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REYKJAVIK, Iceland, Jan. 23, 2025 /PRNewswire/ -- Scientists at deCODE genetics/Amgen have constructed a complete map of how human DNA is mixed as it is passed down during reproduction. The map marks a major step in the understanding of genetic diversity and its impact on health and fertility. It continues 25 years of research at deCODE genetics into how new diversity is generated in the human genome, and its relationship to health and disease.
Bjarni V. Halldorsson and Kari Stefansson, scientists at deCODE genetics, discuss the paper: Complete recombination map of the human-genome, published in Nature today. The paper continues 25 years of research into how new diversity is generated in the human genome, and its relationship to health and disease. The new map, appearing today in the online edition of Nature, is the first to incorporate shorter-scale shuffling, (non crossover) of grandparental DNA, which is difficult to detect due to the high DNA sequence similarity. The map also identifies areas of DNA that are devoid of major reshuffling, likely to protect critical genetic functions or prevent chromosomal problems. This insight offers a clearer picture of why some pregnancies fail and how the genome balances diversity with stability.
While this shuffling, known as recombination, is essential for genetic diversity, errors in the process can lead to serious reproductive issues. These failures can result in genetic errors that prevent pregnancies from continuing, helping to explain why infertility affects around one in ten couples worldwide. Understanding this process offers new hope for improving fertility treatments and diagnosing pregnancy complications.
The research also reveals key differences between men and women in how and where, the genome recombination occurs. Women have fewer non-crossover recombinatios, but their frequency increases with age, which may help explain why older maternal age is associated with higher risks of pregnancy complications and chromosomal disorders of the child. Men, however, do not show this age-related change, although recombination in both sexes can contribute to mutations passed to offspring.
Understanding the recombination process is also important in understanding how humans evolved as a species and what shapes individual differences, including health outcomes. All human genetic diversity can be traced to recombination and de novo mutations, DNA sequence present in the child but not in the parents. The map shows that mutations are elevated near regions of DNA mixing and consequently that the two processes are highly correlated.
Based in Reykjavik, Iceland, deCODE genetics is a global leader in analyzing and understanding the human genome. Using its unique expertise and population resources, deCODE has discovered genetic risk factors for dozens of common diseases. The purpose of understanding the genetics of disease is to use that information to create new means of diagnosing, treating and preventing disease. deCODE genetics is a wholly-owned subsidiary of Amgen (NASDAQ:AMGN).
Video for public use:
https://vimeo.com/1037862873/90309f69c3
REYKJAVIK, Iceland, Jan. 23, 2025 /PRNewswire/ -- Scientists at deCODE genetics/Amgen have constructed a complete map of how human DNA is mixed as it is passed down during reproduction. The map marks a major step in the understanding of genetic diversity and its impact on health and fertility. It continues 25 years of research at deCODE genetics into how new diversity is generated in the human genome, and its relationship to health and disease.
The new map, appearing today in the online edition of Nature, is the first to incorporate shorter-scale shuffling, (non crossover) of grandparental DNA, which is difficult to detect due to the high DNA sequence similarity. The map also identifies areas of DNA that are devoid of major reshuffling, likely to protect critical genetic functions or prevent chromosomal problems. This insight offers a clearer picture of why some pregnancies fail and how the genome balances diversity with stability.
While this shuffling, known as recombination, is essential for genetic diversity, errors in the process can lead to serious reproductive issues. These failures can result in genetic errors that prevent pregnancies from continuing, helping to explain why infertility affects around one in ten couples worldwide. Understanding this process offers new hope for improving fertility treatments and diagnosing pregnancy complications.
The research also reveals key differences between men and women in how and where, the genome recombination occurs. Women have fewer non-crossover recombinatios, but their frequency increases with age, which may help explain why older maternal age is associated with higher risks of pregnancy complications and chromosomal disorders of the child. Men, however, do not show this age-related change, although recombination in both sexes can contribute to mutations passed to offspring.
Understanding the recombination process is also important in understanding how humans evolved as a species and what shapes individual differences, including health outcomes. All human genetic diversity can be traced to recombination and de novo mutations, DNA sequence present in the child but not in the parents. The map shows that mutations are elevated near regions of DNA mixing and consequently that the two processes are highly correlated.
Based in Reykjavik, Iceland, deCODE genetics is a global leader in analyzing and understanding the human genome. Using its unique expertise and population resources, deCODE has discovered genetic risk factors for dozens of common diseases. The purpose of understanding the genetics of disease is to use that information to create new means of diagnosing, treating and preventing disease. deCODE genetics is a wholly-owned subsidiary of Amgen (NASDAQ:AMGN).
Video for public use:
https://vimeo.com/1037862873/90309f69c3
** The press release content is from PR Newswire. Bastille Post is not involved in its creation. **
deCODE genetics: Complete recombination map of the human-genome, a major step in genetics
BARCELONA, Spain, March 1, 2026 /PRNewswire/ -- As MWC 2026 approaches, DOOGEE heads to Barcelona with its new theme: "DOOGEE AI, Explore to More." We invite you to experience our newest flagship devices. Moving beyond just phones, we will showcase a complete device ecosystem, spanning professional rugged phones, outdoor wearables, and smart tablets.
1. "Visible" AI & Smart Audio
Traditional AI feels cold. DOOGEE brings it to life with the AI Concept Phone.
- AI Phone: A visible digital friend on your screen that shows "emotions" based on battery life. Simply "feed" it a document to analyze it instantly, or use the Smart Key for real-time translation.
- AI Camera Headphone: Capture your hike without holding a phone. Featuring an 8MP Camera and 2K HD Recording, it offers a hands-free POV. With EIS stabilization, 32GB storage, and Wi-Fi 6, you can record and transfer videos instantly. The Air Conduction design ensures open-ear safety.
2. Wearables for Every Need
DOOGEE introduces smart wearables to solve specific outdoor problems:
- For Runners: The BoneBeat Run Digital ends battery anxiety with a unique LED Power Display. The BoneBeat Swim Ray features a Dynamic Sport Light for night safety and an IP68 waterproof design for swimming.
- For Kids: The Anyscene Series (4G) gives parents peace of mind with HD Video Calls, Real-time GPS, and an IP68 waterproof build.
- For Pro Athletes: The Anymoving M1 Pro locks your track using 6 Satellite Systems and offers a 15-Day Battery. The Anywise W1 Pro provides Dual-band GPS and Offline Maps on a 1.43" AMOLED display.
3. Rugged & Urban Phones
- S300 Plus Thermal: A pro tool with HD Thermal Imaging, Night Vision, and POC Intercom.
- V Max 2 Pro: The "Battery King" houses a massive 22,000mAh Battery, a Visual Charging Screen, and POC Intercom.
- Fire 7 Ultra: Keeps you connected off-grid with a built-in Bluetooth Walkie-Talkie.
- B10 Pro: Blends elegant styling with IP68/IP69K toughness, featuring a 120Hz display and a Silicon-Carbon Battery for business travelers.
4. Tablets: From Office to Tent
- Tab E3 Max (14"): A portable cinema with a 2.1K Display and 13,500mAh Battery.
- Tab G6 Max (13.4"): Runs Android 16, turning any place into a mobile office.
Experience it firsthand at MWC 2026!
Date: March 2 – 5, 2026
Venue: Fira Gran Via, Barcelona, Spain
Hall: 7 | Booth: 7C58
** This press release is distributed by PR Newswire through automated distribution system, for which the client assumes full responsibility. **
MWC 2026 Preview | DOOGEE AI Redefines Exploration: A Full-Scenario Ecosystem
