Significant anti-tumor responses and reduction of brain metastases observed
SEOUL, South Korea, June 2, 2025 /PRNewswire/ -- J INTS BIO, a company specializing in the development of therapeutics for cancer and rare diseases, officially announced interim results from the global Phase 1/2 clinical trial of JIN-A02, its fourth-generation EGFR-TKI drug candidate, at the American Society of Clinical Oncology 2025 (ASCO 2025), the world's largest oncology conference, held in Chicago, USA.
Professor Byoung Chul Cho from Yonsei Cancer Center, posing with the JIN-A02 poster at the ASCO 2025 (Photo=J INTS BIO)
Professor Byoung Chul Cho from Yonsei Cancer Center, posing with the JIN-A02 poster at the ASCO 2025 (Photo=J INTS BIO)
JIN-A02 is an oral, fourth-generation EGFR-TKI designed to overcome resistance mutations (such as C797S) that develop after treatment failure with third-generation EGFR-TKIs, which are currently the first-line therapy for EGFR-mutant Non-small cell lung cancer (NSCLC). It is currently undergoing clinical trials in South Korea, the United States, Thailand, and other countries. Key efficacy and safety results from Part A (dose escalation) of the multi-center clinical trial (NCT05394831) were presented.
'Confirmed' clinical response observed in patients with disease progression after 3rd Generation EGFR TKI and chemotherapy
One of the key findings of the ASCO presentation was that tumor responses were sustained in specific dose cohorts, with confirmed partial responses (PRs) verified by independent evaluation. Confirmed PRs were observed in 50mg,100mg and 300mg QD dose groups, providing clinical evidence of anti-tumor activity.
In the 50 mg dose group, patients achieved a 77.3% reduction in tumor size, maintaining a PR over six consecutive treatment cycles (from cycle 3 to cycle 13). In the 300 mg dose group, a confirmed PR was observed with a 39.7% tumor size reduction, including a significant reduction in brain metastatic lesions. In the 100 mg dose group, a PR was also reported with a 35.3% reduction in tumor size, and brain metastatic lesions remained stable, further supporting the potential of JIN-A02 in treating brain metastases.
Safety confirmed up to 300 mg, with therapeutic signals in brain metastases
No dose-limiting toxicities (DLTs) or serious adverse events were observed with JIN-A02 at doses up to 300mg, which is six times the dose level when PR was first observed, demonstrating a favorable safety profile even at higher dose levels. The majority of adverse events reported at 300mg were mild (Grade 1-2) and included for the first time, Grade 1 skin rash, diarrhea, and skin desquamation in 3 out of 5 subjects – events commonly associated with EGFR inhibitors and generally considered clinically manageable. Importantly, there were no reports of systemic toxicities such as cardiovascular events or hepatotoxicity, supporting the drug's excellent safety profile. This safety and tolerability have translated into extended treatment durations in real-world settings, with a patient still on JIN-A02 after one year and seven months.
In addition, the trial demonstrated notable responses in brain metastases first noted at 100mg, suggesting that JIN-A02 achieves therapeutically relevant concentrations in brain tissue.
JIN-A02 gains national spotlight as government grants accelerate development
In addition to the ASCO announcement, J INTS BIO continues to achieve noteworthy results in Korea. Recently, it was selected for the '2025 Baby Unicorn Fostering Project' by the Ministry of SMEs and Startups, officially recognizing both our scientific technology and commercialization potential. The 'Baby Unicorn Fostering Project' is a government project that focuses on developing promising startups with innovative technologies and growth potential in the global market as 'potential unicorns'. Companies selected for this project will receive full government support in recognition of their technological prowess and growth potential.
"The ASCO presentation of JIN-A02's ability to induce anti-cancer responses and its ability to respond to brain metastatic lesions is of great significance," said Dr. Anna Jo, CEO. "The government's continued support is a recognition of our technical capabilities and potential for growth. We will take advantage of this opportunity to accelerate global clinical expansion, technology transfer, and indication expansion to realize our goal of early commercialization"
** The press release content is from PR Newswire. Bastille Post is not involved in its creation. **
J INTS BIO to Present Global Clinical Results from JIN-A02, a Fourth-Generation EGFR-TKI, at ASCO 2025
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LAS VEGAS, Jan. 12, 2026 /PRNewswire/ -- Roborock, the global leader in home robotics engineered to simplify daily life, became the most awarded Robotic Vacuum Brand at CES 2026, after announcing its new product line-up for the first half of the year. Under the theme "The Greatest Meeting the Greatest", the brand's keynote presentation led by Roborock's President, Quan Gang, unveiled the Saros Rover, the world's first robotic vacuum with AI-powered wheel-leg architecture that can both navigate stairs and slopes with human-like agility while cleaning them.
Announcements also included the Roborock Saros 20, Roborock Saros 20 Sonic, Roborock F25 ACE Pro, and Roborock Qrevo Curv 2 Flow. These launches happened in partnership with Real Madrid Football Club for the Vacuum Cleaner category, announced ahead of the show's starting date.
Roborock also announced separate to the Real Madrid partnership its entry into the US market for lawnmower products, including the new RockMow X1 LiDAR. Consumers, clients, and interested parties can visit Roborock's Booth #52632 at Venetian Expo CES 2026 from January 6 to January 9th during show hours.
Roborock Saros Rover - The World's First Wheel-Leg Robovac
In a world-first, Roborock introduced at CES 2026 the Roborock Saros Rover, featuring the world's first two-wheel-leg architecture in a robovac. Each wheel-leg provides reach, lift, height, and imitates human mobility, enabling the robot to raise and lower each one of the wheel-legs independently, execute small jumps, agile turns, sudden stops, and directional changes, all while maintaining a level body as the ground changes.
At a software level, Saros Rover harnesses the power of Artificial Intelligence algorithms, in conjunction with complex motion sensors and 3D spatial information to understand its environment and make its wheel-legs react with precision.
The Saros Rover excels in multi-storey homes, where it is able to clean each one of the steps of a staircase as it goes to the second floor, dramatically reducing "no-go" zones and transitioning into cleaning areas previously inaccessible for homes with a single robovac.
The Saros Rover is able to tackle several types of non-flat surfaces, with staircases being the most obvious one. This includes not only traditional staircases but also curved staircases, or even carpeted staircases with bullnose fronts, all while cleaning each one of their steps as it navigates through them. Other types of surfaces that Saros Rover is able to tackle include slopes as well as complex multi-level room thresholds requiring height and power. Saros Rover is a real product in development with an unconfirmed launch date.
The Greatest Meeting The Greatest - Roborock and Real Madrid Football Club join hands
Announced days before the show's beginning, Roborock presents at CES its first activation within the strategic global partnership with Real Madrid Football Club's First Men and First Women teams, widely ranked as one of the greatest football clubs in history. The partnership is solely related to Roborock's extensive portfolio of Vacuum Cleaner products and excludes other product lines from the brand. Under the umbrella theme of "The Greatest Meeting The Greatest", the partnership responds to a deep affinity between the brand ethos of both organizations, which have achieved remarkable historical performance with innovation as common denominator. The partnership will bring Roborock's smart-cleaning innovations to life through stadium exposure, campaigns and player-led storytelling that translate the meaning of "Real Smart Cleaning" from the pitch to the home.
Roborock's early 2026 Robovac line-up: Roborock Saros 20, Roborock Saros 20 Sonic, and Roborock Qrevo Curv 2 Flow
At its keynote, Clarbi Lu, product marketing lead at Roborock, unveiled new smart cleaning products launching in the first half of the year. Leading the lineup are the Roborock Saros 20 and Roborock Saros 20 Sonic, the latest flagship models in the Saros Series. Saros 20 upgrades the StarSight™ Autonomous System 2.0 with enhanced AI object recognition and a new AdaptiLift Chassis 3.0 for improved threshold climbing. Saros 20 Sonic adds RetractSense™ Navigation, an ultra-slim body, and the VibraRise® 5.0 Mopping System. Both use a 35,000 Pa HyperForce® motor and a new RockDock®. The Qrevo Series also expands with the Roborock Qrevo Curv 2 Flow.
Rockmow X1 LiDAR, X1, RockNeo Q1 lead the Roborock North American Roll-Out of Lawnmowers
Roborock has announced its North American expansion into the lawnmower category with three key models. The flagship RockMow X1 LiDAR features Sentisphere™ LiDAR Environmental Perception, 4WD traction, and Active Steering for flawless coverage. Alternatively, the RockMow X1 utilizes RTK and VSLAM navigation alongside a Dynamic Suspension System for industry-leading edge cutting. For smaller gardens, the entry-level RockNeo Q1 makes smart care accessible by combining RTK + VSLAM navigation with Stereo Vision Obstacle Avoidance.
For pricing and availiability, please contact your local Roborock sales or communications representative.
About Roborock
Roborock is a leading smart cleaning brand renowned for its intelligent cleaning solutions. Having become the #1 best-selling robotic vacuum cleaner brand according to IDC*, Roborock enriches lives with its innovative line of robotic, cordless, wet/dry vacuum cleaners, robotic lawn mowers and washer-dryers. Rooted in a user-centric approach, our R&D-driven solutions cater to diverse cleaning needs in millions of homes across more than 170 countries and regions. Headquartered in Beijing and with strategic subsidiaries in key markets, including the United States, Japan, the Netherlands, Poland, Germany, and South Korea, Roborock is dedicated to elevating its market presence worldwide. As of 2026, Roborock serves more than 22 million households. For more information, visit https://global.roborock.com/.
LAS VEGAS, Jan. 12, 2026 /PRNewswire/ -- Roborock, the global leader in home robotics engineered to simplify daily life, became the most awarded Robotic Vacuum Brand at CES 2026, after announcing its new product line-up for the first half of the year. Under the theme "The Greatest Meeting the Greatest", the brand's keynote presentation led by Roborock's President, Quan Gang, unveiled the Saros Rover, the world's first robotic vacuum with AI-powered wheel-leg architecture that can both navigate stairs and slopes with human-like agility while cleaning them.
Announcements also included the Roborock Saros 20, Roborock Saros 20 Sonic, Roborock F25 ACE Pro, and Roborock Qrevo Curv 2 Flow. These launches happened in partnership with Real Madrid Football Club for the Vacuum Cleaner category, announced ahead of the show's starting date.
Roborock also announced separate to the Real Madrid partnership its entry into the US market for lawnmower products, including the new RockMow X1 LiDAR. Consumers, clients, and interested parties can visit Roborock's Booth #52632 at Venetian Expo CES 2026 from January 6 to January 9th during show hours.
Roborock Saros Rover - The World's First Wheel-Leg Robovac
In a world-first, Roborock introduced at CES 2026 the Roborock Saros Rover, featuring the world's first two-wheel-leg architecture in a robovac. Each wheel-leg provides reach, lift, height, and imitates human mobility, enabling the robot to raise and lower each one of the wheel-legs independently, execute small jumps, agile turns, sudden stops, and directional changes, all while maintaining a level body as the ground changes.
At a software level, Saros Rover harnesses the power of Artificial Intelligence algorithms, in conjunction with complex motion sensors and 3D spatial information to understand its environment and make its wheel-legs react with precision.
The Saros Rover excels in multi-storey homes, where it is able to clean each one of the steps of a staircase as it goes to the second floor, dramatically reducing "no-go" zones and transitioning into cleaning areas previously inaccessible for homes with a single robovac.
The Saros Rover is able to tackle several types of non-flat surfaces, with staircases being the most obvious one. This includes not only traditional staircases but also curved staircases, or even carpeted staircases with bullnose fronts, all while cleaning each one of their steps as it navigates through them. Other types of surfaces that Saros Rover is able to tackle include slopes as well as complex multi-level room thresholds requiring height and power. Saros Rover is a real product in development with an unconfirmed launch date.
The Greatest Meeting The Greatest - Roborock and Real Madrid Football Club join hands
Announced days before the show's beginning, Roborock presents at CES its first activation within the strategic global partnership with Real Madrid Football Club's First Men and First Women teams, widely ranked as one of the greatest football clubs in history. The partnership is solely related to Roborock's extensive portfolio of Vacuum Cleaner products and excludes other product lines from the brand. Under the umbrella theme of "The Greatest Meeting The Greatest", the partnership responds to a deep affinity between the brand ethos of both organizations, which have achieved remarkable historical performance with innovation as common denominator. The partnership will bring Roborock's smart-cleaning innovations to life through stadium exposure, campaigns and player-led storytelling that translate the meaning of "Real Smart Cleaning" from the pitch to the home.
Roborock's early 2026 Robovac line-up: Roborock Saros 20, Roborock Saros 20 Sonic, and Roborock Qrevo Curv 2 Flow
At its keynote, Clarbi Lu, product marketing lead at Roborock, unveiled new smart cleaning products launching in the first half of the year. Leading the lineup are the Roborock Saros 20 and Roborock Saros 20 Sonic, the latest flagship models in the Saros Series. Saros 20 upgrades the StarSight™ Autonomous System 2.0 with enhanced AI object recognition and a new AdaptiLift Chassis 3.0 for improved threshold climbing. Saros 20 Sonic adds RetractSense™ Navigation, an ultra-slim body, and the VibraRise® 5.0 Mopping System. Both use a 35,000 Pa HyperForce® motor and a new RockDock®. The Qrevo Series also expands with the Roborock Qrevo Curv 2 Flow.
Rockmow X1 LiDAR, X1, RockNeo Q1 lead the Roborock North American Roll-Out of Lawnmowers
Roborock has announced its North American expansion into the lawnmower category with three key models. The flagship RockMow X1 LiDAR features Sentisphere™ LiDAR Environmental Perception, 4WD traction, and Active Steering for flawless coverage. Alternatively, the RockMow X1 utilizes RTK and VSLAM navigation alongside a Dynamic Suspension System for industry-leading edge cutting. For smaller gardens, the entry-level RockNeo Q1 makes smart care accessible by combining RTK + VSLAM navigation with Stereo Vision Obstacle Avoidance.
For pricing and availiability, please contact your local Roborock sales or communications representative.
About Roborock
Roborock is a leading smart cleaning brand renowned for its intelligent cleaning solutions. Having become the #1 best-selling robotic vacuum cleaner brand according to IDC*, Roborock enriches lives with its innovative line of robotic, cordless, wet/dry vacuum cleaners, robotic lawn mowers and washer-dryers. Rooted in a user-centric approach, our R&D-driven solutions cater to diverse cleaning needs in millions of homes across more than 170 countries and regions. Headquartered in Beijing and with strategic subsidiaries in key markets, including the United States, Japan, the Netherlands, Poland, Germany, and South Korea, Roborock is dedicated to elevating its market presence worldwide. As of 2026, Roborock serves more than 22 million households. For more information, visit https://global.roborock.com/.
** The press release content is from PR Newswire. Bastille Post is not involved in its creation. **
CES 2026: Roborock releases the world's first robotic vacuum with wheel-leg architecture as it joins hands with Real Madrid Football Club
CES 2026: Roborock releases the world's first robotic vacuum with wheel-leg architecture as it joins hands with Real Madrid Football Club
CES 2026: Roborock releases the world's first robotic vacuum with wheel-leg architecture as it joins hands with Real Madrid Football Club
CES 2026: Roborock releases the world's first robotic vacuum with wheel-leg architecture as it joins hands with Real Madrid Football Club
CES 2026: Roborock releases the world's first robotic vacuum with wheel-leg architecture as it joins hands with Real Madrid Football Club
