Jurickson Profar threw out Joey Votto at home and then hit a two-run homer for the San Diego Padres, who won 6-0 Wednesday to hand the Cincinnati Reds their ninth straight loss and their longest skid in five years.

Profar's homer in the fourth inning gave rookie MacKenzie Gore (1-0) all the backing he needed for his first big league win, in his second start. The left-hander held the Reds to four hits in five innings, struck out seven and walked two to complete the three-game sweep.

More Images
San Diego Padres' Jurickson Profar, right, reacts with teammate Manny Machado after hitting a two-run home run during the fourth inning of a baseball game against the Cincinnati Reds, Wednesday, April 20, 2022, in San Diego. (AP PhotoGregory Bull)

Jurickson Profar threw out Joey Votto at home and then hit a two-run homer for the San Diego Padres, who won 6-0 Wednesday to hand the Cincinnati Reds their ninth straight loss and their longest skid in five years.

San Diego Padres' Jurickson Profar reacts after hitting a two-run home run during the fourth inning of a baseball game against the Cincinnati Reds, Wednesday, April 20, 2022, in San Diego. (AP PhotoGregory Bull)

Machado was hit by a pitch on the left shoulder by Gutiérrez (0-3) leading off the fourth. On Tuesday night, Reds catcher Tyler Stephenson was knocked out of the game on a hard slide by Luke Voit. Some Reds players felt it was a dirty play by Voit and Tommy Pham, who played for the Padres the last two seasons, said he wanted to fight the Padres' DH. The Reds asked for a review of the play but umpires ruled it was clean. Voit did not play Wednesday and Machado was the DH.

San Diego Padres' Manny Machado is hit by a pitch while batting during the fourth inning of a baseball game against the Cincinnati Reds, Wednesday, April 20, 2022, in San Diego. (AP PhotoGregory Bull)

Kim Ha-seong homered for the Padres in the seventh, his first. Alfaro had a sacrifice fly and rookie CJ Abrams an RBI double in the eighth.

Cincinnati Reds' Joey Votto, right, is tagged out at home by San Diego Padres catcher Jorge Alfaro while trying to score from second off a single by Colin Moran during the fourth inning of a baseball game Wednesday, April 20, 2022, in San Diego. (AP PhotoGregory Bull)

TRAINER'S ROOM

Cincinnati Reds starting pitcher Vladimir Gutierrez works against a San Diego Padres batter during the first inning of a baseball game Wednesday, April 20, 2022, in San Diego. (AP PhotoGregory Bull)

Padres: RHP Nick Martinez (0-1, 4.50) is scheduled to start the opener of a three-game home series against the Los Angeles Dodgers on Friday night. The Dodgers will start Julio Urias (0-1, 3.86).

Cincinnati Reds' Tommy Pham watches his hit for a single during the first inning of a baseball game against the San Diego Padres, Wednesday, April 20, 2022, in San Diego. (AP PhotoGregory Bull)

Cincinnati Reds' Tommy Pham watches his hit for a single during the first inning of a baseball game against the San Diego Padres, Wednesday, April 20, 2022, in San Diego. (AP PhotoGregory Bull)

Profar, the Padres' left fielder, threw out Votto on the fly on Colin Moran's single to end the fourth and keep the game scoreless. Profar homered to right off Vladimir Gutiérrez with two outs in the bottom of the inning to bring in Manny Machado. It was Profar's fourth.

San Diego Padres' Jurickson Profar, right, reacts with teammate Manny Machado after hitting a two-run home run during the fourth inning of a baseball game against the Cincinnati Reds, Wednesday, April 20, 2022, in San Diego. (AP PhotoGregory Bull)

San Diego Padres' Jurickson Profar, right, reacts with teammate Manny Machado after hitting a two-run home run during the fourth inning of a baseball game against the Cincinnati Reds, Wednesday, April 20, 2022, in San Diego. (AP PhotoGregory Bull)

Machado was hit by a pitch on the left shoulder by Gutiérrez (0-3) leading off the fourth. On Tuesday night, Reds catcher Tyler Stephenson was knocked out of the game on a hard slide by Luke Voit. Some Reds players felt it was a dirty play by Voit and Tommy Pham, who played for the Padres the last two seasons, said he wanted to fight the Padres' DH. The Reds asked for a review of the play but umpires ruled it was clean. Voit did not play Wednesday and Machado was the DH.

Gutierrez hit Padres catcher Jorge Alfaro with a pitch leading off the fifth. Alfaro stole second and scored on Trent Grisham's double.

Cincinnati, shut out for the first time this year, had not lost nine straight since June 9-18, 2017. The Reds went winless on a seven-game West Coast trip that started at Dodger Stadium.

San Diego Padres' Jurickson Profar reacts after hitting a two-run home run during the fourth inning of a baseball game against the Cincinnati Reds, Wednesday, April 20, 2022, in San Diego. (AP PhotoGregory Bull)

San Diego Padres' Jurickson Profar reacts after hitting a two-run home run during the fourth inning of a baseball game against the Cincinnati Reds, Wednesday, April 20, 2022, in San Diego. (AP PhotoGregory Bull)

Kim Ha-seong homered for the Padres in the seventh, his first. Alfaro had a sacrifice fly and rookie CJ Abrams an RBI double in the eighth.

Gutiérrez allowed three runs and two hits in 4 2/3 innings. He walked four and struck out two.

San Diego extended its major league record with 14 consecutive errorless games to open a season.

San Diego Padres' Manny Machado is hit by a pitch while batting during the fourth inning of a baseball game against the Cincinnati Reds, Wednesday, April 20, 2022, in San Diego. (AP PhotoGregory Bull)

San Diego Padres' Manny Machado is hit by a pitch while batting during the fourth inning of a baseball game against the Cincinnati Reds, Wednesday, April 20, 2022, in San Diego. (AP PhotoGregory Bull)

TRAINER'S ROOM

Reds: Placed Stephenson on the seven-day concussion list. Recalled Mark Kolozsvary from the taxi squad.

UP NEXT

Reds: RHP Hunter Greene (1-1, 4.35) is scheduled to start the opener of a three-game home series against St. Louis, which will counter with LHP Steven Matz (1-1, 7.27).

Cincinnati Reds' Joey Votto, right, is tagged out at home by San Diego Padres catcher Jorge Alfaro while trying to score from second off a single by Colin Moran during the fourth inning of a baseball game Wednesday, April 20, 2022, in San Diego. (AP PhotoGregory Bull)

Cincinnati Reds' Joey Votto, right, is tagged out at home by San Diego Padres catcher Jorge Alfaro while trying to score from second off a single by Colin Moran during the fourth inning of a baseball game Wednesday, April 20, 2022, in San Diego. (AP PhotoGregory Bull)

Padres: RHP Nick Martinez (0-1, 4.50) is scheduled to start the opener of a three-game home series against the Los Angeles Dodgers on Friday night. The Dodgers will start Julio Urias (0-1, 3.86).

More AP MLB: https://apnews.com/hub/mlb and https://twitter.com/AP_Sports

Cincinnati Reds starting pitcher Vladimir Gutierrez works against a San Diego Padres batter during the first inning of a baseball game Wednesday, April 20, 2022, in San Diego. (AP PhotoGregory Bull)

Cincinnati Reds starting pitcher Vladimir Gutierrez works against a San Diego Padres batter during the first inning of a baseball game Wednesday, April 20, 2022, in San Diego. (AP PhotoGregory Bull)

Cincinnati Reds' Tommy Pham watches his hit for a single during the first inning of a baseball game against the San Diego Padres, Wednesday, April 20, 2022, in San Diego. (AP PhotoGregory Bull)

Cincinnati Reds' Tommy Pham watches his hit for a single during the first inning of a baseball game against the San Diego Padres, Wednesday, April 20, 2022, in San Diego. (AP PhotoGregory Bull)