Last year, President Donald Trump told pregnant women not to take Tylenol as he promoted unproven ties between the fever reducer and autism and touted an old generic drug as a treatment for the developmental condition.
For nearly three months after that, new research found, Tylenol orders for pregnant women showing up in emergency rooms dropped and prescriptions of the generic drug for children rose. This happened despite sharp criticism of the president's message from doctor groups saying that the drug, leucovorin, shouldn’t be broadly used for autism and Tylenol is safe during pregnancy.
“It just shows that in our country right now, health care has been politicized in a way that political messages are driving and impacting care — and not always for good,” said Dr. Susan Sirota, a pediatrician in Highland Park, Illinois, who wasn’t involved with the research.
Doctors, who published their work Thursday in The Lancet, looked at changes in drug ordering or prescribing compared with projected trends, or what might have happened if things had continued on the same path as before the White House briefing.
They found that orders for Tylenol – also known by the generic names acetaminophen and paracetamol – were 10% lower than predicted for pregnant emergency department patients aged 15 to 44. And outpatient prescriptions of leucovorin for children aged 5 to 17 were 71% higher than expected during the same study period, late September to early December.
Researchers observed no similar shifts in comparable medications, suggesting the changes were directly tied to the briefing.
The research had limitations. For example, it didn’t capture all Tylenol use by pregnant women because most people buy the painkiller over the counter outside of a hospital setting.
Still, it reflected how an unconventional news conference by a political leader could change not just patient behavior but prescribing as well, said co-author Dr. Michael Barnett.
In past administrations, "there are lots of layers of approval and expert consensus" before officials make big announcements about medical topics, said Barnett, who is with Brown University School of Public Health.
Pregnant women generally take Tylenol for pain or fever. Untreated fevers in pregnancy, particularly in the first trimester, increase the risk for miscarriages, preterm birth and other problems, according to the Society for Maternal-Fetal Medicine. Some studies have raised the possibility that taking Tylenol in pregnancy might be associated with a risk of autism, but many others haven’t found a connection.
Leucovorin is a derivative of folic acid used for, among other things, reducing the toxic side effects of certain chemotherapy drugs and treating a rare blood disorder. It has also been studied for a neurological condition known as cerebral folate deficiency and for a subset of autistic children, according to the American Academy of Pediatrics.
The pediatrics group doesn’t recommend routine use of the drug for autistic children. Early, small-scale studies have explored its use, “and some findings suggest potential benefit in carefully selected cases,” the group said.
But evidence remains limited, the pediatrician group said. And in late January, the European Journal of Pediatrics retracted a study evaluating leucovorin as an autism treatment.
Still, after the federal announcement about the drug, Sirota said some families in her practice asked about getting it for their autistic children. She educated them about the evidence, told them about the potential for side effects and didn't prescribe it. Potential side effects include irritability, nausea and vomiting and skin issues like dermatitis.
Sirota said it has been hard to deal with the repercussions of government pronouncements like the ones on autism.
“It feels like a pattern with our government, right? They keep building on these houses of cards that just fall down,” she said. “This politicizing of medicine just in general, and moving away from science, has been so challenging."
The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education and the Robert Wood Johnson Foundation. The AP is solely responsible for all content.
FILE - Tylenol pills in La Habra, Calif., on Sept. 23, 2025. (AP Photo/Jae C. Hong, File)
WASHINGTON (AP) — Lionel Messi bestowed President Donald Trump with a bejeweled pink soccer ball during a White House ceremony honoring Inter Miami for winning last year's MLS Cup.
Miami beat the Vancouver Whitecaps in December for the Major League Soccer title, and the Argentinian superstar was named the league's MVP for the second consecutive season.
“Leo, you came in and you won, and that's something very hard to do, very, very unusual and frankly, there's a lot more pressure put on you than anyone would know, because you sort of expected to win, but almost nobody wins,” Trump said.
Messi, who entered the ceremony alongside Trump, joined Inter Miami in mid-2023 to great fanfare. He did not speak during the event, which turned political at times with Trump addressing the war with Iran, the situation in Venezuela, a possible future announcement regarding Cuba and even tariffs.
Addressing Messi — who famously avoids speaking out on politics — the president stuck mostly to sports.
“You could have gone anywhere in the world. You could have chosen any team in the world, and you chose to go to Miami. I don’t blame you. The weather’s extremely good. Do you go to Doral? You go to Doral and play golf?” Trump said, referencing a golf course he owns. “I just want to thank you for bringing us all on this ride, because you are hot and talented and a great person.”
Among the other Inter Miami stars in attendance were Luis Suárez, Tadeo Allende and Rodrigo De Paul. MLS Commissioner Don Garber sat next to Andrew Giuliani, head of the White House's World Cup task force. Also attending were retired baseball star Alex Rodriguez and members of Trump's cabinet.
Inter Miami was the first MLS team to be invited to the White House during Trump’s two terms in office.
Messi, an eight-time Ballon d'Or winner, led Argentina to the World Cup title in 2022. The 38-year-old is expected to play again for Argentina this summer when the tournament is hosted by the United States, Canada and Mexico.
Soccer's global showcase has been clouded by recent events, including the war with Iran and turmoil in Mexico following the death of cartel leader Nemesio Oseguera in a military operation.
Iran is part of the World Cup field of 48 teams and is set to play a pair of games at SoFi Stadium in Southern California and another in Seattle during the group stage.
Trump opened the ceremony with comments about the conflict with Iran but did not mention the World Cup.
Following military action by the United States and Israel last week, Iran’s top soccer official, Mehdi Taj, said the country could not look to playing in the World Cup with “hope.”
“I really don’t care” if Iran participates, Trump told Politico this week. “I think Iran is a very badly defeated country. They’re running on fumes.”
It's not clear what would happen if Iran pulled out of the World Cup. No team that has qualified for the tournament has withdrawn in the past 75 years.
The World Cup kicks off on June 11 when Mexico plays South Africa in Mexico City.
During the ceremony, Trump spoke about how he saw Brazilian great Pele play with the New York Cosmos. He looked to Messi: “You may be better than Pele,” then asked the crowd, “Who’s better?”
Inter Miami owner Jorge Mas said his team has “changed the culture of football in the United States of America forever.”
“We can play with the big boys, we can play with the heavyweights. Our league can be one of the top leagues in the world,” Mas said. “And it is this ability to dream, to persevere, to have no obstacles ahead of us, that we will continue to be successful. And hopefully, Mr. President, this is not our only visit here celebrating an MLS Cup championship.”
It was the first White House visit for Messi. He was invited by the Biden administration to be presented with the Presidential Medal of Freedom in January 2025 but could not attend because of a scheduling conflict.
Inter Miami will remain in the area to play D.C. United on Saturday.
AP soccer: https://apnews.com/hub/soccer
President Donald Trump receives a soccer ball trophy from Lionel Messi during an event to honor the 2025 Major League Soccer champions Inter Miami in the East Room of the White House, Thursday, March 5, 2026, in Washington. (AP Photo/Julia Demaree Nikhinson)
Lionel Messi, left, and teammates listen to President Donald Trump speak during an event to honor the 2025 Major League Soccer champions Inter Miami in the East Room of the White House, Thursday, March 5, 2026, in Washington. (AP Photo/Julia Demaree Nikhinson)
FILE - Argentina's Lionel Messi hoists the winning team replica of the FIFA World Cup trophy during a celebration ceremony for local fans after an international friendly soccer match against Panama at the Monumental stadium in Buenos Aires, Argentina, March 23, 2023. (AP Photo/Gustavo Garello, file)
Lionel Messi listens to President Donald Trump speak during an event to honor the 2025 Major League Soccer champions Inter Miami in the East Room of the White House, Thursday, March 5, 2026, in Washington. (AP Photo/Julia Demaree Nikhinson)
President Donald Trump shakes hands with Lionel Messi during an event to honor the 2025 Major League Soccer champions Inter Miami in the East Room of the White House, Thursday, March 5, 2026, in Washington. (AP Photo/Julia Demaree Nikhinson)
