Pope Francis heads to Greece Saturday for the second leg of his trip to the region, with meetings in Athens aimed at bolstering recently-mended ties between the Vatican and Orthodox churches.

Francis’ five-day visit to predominantly Orthodox Cyprus and Greece is largely focused on the plight of migrants as Europe hardens its border control policies.

Talks on Saturday will turn to an emerging alliance between the eastern and western branches of Christianity to face major global problems including climate change.

A woman unfolds a carpet outside the Catholic Cathedral Basilica of St. Dionysius the Areopagite, one day ahead of the visit of Pope Francis in Athens, Greece, Friday, Dec. 3, 2021. Francis is on a five-day trip to Cyprus and Greece by drawing attention once again to his call for Europe to welcome migrants. (AP PhotoYorgos Karahalis)

A woman unfolds a carpet outside the Catholic Cathedral Basilica of St. Dionysius the Areopagite, one day ahead of the visit of Pope Francis in Athens, Greece, Friday, Dec. 3, 2021. Francis is on a five-day trip to Cyprus and Greece by drawing attention once again to his call for Europe to welcome migrants. (AP PhotoYorgos Karahalis)

In 2001, Pope John Paul II became the first Catholic leader to visit Greece in more than 1,200 years. Francis has accelerated inter-faith initiatives, as the two churches attempt to shift from centuries of competition and mistrust toward collaboration.

In Athens, Francis will meet the leader of Greece’s Orthodox Church, Archbishop Ieronymos, as well as with the country’s political leadership, Prime Minister Kyriakos Mitsotakis and President Katerina Sakellaropoulou.

At his meeting with the Orthodox church leadership in Cyprus Friday, Francis expressed regret over the “centuries of division” between the two churches.

A man unfolds a carpet inside the Catholic Cathedral Basilica of St. Dionysius the Areopagite, one day ahead of the visit of Pope Francis in Athens, Greece, Friday, Dec. 3, 2021. Francis is on a five-day trip to Cyprus and Greece by drawing attention once again to his call for Europe to welcome migrants. (AP PhotoYorgos Karahalis)

A man unfolds a carpet inside the Catholic Cathedral Basilica of St. Dionysius the Areopagite, one day ahead of the visit of Pope Francis in Athens, Greece, Friday, Dec. 3, 2021. Francis is on a five-day trip to Cyprus and Greece by drawing attention once again to his call for Europe to welcome migrants. (AP PhotoYorgos Karahalis)

Francis invited Orthodox Christian and other religious leaders to the Vatican in October to sign a climate declaration. Supporters of greater Vatican-Orthodox cooperation argue that it could assist beleaguered Christian communities in the Middle East and North Africa.

Orthodox Churches are also seeking alliances as they are involved in a deepening dispute over the independence of the Ukrainian church which was historically governed by the Russian Orthodox Church.

“I think the presence of the pope in Greece and Cyprus signals a return to the normal relationship that we should have ... so that we can move toward what is most important of all: the unity of the Christian world,” Ioannis Panagiotopoulos, an associate professor of divinity and church history at Athens University, told The Associated Press.

A woman hoovers the floor of the Catholic Cathedral Basilica of St. Dionysius the Areopagite, one day ahead of the visit of Pope Francis in Athens, Greece, Friday, Dec. 3, 2021. Francis is on a five-day trip to Cyprus and Greece by drawing attention once again to his call for Europe to welcome migrants. (AP PhotoYorgos Karahalis)

A woman hoovers the floor of the Catholic Cathedral Basilica of St. Dionysius the Areopagite, one day ahead of the visit of Pope Francis in Athens, Greece, Friday, Dec. 3, 2021. Francis is on a five-day trip to Cyprus and Greece by drawing attention once again to his call for Europe to welcome migrants. (AP PhotoYorgos Karahalis)

“So this trip is very significant and it means we can have a real discussion about the major issues, like migration.”

Francis will meet with members of Greece’s small Catholic community and on Sunday will return to the Aegean Sea island of Lesbos, where he visited five years ago to meet with migrants at a detention camp there. He brought a dozen home with him aboard the papal plane.

Volunteers make final adjustments inside the Catholic Cathedral Basilica of St. Dionysius the Areopagite, one day ahed of the visit of Pope Francis in Athens, Greece, Friday, Dec. 3, 2021. Francis is on a five-day trip to Cyprus and Greece by drawing attention once again to his call for Europe to welcome migrants. (AP PhotoYorgos Karahalis)

Volunteers make final adjustments inside the Catholic Cathedral Basilica of St. Dionysius the Areopagite, one day ahed of the visit of Pope Francis in Athens, Greece, Friday, Dec. 3, 2021. Francis is on a five-day trip to Cyprus and Greece by drawing attention once again to his call for Europe to welcome migrants. (AP PhotoYorgos Karahalis)