- South Korean biotech company secures US$8 million in upfront payment for the joint commercialization of the stem cell therapy CARTISTEM® targeting the Japanese knee osteoarthritis market.
SEOUL, South Korea, Dec. 19, 2025 /PRNewswire/ -- MEDIPOST Co., Ltd. (KOSDAQ 078160), a fully integrated cell therapy biotechnology company, today announced a multi-year partnership with Japan's Teikoku Seiyaku Co., Ltd. for the commercialization of CARTISTEM®, an innovative treatment for knee osteoarthritis, in the Japanese market.
Under the terms of the agreement, MEDIPOST K.K. (MEDIPOST's wholly-owend Japanese subsidiary) will grant an exclusive sales, distribution and promotion license for CARTISTEM® in Japan to Teikoku Seiyaku Co. Ltd.. Further, MEDIPOST will supply the drug substance (DS) while retaining all manufacturing rights. Additionally, MEDIPOST will receive an upfront payment of US$8 million, along with a US$10 million short-term regulatory-based milestone and undisclosed sales-based long-term milestones.
In turn, Teikoku Seiyaku Co. Ltd. will leverage its extensive orthopedic hospital and clinic network to promote and distribute CARTISTEM® in order to accelerate CARTISTEM®'s adoption among patients with moderate to severe knee osteoarthritis. Teikoku Seiyaku Co. Ltd. also plans to expand its medical representative division ahead of CARTISTEM®'s approval and as it seeks to address the significant unmet medical needs in Japan's knee osteoarthritis treatment landscape.
About CARTISTEM®
CARTISTEM® is an allogeneic stem cell therapy designed to treat moderate to severe knee osteoarthritis. Since receiving regulatory approval in South Korea in 2012, CARTISTEM® has been administered to more than 35,000 patients over the past 13 years. CARTISTEM® demonstrates the ability to regenerate cartilage in knee osteoarthritis patients and holds the potential to be recognized as a disease-modifying osteoarthritis drug (DMOAD).
About MEDIPOST
Founded in 2000, MEDIPOST is a global stem cell therapy company with integrated capabilities spanning across discovery research with product and clinical development of allogeneic cell therapy pipelines, cord blood banking, and cell and gene therapy contract development and manufacturing (CDMO) business portfolios. MEDIPOST successfully commercialized the world's first regulatory-approved (2012) allogeneic human umbilical cord blood-derived mesenchymal stem/stromal cell (hUCB-MSC) therapy product, CARTISTEM®, for the treatment of knee osteoarthritis patients across all age groups.
About Teikoku Seiyaku
Founded in 1848, Teikoku Seiyaku is dedicated to its mission "For a World Without Pain." Leveraging its expertise in transdermal drug delivery technology, the company develops, manufactures, and markets pharmaceutical products, including transdermal patches and medical narcotics. For osteoarthritis, Teikoku Seiyaku has entered into a basic sales agreement with ReqMed Company, Ltd. regarding exclusive distribution rights in Japan for a subcutaneous injection containing NaPPS (sodium pentosan polysulfate), which is currently in Phase 3 clinical trials in Japan. Going forward, in orthopedics—one of its priority areas—we will expand its dedicated orthopedic team on the scale of 100 members and further strengthen its efforts to deliver treatments for diseases with high unmet medical needs, including osteoarthritis, to patients.
** The press release content is from PR Newswire. Bastille Post is not involved in its creation. **
MEDIPOST Announces the Exclusive Commercialization License Agreement with Teikoku Seiyaku for Knee Osteoarthritis Treatment CARTISTEM® in Japan
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The reopening marks a key milestone in Cole Haan's continued international retail expansion and its commitment to delivering elevated, design-driven experiences across global markets.
SHANGHAI, Dec. 19, 2025 /PRNewswire/ -- Cole Haan, the iconic American lifestyle and premium footwear brand, is pleased to announce the reopening of its newly relocated store in HKRI Taikoo Hui, one of Shanghai's premier luxury and lifestyle destinations. In celebration of the opening, guests will enjoy 15% off all items with any purchase from December 19-31.
This reopening represents a significant moment in Cole Haan's continued strategic growth across Greater China. Taikoo Hui—located in the heart of West Nanjing Road in Shanghai's Jing'an District—attracts a dynamic community of style-conscious professionals, tastemakers, and global travelers. Cole Haan's return to this destination reinforces its commitment to serving this influential consumer base and elevating its premium retail experience in Shanghai.
The store is in partnership with HiMaxx, a pioneering retailer in China, and Cole Haan's distribution partner in the region. Designed under Cole Haan's newest retail concept, the 115-square-meter space introduces a refined evolution of the brand's modern identity featuring brass storefront framing, a central shelving installation that spotlights the season's key styles, oak flooring, and furniture in tonal blues and greens—together creating a warm, inviting, design-forward atmosphere. Situated on the mall's second floor, Cole Haan's new location sits among premium brands, contributing to an elevated shopping experience for visitors.
"We are proud to reopen in one of Shanghai's most dynamic retail destinations," said Adrian Santos, Senior Vice President of International at Cole Haan. "This relocation underscores our ongoing commitment to the China market and our dedication to bringing world-class design, comfort innovation, and a premium shopping experience to consumers in Shanghai. We look forward to welcoming customers into this elevated new space as we continue to grow our presence across the region."
Shoppers will discover highlights from the Winter 2025 Cole Haan Comfortable™ campaign, alongside a limited-edition dual-gender GrandPrø Topspin Sneaker inspired by Lunar New Year. Additional offerings include the brand's newest weather-ready innovations, such as the Men's ZERØGRAND Remastered Waterproof Hiking Boots and Women's Florette Pumps featuring Grand Lux Cushioning Technology, designed for plush, all-day wearability.
Customers can discover the Cole Haan Taikoo Hui location at Shop L281E, 2F, HKRI Taikoo Hui, No.288 Shimen Yi Road, Jing An District, Shanghai, following regular mall hours (Monday–Sunday: 10 AM–10 PM). To view additional locations, visit the online store locator.
ABOUT COLE HAAN
Cole Haan is a global American lifestyle brand available in more than 100 countries, serving always-connected, active professionals with innovative footwear and lifestyle accessories. With a nearly 100-year heritage, Cole Haan infuses its products with time-honored craftsmanship and modern innovation—creating styles designed for work, workout, and weekend. Cole Haan's mission is to inspire customers to live extraordinary lives. To learn more, visit colehaan.com. Follow along @colehaan.
ABOUT TAIKOO HUI
Located at a prime location on the Nanjing Road (West) CBD, HKRI Taikoo Hui is a landmark mixed-use development in Shanghai that offers a diversified trendy and luxury lifestyle. The development comprises a retail mall, two Grade-A office towers, two boutique hotels, a serviced apartment building and a century-old historic mansion named Cha House. The commercial complex features a parallel layout of Shimen Road (No.1), the south-north corridor inside the mall, and Discovery Boulevard, along with two large open-air event venues, North Piazza and South Garden, a multi-functional Event Centre, and a unique Roof Garden in the heart of the city. The remarkable design facilitates seamless connections and close interactions across various buildings and functional spaces, establishing a dynamic destination that sparks boundless imagination regarding modern trends and luxury living.
HKRI Taikoo Hui is a 50-50 joint venture between two Hong Kong-listed companies, HKR International and Swire Properties, which jointly own and manage the complex. Through a pioneering business model that emphasises symbiotic progress with the city, brands and consumers, the complex inherits the vibrant legacy of the century-old Nanjing Road (West) neighbourhood and creates a world-class, bespoke experience, establishing itself as a remarkable new landmark in Shanghai.
ABOUT HIMAXX
HiMaxx is a leading membership-based retail company in China. Since its establishment, it has opened 71 large-scale stores across the country and is rapidly expanding. HiMaxx's core business focuses on the retail of globally renowned brands in apparel, footwear, and beauty products. HiMaxx has established partnerships with numerous world-famous brands and hundreds of distributors. The company's business scope includes brand retail, distribution, E-commerce and commercial real estate operations. With the principle of customer-first, HiMaxx has served millions of members. Visit www.hpcang.com.
PRESS CONTACTS:
Cole Haan
press@colehaan.com
HIMAXX
Cecilia Lai, Marketing Director
laiqiuting@hpcang.com
The reopening marks a key milestone in Cole Haan's continued international retail expansion and its commitment to delivering elevated, design-driven experiences across global markets.
SHANGHAI, Dec. 19, 2025 /PRNewswire/ -- Cole Haan, the iconic American lifestyle and premium footwear brand, is pleased to announce the reopening of its newly relocated store in HKRI Taikoo Hui, one of Shanghai's premier luxury and lifestyle destinations. In celebration of the opening, guests will enjoy 15% off all items with any purchase from December 19-31.
This reopening represents a significant moment in Cole Haan's continued strategic growth across Greater China. Taikoo Hui—located in the heart of West Nanjing Road in Shanghai's Jing'an District—attracts a dynamic community of style-conscious professionals, tastemakers, and global travelers. Cole Haan's return to this destination reinforces its commitment to serving this influential consumer base and elevating its premium retail experience in Shanghai.
The store is in partnership with HiMaxx, a pioneering retailer in China, and Cole Haan's distribution partner in the region. Designed under Cole Haan's newest retail concept, the 115-square-meter space introduces a refined evolution of the brand's modern identity featuring brass storefront framing, a central shelving installation that spotlights the season's key styles, oak flooring, and furniture in tonal blues and greens—together creating a warm, inviting, design-forward atmosphere. Situated on the mall's second floor, Cole Haan's new location sits among premium brands, contributing to an elevated shopping experience for visitors.
"We are proud to reopen in one of Shanghai's most dynamic retail destinations," said Adrian Santos, Senior Vice President of International at Cole Haan. "This relocation underscores our ongoing commitment to the China market and our dedication to bringing world-class design, comfort innovation, and a premium shopping experience to consumers in Shanghai. We look forward to welcoming customers into this elevated new space as we continue to grow our presence across the region."
Shoppers will discover highlights from the Winter 2025 Cole Haan Comfortable™ campaign, alongside a limited-edition dual-gender GrandPrø Topspin Sneaker inspired by Lunar New Year. Additional offerings include the brand's newest weather-ready innovations, such as the Men's ZERØGRAND Remastered Waterproof Hiking Boots and Women's Florette Pumps featuring Grand Lux Cushioning Technology, designed for plush, all-day wearability.
Customers can discover the Cole Haan Taikoo Hui location at Shop L281E, 2F, HKRI Taikoo Hui, No.288 Shimen Yi Road, Jing An District, Shanghai, following regular mall hours (Monday–Sunday: 10 AM–10 PM). To view additional locations, visit the online store locator.
ABOUT COLE HAAN
Cole Haan is a global American lifestyle brand available in more than 100 countries, serving always-connected, active professionals with innovative footwear and lifestyle accessories. With a nearly 100-year heritage, Cole Haan infuses its products with time-honored craftsmanship and modern innovation—creating styles designed for work, workout, and weekend. Cole Haan's mission is to inspire customers to live extraordinary lives. To learn more, visit colehaan.com. Follow along @colehaan.
ABOUT TAIKOO HUI
Located at a prime location on the Nanjing Road (West) CBD, HKRI Taikoo Hui is a landmark mixed-use development in Shanghai that offers a diversified trendy and luxury lifestyle. The development comprises a retail mall, two Grade-A office towers, two boutique hotels, a serviced apartment building and a century-old historic mansion named Cha House. The commercial complex features a parallel layout of Shimen Road (No.1), the south-north corridor inside the mall, and Discovery Boulevard, along with two large open-air event venues, North Piazza and South Garden, a multi-functional Event Centre, and a unique Roof Garden in the heart of the city. The remarkable design facilitates seamless connections and close interactions across various buildings and functional spaces, establishing a dynamic destination that sparks boundless imagination regarding modern trends and luxury living.
HKRI Taikoo Hui is a 50-50 joint venture between two Hong Kong-listed companies, HKR International and Swire Properties, which jointly own and manage the complex. Through a pioneering business model that emphasises symbiotic progress with the city, brands and consumers, the complex inherits the vibrant legacy of the century-old Nanjing Road (West) neighbourhood and creates a world-class, bespoke experience, establishing itself as a remarkable new landmark in Shanghai.
ABOUT HIMAXX
HiMaxx is a leading membership-based retail company in China. Since its establishment, it has opened 71 large-scale stores across the country and is rapidly expanding. HiMaxx's core business focuses on the retail of globally renowned brands in apparel, footwear, and beauty products. HiMaxx has established partnerships with numerous world-famous brands and hundreds of distributors. The company's business scope includes brand retail, distribution, E-commerce and commercial real estate operations. With the principle of customer-first, HiMaxx has served millions of members. Visit www.hpcang.com.
PRESS CONTACTS:
Cole Haan
press@colehaan.com
HIMAXX
Cecilia Lai, Marketing Director
laiqiuting@hpcang.com
** The press release content is from PR Newswire. Bastille Post is not involved in its creation. **
COLE HAAN UNVEILS NEWLY RELOCATED TAIKOO HUI STORE IN SHANGHAI
COLE HAAN UNVEILS NEWLY RELOCATED TAIKOO HUI STORE IN SHANGHAI
COLE HAAN UNVEILS NEWLY RELOCATED TAIKOO HUI STORE IN SHANGHAI
COLE HAAN UNVEILS NEWLY RELOCATED TAIKOO HUI STORE IN SHANGHAI
