SEOUL, South Korea, April 30, 2025 /PRNewswire/ -- J INTS BIO, a company specializing in anticancer and orphan drugs, announced its research findings for the next-generation EGFR-TKI therapeutic 'JIN-A02' (clinical Phase 1/2 results) and the ovarian cancer treatment candidate 'JIN-001' (preclinical results) at the American Association for Cancer Research (AACR) 2025, held in Chicago from April 25 to 30. In this presentation, J INTS BIO demonstrated its innovative drug development capabilities on a global stage, attracting significant attention from both academia and the industry.
'JIN-A02': New Hope for Overcoming Resistance – 4th Generation EGFR-TKI Clinical Results
Non-small cell lung cancer (NSCLC) accounts for approximately 85% of all lung cancer cases worldwide, and among these, EGFR mutations are considered a major therapeutic target. JIN-A02, introduced at AACR 2025, showed outstanding therapeutic efficacy in patients who developed resistance to existing third-generation EGFR-TKIs. In particular, JIN-A02 demonstrated remarkable antitumor activity in patients with EGFR C797S mutation—currently a mutation for which no approved targeted therapies exist—thus opening a new avenue for treatment options.
In the clinical trial, a patient in the 300 mg cohort showed complete clearance of circulating tumor DNA (ctDNA) harboring either the C797S or Ex19del mutation, and ctDNA carrying the T790M mutation was reduced by over 90%. Clinically, a partial response (PR) was observed, with tumor size reductions of up to 39.7%, and notable shrinkage of intracranial metastatic lesions. These findings are particularly important for NSCLC patients, in whom brain metastases are common. Furthermore, no dose-limiting toxicities (DLTs) or serious adverse events were observed up to the 300 mg dose, highlighting the excellent safety profile of JIN-A02. This safety profile is expected to be particularly beneficial for patients requiring long-term treatment and combination therapies.
Currently, JIN-A02 is undergoing multinational clinical trials in Korea, the United States, Thailand, and other countries, and it is being closely watched as a potential groundbreaking treatment option for EGFR-mutant NSCLC patients.
'JIN-001': An Innovative New Drug Targeting Refractory Ovarian Cancer
Also presented was 'JIN-001,' J INTS BIO's second-generation synthetic HSP90 inhibitor, developed as a new strategy to overcome resistance to existing ovarian cancer treatments. Ovarian cancer remains one of the deadliest gynecological malignancies, as it is often diagnosed at an advanced stage when effective treatment options are extremely limited.
The preclinical study demonstrated that JIN-001, when combined with the chemotherapeutic agent cisplatin, significantly enhanced tumor suppression compared to cisplatin alone. Notably, even at low concentrations (≤0.1 μM), JIN-001 enhanced the antitumor activity of cisplatin against both cisplatin-sensitive and cisplatin-resistant ovarian cancer cells, compared to cisplatin alone. Moreover, the combination therapy significantly reduced the expression of key signaling proteins related to cisplatin resistance, contributing to a sustained antitumor effect.
Based on these promising results, J INTS BIO is planning additional preclinical studies and aims to rapidly advance JIN-001 into clinical trials, with the goal of establishing a new standard of care for the treatment of refractory and multidrug-resistant ovarian cancer.
Led by the presentation at AACR 2025, J INTS BIO aims to further strengthen its competitiveness in the global oncology market and solidify its position as a frontrunner in next-generation anticancer drug development. The company also outlined its vision to continue delivering innovative therapies through ongoing research and development efforts, offering new hope to cancer patients worldwide.
** The press release content is from PR Newswire. Bastille Post is not involved in its creation. **
J INTS BIO Presents Research Results for Next-Generation Innovative Anticancer Therapeutics 'JIN-A02' and 'JIN-001' at AACR 2025
HANOI, Vietnam, Jan. 3, 2026 /PRNewswire/ -- Travellive Media Group is pleased to announce the HOTLIST Travellive Editor's Pick 2025 (HOTLIST 2025), a curated project honouring outstanding brands, destinations, and individuals that have made significant contributions to the development of Vietnam's tourism industry over the past year.
HOTLIST is a expert-curated list reflecting the evolving values of the market at each stage of development. The selection process combines the expertise of a prestigious advisory council comprising both domestic and international experts, based on key criteria including quality, innovation, social impact, and sustainable growth potential.
Last year, HOTLIST 2024 made a strong impression on the tourism, hospitality, and service community by recognising more than 40 brands and 12 inspiring individuals across 28 categories spanning hospitality and resorts, destinations, technology, and experiential initiatives. The year also marked the first time HOTLIST expanded into a professional event series, featuring The Insiders Forum and the Honor Ceremony, attracting over 700 guests including senior business leaders and experts from various fields.
HOTLIST 2025: From Seed to Harvest
Entering 2025, HOTLIST is developed under the theme "From Seed to Harvest" inspired by rice, a symbol deeply rooted in Vietnam's wet-rice civilisation and cultural identity. From planting ideas and nurturing resources to harvesting sustainable achievements, this metaphor reflects the authentic development journey of projects, brands, and destinations within the tourism and hospitality industry.
At a time when the tourism sector faces multiple challenges such as climate change, shifting traveller behaviour, and global competition, the spirit of "From Seed to Harvest" underscores the importance of long-term vision, perseverance, and adaptability.
This year, HOTLIST 2025 introduces a public voting component in the final evaluation stage, enabling the community and industry professionals to participate directly in the selection process. Beyond fostering engagement, this initiative also provides an opportunity for audiences to share their firsthand experiences with the shortlisted brands and projects.
HOTLIST 2025 Honourees
HOTLIST 2025 expands its scope across key tourism sectors, featuring 07 main categories: Hospitality; Aviation; Travel Design & Experiences; Destination; Technology & Innovations; Sustainability and Community Projects & Voices. Each category aims to identify exemplary individuals and brands that play a guiding role in shaping the future of Vietnam's tourism and hospitality industry.
This year's list continues to acknowledge well-established brands such as Four Seasons Resort The Nam Hai, Hoi An; Topas Ecolodge; Six Senses Ninh Van Bay; P'apiu Resort; Wink Hotels, among others. It also introduces international brands that have made a positive impact on the Vietnamese market, including voco Quang Binh Resort by IHG, Park Hyatt Phu Quoc, and Hyatt Place Halong Bay, Bai Chay. In the Aviation category, STARLUX AIRLINES was selected for its premium flight experience.
The expansion and diversification of award categories reflect HOTLIST's commitment to comprehensively capturing industry dynamics, while encouraging responsible development models that respect local identity and generate positive social impact.
As part of its mission to deliver practical value to the tourism industry, HOTLIST 2025 will host The Insiders Forum in Hanoi (7 January 2026, Sheraton Hanoi West) and Ho Chi Minh City (19 January 2026, JW Marriott Hotel & Suites Saigon). The forums will gather business leaders, experts, and researchers to share insights and discuss key topics shaping tourism landscape.
On 19 January 2026, The Honor Ceremony will take place in Ho Chi Minh City to officially recognise and present certificates to the brands, projects, and individuals featured in HOTLIST 2025. The event will also serve as a B2B networking platform for industry stakeholders.
Through each edition, HOTLIST Travellive Editor's Pick has gradually become a highly anticipated annual reference point for the tourism community, built on credibility, sustainability-driven orientation, and a series of professional programmes. Through recognition activities, dialogue forums, and community connections, Travellive not only highlights market excellence but also actively contributes to promoting sustainable thinking and elevating standards within tourism industry.
This year, HOTLIST 2025 is supported by The Brand Promise (Co-organiser of The Insiders Forum), PR Newswire (Media Partner), and sponsoring brands including BMWines, Lady Triệu (drink experiences), and Cocoon, Jourdeness (gifts). HOTLIST 2025 continues to amplify meaningful stories, connect outstanding individuals and organisations, and share positive values with the wider public.
** The press release content is from PR Newswire. Bastille Post is not involved in its creation. **
HOTLIST 2025 "From Seed to Harvest": A Story of Resilience and Transformation
