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Blue Jays rookie Trey Yesavage holds down Dodgers for 4 innings in historic World Series start

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Blue Jays rookie Trey Yesavage holds down Dodgers for 4 innings in historic World Series start
Sport

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Blue Jays rookie Trey Yesavage holds down Dodgers for 4 innings in historic World Series start

2025-10-25 13:32 Last Updated At:13:40

TORONTO (AP) — Standout rookie starter Trey Yesavage didn't have his best stuff but limited the Los Angeles Dodgers to two runs over four innings for the Toronto Blue Jays in Game 1 of the World Series on Friday night. Toronto rallied for an 11-4 win.

The 22-year-old Yesavage was making just his seventh major league appearance. He became the second-youngest pitcher to start a World Series opener behind Brooklyn’s Ralph Branca, who was 21 years, 267 days old for Game 1 in 1947 at Yankee Stadium.

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Toronto Blue Jays pitcher Trey Yesavage throws against the Los Angeles Dodgers during the third inning in Game 1 of baseball's World Series, Friday, Oct. 24, 2025, in Toronto. (AP Photo/Brynn Anderson)

Toronto Blue Jays pitcher Trey Yesavage throws against the Los Angeles Dodgers during the third inning in Game 1 of baseball's World Series, Friday, Oct. 24, 2025, in Toronto. (AP Photo/Brynn Anderson)

Toronto Blue Jays pitcher Trey Yesavage (39) looks on after giving up a run against the Los Angeles Dodgers during third inning Game 1 World Series playoff MLB baseball action in Toronto on Friday, Oct. 24, 2025. (Nathan Denette/The Canadian Press via AP)

Toronto Blue Jays pitcher Trey Yesavage (39) looks on after giving up a run against the Los Angeles Dodgers during third inning Game 1 World Series playoff MLB baseball action in Toronto on Friday, Oct. 24, 2025. (Nathan Denette/The Canadian Press via AP)

Toronto Blue Jays pitcher Trey Yesavage (39) reacts on the mound during the second inning in Game 1 of baseball's World Series, Friday, Oct. 24, 2025, in Toronto. (Nathan Denette/The Canadian Press via AP)

Toronto Blue Jays pitcher Trey Yesavage (39) reacts on the mound during the second inning in Game 1 of baseball's World Series, Friday, Oct. 24, 2025, in Toronto. (Nathan Denette/The Canadian Press via AP)

Toronto Blue Jays pitcher Trey Yesavage throws against the Los Angeles Dodgers during the first inning in Game 1 of baseball's World Series, Friday, Oct. 24, 2025, in Toronto. (AP Photo/Brynn Anderson)

Toronto Blue Jays pitcher Trey Yesavage throws against the Los Angeles Dodgers during the first inning in Game 1 of baseball's World Series, Friday, Oct. 24, 2025, in Toronto. (AP Photo/Brynn Anderson)

Toronto Blue Jays pitcher Trey Yesavage delivers against the Los Angeles Dodgers during first inning of Game 1 of baseball's World Series in Toronto, Friday, Oct. 24, 2025. (Frank Gunn/The Canadian Press via AP)

Toronto Blue Jays pitcher Trey Yesavage delivers against the Los Angeles Dodgers during first inning of Game 1 of baseball's World Series in Toronto, Friday, Oct. 24, 2025. (Frank Gunn/The Canadian Press via AP)

“It was an insane experience that I’ll remember for the rest of my life,” Yesavage said. “I wish personally I could have done a little bit better, but that’s why this is a team sport, and we have nine other guys on the field.”

Yesavage's best pitch during a breakout postseason has been his splitter, but he used it sparingly against Shohei Ohtani and the Dodgers.

"He wasn’t as sharp as we wanted him to be, but he did a good job," Blue Jays catcher Alejandro Kirk said through an interpreter.

Just 10 of Yesavage's 80 pitchers were splitters, and he instead leaned on his slider while allowing five hits, striking out five and walking three. His fastball velocity was down nearly 1 mph from his usual average.

“Didn’t have as much of a feel for it as I have in previous starts,” Yesavage said of the splitter, adding that with five righties in Los Angeles' lineup, he thought the slider would be more effective.

Dodgers manager Dave Roberts said his team tried to lay off Yesavage's splitter.

"He lives and dies by that split, certainly versus left," Roberts said. "We really tried to stay stubborn in the hitting zone."

Left-hander Mason Fluharty replaced Yesavage to begin the fifth with Ohtani and the top of the Dodgers' order due up.

It was Yesavage's fourth postseason start after just three regular-season outings. A first-round draft pick in 2024 who made his major league debut at Tampa Bay on Sept. 15, he became only the second pitcher to make a World Series start that raised his postseason start total above his regular-season career total, according to the Elias Sports Bureau.

Yesavage opened the game by striking out Ohtani, then retired Mookie Betts and Freddie Freeman on grounders.

The right-hander walked the leadoff batters in the second and third innings, leading to two runs. Kiké Hernández hit an RBI single in the second, one of three straight singles, but Yesavage escaped a bases-loaded jam by striking out Andy Pages and getting Ohtani to ground out.

“The way he settled down in that inning, I think for sure that won us the game,” Blue Jays outfielder Myles Straw said. “That was big time, obviously, against Shohei. Everyone in the world knows how that could end up. He did a really good job of just settling down and getting that ground out.”

Will Smith made it 2-0 with an RBI single in the third, but Freeman got caught in a rundown on Smith’s hit. Smith advanced to third on Teoscar Hernández’s grounder before Yesavage struck out Max Muncy to end the inning, the first of three straight swinging strikeouts for Yesavage.

Selected 20th overall in last year’s amateur draft from East Carolina University, Yesavage is the youngest player in this year’s World Series. He began the season at Class A Dunedin, was promoted to High-A Vancouver on May 20, then Double-A New Hampshire on June 12 and Triple-A Buffalo on Aug. 12.

Yesavage went 1-0 with a 3.21 ERA in three starts in September, striking out 16 in 14 innings. He beat the Yankees with 5 1/3 scoreless and hitless innings in Game 2 of the Division Series as he struck out 11, a franchise postseason record. He lost Game 2 of the American League Championship Series against Seattle when he allowed five runs in four innings, then won Game 6 on Sunday when he gave up two runs in 5 2/3 innings.

Yesavage has challenged hitters with an unusual arm angle. His 69% release angle is highest among right-handers in the postseason — 90% is over the top and zero is sidearm.

AP MLB: https://apnews.com/hub/mlb

Toronto Blue Jays pitcher Trey Yesavage throws against the Los Angeles Dodgers during the third inning in Game 1 of baseball's World Series, Friday, Oct. 24, 2025, in Toronto. (AP Photo/Brynn Anderson)

Toronto Blue Jays pitcher Trey Yesavage throws against the Los Angeles Dodgers during the third inning in Game 1 of baseball's World Series, Friday, Oct. 24, 2025, in Toronto. (AP Photo/Brynn Anderson)

Toronto Blue Jays pitcher Trey Yesavage (39) looks on after giving up a run against the Los Angeles Dodgers during third inning Game 1 World Series playoff MLB baseball action in Toronto on Friday, Oct. 24, 2025. (Nathan Denette/The Canadian Press via AP)

Toronto Blue Jays pitcher Trey Yesavage (39) looks on after giving up a run against the Los Angeles Dodgers during third inning Game 1 World Series playoff MLB baseball action in Toronto on Friday, Oct. 24, 2025. (Nathan Denette/The Canadian Press via AP)

Toronto Blue Jays pitcher Trey Yesavage (39) reacts on the mound during the second inning in Game 1 of baseball's World Series, Friday, Oct. 24, 2025, in Toronto. (Nathan Denette/The Canadian Press via AP)

Toronto Blue Jays pitcher Trey Yesavage (39) reacts on the mound during the second inning in Game 1 of baseball's World Series, Friday, Oct. 24, 2025, in Toronto. (Nathan Denette/The Canadian Press via AP)

Toronto Blue Jays pitcher Trey Yesavage throws against the Los Angeles Dodgers during the first inning in Game 1 of baseball's World Series, Friday, Oct. 24, 2025, in Toronto. (AP Photo/Brynn Anderson)

Toronto Blue Jays pitcher Trey Yesavage throws against the Los Angeles Dodgers during the first inning in Game 1 of baseball's World Series, Friday, Oct. 24, 2025, in Toronto. (AP Photo/Brynn Anderson)

Toronto Blue Jays pitcher Trey Yesavage delivers against the Los Angeles Dodgers during first inning of Game 1 of baseball's World Series in Toronto, Friday, Oct. 24, 2025. (Frank Gunn/The Canadian Press via AP)

Toronto Blue Jays pitcher Trey Yesavage delivers against the Los Angeles Dodgers during first inning of Game 1 of baseball's World Series in Toronto, Friday, Oct. 24, 2025. (Frank Gunn/The Canadian Press via AP)

NEWARK, Del.--(BUSINESS WIRE)--Jan 15, 2026--

QPS Holdings, LLC (QPS), an award-winning contract research organization (CRO) focused on bioanalysis and clinical trials announces the successful implementation of Oracle Argus, a premier pharmacovigilance system designed to support comprehensive safety case management for clinical trials.

This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20260115711485/en/

The adoption of the Oracle Argus drug safety platform underscores QPS’s commitment to advancing patient safety, regulatory compliance, and operational excellence across its clients’ clinical drug development programs. Integrating this industry-standard safety platform strengthens QPS’ ability to capture, manage, and report adverse events in accordance with global regulatory requirements.

“Ensuring patient safety and data integrity is at the heart of what we do when conducting clinical trials,” said Derek Grimes, Executive Vice President of QPS. “Oracle Argus provides us with a robust, scalable solution to support the growing needs of our customer’s clinical trial portfolios and the evolving expectations of regulatory authorities worldwide.”

“Oracle Argus provides QPS Holdings, LLC with a trusted, globally recognized drug safety platform that supports compliance with stringent pharmacovigilance standards and regulations, while streamlining end-to-end safety operations and insights at scale,” said Seema Verma, executive vice president and general manager, Oracle Health and Life Sciences. “With our industry-leading solutions, QPS Holdings, LLC can further transform and elevate its safety case management for customers worldwide.”

The deployment of Oracle Argus will enable QPS to:

As the demand for innovative therapies continues to rise, CROs play a critical role in managing both development speed and patient safety. By leveraging the Oracle Argus platform, QPS is well-positioned to deliver on its mission to accelerate pharmaceutical breakthroughs across the globe by delivering custom-built research services.

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ABOUT QPS HOLDINGS, LLC

QPS is a global, full-service, GLP/GCP-compliant contract research organization (CRO) delivering the highest grade of discovery, bioanalysis, preclinical and clinical drug development services. Since 1995, QPS has grown from a small bioanalysis shop into a full-service CRO with 1,200+ employees in the US, Europe, Asia and India. Today, QPS offers expanded pharmaceutical contract R&D services with special expertise in pharmacology, DMPK, toxicology, bioanalysis, translational medicine, PBMC processing, central safety labs, clinical trials, and clinical research services. An award-winning leader focused on bioanalysis and clinical trials, QPS is known for proven quality standards, technical expertise, a flexible approach to research, client satisfaction, turnkey laboratories, Phase I/II clinical units, and multi-site clinical research services. For more information, visit http://www.qps.com or email info@qps.com.

ABOUT ORACLE ARGUS

Oracle Argus is an industry-leading, trusted solution for processing, analyzing, and reporting adverse event cases originating in pre-market and post-market drugs, biologics, vaccines, devices, and combination products. Oracle has been a Leader in the IDC MarketScape: Worldwide Life Science R&D Pharmacovigilance Technology Solutions and Consulting Services 2025 Vendor Assessment (doc # US53669225, July 2025). To learn more about Oracle’s pharmacovigilance portfolio visit: https://www.oracle.com/life-sciences/safety-solutions/argus-safety-case-management/. Trademarks: Oracle, Java, MySQL and NetSuite are registered trademarks of Oracle Corporation.

Derek Grimes, EVP, Global Head of Clinical Research at QPS Holdings, LLC.

Derek Grimes, EVP, Global Head of Clinical Research at QPS Holdings, LLC.

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