REYKJAVIK, Iceland, Jan. 23, 2025 /PRNewswire/ -- Scientists at deCODE genetics/Amgen have constructed a complete map of how human DNA is mixed as it is passed down during reproduction. The map marks a major step in the understanding of genetic diversity and its impact on health and fertility. It continues 25 years of research at deCODE genetics into how new diversity is generated in the human genome, and its relationship to health and disease.
The new map, appearing today in the online edition of Nature, is the first to incorporate shorter-scale shuffling, (non crossover) of grandparental DNA, which is difficult to detect due to the high DNA sequence similarity. The map also identifies areas of DNA that are devoid of major reshuffling, likely to protect critical genetic functions or prevent chromosomal problems. This insight offers a clearer picture of why some pregnancies fail and how the genome balances diversity with stability.
While this shuffling, known as recombination, is essential for genetic diversity, errors in the process can lead to serious reproductive issues. These failures can result in genetic errors that prevent pregnancies from continuing, helping to explain why infertility affects around one in ten couples worldwide. Understanding this process offers new hope for improving fertility treatments and diagnosing pregnancy complications.
The research also reveals key differences between men and women in how and where, the genome recombination occurs. Women have fewer non-crossover recombinatios, but their frequency increases with age, which may help explain why older maternal age is associated with higher risks of pregnancy complications and chromosomal disorders of the child. Men, however, do not show this age-related change, although recombination in both sexes can contribute to mutations passed to offspring.
Understanding the recombination process is also important in understanding how humans evolved as a species and what shapes individual differences, including health outcomes. All human genetic diversity can be traced to recombination and de novo mutations, DNA sequence present in the child but not in the parents. The map shows that mutations are elevated near regions of DNA mixing and consequently that the two processes are highly correlated.
Based in Reykjavik, Iceland, deCODE genetics is a global leader in analyzing and understanding the human genome. Using its unique expertise and population resources, deCODE has discovered genetic risk factors for dozens of common diseases. The purpose of understanding the genetics of disease is to use that information to create new means of diagnosing, treating and preventing disease. deCODE genetics is a wholly-owned subsidiary of Amgen (NASDAQ:AMGN).
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deCODE genetics: Complete recombination map of the human-genome, a major step in genetics
PORT VILA, Vanuatu, Feb. 15, 2025 /PRNewswire/ -- Vantage Markets is proud to announce its success at the 5th Annual Business Tabloid Awards, held on 23rd January 2025 in Dubai. The Annual Business Tabloid Awards celebrate outstanding achievements across industries, including banking, finance, technology, and leadership. Winners are selected by a panel of industry experts, who evaluate nominees based on innovation, performance, and impact. Receiving three awards at this distinguished event reflects Vantage's global commitment to excellence in the financial services industry.
The event brought together industry leaders and influencers to celebrate excellence across various sectors, including banking, finance, technology, and trading. The evening commenced with a networking session, providing an invaluable opportunity for professionals to connect and exchange insights. Followed by the award presentation ceremony, where Vantage was honored for its excellence, reflecting its commitment to providing quality trading solutions.
Marc Despallieres, CEO of Vantage Markets, shared his thoughts on the achievement: "Winning these three awards at the Business Tabloid Awards is a testament to our commitment to excellence, innovation, and client-centricity. These accolades reflect the hard work of our team and the trust our clients place in us. We are proud to have been recognized for our excellence in APAC, LATAM, and MENA, reflecting our commitment to empowering our traders."
As Vantage continues to expand its presence and deliver value to its clients, the company is committed to maintaining its reputation for excellence and innovation.
For more information on Vantage's award-winning services, visit Vantage Markets.
About Vantage
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** The press release content is from PR Newswire. Bastille Post is not involved in its creation. **
Vantage Honored with Three Prestigious Awards at the 5th Annual Business Tabloid Awards
Vantage Honored with Three Prestigious Awards at the 5th Annual Business Tabloid Awards