HydroPeptide Unveils Collagen ReActivate PM: A Groundbreaking Nighttime Treatment Rooted in 20 Years of Peptide Science

BELLEVUE, Wash.--(BUSINESS WIRE)--May 12, 2025--

HydroPeptide, a pioneer in peptide science and regenerative skincare, is redefining nighttime skincare with the launch of Collagen ReActivate PM Lifting Treatment Moisturizer + Retinol. This next-generation formula is designed with collagen-optimizing NIMNI™ Technology, time-release retinol, and regenerative peptides to visibly lift, firm, and restore optimal skin health while you sleep.

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The result of over two decades of clinical research, Collagen ReActivate PM was developed in collaboration with Dr. Marcel Nimni, a pioneer in the discovery of Type II collagen. This launch represents a major advancement in the company’s mission to support skin health at the cellular level and underscores its continued commitment to ingredient integrity, clinical efficacy, and exceptional user experience.

“Collagen ReActivate PM is a culmination of everything we stand for,” says Annette Rubin, CEO of HydroPeptide. “This formulation reflects decades of scientific discovery, our unwavering dedication to high-performing peptides, and our belief that clinical skincare should feel as incredible as it performs. More than a mere moisturizer, this is a next-generation solution designed to support skin regeneration during the body’s most crucial restorative period.”

Regenerative Technology Ahead of Its Time

Collagen ReActivate PM is the only treatment on the market formulated with NIMNI™ Technology. This proprietary blend of amino acids and antioxidants is clinically proven to optimize collagen production. By supporting this process in three key ways—strengthening and enhancing the skin’s structural integrity, feeding cells the nutrients they need to maintain healthy and abundant collagen, and signaling the skin to increase collagen production—NIMNI™ Technology is shown to increase collagen synthesis by 200% at 90 hours after application.

The Power of a Serum in a Luxurious Cream

Collagen ReActivate PM integrates NIMNI™ Technology with highly concentrated actives proven to transform skin. Time-release retinol (0.25%) enhances skin texture and tone while biomimetic peptides (SYN ® -TC and Neodermyl ® ) and antioxidants (vitamin C and Ellagi-C™) work synergistically to improve firmness, reduce the look of fine lines, and brighten skin.

Clinically Proven Results

According to a study published in the Journal of Drugs in Dermatology:

Clean, science-forward formulation

Like all HydroPeptide products, Collagen ReActivate PM is free of parabens, phthalates, sulfates, genotoxins, and harmful fragrance. The formula is vegan, gluten-free, not tested on animals, and has a skin-healthy pH of 6.9.

HydroPeptide continues to redefine skin health with formulas that improve skin's cellular function to deliver clinical-grade results that go beyond the surface. For more information, visit HydroPeptide.com.

Photo: HydroPeptide

COPENHAGEN, Denmark (AP) — President Donald Trump suggested Friday that he may punish countries with tariffs if they don’t back the U.S. controlling Greenland, a message that came as a Congressional delegation met Danish and Greenlandic lawmakers in Copenhagen and sought to lower tensions.

Trump for months has insisted that the U.S. should control Greenland, a semiautonomous territory of NATO ally Denmark, and said earlier this week that anything less than the Arctic island being in U.S. hands would be “unacceptable.”

“I may put a tariff on countries if they don’t go along with Greenland,” he said Friday, without providing details. “We need Greenland for national security.”

He had not previously mentioned using tariffs to try to force the issue.

Earlier this week, the foreign ministers of Denmark and Greenland met in Washington this week with U.S. Vice President JD Vance and Secretary of State Marco Rubio.

That encounter didn’t resolve the deep differences, but did produce an agreement to set up a working group — on whose purpose Denmark and the White House then offered sharply diverging public views. Greenland is a semiautonomous territory of Denmark, a NATO ally of the U.S.

President Donald Trump speaks during an event to promote investment in rural health care in the East Room of the White House, Friday, Jan. 16, 2026, in Washington. (AP Photo/Alex Brandon)