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Oklo and DOE Partner to Deploy Radioisotope Pilot Facility Supporting Cancer Care and U.S. Medical Supply Chains

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Oklo and DOE Partner to Deploy Radioisotope Pilot Facility Supporting Cancer Care and U.S. Medical Supply Chains
News

News

Oklo and DOE Partner to Deploy Radioisotope Pilot Facility Supporting Cancer Care and U.S. Medical Supply Chains

2026-01-07 21:04 Last Updated At:21:11

SANTA CLARA, Calif.--(BUSINESS WIRE)--Jan 7, 2026--

Oklo Inc. (NYSE: OKLO) (“Oklo”), an advanced nuclear technology company, announced today that it has signed a U.S. Department of Energy (DOE) Other Transaction Agreement (OTA) to support the design, construction, and operation of a radioisotope pilot plant (“Radioisotope Pilot Facility”) under the DOE Reactor Pilot Program (RPP). Signing the OTA is a major milestone which marks the transition from project selection and planning into active execution under DOE authorization.

This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20260107011601/en/

“This OTA establishes a framework for execution and risk reduction. By building and operating a pilot reactor, we generate the data and experience to streamline future commercial deployments, improve regulatory efficiency, and deliver long-term value,” said Jacob DeWitte, co-founder and CEO of Oklo.

Atomic Alchemy Inc., an Oklo subsidiary, is using the Radioisotope Pilot Facility to lay the groundwork for future commercial plants that make medical and research radioisotopes in the United States. These radioisotopes are essential for diagnosing cancer, treating disease, powering medical research, and supporting national security. Today, many are produced overseas or in aging facilities. By first operating a pilot plant, Oklo can then scale into reliable, domestic production that helps ensure hospitals, researchers, and patients have consistent access to these lifesaving materials.

With the OTA now in place, Atomic Alchemy will focus its near-term resources on building the Radioisotope Pilot Facility under DOE authorization. As part of this learn-first-then-scale strategy, Atomic Alchemy has withdrawn its previously submitted Nuclear Regulatory Commission construction permit application for the Meitner-1 commercial radioisotope production facility at Idaho National Laboratory to focus on the Radioisotope Pilot Facility.

Oklo views the RPP as an enabler and accelerator to deliver advanced nuclear technologies that strengthen U.S. energy security, healthcare infrastructure, and industrial leadership.

About Oklo Inc.: Oklo Inc. is developing fast fission power plants to deliver clean, reliable, affordable energy at scale, establishing a domestic supply chain for critical radioisotopes, and advancing nuclear fuel recycling to convert nuclear waste into clean energy. Oklo was the first to receive a site use permit from the U.S. Department of Energy for a commercial advanced fission plant, was awarded fuel from Idaho National Laboratory, and submitted the first custom combined license application for an advanced reactor to the U.S. Nuclear Regulatory Commission. Oklo is also developing advanced fuel recycling technologies in collaboration with the U.S. Department of Energy and U.S. National Laboratories.

Forward-Looking Statements

This press release includes statements that express Oklo’s opinions, expectations, objectives, beliefs, plans, intentions, strategies, assumptions, forecasts or projections regarding future events or future results and therefore are, or may be deemed to be, “forward-looking statements.” The words “may,” “will,” “could,” “should,” “expects,” “anticipates,” “intends,” “plans,” “believes,” “seeks,” “estimates,” “continue,” “might,” “possible,” “potential,” “predict,” “project,” “goal,” “would,” “commit,” or, in each case, their negative or other variations or comparable terminology, and similar expressions may identify forward-looking statements, but the absence of these words does not mean that a statement is not forward-looking. These forward-looking statements include all matters that are not historical facts. They appear in a number of places throughout this press release and include statements regarding our intentions, beliefs or current expectations concerning, among other things, results of operations, financial condition, liquidity, prospects, growth, strategies and the markets in which Oklo operates. Such forward-looking statements are based on information available as of the date of this press release, and current expectations, forecasts and assumptions, and involve a number of judgments, risks and uncertainties.

As a result of a number of known and unknown risks and uncertainties, the actual results or performance of Oklo may be materially different from those expressed or implied by these forward-looking statements. The following important risk factors could affect Oklo’s future results and cause those results or other outcomes to differ materially from those expressed or implied in the forward-looking statements: risks related to the development and deployment of Oklo’s powerhouses; the risk that Oklo is pursuing an emerging market with no commercial project operating and regulatory uncertainties; risks related to acquisitions, divestitures, or joint ventures we may engage in; the need for financing to construct plants, which remain subject to market, financial, political, and legal conditions; risks related to an inability to raise additional capital to support our business and sustain our growth on favorable terms; the effects of competition; risks related to accessing high-assay low-enriched uranium, plutonium, and other fuels at acceptable costs (including recycled fuels); risks related to our supply chain; risks related to power purchase agreements; risks related to human capital; risks related to our intellectual property; risks related to cybersecurity and data privacy; changes in applicable laws or regulations, including tariffs; the outcome of any government and regulatory proceedings and investigations and inquiries; and the other factors set forth in our documents we have filed with the U.S. Securities and Exchange Commission (the “SEC”).

The foregoing list of factors is not exhaustive. You should carefully consider the foregoing factors and the other risks and uncertainties of the other documents filed by Oklo from time to time with the SEC. The forward-looking statements contained in this press release are based on current expectations and beliefs concerning future developments and their potential effects on Oklo. There can be no assurance that future developments affecting Oklo will be those that Oklo has anticipated. Oklo undertakes no obligation to update or revise any forward-looking statements to reflect events or circumstances after the date of this presentation, except as may be required by law.

Render of Atomic Alchemy radioisotope pilot facility (Image: Hillside Architecture, PLLC)

Render of Atomic Alchemy radioisotope pilot facility (Image: Hillside Architecture, PLLC)

ALEPPO, Syria (AP) — Syrian authorities warned civilians to leave a contested area in the northern city of Aleppo on Thursday and opened a corridor for them to evacuate for a second day as clashes intensified between government and Kurdish forces.

The government of Aleppo province gave residents until 1 p.m. local time to evacuate in coordination with the army. State news agency SANA, citing the army, said the military would begin “targeted operations” against the Kurdish-led Syrian Democratic Forces in the neighborhoods of Sheikh Maqsoud, Achrafieh and Bani Zaid half an hour after that deadline.

The military later issued a series of maps with the areas under evacuation order.

An Associated Press journalist at the scene heard sporadic sounds of shelling as civilians streamed out of the area Thursday morning. Nearly 140,000 people have been displaced across the province, according to Aleppo’s Directorate of Social Affairs and Labor.

“There’s a large percentage of them with difficult medical issues, elderly people, women, and children,” said Mohammad Ali, operations director with the Syrian Civil Defense in Aleppo.

The SDF has said that at least eight civilians were killed in the Kurdish-majority neighborhoods, while government officials reported at least seven civilians and one soldier have been killed in the surrounding government-controlled areas in the fighting that broke out Tuesday. Dozens more on both sides have been wounded.

Each side has accused the other of deliberately targeting civilian neighborhoods and infrastructure.

Clashes intensified in the afternoon, with exchanges of shelling and drone strikes, and tanks could be seen rolling into the contested neighborhoods.

St. Ephrem Syrian Orthodox Church in Aleppo city was hosting about 100 people who had fled the fighting. Parishioners donated mattresses, blankets and food, priest Adai Maher said.

“As soon as the problems started and we heard the sounds (of clashes), we opened our church as a shelter for people who are fleeing their homes," he said.

Among them was Georgette Lulu, who said her family is planning to travel to the city of Hasakeh in SDF-controlled northeast Syria when the security situation allows.

“There was a lot of bombing and loud noises and a shell landed next to our house,” she said. “I’ve been through these circumstances a lot so I don’t get frightened, but my niece was really afraid so we had to come to the church.”

Hassan Nader, a representative of the Ministry of Social Affairs in Aleppo said about 4,000 were staying in shelters in the city while tens of thousands had gone to other areas of the province, and the ministry was working with NGOs to supply them with food, medicine and other necessities.

The clashes come amid an impasse in political negotiations between the central state and the SDF.

The leadership in Damascus under interim President Ahmad al-Sharaa signed a deal in March with the SDF, which controls much of the northeast, for it to merge with the Syrian army by the end of 2025. There have been disagreements on how it would happen. In April, scores of SDF fighters left Sheikh Maqsoud and Achrafieh as part of the deal.

Officials from the central government and SDF met again on Sunday in Damascus, but government officials said that no tangible progress had been made.

Some of the factions that make up the new Syrian army, formed after the fall of former President Bashar Assad in a rebel offensive in December 2024, were previously Turkey-backed insurgent groups that have a long history of clashing with Kurdish forces.

In the city of Qamishli in the Kurdish-controlled northeast, thousands of protesters gathered Thursday, chanting, “SDF, we are with you until death.”

Sawsan Khalil, a protester in Qamishli who was displaced from Afrin in Aleppo province in a 2018 Turkish offensive against Kurdish forces there, called for the international community “to feel for the Syrian people who have been killed for no reason” in Aleppo.

Izzeddin Gado, co-chair of the Qamishli City Council accused the government forces of “following a foreign and regional agenda from Turkey.”

The SDF has for years been the main U.S. partner in Syria in fighting against the Islamic State group, but Turkey considers the SDF a terrorist organization because of its association with the Kurdistan Workers’ Party, or PKK, which has waged a long-running insurgency in Turkey. A peace process is now underway.

Despite the long-running U.S. support for the SDF, the Trump administration in the U.S. has also developed close ties with al-Sharaa’s government and has pushed the Kurds to implement the March deal.

A U.S. State Department official said in a statement Thursday that the U.S. “is closely monitoring the situation” and urged “restraint on all sides.” It said U.S. envoy Tom Barrack is trying to facilitate dialogue between the two sides.

“All parties should focus on how to build a peaceful, stable Syria that protects and serves the interests of all Syrians, rather than pushing the country back into a cycle of violence,” the statement said.

Turkey’s Ministry of National Defense said Thursday that the “operation is being carried out entirely by the Syrian Army” while Turkey is “closely monitoring.”

“Syria’s security is our security,” the statement said, adding that “Turkey will provide the necessary support should Syria request it.”

Turkish Foreign Minister Hakan Fidan described the SDF as the “greatest obstacle for peace in Syria.”

The United Nations expressed concern at the violence and called for de-escalation.

Associated Press writers Suzan Fraser in Ankara and Andrew Wilks in Istanbul and Hogir Al Abdo in Qamishli, Syria contributed to this report. Sewell reported from Beirut.

Residents flee the Sheikh Maqsoud and Achrafieh neighbourhoods after clashes erupted Tuesday between Syrian government forces and Kurdish fighters in a contested area of the northern city of Aleppo, Syria, Thursday, Jan. 8, 2026. (AP Photo/Ghaith Alsayed)

Residents flee the Sheikh Maqsoud and Achrafieh neighbourhoods after clashes erupted Tuesday between Syrian government forces and Kurdish fighters in a contested area of the northern city of Aleppo, Syria, Thursday, Jan. 8, 2026. (AP Photo/Ghaith Alsayed)

Demonstrators chant slogans in support of the Kurdish-led Syrian Democratic Forces (SDF) during a protest in Qamishli, northeastern Syria, Thursday, Jan. 8, 2026. (AP Photo/Hogir Al Abdo)

Demonstrators chant slogans in support of the Kurdish-led Syrian Democratic Forces (SDF) during a protest in Qamishli, northeastern Syria, Thursday, Jan. 8, 2026. (AP Photo/Hogir Al Abdo)

Residents flee the Sheikh Maqsoud and Achrafieh neighborhoods after clashes broke out on Tuesday between Syrian government forces and Kurdish fighters in a contested area of the northern city of Aleppo, Syria, Wednesday, Jan. 7, 2026. (AP Photo/Omar Albam)

Residents flee the Sheikh Maqsoud and Achrafieh neighborhoods after clashes broke out on Tuesday between Syrian government forces and Kurdish fighters in a contested area of the northern city of Aleppo, Syria, Wednesday, Jan. 7, 2026. (AP Photo/Omar Albam)

Syrian government soldiers sit on their armoured personnel carrier (APC) following clashes with Kurdish fighters in a contested area of the northern city of Aleppo, Syria, Wednesday, Jan. 7, 2026. (AP Photo/Ghaith Alsayed)

Syrian government soldiers sit on their armoured personnel carrier (APC) following clashes with Kurdish fighters in a contested area of the northern city of Aleppo, Syria, Wednesday, Jan. 7, 2026. (AP Photo/Ghaith Alsayed)

A car burns during clashes between Kurdish fighters and Syrian government forces in a contested area of the northern city of Aleppo, Syria, Wednesday, Jan. 7, 2026. (AP Photo/Omar Albam)

A car burns during clashes between Kurdish fighters and Syrian government forces in a contested area of the northern city of Aleppo, Syria, Wednesday, Jan. 7, 2026. (AP Photo/Omar Albam)

An aerial view shows Syrian residents in vehicles, queueing to flee from Sheikh Maqsoud and Achrafieh neighborhoods after clashes broke out on Tuesday between Syrian government forces and Kurdish fighters in a contested area of the northern city of Aleppo, Syria, Wednesday, Jan. 7, 2026. (AP Photo/Omar Albam)

An aerial view shows Syrian residents in vehicles, queueing to flee from Sheikh Maqsoud and Achrafieh neighborhoods after clashes broke out on Tuesday between Syrian government forces and Kurdish fighters in a contested area of the northern city of Aleppo, Syria, Wednesday, Jan. 7, 2026. (AP Photo/Omar Albam)

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