A natural breakthrough in protecting cereals and field crops

BASEL, Switzerland & CHASSIEU, France--(BUSINESS WIRE)--Nov 18, 2025--

Amoebas. These single-celled microorganisms are now at the heart of one of agriculture’s latest biological innovation – a bio-fungicide capable of protecting wheat and other cereal crops from crippling fungal diseases that cost global agriculture billions of dollars in annual crop losses and quality.

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This new development, made from the lysate of the amoeba Willaertia magna C2c Maky, holds strong potential to advance biological crop protection. In trials, the candidate demonstrated its effectiveness in combating the fungi responsible for these fungal diseases and helped activate the plants' defence responses. As a next‑generation biological, it is built on a biological active substance and designed to fit modern integrated crop management.

Syngenta Crop Protection, a global leader in biologicals and other innovative crop protection technologies, and French greentech innovator Amoéba SA, have now signed a Memorandum of Understanding to develop and commercialize groundbreaking biocontrol solutions for the EU and UK markets, focusing on cereals and field crops. The parties plan to negotiate a definitive distribution agreement with a target timeline of spring 2026. This strategic collaboration aims to offer farmers advanced biological solutions that enhance the sustainability of their farming practices, address the challenge of increasing pest resistance to existing products, and offer relief to farmers facing a shrinking toolbox of crop protection technologies.

The initial focus of the partnership will be on combating the main wheat diseases, namely septoria tritici blotch (STB) and yellow rust. These two diseases are among the most economically damaging wheat diseases across Europe and the UK, impacting an estimated 9-12 million hectares of wheat annually. In Germany alone, STB causes yield losses of 5-50% and costs of €1.5 billion annually, while yellow rust can reduce yields by 10-70% and even lead to total crop failure in susceptible varieties, according to recognized industry and academic sources.

Matthew Pickard, Syngenta’s Head of Seedcare and Biologicals for Europe, said: “At Syngenta, we are committed to deliver advanced, effective biological solutions at the cutting edge of science. We’re proud to work with Amoéba to offer nature-inspired solutions that empower farmers in these important markets.”

“We are very pleased with the collaboration with Syngenta, a global leader in agricultural innovation,” affirms Benoit Villers,Chairman of the Board of Amoéba and Jean-François Doucet, CEO of Amoéba. "This agreement, which should lead to distribution and development partnerships between our two companies, is a major step forward for Amoéba. It gives us the opportunity to combine our scientific expertise with Syngenta's widely recognised leadership in cereal protection and the marketing of biocontrol solutions. Finally, it perfectly illustrates how collaboration between innovators in the sector can make a difference for farmers while paving the way for broader applications in field crops."

Founded in 2010, Amoéba has developed a patented biocontrol application based on lysate from the amoeba Willaertia magna, which received the prestigious Bernard Blum Gold Medal in October 2025 as the most promising biocontrol solution worldwide. In June 2025, the active substance received EU approval following EFSA’s scientific assessment and a European Commission decision. Product‑specific authorizations are in progress.

About Syngenta

Syngenta is a global leader in agricultural innovation with a presence in more than 90 countries. Syngenta is focused on developing technologies and farming practices that empower farmers, so they can make the transformation required to feed the world’s population while preserving our planet. Its bold scientific discoveries deliver better benefits for farmers and society on a bigger scale than ever before. Guided by its Sustainability Priorities, Syngenta is developing new technologies and solutions that support farmers to grow healthier plants in healthier soil with a higher yield. Syngenta Crop Protection is headquartered in Basel, Switzerland; Syngenta Seeds is headquartered in the United States. Read our stories and follow us on LinkedIn, Instagram & X.

About Amoéba

Founded in 2010, Amoéba is a greentech company based in Chassieu (Lyon, France) whose ambition is to become a major player in the treatment of microbiological risk based on the patented use of amoebae in the plant protection and cosmetics sectors.

With know-how that is unique in the world and protected by numerous patents, Amoéba is currently the only company capable of exploiting the full potential of the Willaertia amoeba on an industrial scale and cultivating it in sufficient volumes to offer biological solutions that constitute a viable alternative to the chemical products widely used today. Amoéba is currently focusing on the global biocontrol market for plant protection and on the cosmetics market. As the marketing of plant protection products is subject to obtaining local regulatory authorisations, the Company has carried out the necessary regulatory procedures and filed registration dossiers in Europe and the United States. The active substance has obtained approval in 2022 in the USA and in 2025 in Europe. Product approvals have been granted in the USA and are expected in the coming months in Europe.

The cosmetic application does not require prior approval from a competent authority in Europe or the United States. The cosmetic ingredient is already registered on the INCI (International Nomenclature of Cosmetic Ingredients) list, paving the way for it to be marketed worldwide except in China, where local approval is required.

Amoéba is listed on Euronext Growth (ALMIB). The company is a member of the Bpifrance Excellence network and is eligible for the PEA-PME scheme.

For more information, visit www.amoeba-nature.com

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Syngenta’s Cautionary Statement Regarding Forward-Looking Statements

This document may contain forward-looking statements, which can be identified by terminology such as ‘expect’, ‘would’, ‘will’, ‘potential’, ‘plans’, ‘prospects’, ‘estimated’, ‘aiming’, ‘on track’ and similar expressions. Such statements may be subject to risks and uncertainties that could cause the actual results to differ materially from these statements. For Syngenta, such risks and uncertainties include risks relating to legal proceedings, regulatory approvals, new product development, increasing competition, customer credit risk, general economic and market conditions, compliance and remediation, intellectual property rights, implementation of organizational changes, impairment of intangible assets, consumer perceptions of genetically modified crops and organisms or crop protection chemicals, climatic variations, fluctuations in exchange rates and/or commodity prices, single source supply arrangements, political uncertainty, natural disasters, and breaches of data security or other disruptions of information technology. Syngenta assumes no obligation to update forward-looking statements to reflect actual results, changed assumptions or other factors.

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Syngenta and Amoeba SA to develop and commercialize biocontrol solutions for EU and UK

The risk of a catastrophic explosion at a damaged chemical tank in Southern California has been eliminated following a close overnight inspection that confirmed a crack in the tank relieved pressure and cooled the chemical, authorities said Monday.

Officials said crews conducted tank temperature checks at night to reduce risks to firefighters, avoiding daytime operations when heat from the tank made conditions around it most dangerous. The overnight mission allowed crews to verify the crack and confirm temperatures were falling, Orange County Fire Authority division chief Craig Covey said Monday morning.

Covey said the results of overnight evaluation of the tank — that the temperature inside had dropped and that pressure had been released — was “incredibly positive news.”

However, evacuation orders remained in place for about 50,000 people in Garden Grove, California, located south of Los Angeles.

Covey said falling temperatures and the release of pressure from the tank were allowing officials to “turn the corner on this incident” after days of concern about a possible explosion.

There has been no chemical leak as of early Monday, but the Orange County Fire Authority said the risk to public safety is “ongoing.”'

After the tank overheated Thursday and began venting vapors, firefighters have repeatedly sprayed the tank with water in an attempt to cool the chemical inside, methyl methacrylate, which is used to make plastic parts.

The tank's interior reached 100 degrees (37.7 Celsius) Sunday, an increase of 10 degrees Fahrenheit (5.5 Celsius) since Saturday, according to Democratic state Sen. Tom Umberg. On Monday, Covey said the temperature fell to 93 degrees F (33.9 degrees C).

Gov. Gavin Newsom declared a state of emergency Saturday and said he asked President Donald Trump to issue an emergency declaration to bolster federal support for local and state officials.

The tank at GKN Aerospace Transparency Systems, which makes parts for commercial and military aircraft, holds 6,000 to 7,000 gallons (22,700 to 26,500 liters) of methyl methacrylate used to make plastic parts.

The first goal of firefighters was to cool off the chemical inside the tank to prevent a leak or explosion.

Drones were monitoring temperatures at 10-minute intervals to watch for any spikes. Containment barriers were set up to prevent the chemical from getting into storm drains or reaching creeks or the nearby ocean in the event of a spill, Covey said earlier.

As the interior temperature rises, methyl methacrylate converts from a liquid to a gas and increases the pressure, according to Purdue University engineering professor Andrew Whelton, who had said earlier that the crack could mean product or pressure is being released, reducing the chance of explosion.

“Think of a soda can. If you leave it in a hot car it can explode,” Whelton said. “But if you put a hole in the can, the product is released and the can itself doesn’t explode.”

An explosion that could spread the chemical over a broad area and send shrapnel flying would be the worst-case scenario, he said.

Aerial photos taken by The Associated Press showed streets in the area were empty Sunday, while several evacuation shelters were open. At a high school in neighboring La Palma, people slept in cars or on mats and sleeping bags on the asphalt.

Garden Grove is next to Anaheim, home to Disneyland’s two theme parks, which were not under evacuation orders. Park officials said they were monitoring the situation.

Exposure to methyl methacrylate can cause serious respiratory problems, neurological problems and irritation to the skin, eyes and throat, according to fact sheets about the chemical.

Whelton said if an explosion occurs, it will be crucial to conduct detailed air monitoring specifically for methyl methacrylate and not just generic tests for volatile organic compounds as officials did after a 2023 train derailment in East Palestine, Ohio, which released more than 115,000 gallons (435,000 liters) of vinyl chloride after officials blew open five tank cars and burned the chemical.

Orange County health officials said the chemical is easy to smell and people may notice it over a large area without being harmed.

Some Garden Grove residents filed a class-action federal lawsuit Saturday against GKN Aerospace Transparency Systems, which operates the facility where the tank is located. Lawyers for the residents argued that regardless of what happens, property values in the surrounding community are sure to be impacted.

GKN Aerospace did not comment on the lawsuit but has apologized to residents and businesses forced to evacuate. It said Sunday it was “working around the clock to mitigate the risk of a leak.”

GKN Aerospace agreed in 2025 to pay state regulators more than $900,000 to settle violations involving recordkeeping, permitting issues and nitrogen oxide emissions, according to a report on the South Coast Air Quality Management District website.

Associated Press journalist Ethan Swope in Garden Grove, California, contributed to this report.

An evacuation map is displayed at the incident command post at the Los Alamitos Race Course in Cypress, Calif., on Sunday, May 24, 2026. (AP Photo/Ethan Swope)

Water is sprayed on a damaged tank at GKN Aerospace in Garden Grove, Calif., on Sunday, May 24, 2026, after the tank containing a chemical used to make plastic parts overheated Thursday. (AP Photo/Ethan Swope)

The streets remain empty in Garden Grove, Calif., on Sunday, May 24, 2026, after a storage tank containing a chemical used to make plastic parts overheated Thursday at an aerospace plastics facility. (AP Photo/Ethan Swope)

Emergency personnel work at the incident command post at the Los Alamitos Race Course Sunday, May 24, 2026, in Cypress, Calif. (AP Photo/Ethan Swope)

Water is sprayed on a damaged tank at GKN Aerospace in Garden Grove, Calif., on Sunday, May 24, 2026, after the tank containing a chemical used to make plastic parts overheated Thursday. (AP Photo/Ethan Swope)