Amorepacific Research Confirms Potential of Microalgal-Derived PDRNs in Skin Regeneration and Wound Healing

New findings suggest 'BluePDRNâ„¢' offers a sustainable, scalable alternative to traditional animal-derived PDRNs

SEOUL, South Korea, April 29, 2025 /PRNewswire/ -- Amorepacific revealed research findings confirming the skin-regenerative effects of polydeoxyribonucleotides (PDRNs) extracted from a microalgal source, Chlorella protothecoides. The findings were published in the international journal Archives of Dermatological Research under the title, "Effects of Chlorella protothecoides-derived polydeoxyribonucleotides on skin regeneration and wound-healing."

PDRNs have been garnering attention in recent years for its efficacy in enhancing skin regeneration and wound healing. In Korea, PDRNs that have been purified can be found in various applications, including pharmaceuticals, medical devices and cosmetics. Traditionally, PDRNs are extracted from animal-derived sources like salmon or trout, but Amorepacific turned its attention to Chlorella protothecoides to develop an animal-free alternative that is sustainable and scalable.

The pioneering research on Chlorella-derived PDRNs, led by Amorepacific's R&I Center, was conducted as part of the Ministry of Oceans and Fisheries' project to develop marine biomaterial formulation technology. Through this initiative, Amorepacific successfully developed a production process for high-yield, low-molecular-weight, microalgal-derived PDRNs dubbed 'BluePDRNâ„¢', consequently shedding light on its mechanism of action and skin regenerative effects.

Research results showed BluePDRNâ„¢ displayed wound closure effects equivalent to those of salmon-derived PDRN^[1], with each molecule being approximately 1/20th the size of a salmon-derived PDRN molecule^[2]. It also promoted the expression of collagen accumulation and angiogenesis, both of which are essential for healthy skin. Like traditional animal-derived PDRNs, BluePDRNâ„¢ demonstrated skin regeneration efficacy through an adenosine A2A receptor (A2AR)-dependent mechanism.

Notably, the regenerative benefits of BluePDRN^TM were also observed in skin tissue with epidermal damage caused by photoaging, as demonstrated in experiments conducted by Outer Biosciences Inc., a biotechnology company in Boston, MA, USA that researches ingredients for skin health.

Byung-Fhy Suh, CTO of Amorepacific R&I Center, said, "This research is highly significant as it reveals the efficacy of sustainable, vegan PDRNs derived from microalgae. Amorepacific will continue its efforts to deliver safer and more effective products to customers around the world."

Amorepacific has applied for a patent on the production technology behind BluePDRNâ„¢, "Manufacturing technology for low-molecular-weight PDRN isolated from microalgae (Chlorella) using a continuous modular process." The company has also received a New Excellent Technology (NET) certification and a minister's commendation from the Ministry of Oceans and Fisheries.

[1] Results from Amorepacific R&I Center tests on ex vivo skin and reconstructed human epidermis

[2] Each BluePDRNâ„¢ being approximately 24 kDa in size (1/20th the size of a salmon-derived PDRN molecule), according to measurement of molecular weight by Korea Polymer Testing & Research Institute

^[1] Results from Amorepacific R&I Center tests on ex vivo skin and reconstructed human epidermis

^[2] Each BluePDRNâ„¢ being approximately 24 kDa in size (1/20^th the size of a salmon-derived PDRN molecule), according to measurement of molecular weight by Korea Polymer Testing & Research Institute

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Amorepacific Research Confirms Potential of Microalgal-Derived PDRNs in Skin Regeneration and Wound Healing

Amorepacific Research Confirms Potential of Microalgal-Derived PDRNs in Skin Regeneration and Wound Healing

SHANGHAI, April 4, 2026 /PRNewswire/ -- From April 2 to 31, the Assembly Character Toys brand Blokees made its debut at the 2026 Thailand Toy Expo. Blokees unveiled its two major categories — Blokees Model Kits and Blokees Wheels, highlighting a diverse product matrix of more than 300 products across 17 globally recognized IPs, including Ultraman, Transformers, DC, Evangelion, Naruto, Minions, Jurassic World, Hatsune Miku, and Hero Infinity. Four new model kits also made their global debut, emerging as key highlights of the event.

Mario Maurer attended the opening ceremony of Blokees Thailand Toy Expo as a special guest and engaged in interactive exchanges with consumers.

In the Blokees Model Kits category, Blokees exhibited its Champion, Legend, and Fantastic Series, featuring popular IPs such as Transformers, DC, Mega Man, Saint Seiya, Evangelion, and Naruto. More than 50 products were presented to consumers. Among them, four newly launched items—including Blokees Saint Seiya-Champion Class-12-Phoenix Ikki, Blokees Saint Seiya-Champion Class-14-Andromeda Shun, Blokees DC-Champion Class 05-Batman (HUSH), and Blokees DC-Champion Class 06-Catwoman (Hush)—drew strong interest from fans.

Blokees also highlighted its HERO5 and HERO10 series, featuring well-known IPs including Transformers, Saint Seiya, and Naruto, catering to consumers of hero-themed collectible models.

The DaaLaMode series introduced a range of products inspired by popular IPs such as Hatsune Miku, appealing to female consumers. Meanwhile, the TERRAVENTURE series presented nature and creature-themed model kits based on Jurassic World, further expanding Blokees' offerings across different consumer segments.

In the Blokees Wheels category, which integrates construction, play, and customization, products are organized into the C, E, and S series. The lineup includes IP-based offerings from Transformers, Ultraman, and Batman, with upcoming collaborations featuring Fast & Furious and Ford.

In addition, Blokees highlighted its global consumer ecosystem, BFC (Blokees Family Creator). Selected works from 2025 The 3rd BFC Creation Contest Stellar Season were exhibited in Thailand for the first time, reflecting strong user creativity and engagement. 2026 The 4th BFC Creation Contest Season of Awakening has officially launched, further encouraging global participation.

Under its "Universally appealing, Stepwise pricing, Globally promoting" strategy, Blokees continues to expand across Southeast Asia, Europe, North America, and Latin America. Thailand is rapidly becoming a strategic hub in its regional expansion, as the company strengthens both product innovation and community-driven growth worldwide.

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Blokees made its debut at 2026 Thailand Toy Expo, exhibiting multiple products