HydroPeptide Unveils Collagen ReActivate PM: A Groundbreaking Nighttime Treatment Rooted in 20 Years of Peptide Science

BELLEVUE, Wash.--(BUSINESS WIRE)--May 12, 2025--

HydroPeptide, a pioneer in peptide science and regenerative skincare, is redefining nighttime skincare with the launch of Collagen ReActivate PM Lifting Treatment Moisturizer + Retinol. This next-generation formula is designed with collagen-optimizing NIMNI™ Technology, time-release retinol, and regenerative peptides to visibly lift, firm, and restore optimal skin health while you sleep.

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The result of over two decades of clinical research, Collagen ReActivate PM was developed in collaboration with Dr. Marcel Nimni, a pioneer in the discovery of Type II collagen. This launch represents a major advancement in the company’s mission to support skin health at the cellular level and underscores its continued commitment to ingredient integrity, clinical efficacy, and exceptional user experience.

“Collagen ReActivate PM is a culmination of everything we stand for,” says Annette Rubin, CEO of HydroPeptide. “This formulation reflects decades of scientific discovery, our unwavering dedication to high-performing peptides, and our belief that clinical skincare should feel as incredible as it performs. More than a mere moisturizer, this is a next-generation solution designed to support skin regeneration during the body’s most crucial restorative period.”

Regenerative Technology Ahead of Its Time

Collagen ReActivate PM is the only treatment on the market formulated with NIMNI™ Technology. This proprietary blend of amino acids and antioxidants is clinically proven to optimize collagen production. By supporting this process in three key ways—strengthening and enhancing the skin’s structural integrity, feeding cells the nutrients they need to maintain healthy and abundant collagen, and signaling the skin to increase collagen production—NIMNI™ Technology is shown to increase collagen synthesis by 200% at 90 hours after application.

The Power of a Serum in a Luxurious Cream

Collagen ReActivate PM integrates NIMNI™ Technology with highly concentrated actives proven to transform skin. Time-release retinol (0.25%) enhances skin texture and tone while biomimetic peptides (SYN ® -TC and Neodermyl ® ) and antioxidants (vitamin C and Ellagi-C™) work synergistically to improve firmness, reduce the look of fine lines, and brighten skin.

Clinically Proven Results

According to a study published in the Journal of Drugs in Dermatology:

Clean, science-forward formulation

Like all HydroPeptide products, Collagen ReActivate PM is free of parabens, phthalates, sulfates, genotoxins, and harmful fragrance. The formula is vegan, gluten-free, not tested on animals, and has a skin-healthy pH of 6.9.

HydroPeptide continues to redefine skin health with formulas that improve skin's cellular function to deliver clinical-grade results that go beyond the surface. For more information, visit HydroPeptide.com.

Photo: HydroPeptide

A Ukrainian drone strike killed one person and wounded three others in the Russian city of Voronezh, local officials said Sunday.

A young woman died overnight in a hospital intensive care unit after debris from a drone fell on a house during the attack on Saturday, regional Gov. Alexander Gusev said on Telegram.

Three other people were wounded and more than 10 apartment buildings, private houses and a high school were damaged, he said, adding that air defenses shot down 17 drones over Voronezh. The city is home to just over 1 million people and lies some 250 kilometers (155 miles) from the Ukrainian border.

The attack came the day after Russia bombarded Ukraine with hundreds of drones and dozens of missiles overnight into Friday, killing at least four people in the capital Kyiv, according to Ukrainian officials.

For only the second time in the nearly four-year war, Russia used a powerful new hypersonic missile that struck western Ukraine in a clear warning to Kyiv and NATO.

The intense barrage and the launch of the nuclear-capable Oreshnik missile followed reports of major progress in talks between Ukraine and its allies on how to defend the country from further aggression by Moscow if a U.S.-led peace deal is struck.

Ukrainian President Volodymyr Zelenskyy said Saturday in his nightly address that Ukrainian negotiators “continue to communicate with the American side.”

Chief negotiator Rustem Umerov was in contact with U.S. partners Saturday, he said.

Separately, Ukraine’s General Staff said Russia targeted Ukraine with 154 drones overnight into Sunday and 125 were shot down.

Follow the AP’s coverage of the war in Ukraine at https://apnews.com/hub/russia-ukraine

This photo provided by the Ukrainian Security Service on Friday, Jan. 9, 2026, shows a fragment believed to be a part of a Russian Oreshnik intermediate range hypersonic ballistic missile that hit the Lviv region. (Ukrainian Security Service via AP)

President of Ukraine Volodymyr Zelenskyy, second left, listens to British Defense Secretary John Healey during their meeting in Kyiv, Ukraine, Friday, Jan. 9, 2026. (AP Photo/Danylo Antoniuk)