NEW YORK--(BUSINESS WIRE)--Jul 8, 2025--
In 2025, Bonerge initiated a clinical trial (Registration #NCT06990256) investigating the effects of Urolithin A and Fisetin on sleep quality, targeting sleep disorders through the lens of ageing biology.
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This randomized, quadruple-blind (participants, healthcare providers, researchers, assessors), placebo-controlled study will enroll over 80 participants aged 45-70. They will be divided into four groups: Urolithin A alone, Fisetin alone, Urolithin A + Fisetin combination, and placebo control. The 12-week intervention represents the first systematic evaluation of Urolithin A's potential to resynchronize circadian rhythms and mitigate age-related sleep disturbances.
Key Study Design Features:
Inclusion Criteria: Targets subclinical individuals with impaired sleep quality (PSQI score >5) but no pathological diagnosis, excluding those dependent on caffeine/alcohol.
Multidimensional Assessment:
Subjective : Sleep quality scores, chronotype questionnaire, daytime dysfunction scales.
Objective : Continuous actigraphy monitoring, polysomnography (PSG) analysis.
Biomarkers : NAD+ levels, DNA methylation age, inflammatory markers (IL-6, TNF-α), cortisol rhythm, circadian proteins (BMAL1, PER2), insulin resistance (HOMA-IR), immunoglobulin levels.
"We aim to uncover the causal link between sleep disorders and ageing using epigenetic clocks and metabolic markers, beyond just tracking sleep duration," stated Professor Chen, the lead investigator. "Combining Urolithin A, a circadian regulator, with the senolytic Fisetin explores synergy for novel solutions, like menopausal sleep issues."
Scientific Commitment: Building a Health Ecosystem
As a leading high-quality ingredient producer, Bonerge's R&D follows a pipeline of 'ingredient science, mechanistic research, clinical translation'. The company is actively seeking global clinical partners from academia and industry to explore Urolithin A's potential in sleep health and cellular ageing intervention.
Amidst the anti-ageing industry's shift from consumerism to scientific rigor, Bonerge positions Urolithin A not just as a standalone ingredient, but as a catalyst for evidence-based solutions. Focused on core mechanisms like cellular senescence, Bonerge develops innovative ingredients targeting cellular health, forming a robust "health ecosystem." Key components include:
Fisetin: Potent senolytic selectively clearing senescent cells and reducing their formation, retarding aging in skin, ovarian, and neural tissues.
Urolithin A: Regulates circadian rhythms, boosts endogenous NAD+ synthesis, enhances cellular repair, and improves sleep quality and reproductive health.
L-Ergothioneine: Unique antioxidant with a dedicated transporter (OCTN1), accumulating in high-stress tissues to neutralize ROS, protecting DNA and telomeres.
PQQ Disodium: Activates the PGC-1α/PPARγ pathway, driving mitochondrial DNA replication and biogenesis.
S - Equol: Natural, non-steroidal estrogenic metabolite with high affinity for ERβ, offering a safer alternative for menopause health.
About Bonerge
Bonerge firmly contends that the future of anti-ageing hinges on evidence-based solutions. These solutions are grounded in well-defined biological mechanisms, supported by robust scientific data, and tailored to precise applications, ultimately delivering comprehensive, science-validated health benefits. For more detailed information about our clinical findings, discover more about us at http://www.bonerge.com.
Bonerge’s featured ingredients StanYouth® Urolithin A and BeFisetin® Fisetin enter clinical validation for sleep and wellbeing.
Iran fired missiles at Israel and some Gulf nations while explosions could be heard around Tehran and the central Iranian city of Isfahan on Friday, as the United States prepared to further reinforce its already significant military forces in the Middle East.
As the war that began Feb. 28 was to enter its sixth week, Israel, Bahrain, Kuwait warned about incoming missile fire, although it was unclear if anything was struck. Activists reported strikes around Tehran and the central city of Isfahan but it wasn’t immediately clear what was hit.
Iran’s attacks on Gulf region energy infrastructure and its tight grip on the Strait of Hormuz, through which a fifth of the world’s oil and natural gas transits in peacetime, has sent oil prices skyrocketing.
Oil prices surged while Asian financial markets rose moderately during cautious trading. Benchmark U.S. crude rose 11.4% to $111.54 a barrel. The price of Brent crude, the international standard, jumped 7.8% to $109.03 per barrel.
U.S. President Donald Trump said U.S. forces will keep hitting Iran “very hard” in the next two or three weeks.
The largest American aircraft carrier in service sailed out of Split, in Croatia and “remains poised for full mission tasking in support of national objectives in any area of operation,” the Navy’s 6th Fleet announced.
It was unclear where it was going. The USS Abraham Lincoln remains in the Arabian Sea and the USS George H. W. Bush aircraft carrier departed Norfolk on Wednesday to head to the Mideast.
Here is the latest:
Oil prices continued to surge on worries of a prolonged Iran war but the Asian markets that were open Friday rose moderately in cautious trading, while others were closed for the Good Friday holidays.
Benchmark U.S. crude rose 11.4% to $111.54 a barrel. The price of Brent crude, the international standard, jumped 7.8% to $109.03 per barrel.
The U.S. only relies on the Persian Gulf for a fraction of the oil it imports, but oil is a commodity and prices are set in a global market.
The situation is very different in Asia. Japan, for example, relies on access to the Strait of Hormuz for much of the nation’s oil import needs and would need to rely on alternative routes. But some analysts say Japan and oher nations are counting on an agreement with Iran to allow transports.
Japan’s benchmark Nikkei 225 gained 0.9% in Friday morning trading to 52,938.62. South Korea’s Kospi jumped 2.1% to 5,344.41. The Shanghai Composite sank 0.5% to 3,899.57. Trading was closed in Hong Kong, Singapore, Australia, New Zealand, the Philippines, Indonesia and India.
Wall Street, where trading is closed Friday, finished its first winning week since the start of the Iran war, although trading started out with a decline driven by a surge in oil prices.
Bangladesh is curtailing office hours and enforcing early closure of malls and shops beginning Friday to handle its energy crisis related to the war.
The country’s cabinet ordered 30% spending cuts for fuel and power at government offices, suspended some staff training and stopped purchases of new vehicles, ships and aircraft. Decorative lighting will not be allowed for celebrations.
Bangladesh, a nation of more than 170 million people, is seeking alternative fuel sources and $2.5 billion in external financing for imports, which account for 95% of its fuel.
Australian Energy Minister Chris Bowen on Friday urged motorists getting away for a long weekend during the Easter holiday to fill up in cities because most of the nation’s fuel shortages are in rural areas.
Among 2,400 gas stations in New South Wales, Australia’s most populous state, 182 had run out of diesel by Friday.
In Australia’s second-most populous state, Victoria, 76 gas stations were out of diesel. In the remaining states ranked by the most populous first, Queensland had 75 stations without diesel, Western Australia had 37, South Australia had 28 and in Tasmania there were seven.
“For those Australians planning a road trip this weekend, given our shortages are predominantly in rural and regional Australia, it makes sense to fill up in the city to help the country if you can,” Bowen said in Sydney.
The government, which blamed regional shortages on panic buying and distribution problems, is concentrating on delivering fuel to farmers for planting crops.
Palestinian Muslims attend Friday prayers outside Jerusalem's Old City due to restrictions linked to the Iran war, April 3, 2026. (AP Photo/Mahmoud Illean)
Tamara and her sister Amal color pictures on the floor as their parents, Sara and Ahmed, who fled their village of Khiyam in southern Lebanon due to Israeli bombardment, sit inside a tent used as a shelter in Beirut, Lebanon, Friday, April 3, 2026. (AP Photo/Emilio Morenatti)
A painting lies on the floor of a residential building damaged by recent U.S.-Israeli strikes in Fardis, west of Tehran, Iran, Friday, April 3, 2026. (AP Photo/Vahid Salemi)
Journalists from foreign media based in Tehran document damage from U.S.-Israeli strikes in a residential area of the town of Fardis, west of Tehran, Iran, Friday, April 3, 2026. (AP Photo/Vahid Salemi)
Mohammad Qubaisi, 53, with burn wounds from an Israeli airstrike on southern Lebanon undergoes surgery by Dr. Mohammed Ziara, left, and his team, at the Sidon Government Hospital in Sidon, Lebanon, Thursday, April 2, 2026. (AP Photo/Emilio Morenatti)
Israeli security forces and rescue teams inspect a site struck by an Iranian missile in Petah Tikva, Israel,Thursday, April 2, 2026. (AP Photo/Ohad Zwigenberg)
A newly constructed bridge struck by U.S. airstrikes Thursday is seen in Karaj, west of Tehran, Iran, Friday, April 3, 2026. (AP Photo/Vahid Salemi)
A newly constructed bridge struck by U.S. airstrikes Thursday is seen in Karaj, west of Tehran, Iran, Friday, April 3, 2026. (AP Photo/Vahid Salemi)
A bridge struck by U.S. airstrikes on Thursday is seen in the town of Karaj, west of Tehran, Iran, Friday, April 3, 2026. (AP Photo/Vahid Salemi)
Israeli security forces and rescue teams inspect a site struck by an Iranian missile in Petah Tikva, Israel,Thursday, April 2, 2026. (AP Photo/Ohad Zwigenberg)
Members from the Popular Mobilization Forces attend a funeral of fighters who were killed in a U.S. airstrike, in Tal Afar, Nineveh province, north of Baghdad, Iraq, Thursday, April 2, 2026. (AP Photo/Hadi Mizban)
A man with burn wounds from an Israeli airstrike on southern Lebanon sits on a bed at the Sidon Government Hospital in Sidon, Lebanon, Thursday, April 2, 2026. (AP Photo/Emilio Morenatti)
A boy who fled with his family following Israeli strikes in southern Lebanon sits inside the van they are using as shelter in Sidon, Lebanon, Thursday, April 2, 2026. (AP Photo/Emilio Morenatti)
President Donald Trump arrives from the Blue Room to speak about the Iran war from the Cross Hall of the White House on Wednesday, April 1, 2026, in Washington. (AP Photo/Alex Brandon, Pool)
