Not even an off-day for Karim Benzema was enough to keep Real Madrid from moving closer to clinching the Spanish league title.

Benzema missed two penalty kicks seven minutes apart in the second half but Madrid went on to earn a 3-1 win at Osasuna Wednesday to open a 17-point lead over second-place Atletico Madrid, which can no longer catch its rival as both teams have five games left to play. Barcelona is 18 points back but has seven games left to play, meaning it still has a theoretical chance to catch Madrid.

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Real Madrid's Karim Benzema takes a penalty kick which was saved by Osasuna's goalkeeper Sergio Herrera during a Spanish La Liga soccer match between Osasuna and Real Madrid at El Sadar stadium in Pamplona, Spain, Wednesday, April 20, 2022. (AP PhotoAlvaro Barrientos)

Not even an off-day for Karim Benzema was enough to keep Real Madrid from moving closer to clinching the Spanish league title.

Real Madrid's Karim Benzema reacts after his penalty kick was saved by Osasuna's goalkeeper Sergio Herrera during a Spanish La Liga soccer match between Osasuna and Real Madrid at El Sadar stadium in Pamplona, Spain, Wednesday, April 20, 2022. (AP PhotoAlvaro Barrientos)

Benzema is the league’s leading scorer with 25 goals and has netted 15 times in the last 10 matches in all competitions. The French striker scored hat tricks and decisive goals to help Madrid reach the Champions League semifinals.

Real Madrid's David Alaba, 2nd left, celebrates with Karim Benzema after scoring the opening goal during a Spanish La Liga soccer match between Osasuna and Real Madrid at El Sadar stadium in Pamplona, Spain, Wednesday, April 20, 2022. (AP PhotoAlvaro Barrientos)

Alaba had to be substituted at halftime because of an injury, creating a concern ahead of Madrid’s first leg against Manchester City in the semifinals of the Champions League next week.

Real Madrid's David Alaba, centre right, celebrates with Karim Benzema after scoring the opening goal during a Spanish La Liga soccer match between Osasuna and Real Madrid at El Sadar stadium in Pamplona, Spain, Wednesday, April 20, 2022. (AP PhotoAlvaro Barrientos)

It was the fourth time in the last five matches that Atlético failed to score. It had been winless in three games in a row before a last-minute 2-1 win against Espanyol on Sunday.

Osasuna players protest the referee's decision to award a second penalty to Real Madrid during a Spanish La Liga soccer match between Osasuna and Real Madrid at El Sadar stadium in Pamplona, Spain, Wednesday, April 20, 2022. (AP PhotoAlvaro Barrientos)

Granada had lost two in a row and had conceded 12 goals in its last four matches, but Atlético managed only one shot on target from 22 total attempts at the Wanda Metropolitano Stadium.

Real Madrid's Marco Asensio, left, celebrates with Lucas Vazquez, centre and Dani Ceballos after scoring his side's second goal during a Spanish La Liga soccer match between Osasuna and Real Madrid at El Sadar stadium in Pamplona, Spain, Wednesday, April 20, 2022. (AP PhotoAlvaro Barrientos)

GETAFE MOVES UP

Real Madrid's Marco Asensio celebrates after scoring his side's second goal during a Spanish La Liga soccer match between Osasuna and Real Madrid at El Sadar stadium in Pamplona, Spain, Wednesday, April 20, 2022. (AP PhotoAlvaro Barrientos)

Sitting in 14th place, Getafe is unbeaten in four straight league games.

Benzema went scoreless for only the second time in the last 11 games in all competitions. Both of his penalty kicks were saved by Osasuna goalkeeper Sergio Herrera in the 52nd and 59th minutes.

Real Madrid's Karim Benzema takes a penalty kick which was saved by Osasuna's goalkeeper Sergio Herrera during a Spanish La Liga soccer match between Osasuna and Real Madrid at El Sadar stadium in Pamplona, Spain, Wednesday, April 20, 2022. (AP PhotoAlvaro Barrientos)

Real Madrid's Karim Benzema takes a penalty kick which was saved by Osasuna's goalkeeper Sergio Herrera during a Spanish La Liga soccer match between Osasuna and Real Madrid at El Sadar stadium in Pamplona, Spain, Wednesday, April 20, 2022. (AP PhotoAlvaro Barrientos)

Benzema is the league’s leading scorer with 25 goals and has netted 15 times in the last 10 matches in all competitions. The French striker scored hat tricks and decisive goals to help Madrid reach the Champions League semifinals.

Madrid defender David Alaba opened the scoring in the 12th minute and forward Marco Asensio added to the lead in the 45th after the hosts had equalized through Ante Budimir in the 13th. Lucas Vázquez sealed the victory in stoppage time.

Osasuna, sitting in ninth place and coming off two straight victories, had a goal disallowed for offside in the 32nd.

Real Madrid's Karim Benzema reacts after his penalty kick was saved by Osasuna's goalkeeper Sergio Herrera during a Spanish La Liga soccer match between Osasuna and Real Madrid at El Sadar stadium in Pamplona, Spain, Wednesday, April 20, 2022. (AP PhotoAlvaro Barrientos)

Real Madrid's Karim Benzema reacts after his penalty kick was saved by Osasuna's goalkeeper Sergio Herrera during a Spanish La Liga soccer match between Osasuna and Real Madrid at El Sadar stadium in Pamplona, Spain, Wednesday, April 20, 2022. (AP PhotoAlvaro Barrientos)

Alaba had to be substituted at halftime because of an injury, creating a concern ahead of Madrid’s first leg against Manchester City in the semifinals of the Champions League next week.

ATLÉTICO STALLS

Atlético Madrid’s struggles in attack continued in a 0-0 draw at home against relegation-threatened Granada.

Real Madrid's David Alaba, 2nd left, celebrates with Karim Benzema after scoring the opening goal during a Spanish La Liga soccer match between Osasuna and Real Madrid at El Sadar stadium in Pamplona, Spain, Wednesday, April 20, 2022. (AP PhotoAlvaro Barrientos)

Real Madrid's David Alaba, 2nd left, celebrates with Karim Benzema after scoring the opening goal during a Spanish La Liga soccer match between Osasuna and Real Madrid at El Sadar stadium in Pamplona, Spain, Wednesday, April 20, 2022. (AP PhotoAlvaro Barrientos)

It was the fourth time in the last five matches that Atlético failed to score. It had been winless in three games in a row before a last-minute 2-1 win against Espanyol on Sunday.

The result left Diego Simeone’s team in second place, one point ahead of both Barcelona and Sevilla. The Catalan club visits sixth-place Real Sociedad on Thursday, while Sevilla plays at second-to-last place Levante.

Atlético opened a four-point cushion over fifth-place Real Betis, the first team outside the Champions League qualification places. Manuel Pellegrini’s Betis lost 1-0 to Elche at home on Tuesday.

Real Madrid's David Alaba, centre right, celebrates with Karim Benzema after scoring the opening goal during a Spanish La Liga soccer match between Osasuna and Real Madrid at El Sadar stadium in Pamplona, Spain, Wednesday, April 20, 2022. (AP PhotoAlvaro Barrientos)

Real Madrid's David Alaba, centre right, celebrates with Karim Benzema after scoring the opening goal during a Spanish La Liga soccer match between Osasuna and Real Madrid at El Sadar stadium in Pamplona, Spain, Wednesday, April 20, 2022. (AP PhotoAlvaro Barrientos)

Granada had lost two in a row and had conceded 12 goals in its last four matches, but Atlético managed only one shot on target from 22 total attempts at the Wanda Metropolitano Stadium.

Granada coach Aitor Karanka made his debut. The team stayed in the relegation zone despite the draw, one point from safety in 18th place.

Atlético has only 11 points of 30 possible against the bottom five clubs in the standings — Mallorca, Cádiz, Granada, Levante and Alavés.

Osasuna players protest the referee's decision to award a second penalty to Real Madrid during a Spanish La Liga soccer match between Osasuna and Real Madrid at El Sadar stadium in Pamplona, Spain, Wednesday, April 20, 2022. (AP PhotoAlvaro Barrientos)

Osasuna players protest the referee's decision to award a second penalty to Real Madrid during a Spanish La Liga soccer match between Osasuna and Real Madrid at El Sadar stadium in Pamplona, Spain, Wednesday, April 20, 2022. (AP PhotoAlvaro Barrientos)

GETAFE MOVES UP

Getafe moved five points clear of the relegation zone with a 2-0 win at Celta Vigo, with Borja Mayoral scoring a goal in each half.

It was the first away win for Getafe after 16 consecutive matches without a road victory, dating to last season.

Real Madrid's Marco Asensio, left, celebrates with Lucas Vazquez, centre and Dani Ceballos after scoring his side's second goal during a Spanish La Liga soccer match between Osasuna and Real Madrid at El Sadar stadium in Pamplona, Spain, Wednesday, April 20, 2022. (AP PhotoAlvaro Barrientos)

Real Madrid's Marco Asensio, left, celebrates with Lucas Vazquez, centre and Dani Ceballos after scoring his side's second goal during a Spanish La Liga soccer match between Osasuna and Real Madrid at El Sadar stadium in Pamplona, Spain, Wednesday, April 20, 2022. (AP PhotoAlvaro Barrientos)

Sitting in 14th place, Getafe is unbeaten in four straight league games.

Celta, in 11th place, lost its second in a row at home.

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Real Madrid's Marco Asensio celebrates after scoring his side's second goal during a Spanish La Liga soccer match between Osasuna and Real Madrid at El Sadar stadium in Pamplona, Spain, Wednesday, April 20, 2022. (AP PhotoAlvaro Barrientos)

Real Madrid's Marco Asensio celebrates after scoring his side's second goal during a Spanish La Liga soccer match between Osasuna and Real Madrid at El Sadar stadium in Pamplona, Spain, Wednesday, April 20, 2022. (AP PhotoAlvaro Barrientos)

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