JOHANNESBURG (AP) — Researchers and scientists in South Africa on Tuesday launched clinical trials on the first domestically developed vaccine.
The oral cholera vaccine, developed by the Cape Town-based pharmaceutical firm Biovac, is currently undergoing trials to determine its safety in adults and will be followed by trials to compare it to existing cholera vaccines that are already in the market.
Depending on the results, the vaccine could be approved and ready for use in Africa by 2028, Health Minister Aaron Motsoaledi said.
The development of the vaccine has been praised as a significant milestone for vaccine access in the country and across the rest of the continent.
Motsoaledi said that while South Africa experienced relatively low levels of cholera, many countries in Africa often hit hard by outbreaks would greatly benefit. He said the COVID-19 pandemic exposed how vulnerable African countries were to pandemics as they relied on imported vaccines.
South Africa often experiences cholera outbreaks due to cross-border movements. Other causes includes a lack of clean water in communities such as Hammanskraal, in the capital Pretoria, where provision of clean water remains a major problem.
A cholera outbreak in 2023 led to the death of 47 people and over 1,400 reported cases, but neighboring countries like Malawi, Mozambique and Zimbabwe have experienced far higher cases and deaths.
“When we can research, develop and manufacture vaccines locally, we reduce our vulnerability to supply chain disruptions, geopolitical pressures, international market competition and vaccine nationalism, which was apparent at the height of the COVID-19 pandemic,” said Motsoaledi.
The trials are being held in the provinces of Gauteng, Eastern Cape and KwaZulu-Natal, where cholera cases have previously been reported.
“This development addresses a critical, life-saving need, given the ongoing global shortages of the vaccine amid recurring cholera outbreaks,” said Biovac CEO Morena Makhoana.
Lerato Maleka, 44, who is one of the first participants in the clinical trial, said she enrolled because of the water issues in South Africa.
“I haven't had cholera, but we know that sometimes they don't maintain water and people died in Hammanskraal from cholera by drinking water, so I wanted to be safe from that,” said Maleka.
She said even though there had never been an outbreak where she lives in Diepkloof, Soweto, they often had to boil tap water as it was not clean.
Shadrack Makutu, 37, a resident from Limpopo province, is another participants who has previously experienced an outbreak in his village of Bushbuckridge.
“I do know people who share water with animals, so I know a few people who have been affected by this cholera,” said Makutu.
The World Health Organization estimates that as many as 4 million people around the world are affected by cholera every year, with between 21,000 and 143,000 people dying from it annually.
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South African Medical Research Council head Prof Glenda Grey administers a cholera vaccine to Shadrack Makutu, a participant in the clinical trials for the vaccine developed by Biovac at the Chris Hani Baragwanath Hospital in Soweto, South Africa, Tuesday, Nov. 11, 2025. (AP Photo/ Alfonso Nqunjana)
DUBAI, United Arab Emirates (AP) — Iran kept up its attacks on Israel and Persian Gulf neighbors on Wednesday as airstrikes pounded Tehran and U.S. President Donald Trump again made contradictory statements about whether he was ready to wind down the war or escalate it.
Trump struck a belligerent tone Wednesday in a Truth Social post, demanding that Iran stop blocking the Strait of Hormuz — the waterway vital to global oil supplies — or the U.S. would bomb the Islamic Republic “back to the Stone Ages.” A day earlier, Trump said the U.S. “will not have anything to do with” ensuring the security of ships passing through Hormuz; that was an apparent backtrack from a previous threat to attack Iran's power grid if it didn't open the strait by April 6.
Trump, who is scheduled to give a televised address Wednesday evening, said Tuesday he could walk away from the war in two to three weeks once he felt confident Iran would not be able to build a nuclear weapon — even if Tehran does not agree to a ceasefire.
But his latest Truth Social post struck a harder line as more American troops move into the region for a possible ground offensive after weeks of airstrikes targeting Iran.
Trump also claimed Wednesday that “Iran's New Regime President” wanted a ceasefire. It wasn't clear to whom the U.S. president was referring since Iran still has the same president. Iran’s Foreign Ministry spokesman, Esmail Baghaei, called Trump's claim “false and baseless,” according to a report on Iranian state television.
Speaking earlier to Al Jazeera, Iranian Foreign Minister Abbas Araghchi signaled Tehran’s willingness to keep fighting. “You cannot speak to the people of Iran in the language of threats and deadlines,” he said. “We do not set any deadline for defending ourselves.”
Since the war began on Feb. 28, Trump has offered shifting objectives and repeatedly has said it could be over soon while also threatening to widen the conflict. Thousands of additional U.S. troops are currently heading to the Middle East, and speculation abounds about the purpose of their deployment.
Just days ago, Trump threatened to attack Iran’s Kharg Island oil export hub. And there has also been speculation about whether the U.S. could decide to send in military forces to secure Iran’s uranium stockpile — a complex and risky operation, fraught with radiation and chemical dangers, according to experts and former government officials.
Adding to the confusion is what role Israel - which has been bombing Iran alongside the U.S. — might play in any of these scenarios.
Trump has been under growing pressure to end the war as oil prices have skyrocketed, pushing up the cost of gasoline, food and other goods. The spot price of Brent crude, the international standard, was up more than 40% since the start of the war, trading at more than $103 a barrel on Wednesday.
The U.S. has presented Iran with a 15-point plan aimed at bringing about a ceasefire, including a demand for the strait to be reopened and for its nuclear program to be rolled back.
Iran insists its nuclear program is peaceful. And in a report last week by Iranian state TV's English-language broadcaster, an anonymous official was quoted as saying Iran had its own demands to end the fighting, including retaining sovereignty over the strait.
In the interview with Al Jazeera, Araghchi acknowledged receiving direct messages from U.S. Mideast envoy Steve Witkoff. He insisted, however, that there were no direct negotiations and said Iran has no faith that talks with the U.S. could yield any results, saying “the trust level is at zero.”
He warned against any U.S. attempt to launch a ground offensive, saying “we are waiting for them.”
In a deal ostensibly to give diplomacy a chance, U.S. officials have given “clear assurances” that Araghchi and Iran's Parliamentary Speaker Mohammad Bagher Qalibaf won't be targeted, according to three officials who spoke on condition of anonymity because they're not authorized to speak publicly about the matter.
A cruise missile slammed into an oil tanker off Qatar’s coast Wednesday, the Defense Ministry said. The crew was evacuated and no casualties were reported. A Kuwaiti oil tanker came under attack off Dubai the day before, one of more than 20 ships attacked by Iran during the war.
In the United Arab Emirates, a person was killed when he was hit by debris from an intercepted drone in Fujairah, one of the country’s seven emirates.
In Kuwait, the state-run KUNA news agency said a drone hit a fuel tank at Kuwait International Airport, sparking a large fire.
Jordan’s military said it intercepted a ballistic missile and two drones fired from Iran in the last 24 hours. No casualties were reported. Two drones were also intercepted in Saudi Arabia.
In Israel, sirens sounded to warn of incoming missiles and AP reporters heard loud booms in Tel Aviv as the windows of buildings shook from the reverberations. There were no immediate reports of damage or casualties.
An airstrike on Tehran appeared to have hit the former U.S. Embassy compound, which has been controlled by Iran’s Revolutionary Guard since American diplomats were held hostage there in 1979. Witnesses said buildings outside the massive compound had their windows blown out.
In Lebanon, at least five people were killed in an Israeli strike on a Beirut neighborhood.
Israel invaded southern Lebanon after the Iran-linked Hezbollah militant group began launching missiles into northern Israel days after the outbreak of the war. Many Lebanese fear another prolonged military occupation.
More than 1,200 people have been killed in Lebanon and more than 1 million displaced, according to authorities. Ten Israeli soldiers have also died there.
In Iran, authorities say more than 1,900 people have been killed, while 19 have been reported dead in Israel. More than two dozen people have died in Gulf states and the occupied West Bank, while 13 U.S. service members have been killed.
Rising reported from Bangkok. Associated Press writers Giovanna Dell’Orto in Miami, Farnoush Amiri in New York and Samy Magdy in Cairo contributed to this report.
A young girl is comforted by her father and Israeli soldiers as they take cover in a bomb shelter during air raid sirens warning of incoming Iranian missile strikes in Bnei Brak, Israel, Wednesday, April 1, 2026. (AP Photo/Oded Balilty)
People inspect the site of an Israeli strike amid debris and damaged vehicles in Beirut, Lebanon, Wednesday, April 1, 2026. (AP Photo/Hassan Ammar)
A man feeds stray cats in Tehran, Iran, Tuesday, March 31, 2026. (AP Photo/Vahid Salemi)
The Indian flagged LPG carrier Jag Vasant transporting liquefied petroleum gas, is seen at the Mumbai Port in Mumbai, India, after it arrived clearing the Strait of Hormuz, Wednesday, April 1, 2026. (AP Photo/Rafiq Maqbool)
Firefighters and rescue workers work at the site of Israeli airstrikes, in Beirut, Lebanon, Wednesday, April 1, 2026. (AP Photo/Hussein Malla)
A firefighter extinguishes a car at the site of Israeli airstrikes, in Beirut, Lebanon, Wednesday, April 1, 2026. (AP Photo/Hussein Malla)
Israel's rescue teams and residents take shelter as sirens sounds next to a site struck by an Iranian missile in Bnei Brak, Wednesday, April 1, 2026. (AP Photo/Oded Balilty)
A police vehicle is seen through a shattered windshield at the site of an Israeli strike in Beirut, Lebanon, Wednesday, April 1, 2026. (AP Photo/Hassan Ammar)
Two men ride scooters past charred debris at the site of an Israeli strike in Beirut, Lebanon, Wednesday, April 1, 2026. (AP Photo/Hassan Ammar)
