BEIJING, March 25, 2026 /PRNewswire/ -- A research team led by Prof. Hesheng Liu, founder and Chief Scientific Officer of Galaxy Brain Scientific Inc., has published a study in Nature Neuroscience demonstrating that Deep Brain Stimulation (DBS) achieves therapeutic efficacy in Parkinson's disease (PD) by remodeling the SPARK circuit. (https://www.nature.com/articles/s41593-026-02228-w)
The findings build directly on the team's previous identification of a core cortico-subcortical PD circuit derived from the somato-cognitive action network (SCAN), the SPARK (SCAN-Parkinson's) circuit, as reported in their study published in Nature in February 2026 (https://doi.org/10.1038/s41586-025-10059-1), which first characterized this circuit in PD. These results provide mechanistic evidence that neuromodulation therapies exert their effects through modulation of this circuit, and offer a circuit-level framework for the development of personalized, non-invasive precision treatment strategies.
This study establishes the world's largest longitudinal DBS-fMRI dataset to date, derived from a systematic one-year follow-up of 14 PD patients. With over 200 hours of high-quality imaging data collected, the research team successfully provides mechanistic insights into how DBS exerts its effects by modulating the SPARK circuit, yielding two key findings:
First, the study reveals that the SPARK circuit is the critical response region for DBS neuromodulation. The research provides powerful evidence that the SPARK circuit is not only the pathological origin of PD but also the core target through which neuromodulation exerts its effects.
Second, the study confirms that DBS remodels abnormal functional connectivity within the SPARK circuit. These results are highly consistent with the team's previous research published in Nature, proving that the clinical efficacy of DBS essentially stems from the long-term regulation and functional remodeling of abnormal SPARK connectivity.
These findings imply that non-invasive interventions targeting the SPARK circuit are supported by the same biological foundation as surgical neuromodulation.
Furthermore, the research revealed significant individual variability in brain functional networks across patients, which directly influence the clinical outcomes of neuromodulation therapies. This discovery points toward a new direction for the field: a paradigm shift from traditional, empirical "trial-and-error" parameter tuning toward a personalized precision treatment model rooted in individual brain circuits.
Leveraging its proprietary Personalized Brain Functional Sectors (pBFS) technology and a specialized precision circuit stimulation system, Galaxy Brain Scientific has achieved the clinical application of personalized, non-invasive precision intervention. This approach enables a "one-person-one-strategy" model for individualized care. Clinical trials have confirmed that by using the precision circuit stimulation system to deliver non-invasive intervention to each patient's unique SPARK target, clinical efficacy is more than double that of traditional stimulation targets.
Galaxy Brain Scientific is already moving to bring these insights to the clinical frontline, having begun a pivotal registration trial for Class III devices dedicated to treating PD. "Our goal is to redefine the treatment paradigm for brain disorders," added Prof. Liu. "By moving from 'one-size-fits-all' to 'one-person-one-strategy', we are now pioneering the application of this technology to treat complex conditions beyond Parkinson's, including autism and Alzheimer's disease."
About Galaxy Brain Scientific
Galaxy Brain Scientific (https://www.gb-scientific.cn) is a world-leading platform for the translation and industrialization of brain science research. Guided by its mission to "Advancing brain cognition and conquering brain diseases", the company provides safe, non-invasive, and personalized precision treatment solutions for major brain disorders such as Parkinson's disease, Alzheimer's disease, and autism, striving to become a leader in the global field of brain disease diagnosis and treatment.
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From SCAN to SPARK: Galaxy Brain Scientific Enables a New Paradigm in Non-invasive, Personalized Precision Treatment for Parkinson's Disease
Local cuisine emerges as the region's strongest dining force, as traditional restaurant settings give way to fluid, social spaces
SINGAPORE, Oct. 6, 2026 /PRNewswire/ -- Marriott International has unveiled Future of Food 2027, its latest report exploring food and beverage trends across Asia Pacific excluding China. Drawing on conversations with leading chefs, hospitality experts and regional influencers, alongside insights from Marriott International properties across the region, the report reveals a pivotal transformation: the rise of place. As dining breaks free from traditional restaurant boundaries into fluid, social formats, diners increasingly seek experiences that are hyper-local, authentic and deeply connected to their destination.
Across Asia Pacific excluding China, diners are increasingly seeking authenticity and connection. Demand for authentic local signature dishes is surging, with 95% of surveyed properties identifying this as the biggest trend in their market. At the same time, dining is no longer confined to the traditional restaurant setting. Guests are gathering across bars, lounges, counters and flexible spaces, turning hotels into social and cultural hubs where guests move fluidly throughout the day. The result is a new era of dining where the story behind what people eat and where they eat matters more than ever.
"Across Asia Pacific, we're witnessing a shift toward intimate, locally-rooted experiences, where smaller, intentional spaces replace traditional formal dining models," said Petr Raba, Vice President of Food & Beverage, Marriott International, Asia Pacific excluding China. "Hotels are becoming cultural storytellers, embedding regional talent, locally sourced ingredients and authentic connection into every aspect of the dining experience to create spaces that feel distinctly of their place."
Key Trends Shaping the Future of Food
- The Spatial Shift
Dining is moving beyond the traditional restaurant model as guests increasingly lean toward more flexible, social and experience-led spaces. Across Asia Pacific excluding China, nearly half of the surveyed properties report a growing demand for casual venues such as lounges, bars and outdoor settings, while emerging concepts are embracing intimate 40 to 60-seat footprints with distinct identities. In Vietnam, 71% of surveyed properties report growth in bar and lounge dining, reflecting the growing appeal of more fluid dining experiences. An invisible layer of technology is supporting this shift, with AI enhancing everything from menu development and marketing to staffing and guest insights, allowing teams to focus on delivering more personalized hospitality. 100% of restaurants and bars surveyed in Thailand are already using AI in their operations. - The Local Advantage
Local cuisine has become the defining force shaping dining decisions across the region. Demand for authentic local signature dishes is now the strongest trend identified by 95% of the surveyed properties and outweighing value for money when guests choose where to dine. Hotels are responding by building menus around ingredients and stories rooted in their destinations. At Hearth at The Ritz-Carlton, Perth, for example, a signature dish featuring local Wagin duck showcases Western Australia's produce while reflecting the restaurant's seasonal, locally driven philosophy. Over the past year, four in five properties have introduced new local ingredients from Kyoto vegetables in Japan to Kampot sea salt in Cambodia-inspired menus and indigenous spices across Southeast Asia, while nearly three-quarters report local ingredients appearing more frequently in beverage menus. This trend is particularly pronounced in India and Indonesia, where demand for local signature cuisine reaches 71% and 67% respectively, highlighting a growing desire for dining experiences that tell the story of a destination. - 99-Minute Fine Dining
Fine dining is undergoing a temporal revolution with up to five memorable courses delivered in under two hours, replacing four-hour tasting menus with ten-plus courses. Across the region, 58% of properties report that the average fine dining experiences last between 1.5 and 2 hours. Singapore has emerged as one of the region's fastest-paced fine dining markets with 85% of restaurants reporting an average time of 1.5 hours. Restaurants are adapting by simplifying menus, introducing more a la carte options and focusing on standout moments over the number of courses. In South Korea, one in five establishments have already reduced the number of courses served, while 30% of fine-dining restaurants in the Philippines have introduced a la carte menus. Australia sees both fewer courses and shorter service times, with the conversation shifting toward "wow moments" rather than course quantity.
Additional Report Highlights:
- Eat Well, Eating Your Age: Wellness has become a core dining consideration, with ingredients rooted in Asia Pacific's rich food traditions finding renewed relevance among modern travelers. Today, 97% of surveyed Marriott International properties in Asia Pacific excluding China serve dishes associated with health and longevity, while wellness increasingly extends beyond the plate to healthier mini-bars and wellness-focused turndown experiences.
- The Modern Menu: Across Asia Pacific, menus are becoming more expressive and multi-sensory, with texture rising alongside flavor as a defining element of the dining experience. At the same time, plant-forward dining is accelerating, prompting Marriott International to introduce its APEC Plant-Forward Program across the region in 2027, making it one of the first major global hotel groups to integrate plant-forward dining into its operational foundation permanently.
- Alcohol Alternatives: The low- and no-alcohol movement has evolved from niche trend to hospitality mainstay, with 42% of Marriott International restaurants and bars surveyed in Asia Pacific excluding China reporting increased sales of non-alcoholic beverages. From premium spirits to alcohol-free pairings, guests are increasingly seeking sophisticated alternatives without compromise.
Looking Ahead
Asia Pacific's F&B landscape is fundamentally shifting toward authenticity and intentionality. Hotels and restaurants thriving in 2027 are those that understand their place deeply - its ingredients, culture, people and design experiences around that foundation. They are creating smaller, more distinctive spaces where technology elevates genuine hospitality, while telling stories that connect guests emotionally to destination and cuisine. The result is a regional dining scene that feels less like a global template adaptation and more like a collection of distinctive, culturally rooted experiences.
About Marriott International
Marriott International, Inc. (Nasdaq: MAR) is based in Bethesda, Maryland, USA, and encompasses a portfolio of compelling brands across luxury, premium, select, midscale, extended stay, and all-inclusive, with over 10,000 properties in 148 countries and territories, as of June 30, 2026. Marriott franchises, operates, and licenses hotel, residential, timeshare, yacht, outdoor, and other lodging products all around the world. The company offers Marriott Bonvoy®, its highly awarded travel platform. For more information, please visit our website at www.marriott.com, and for the latest company news, visit www.marriottnewscenter.com. In addition, connect with us on Facebook and @MarriottIntl on X and Instagram.
Download the full Future of Food 2027 reporthere to explore the complete trends shaping Asia Pacific's culinary future.
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THE RISE OF PLACE: MARRIOTT INTERNATIONAL REVEALS ASIA PACIFIC'S FUTURE OF FOOD
