BEIJING, March 25, 2026 /PRNewswire/ -- A research team led by Prof. Hesheng Liu, founder and Chief Scientific Officer of Galaxy Brain Scientific Inc., has published a study in Nature Neuroscience demonstrating that Deep Brain Stimulation (DBS) achieves therapeutic efficacy in Parkinson's disease (PD) by remodeling the SPARK circuit. (https://www.nature.com/articles/s41593-026-02228-w)
The findings build directly on the team's previous identification of a core cortico-subcortical PD circuit derived from the somato-cognitive action network (SCAN), the SPARK (SCAN-Parkinson's) circuit, as reported in their study published in Nature in February 2026 (https://doi.org/10.1038/s41586-025-10059-1), which first characterized this circuit in PD. These results provide mechanistic evidence that neuromodulation therapies exert their effects through modulation of this circuit, and offer a circuit-level framework for the development of personalized, non-invasive precision treatment strategies.
This study establishes the world's largest longitudinal DBS-fMRI dataset to date, derived from a systematic one-year follow-up of 14 PD patients. With over 200 hours of high-quality imaging data collected, the research team successfully provides mechanistic insights into how DBS exerts its effects by modulating the SPARK circuit, yielding two key findings:
First, the study reveals that the SPARK circuit is the critical response region for DBS neuromodulation. The research provides powerful evidence that the SPARK circuit is not only the pathological origin of PD but also the core target through which neuromodulation exerts its effects.
Second, the study confirms that DBS remodels abnormal functional connectivity within the SPARK circuit. These results are highly consistent with the team's previous research published in Nature, proving that the clinical efficacy of DBS essentially stems from the long-term regulation and functional remodeling of abnormal SPARK connectivity.
These findings imply that non-invasive interventions targeting the SPARK circuit are supported by the same biological foundation as surgical neuromodulation.
Furthermore, the research revealed significant individual variability in brain functional networks across patients, which directly influence the clinical outcomes of neuromodulation therapies. This discovery points toward a new direction for the field: a paradigm shift from traditional, empirical "trial-and-error" parameter tuning toward a personalized precision treatment model rooted in individual brain circuits.
Leveraging its proprietary Personalized Brain Functional Sectors (pBFS) technology and a specialized precision circuit stimulation system, Galaxy Brain Scientific has achieved the clinical application of personalized, non-invasive precision intervention. This approach enables a "one-person-one-strategy" model for individualized care. Clinical trials have confirmed that by using the precision circuit stimulation system to deliver non-invasive intervention to each patient's unique SPARK target, clinical efficacy is more than double that of traditional stimulation targets.
Galaxy Brain Scientific is already moving to bring these insights to the clinical frontline, having begun a pivotal registration trial for Class III devices dedicated to treating PD. "Our goal is to redefine the treatment paradigm for brain disorders," added Prof. Liu. "By moving from 'one-size-fits-all' to 'one-person-one-strategy', we are now pioneering the application of this technology to treat complex conditions beyond Parkinson's, including autism and Alzheimer's disease."
About Galaxy Brain Scientific
Galaxy Brain Scientific (https://www.gb-scientific.cn) is a world-leading platform for the translation and industrialization of brain science research. Guided by its mission to "Advancing brain cognition and conquering brain diseases", the company provides safe, non-invasive, and personalized precision treatment solutions for major brain disorders such as Parkinson's disease, Alzheimer's disease, and autism, striving to become a leader in the global field of brain disease diagnosis and treatment.
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From SCAN to SPARK: Galaxy Brain Scientific Enables a New Paradigm in Non-invasive, Personalized Precision Treatment for Parkinson's Disease
BEIJING, March 25, 2026 /PRNewswire/ -- This is a news report from China Daily:
The 2026 ZGC International Technology Trade Fair is set to open on Wednesday afternoon, poised to achieve its highest-ever investor turnout.
As it drives the development of a global "buy and sell" technology network, this year's fair will anchor itself in global sci-tech trends and ground itself in Beijing's strategic positioning and key industrial layout, holding more than 20 transaction and matchmaking events. Over 500 technology projects from across China and abroad will be presented, with registered investment institutions reaching a historic high, organizers said.
Following the "1+8+N" framework, the fair comprises one opening ceremony, eight signature events and multiple satellite sessions.
The opening ceremony will bring together a range of guests from global and domestic innovation hubs, including the Beijing-Tianjin-Hebei region, the Yangtze River Delta and the Guangdong-Hong Kong-Macao Greater Bay Area.
Attendees will include scientific research teams, tech companies, industry leaders, technology transfer service platforms, venture capital institutions and science and technology parks. The event will feature the collective signing of a series of projects spanning technology transfer, investment and financing and ecosystem cooperation, alongside the release of talent development policies for the sci-tech service sector and the launch of the "blue vest" technology manager program.
The fair aims to strengthen the interconnection of global innovation resources, building a worldwide technology transaction network. It will deepen cross-border cooperation by hosting dedicated sessions for five key countries, including Switzerland and the United Kingdom, gathering technology managers and over 100 international guests to advance cross-border technology transfer. In upgrading regional collaboration, the fair will gather over 70 regional technological achievements through the Beijing-Tianjin-Hebei tech transfer and matchmaking event. It will establish a "patient capital + scenario-driven" model and work with the Yangtze River Delta and the GBA to build an ecosystem for tech commercialization.
Eight signature events are to be held during the fair, including a forum on technology transfer with 50 participants; the annual meeting of a global technology manager network; a matchmaking conference for integrated innovation among enterprises of all sizes; dedicated sessions on technology transfer from universities and research institutes; a technology matchmaking session focusing on selected key countries; a conference on Beijing-Tianjin-Hebei technology transactions; a special session on major scientific achievements; and a district chiefs' dialogue session.
New on-site service formats will be introduced, such as a technology transaction "consultation room", the "blue vest" technology managers, the "achievement store" and a livestreaming channel for sci-tech transformation.
Compared with previous sessions, this year's fair will be more professional, far-reaching and impactful. Guided by industrial needs, it focuses on cutting-edge fields such as artificial intelligence, embodied AI and life sciences, and taps into high-value resources such as national key labs and regional transfer centers.
"The fair will further highlight its role as an 'accelerator' and a 'bridge for connectivity' through prominent activities and innovative initiatives, creating a technology exchange event focused on 'buying globally, selling globally' and advancing international scientific collaboration as well as technology commercialization," said an official from the Beijing Science and Technology Commission and Administrative Commission of Zhongguancun Science Park.
The ZGC International Technology Trade Fair, an integral part of the Zhongguancun Forum, was first held in 2020. Focused on buying globally and selling globally, it aims to create a Beijing-based platform for global communication and cooperation, showcasing cutting-edge sci-tech achievements, and hosting supply-demand matchmaking, exchanges and negotiations. It is committed to building a technology transaction ecosystem and growing into a globally influential hub for technology transfer and trade.
The ZGC International Technology Trade Center, the venue for this year's fair, officially commenced operations on March 16. Jointly established by the Beijing Science and Technology Commission and Administrative Commission of Zhongguancun Science Park and other partners, the center offers a "full-chain, one-stop" integrated service system. This covers project aggregation, exhibition and road shows, technology assessment, transactions, scenario matching and venture capital. It has attracted more than 90 domestic and international institutions, providing support for the fair.
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Money talks: investor turnout to set record
