Manny Machado had a two-run homer among his three hits and Sean Manaea pitched six strong innings for the San Diego Padres, who won 4-1 on Monday night to hand the Cincinnati Reds their seventh straight loss.

The Padres extended their major league record with 12 straight errorless games to open a season.

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San Diego Padres right fielder Wil Myers, right, collides with second baseman Jake Cronenworth as he is unable to catch a foul ball hit by Cincinnati Reds' Tyler Stephenson during the third inning of a baseball game Monday, April 18, 2022, in San Diego. (AP PhotoGregory Bull)

Manny Machado had a two-run homer among his three hits and Sean Manaea pitched six strong innings for the San Diego Padres, who won 4-1 on Monday night to hand the Cincinnati Reds their seventh straight loss.

San Diego Padres' Jorge Alfaro reacts after striking out during the sixth inning of a baseball game against the Cincinnati Reds, Monday, April 18, 2022, in San Diego. (AP PhotoGregory Bull)

That was the extent of the Reds' scoring, though. The Padres came right back when Austin Nola hit a leadoff single and Machado followed with a line-shot homer to left field off Nick Lodolo (0-2), who was making his second big league start.

San Diego Padres' Jurickson Profar reacts after striking out to end the fifth inning of a baseball game against the Cincinnati Reds, Monday, April 18, 2022, in San Diego. (AP PhotoGregory Bull)

Lodolo allowed three runs and six hits in five innings, struck out eight and walked two.

Cincinnati Reds' Tommy Pham gestures after hitting a single during the fifth inning of a baseball game against the San Diego Padres, Monday, April 18, 2022, in San Diego. (AP PhotoGregory Bull)

TRAINER'S ROOM

Cincinnati Reds' Tommy Pham hits a single during the fourth inning of a baseball game against the Cincinnati Reds, Monday, April 18, 2022, in San Diego. (AP PhotoGregory Bull)

The middle game of the series Tuesday night features Reds LHP Reiver Sanmartin (0-1, 6.14 ERA) against Padres RHP Joe Musgrove (1-0, 1.42).

The Reds took a rare lead when Tommy Pham, who played with the Padres the last two seasons before leaving as a free agent, hit a solo homer with two outs in the first. It was his first of the season and doubled his hit total. Pham finished with three hits.

San Diego Padres right fielder Wil Myers, right, collides with second baseman Jake Cronenworth as he is unable to catch a foul ball hit by Cincinnati Reds' Tyler Stephenson during the third inning of a baseball game Monday, April 18, 2022, in San Diego. (AP PhotoGregory Bull)

San Diego Padres right fielder Wil Myers, right, collides with second baseman Jake Cronenworth as he is unable to catch a foul ball hit by Cincinnati Reds' Tyler Stephenson during the third inning of a baseball game Monday, April 18, 2022, in San Diego. (AP PhotoGregory Bull)

That was the extent of the Reds' scoring, though. The Padres came right back when Austin Nola hit a leadoff single and Machado followed with a line-shot homer to left field off Nick Lodolo (0-2), who was making his second big league start.

Kim Ha-seong hit an RBI single in the fourth. Machado doubled leading off the seventh, advanced on Jake Cronenworth's groundout and scored on Luke Voit's sacrifice fly.

Manaea (2-1) held Cincinnati to one run and six hits in six innings, struck out six and walked two. Taylor Rogers pitched the ninth for his fifth save in as many chances.

San Diego Padres' Jorge Alfaro reacts after striking out during the sixth inning of a baseball game against the Cincinnati Reds, Monday, April 18, 2022, in San Diego. (AP PhotoGregory Bull)

San Diego Padres' Jorge Alfaro reacts after striking out during the sixth inning of a baseball game against the Cincinnati Reds, Monday, April 18, 2022, in San Diego. (AP PhotoGregory Bull)

Lodolo allowed three runs and six hits in five innings, struck out eight and walked two.

USING THEIR HANDS

Soccer stars Alex Morgan and Abby Dahlkemper of the expansion San Diego Wave of the National Women's Soccer League threw out the ceremonial first pitches, to Joe Musgrove and rookie C.J. Abrams.

San Diego Padres' Jurickson Profar reacts after striking out to end the fifth inning of a baseball game against the Cincinnati Reds, Monday, April 18, 2022, in San Diego. (AP PhotoGregory Bull)

San Diego Padres' Jurickson Profar reacts after striking out to end the fifth inning of a baseball game against the Cincinnati Reds, Monday, April 18, 2022, in San Diego. (AP PhotoGregory Bull)

TRAINER'S ROOM

Padres: Relief pitcher Austin Adams has a strained right forearm and will be shut down for at least six weeks, manager Bob Melvin said. ... Fernando Tatis Jr., on the IL with a fractured left wrist, made some throws at shortstop. Melvin said he saw the video of Tatis tripping while playing soccer in the outfield before Sunday night's game. “Visually maybe not the best look," Melvin said. "I talked to him a little bit about that, but he's trying to get a little bit of conditioning. He is protected as far as the hand goes.”

UP NEXT

Cincinnati Reds' Tommy Pham gestures after hitting a single during the fifth inning of a baseball game against the San Diego Padres, Monday, April 18, 2022, in San Diego. (AP PhotoGregory Bull)

Cincinnati Reds' Tommy Pham gestures after hitting a single during the fifth inning of a baseball game against the San Diego Padres, Monday, April 18, 2022, in San Diego. (AP PhotoGregory Bull)

The middle game of the series Tuesday night features Reds LHP Reiver Sanmartin (0-1, 6.14 ERA) against Padres RHP Joe Musgrove (1-0, 1.42).

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Cincinnati Reds' Tommy Pham hits a single during the fourth inning of a baseball game against the Cincinnati Reds, Monday, April 18, 2022, in San Diego. (AP PhotoGregory Bull)

Cincinnati Reds' Tommy Pham hits a single during the fourth inning of a baseball game against the Cincinnati Reds, Monday, April 18, 2022, in San Diego. (AP PhotoGregory Bull)