates with Lille's Renato Sanches after scoring the second goal from the penalty spot during the French League One soccer match between Angers and Lille at the Raymond Kopa Stadium in Angers, France, Sunday May 23, 2021. (AP PhotoLewis Joly)
Angers scored an injury-time consolation but Lille had just a few seconds to wait after restarting the game before celebrating a remarkable achievement.
Lille lost only three games compared to eight for PSG.
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PSG's Neymar reacts at the end of the French League One soccer match between Brest and Paris Saint-Germain at the Stade Francis-Le Ble stadium in Brest, France, Sunday, May 23, 2021. (AP PhotoThibault Camus)
PSG's Neymar reacts at the end of the French League One soccer match between Brest and Paris Saint-Germain at the Stade Francis-Le Ble stadium in Brest, France, Sunday, May 23, 2021. (AP PhotoThibault Camus)