Oklo and DOE Partner to Deploy Radioisotope Pilot Facility Supporting Cancer Care and U.S. Medical Supply Chains

SANTA CLARA, Calif.--(BUSINESS WIRE)--Jan 7, 2026--

Oklo Inc. (NYSE: OKLO) (“Oklo”), an advanced nuclear technology company, announced today that it has signed a U.S. Department of Energy (DOE) Other Transaction Agreement (OTA) to support the design, construction, and operation of a radioisotope pilot plant (“Radioisotope Pilot Facility”) under the DOE Reactor Pilot Program (RPP). Signing the OTA is a major milestone which marks the transition from project selection and planning into active execution under DOE authorization.

This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20260107011601/en/

“This OTA establishes a framework for execution and risk reduction. By building and operating a pilot reactor, we generate the data and experience to streamline future commercial deployments, improve regulatory efficiency, and deliver long-term value,” said Jacob DeWitte, co-founder and CEO of Oklo.

Atomic Alchemy Inc., an Oklo subsidiary, is using the Radioisotope Pilot Facility to lay the groundwork for future commercial plants that make medical and research radioisotopes in the United States. These radioisotopes are essential for diagnosing cancer, treating disease, powering medical research, and supporting national security. Today, many are produced overseas or in aging facilities. By first operating a pilot plant, Oklo can then scale into reliable, domestic production that helps ensure hospitals, researchers, and patients have consistent access to these lifesaving materials.

With the OTA now in place, Atomic Alchemy will focus its near-term resources on building the Radioisotope Pilot Facility under DOE authorization. As part of this learn-first-then-scale strategy, Atomic Alchemy has withdrawn its previously submitted Nuclear Regulatory Commission construction permit application for the Meitner-1 commercial radioisotope production facility at Idaho National Laboratory to focus on the Radioisotope Pilot Facility.

Oklo views the RPP as an enabler and accelerator to deliver advanced nuclear technologies that strengthen U.S. energy security, healthcare infrastructure, and industrial leadership.

About Oklo Inc.: Oklo Inc. is developing fast fission power plants to deliver clean, reliable, affordable energy at scale, establishing a domestic supply chain for critical radioisotopes, and advancing nuclear fuel recycling to convert nuclear waste into clean energy. Oklo was the first to receive a site use permit from the U.S. Department of Energy for a commercial advanced fission plant, was awarded fuel from Idaho National Laboratory, and submitted the first custom combined license application for an advanced reactor to the U.S. Nuclear Regulatory Commission. Oklo is also developing advanced fuel recycling technologies in collaboration with the U.S. Department of Energy and U.S. National Laboratories.

Forward-Looking Statements

This press release includes statements that express Oklo’s opinions, expectations, objectives, beliefs, plans, intentions, strategies, assumptions, forecasts or projections regarding future events or future results and therefore are, or may be deemed to be, “forward-looking statements.” The words “may,” “will,” “could,” “should,” “expects,” “anticipates,” “intends,” “plans,” “believes,” “seeks,” “estimates,” “continue,” “might,” “possible,” “potential,” “predict,” “project,” “goal,” “would,” “commit,” or, in each case, their negative or other variations or comparable terminology, and similar expressions may identify forward-looking statements, but the absence of these words does not mean that a statement is not forward-looking. These forward-looking statements include all matters that are not historical facts. They appear in a number of places throughout this press release and include statements regarding our intentions, beliefs or current expectations concerning, among other things, results of operations, financial condition, liquidity, prospects, growth, strategies and the markets in which Oklo operates. Such forward-looking statements are based on information available as of the date of this press release, and current expectations, forecasts and assumptions, and involve a number of judgments, risks and uncertainties.

As a result of a number of known and unknown risks and uncertainties, the actual results or performance of Oklo may be materially different from those expressed or implied by these forward-looking statements. The following important risk factors could affect Oklo’s future results and cause those results or other outcomes to differ materially from those expressed or implied in the forward-looking statements: risks related to the development and deployment of Oklo’s powerhouses; the risk that Oklo is pursuing an emerging market with no commercial project operating and regulatory uncertainties; risks related to acquisitions, divestitures, or joint ventures we may engage in; the need for financing to construct plants, which remain subject to market, financial, political, and legal conditions; risks related to an inability to raise additional capital to support our business and sustain our growth on favorable terms; the effects of competition; risks related to accessing high-assay low-enriched uranium, plutonium, and other fuels at acceptable costs (including recycled fuels); risks related to our supply chain; risks related to power purchase agreements; risks related to human capital; risks related to our intellectual property; risks related to cybersecurity and data privacy; changes in applicable laws or regulations, including tariffs; the outcome of any government and regulatory proceedings and investigations and inquiries; and the other factors set forth in our documents we have filed with the U.S. Securities and Exchange Commission (the “SEC”).

The foregoing list of factors is not exhaustive. You should carefully consider the foregoing factors and the other risks and uncertainties of the other documents filed by Oklo from time to time with the SEC. The forward-looking statements contained in this press release are based on current expectations and beliefs concerning future developments and their potential effects on Oklo. There can be no assurance that future developments affecting Oklo will be those that Oklo has anticipated. Oklo undertakes no obligation to update or revise any forward-looking statements to reflect events or circumstances after the date of this presentation, except as may be required by law.

Render of Atomic Alchemy radioisotope pilot facility (Image: Hillside Architecture, PLLC)

NEW YORK (AP) — Stocks recovered most of their earlier losses as volatility returned to Wall Street after two days of solid gains.

The S&P 500 fell 0.2% after slumping as much as 1.5% in early trading Thursday. The Dow Jones Industrial Average shed 154 points, or 0.3% as of 12:35 p.m. Eastern. The Nasdaq composite fell 0.3%. Stocks in Europe pared their losses.

Oil prices remained elevated although down from earlier highs. The price for a barrel of U.S. crude rose close to $114 a barrel at one point.

The unsettled trading follows a national address late Wednesday from President Donald Trump, where he vowed the U.S. will continue to attack Iran and failed to offer a clear timetable for ending the conflict in the Middle East. Those comments appeared to dim the hopes for a near-term conclusion to the war that had pushed stocks higher through most the week.

Major indexes are still on track to close out the week with gains. Thursday is the last day of trading on Wall Street this week with with the stock market closed on Good Friday.

Crude oil prices have been the main force behind the sharp swings for stocks globally. Shipping traffic has been severely curtailed in the Strait of Hormuz, where a fifth of the world’s traded oil passes through during peacetime.

The price of Brent crude, the international standard, jumped 6.5% to $107.72. per barrel. Benchmark U.S. crude rose 11.3% to $111.44 per barrel. Prices had been sliding back toward $100 per barrel prior to Trump’s address on Wednesday. The U.S. only relies on the Persian Gulf for a fraction of the oil it imports, but oil is a commodity and prices are set in a global market. A disruption anywhere affects prices everywhere.

Markets have been broadly sliding since the war began, with indexes often rising and falling sharply along with statements from Trump about the direction of the war. Just on Monday, the S&P 500 briefly neared a 10% drop from its record, a steep-enough fall that professional investors have a name for it: a “correction. The index gained ground Tuesday and Wednesday on hope that the war could end soon.

“For markets, a prolonged conflict increases the risk of sustained pressures on inflation, global growth, interest rates, and equity valuations,” wrote Adam Turnquist, chief technical strategist for LPL Financial, in a note to investors.

Airlines and other travel-related companies were among the biggest losers on Thursday. United Airlines fell 4.1% and Carnival shed 4%.

Tesla fell 4.4% after a report showing that sales over the past three months fell short of analysts' expectations.

Several big technology stocks gained ground to help offset losses elsewhere in the market. Intel jumped 3% and Advanced Micro Devices rose 1.6%.

Treasury yields remained relatively steady in the bond market. The yield on the 10-year Treasury fell to to 4.30% from 4.32%.

Wall Street is worried that higher energy prices are adding to already stubbornly high inflation. Rising fuel prices take a bigger chunk out of consumers' wallets in several ways. Directly, gasoline prices in the U.S. have surged more than 33 percent from a month ago to average $4.08 per gallon, according to the auto club AAA.

Indirectly, rising fuel prices tend to make a wide range of services and goods more expensive. Flights become more expensive as airlines raise ticket prices to offset rising fuel costs. Consumer goods become more expensive as shipping and transportation costs rise.

Inflation has been stubbornly above the Federal Reserve's 2% target. The war and its corresponding surge in energy prices effectively pushes inflation higher and that has dashed hopes for the Fed to cut interest rates. Wall Street had hoped for the central bank to cut rates in order to help offset a weakening job market. Lower interest rates could help stimulate the economy by lowering borrowing costs, but they also risk worsening inflation.

Traders came into 2026 forecasting several cuts to the Fed's benchmark interest rate, which influences rates for mortgages and other loans. They are now expecting the benchmark rate to remain steady this year.

The war with Iran has overshadowed many of the other moving pieces within the economy that the Fed and Wall Street have been monitoring. It remains a mixed picture. Reports this week revealed that consumers remain confident and are still spending, though inflation remains a big concern. A report Thursday showed that mortgage rates continue climbing, posing an obstacle for prospective home buyers. Another update Friday will give a more detailed view of the job market.

Associated Press journalists Chan Ho-Him and Matt Ott contributed to this report.

Fishing boats dot the sea as cargo ships, in the background, sail through the Arabian Gulf toward the Strait of Hormuz off the United Arab Emirates, Friday, March 27, 2026. (AP Photo)

Perople walk in front of an electronic stock board showing Japan's Nikkei index at a securities firm Thursday, April 2, 2026, in Tokyo. (AP Photo/Eugene Hoshiko)

President Donald Trump speaks about the Iran war from the Cross Hall of the White House on Wednesday, April 1, 2026, in Washington. (Doug Mills/The New York Times via AP Pool)

Persons walk in front of an electronic stock board showing Japan's Nikkei index at a securities firm Thursday, April 2, 2026, in Tokyo. (AP Photo/Eugene Hoshiko)