PITTSBURGH (AP) — Paul Skenes might still be relatively new in the major leagues. The Pittsburgh Pirates star isn't new to baseball.
The 22-year-old has been pitching for a while. He knows that some days — hopefully most of them — he's going to have dominant stuff that bends pitches to his will and leaves bats flailing in pursuit.
Tuesday night against St. Louis was not one of those outings. The Cardinals touched Skenes for three runs in the third and two more in the sixth in a 5-3 loss that dropped Skenes to 0-3 against Pittsburgh's longtime NL Central rival.
Skenes didn't blame the worst start of his still-young career on chilly temperatures or his still-developing relationship with catcher Endy Rodriguez. He simply missed spots a couple of times and the Cardinals made him pay for it.
“It’s not like they hit the ball into the river or anything like that,” said Skenes after giving up five runs, the most he's surrendered in his 26 big league starts. "They just found some holes and I got behind in some counts and kind of let them get good swings off. Not going to sweat it. It is what it is.”
Skenes zipped through the first two innings, retiring six batters without going to so much as a two-ball count. His quickly faltered in the third.
Pedro Pages singled on the first pitch he saw, Masyn Winn followed one batter later with a sharp single to left and Victor Scott II hit the first triple of his big league career on a shot to deep right-center field that scored two. Scott then trotted home on Brendon Donovan's run-scoring base hit.
While Skenes said his stuff felt “good,” his mistakes often wound up closer to the middle of the plate than usual. And the Cardinals pounced.
“It’s funny, a lot of the times you get away with those,” Skenes said. "Just didn’t get away with them today. Kind of is what it is.”
The 22-year-old reigning National League Rookie of the Year overpowered Miami and Tampa Bay to start the season. Skidding St. Louis, which had dropped six of seven coming in, proved to be a step up in competition.
The start was Skenes second with Rodriguez behind the plate. Skenes worked almost exclusively with veteran Yasmani Grandal last season, leaning on the veteran as he adjusted to life as one of the game's brightest young stars.
Skenes and Rodriguez kept it simple in Tampa last week, relying heavily on a couple of pitches against the Rays. Skenes dipped into his quickly expanding repertoire — not complete with a two-seam fastball and a split-fingered fastball — this time out, a step in the right direction.
Perhaps even more encouraging, there were times when Skenes would get ready to signal Rodriguez to call a specific pitch when Skenes' pitch comm would buzz with that exact call.
“That happened with Endy quite a few times today,” Skenes said. "We’re thinking very similarly. I don’t think I shook today. I’m a fan of the game that he called and that we called together. It just comes down to executing.”
The last truly bumpy start for Skenes came back home in Southern California when the Los Angeles Dodgers chipped away for four runs in five innings. He responded by winning each of his next two starts, giving up all of two runs in the process.
“We haven’t seen a lot of rough ones (from him),” Pirates manager Derek Shelton said. "But everything that has been on his plate, he’s handled very well. I expect him to come out the next time and be what we expect.”
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Pittsburgh Pirates pitcher Paul Skenes delivers during the first inning of a baseball game against the St. Louis Cardinals in Pittsburgh, Tuesday, April 8, 2025. (AP Photo/Gene J. Puskar)
Pittsburgh Pirates pitcher Paul Skenes delivers during the first inning of a baseball game against the St. Louis Cardinals in Pittsburgh, Tuesday, April 8, 2025. (AP Photo/Gene J. Puskar)
Pittsburgh Pirates pitcher Paul Skenes delivers during the first inning of a baseball game against the St. Louis Cardinals in Pittsburgh, Tuesday, April 8, 2025. (AP Photo/Gene J. Puskar)
DUBAI, United Arab Emirates (AP) — Iran vowed revenge Sunday after the killing of its supreme leader and traded strikes with Israel as part of a widening war prompted by a surprise U.S. and Israeli bombardment. The U.S. military said three service members have been killed, the first known American casualties from the conflict.
Blasts in Tehran sent a huge plume of smoke into the sky in an area of government buildings. Iranian authorities say more than 200 people have been killed since the start of the U.S. and Israeli strikes that killed Ayatollah Ali Khamenei and other senior leaders. Iran fired missiles at targets in Israel and Gulf Arab states in retaliation while Israel pledged "non-stop" strikes against Iran's leaders and military.
In Israel, loud explosions caused by missile impacts or interceptions could be heard in Tel Aviv. Israel’s rescue services said nine people were killed and 28 wounded in a strike that hit a synagogue in the central town of Beit Shemesh, bringing the overall death toll in the country to 11. Eleven people were still missing after the strike, police said, as rescue crews combed the rubble.
The strikes and counterattacks underscored how the killing of Khamenei, and U.S. President Donald Trump ’s calls for the overthrow of the decades-old Islamic Republic, carried the potential for a prolonged conflict that could envelop the Middle East. It also represents a startling show of military might for an American president who swept into office on an “America First” platform and vowed to keep out of “forever wars.”
In Tehran, there was little sign that Iranians had heeded Trump's call for an uprising against the government.
The streets were largely deserted as people sheltered during heavy airstrikes, witnesses told The Associated Press, speaking anonymously for fear of retribution. The paramilitary Basij, which has played a central role in crushing protests, has set up checkpoints across the city, they said.
The U.S. military said three service members were killed and five others seriously wounded, without providing further details. It said several others suffered minor injuries and concussions.
In the 12-day war last June, Israeli and American strikes greatly weakened Iran’s air defenses, military leadership and nuclear program. But the killing of Khamenei, who had ruled Iran for more than three decades, creates a leadership vacuum, increasing the risk of regional instability.
Iranian President Masoud Pezeshkian said in a prerecorded message that a new leadership council had begun its work. The country's foreign minister, Abbas Araghchi, said a new supreme leader would be chosen in “one or two days.”
As word spread of Khamenei’s death, some in Tehran could be seen cheering from rooftops, witnesses said. Others mourned as a black flag was raised over the Imam Reza shrine in Mashhad.
“You have crossed our red line and must pay the price,” Iran’s parliamentary speaker, Mohammad Bagher Qalibaf, said in a televised address. “We will deliver such devastating blows that you yourselves will be driven to beg.”
Trump warned against retaliation.
“THEY BETTER NOT DO THAT,” he said in a social media post. “IF THEY DO, WE WILL HIT THEM WITH A FORCE THAT HAS NEVER BEEN SEEN BEFORE!”
In a sign of how the attack could stoke regional unrest, hundreds of people stormed the U.S. Consulate in Pakistan’s port city of Karachi. Police and paramilitary forces used batons and fired tear gas to disperse the crowd, and at least nine people were killed in the clashes, authorities said.
As U.S. and Israeli strikes have pounded Iran, the Islamic Republic has retaliated with missiles and drone attacks on Israel and nearby Arab Gulf countries hosting U.S. forces.
The air war could rattle global markets, particularly if Iran makes the Strait of Hormuz unsafe for commercial traffic. Around 20% of the world's traded oil passes through the vital waterway.
While Iran struck U.S. bases in Bahrain and the United Arab Emirates, the attacks have also hit outside of military installations, including a hotel in the Emirati city of Dubai, and Kuwait’s international airport. At least four people have been killed in strikes on Gulf countries.
Araghchi, Iran’s foreign minister, blamed such strikes on the U.S. and Israel for starting the war. He said he had spoken to his counterparts in the Gulf countries and urged them to pressure the U.S. and Israel to end it.
Israel’s Defense Minister Israel Katz said Sunday that Israel will have “a non-stop air train” of strikes against Iranian military and leadership targets. The U.S. military said it had struck an Iranian warship at a port on the Gulf of Oman that was now sinking.
Flights across the Middle East were disrupted, and air defense fire thudded over Dubai. The United Arab Emirates’ commercial capital has long drawn business and expatriates by billing itself as a safe haven in a volatile region.
As supreme leader, Khamenei had final say on all major policies since 1989. He led Iran’s clerical establishment and the Revolutionary Guard, the two main centers of power in the governing theocracy.
An Iranian medical professional in northern Iran said he and colleagues spent the early hours of Sunday celebrating Khamenei's death indoors because armed security forces are still heavily deployed in his city.
There were forces stopping and interrogating people celebrating in their cars but there was no gunfire, said the doctor, who spoke on condition of anonymity for fear of reprisal.
“It was one of the best nights, if not the best night of our lives,” the doctor said in a voice message from the city of Rasht. In fact, “it was actually my first time ever smoking a cigarette. It was a very very nice time. We didn’t sleep at all. And we don’t even feel tired.”
In southern Iran, at least 115 people were reported killed when a girls’ school was struck, and dozens more were wounded, the local governor told Iranian state TV. The Israeli military said it was not aware of strikes in the area. The U.S. military said it was looking into the reports.
Tensions have escalated in recent weeks as the Trump administration built up the largest force of American warships and aircraft in the Middle East in decades. The president insisted he wanted a deal to constrain Iran’s nuclear program while the country struggled with growing dissent following nationwide protests.
Democrats decried that Trump had taken action without congressional authorization. The White House said it had briefed several Republican and Democratic leaders in Congress in advance.
Though Trump had pronounced the Iranian nuclear program obliterated in strikes last year, the country was rebuilding infrastructure that it had lost, according to a senior U.S. official who spoke to reporters on condition of anonymity to discuss Trump’s decision-making process. The official said intelligence showed that Iran had developed the capability to produce its own high-quality centrifuges, an important step in developing the highly enriched uranium needed for weapons.
Iran has said it has not enriched since June, though it has maintained its right to do so while saying its nuclear program is entirely peaceful. It has also blocked international inspectors from visiting the sites the U.S. bombed. Satellite photos analyzed by AP have shown new activity at two of those sites.
Lidman reported from Tel Aviv, Israel; Boak from West Palm Beach, Florida; and Tucker from Washington. Associated Press writers Joe Federman in Jerusalem, Sarah El Deeb in Beirut, Amir Radjy in Cairo, Aamer Madhani and Konstantin Toropin in Washington, Sam Mednick in Tel Aviv, Israel, Farnoush Amiri in New York, David Rising in Bangkok and AP journalists around the world contributed to this report.
Shiite Muslims hold the portraits of Iranian leaders during a rally to condemn the killing of Iranian Supreme Leader Ayatollah Ali Khamenei, in Quetta, Pakistan, Sunday, March 1, 2026. (AP Photo/Arshad Butt)
Iraqis hold a portrait of Iranian supreme Leader Ayatollah Ali Khamenei during a protest against U.S. and Israeli attacks on multiple cities across Iran, at a bridge leading to the fortified Green Zone where the U.S. Embassy is located, in Baghdad, Iraq, Sunday, March 1, 2026. (AP Photo/Hadi Mizban)
Israeli air defense system fires to intercept missiles during an Iranian attack over central Israel, Sunday, March 1, 2026. (AP Photo/Ohad Zwigenberg)
Israeli air defense system fires to intercept missiles during an Iranian attack over central Israel, Sunday, March 1, 2026. (AP Photo/Ohad Zwigenberg)
Government supporters chant slogans as they gather in mourning after state TV officially announced the death of Iranian Supreme Leader Ayatollah Ali Khamenei, in Tehran, Iran, Sunday, March 1, 2026. (AP Photo/Vahid Salemi)
A plume of smoke rises after a strike in Tehran, Iran, Sunday, March 1, 2026. (AP Photo/Vahid Salemi)
Smoke rises up after a strike in Tehran, Iran, Sunday, March 1, 2026. (AP Photo/Vahid Salemi)
Government supporters gather in mourning after state TV officially announced the death of Iranian Supreme Leader Ayatollah Ali Khamenei, in Tehran, Iran, Sunday, March 1, 2026. (AP Photo/Vahid Salemi)
Government supporters chant slogans as they gather in mourning after state TV officially announced the death of Iranian Supreme Leader Ayatollah Ali Khamenei, shown in the poster, in Tehran, Iran, Sunday, March 1, 2026. (AP Photo/Vahid Salemi)
Government supporters gather in mourning after state TV officially announced the death of Iranian Supreme Leader Ayatollah Ali Khamenei, in Tehran, Iran, Sunday, March 1, 2026. (AP Photo/Vahid Salemi)
Rescue workers and military personnel survey the scene of a direct hit a day after an Iranian missile struck in Tel Aviv, Israel, Sunday, March 1, 2026. (AP Photo/Oded Balilty)
A government supporter holds a picture of the Iranian Supreme Leader Ayatollah Ali Khamenei during a gathering after state TV officially announced the death of Khamenei, in Tehran, Iran, Sunday, March 1, 2026. (AP Photo/Vahid Salemi)
Israel's air defense missile fires to intercept missiles from Iran over Israel, Sunday, March 1, 2026. (AP Photo/Ariel Schalit)
Government supporters mourn in a gathering after state TV officially announced the death of Iranian Supreme Leader Ayatollah Ali Khamenei, in Tehran, Iran, Sunday, March 1, 2026. (AP Photo/Vahid Salemi)
Government supporters chant slogans as they gather in mourning after state TV officially announced the death of Iranian Supreme Leader Ayatollah Ali Khamenei, in Tehran, Iran, Sunday, March 1, 2026. (AP Photo/Vahid Salemi)
