WASHINGTON (AP) — The Biden administration is taking a more hands-off approach than usual during a week of dramatic escalation between Israel and Hezbollah militants in Lebanon, with top U.S. officials holding back from full-on crisis diplomacy for fear of making matters worse.
The public restraint follows explosions of the militant group's pagers and walkie-talkies and an Israeli airstrike targeting a senior Hezbollah operative in Beirut, which threaten to spur all-out war between Israel and its enemies in the Middle East and doom already faltering negotiations for a cease-fire in the Hamas conflict in Gaza.
The escalation came even as two Biden administration officials stopped in the region this week to appeal for calm. It heightens the impression that Israeli Prime Minister Benjamin Netanyahu's hard-right government is paying ever less attention to the mediation efforts of its key ally, despite depending on the U.S. for weapons and military support.
“The United States looks like a deer in the headlights right now,” said Brian Katulis, a senior fellow for U.S. foreign policy at the Middle East Institute think tank in Washington. “In terms of words, deeds and action ... it's not driving events, it's reacting to events.”
There has been no publicly acknowledged U.S. contact with Netanyahu since senior White House official Amos Hochstein visited Israel on Monday to warn against escalation. The first wave of device explosions — widely blamed on Israel, which didn’t acknowledge responsibility — struck the next day.
And Gaza cease-fire negotiations were at such a delicate point that Secretary of State Antony Blinken visited only Egypt in a trip to the region this week because traveling to Israel in support of a deal might cause Netanyahu to say something that undermines the U.S.-led mediation, U.S. officials said.
Asked if the U.S. still had hope for a deal in Gaza — which the administration calls crucial to calming regional conflict — President Joe Biden said Friday that he did and his team is pressing for it.
“If I ever said it wasn’t realistic, we might as well leave,” Biden told reporters. “A lot of things don’t look realistic until we get them done. We have to keep at it.”
In the meantime, the White House and State Department have declined to comment publicly on the Hezbollah devices exploding Tuesday and Wednesday, killing at least 37 people and injuring thousands more, including civilians, in what analysts believe was a highly sophisticated Israeli intelligence operation.
Nor would they offer any assessment of an airstrike Friday in a densely populated part of Beirut — the deadliest such strike on Lebanon’s capital in years — which killed a Hezbollah commander. The Israeli military said 15 other operatives also were killed. Lebanon's health ministry said Saturday the strike killed at least 31 people, including seven women and three children.
Netanyahu and Hamas have followed past rounds of direct U.S. diplomatic outreach with fiery rhetoric or surprise attacks that the U.S. sees as setting back the effort for a truce.
Blinken appeared to loop in the pager explosions as the latest example of that.
When mediators seem to make progress in a Gaza deal, often there's an “incident, something that makes the process more difficult, that threatens to slow it, stop it, derail it,” Blinken said in Egypt, in response to reporters' questions about the pager attacks.
There may yet be high-level contact with Netanyahu when he travels to New York for next week’s U.N. General Assembly gathering of world leaders, said U.S. officials with knowledge of the discussions who spoke anonymously to discuss the administration’s strategy. But the officials also acknowledge that the situation has become so precarious that taking a public stance either firmly in support or critical of Israel would probably do more harm than good.
In Washington, State Department spokesman Matthew Miller batted away a question about whether months of Biden administration visits to the Middle East without a cease-fire deal to show for them was making Blinken and other officials look like “furniture” in regional capitals.
“So far, we have been successful of keeping it from turning into an all-out regional war,” Miller said. He credited U.S. messaging — sometimes through intermediaries, to Iran, its militia allies in the region and to Israel.
The Biden administration pointed out that Defense Secretary Lloyd Austin has been in contact this week with his Israeli counterpart, Yoav Gallant. Gallant's job, however, is said to be in jeopardy.
Critics accuse the administration of pushing a deal on Gaza that’s repeatedly failed to win buy-in from the warring sides and has been outpaced by the growth of the conflict. The administration could do more diplomatically, including by working harder to rally Middle Eastern countries to intensify pressure on Israel, Iran and the latter’s proxies to stop fighting, said Katulis, the Middle East Institute analyst.
U.S. officials rejected assertions that they have given up on either a Gaza cease-fire or preventing the conflict from spreading to all-out war in Lebanon.
“We'd be the first ones to recognize ... that we are not closer to achieving that than we were even a week or so ago,” national security spokesman John Kirby said Friday.
“But ain't nobody giving up," Kirby said, reiterating that the U.S. was working with fellow mediators Qatar and Egypt to put together a final Gaza proposal to present to Israel and Hamas. “We're still going to keep the shoulder to the wheel. We're still going to keep trying on this.”
Associated Press writer Aamer Madhani contributed to this report.
U.S. Secretary of State Antony Blinken shakes hands with Egypt's Foreign Minister Badr Abdelatty during a joint press conference in Tahrir Palace in Cairo, Egypt Wednesday, Sept. 18, 2024. (Evelyn Hockstein/Pool Photo via AP)
U.S. Secretary of State Antony Blinken attends a joint press conference with Egypt's Foreign Minister Badr Abdelatty in Tahrir Palace in Cairo, Egypt Wednesday, Sept. 18, 2024. (Evelyn Hockstein/Pool Photo via AP)
People gather near a damaged building at the scene of an Israeli missile strike in the southern suburbs of Beirut, Friday, Sept. 20, 2024. (AP Photo/Bilal Hussein)
STOCKHOLM (AP) — The Nobel Prize in physiology or medicine was awarded Monday to Americans Victor Ambros and Gary Ruvkun for their discovery of microRNA, tiny pieces of genetic material that alter how genes work at the cellular level and could lead to new ways of treating cancer.
The Nobel Assembly at the Karolinska Institute, which awarded the prize, said the duo's discovery is “proving to be fundamentally important" in understanding how organisms develop and function.
MicroRNA have opened up scientists’ approaches to treating diseases like cancer by helping to regulate how genes work at the cellular level, according to Dr. Claire Fletcher, a lecturer in molecular oncology at Imperial College London.
Fletcher said microRNA provide genetic instructions to tell cells to make new proteins and that there were two main areas where microRNA could be helpful: in developing drugs to treat diseases and in serving as biomarkers.
“MicroRNA alters how genes in the cell work,” said Fletcher, who is an outside expert not associated with the Nobel prize.
“If we take the example of cancer, we’ll have a particular gene working overtime, it might be mutated and working in overdrive,” she said. “We can take a microRNA that we know alters the activity of that gene and we can deliver that particular microRNA to cancer cells to stop that mutated gene from having its effect.”
Ambros performed the research that led to his prize at Harvard University. He is currently a professor of natural science at the University of Massachusetts Medical School. Ruvkun's research was performed at Massachusetts General Hospital and the Harvard Medical School, where he’s a professor of genetics, said Thomas Perlmann, Secretary-General of the Nobel Committee.
Perlmann said he spoke to Ruvkun by phone shortly before the announcement.
“It took a long time before he came to the phone and sounded very tired, but he quite rapidly was quite excited and happy, when he understood what it was all about,” Perlmann said.
Last year, the Nobel Prize in Physiology or Medicine went to Hungarian-American Katalin Karikó and American Drew Weissman for discoveries that enabled the creation of mRNA vaccines against COVID-19 that were critical in slowing the pandemic.
The prize carries a cash award of 11 million Swedish kronor ($1 million) from a bequest left by the prize’s creator, Swedish inventor Alfred Nobel.
The announcement launched this year’s Nobel prizes award season.
Nobel announcements continue with the physics prize on Tuesday, chemistry on Wednesday and literature on Thursday. The Nobel Peace Prize will be announced Friday and the Nobel Memorial Prize in Economic Sciences on Oct. 14.
The laureates are invited to receive their awards at ceremonies on Dec. 10, the anniversary of Nobel’s death.
Fletcher said there are clinical trials ongoing to see how microRNA approaches might help treat skin cancer, but that there aren’t yet any drug treatments approved by drug regulators. She expected that might happen in the next five to 10 years.
She said microRNA represent another way of being able to control the behaviour of genes to treat and track various diseases.
“The majority of therapies we have at the moment are targeting proteins in cells,” she said. “If we can intervene at the microRNA level, it opens up a whole new way of us developing medicines and us controlling the activity of genes whose levels might be altered in diseases.”
Corder reported from The Hague, Netherlands, Cheng reported from London.
This undated picture released by Mass General shows American molecular biologist Gary Ruvkun. (Joshua Touster via AP)
This undated picture released by UMass shows Victor Ambros, PhD, the Silverman Chair in Natural Sciences and professor of molecular medicine. (UMass via AP)
Olle Kämpe, right, professor of clinical endocrinology, explains the work of this year's Nobel Prize in Physiology or Medicine laureates Americans Victor Ambros, and Gary Ruvkun during a press conference at the Karolinska Institute in Stockholm, Sweden, on Monday, Oct. 7, 2024. (Christine Olsson/TT News Agency via AP)
Olle Kämpe, right, professor of clinical endocrinology, explains the work of this year's Nobel Prize in Physiology or Medicine laureates Americans Victor Ambros, and Gary Ruvkun, pictured on the screen, during a press conference at the Karolinska Institute in Stockholm, Sweden, on Monday, Oct. 7, 2024. (Christine Olsson/TT News Agency via AP)
Americans Victor Ambros, left, and Gary Ruvkun, are seen on a screen after being awarded this year's Nobel Prize in Physiology or Medicine during a press conference to announce the winners at the Karolinska Institute in Stockholm, Sweden, on Monday, Oct. 7, 2024. (Christine Olsson/TT News Agency via AP)
Nobel Committee chairman Thomas Perlmann, right, announces Americans Victor Ambros, left, and Gary Ruvkun, seen on a screen being awarded this year's Nobel Prize in Physiology or Medicine, during a press conference at the Karolinska Institute in Stockholm, Sweden, on Monday, Oct. 7, 2024. (Christine Olsson/TT News Agency via AP)
FILE - A close-up view of a Nobel Prize medal at the National Institutes of Health (NIH) in Bethesda, Md., Tuesday, Dec. 8, 2020. (AP Photo/Jacquelyn Martin, File)
FILE - A bust of Alfred Nobel on display following a press conference at the Karolinska Institute in Stockholm, Sweden, on Monday, Oct. 3, 2022. (Henrik Montgomery/TT News Agency via AP, File)