Brewers' Jacob Misiorowski leaves with cramping again after another dominating performance

MILWAUKEE (AP) — Jacob Misiorowski says he isn’t particularly concerned about the cramping that has caused him to leave two of his last three starts.

Misiorowski came out for the eighth inning Wednesday but left with a cramp in his right quadriceps after throwing one warmup pitch in the Milwaukee Brewers’ 3-1 loss to the San Diego Padres.

He had a no-hit bid through 5 1/3 innings in an 8-1 victory at Washington on May 1 before departing that game with a right hamstring cramp.

“Probably the exact same, but it was the quad this time instead of the hamstring,” Misiorowski said. “Nothing we haven’t seen before, so it’ll be fine. I’m ready to go.”

Cramping appears to be the only significant obstacle for the hard-throwing 24-year-old right-hander, who hasn’t allowed a run in his last three outings.

“He puts so much into it. … We have people here to get it under control,” Brewers manager Pat Murphy said. “I don’t think it’s a concern.”

Misiorowski struck out 10 and allowed four hits and no walks, leaving with a 1-0 lead. The Padres rallied to win on Gavin Sheets’ three-run homer off Abner Uribe with two outs in the ninth inning.

That came five nights after Misiorowski struck out 11 and allowed two hits and two walks in a 6-0 victory over the New York Yankees. He had eight strikeouts and two walks against the Nationals.

He has struck out at least eight batters in each of his last five starts to tie Ben Sheets for the second-longest such streak in Brewers history. Corbin Burnes owns the franchise record with seven straight games of at least eight strikeouts in his Cy Young Award-winning season of 2021.

Misiorowski throws the hardest of any starting pitcher in the big leagues.

Against the Yankees, Misiorowski had 10 pitches go at least 103 mph and had three pitches of 103.6 mph, the highest velocity any starter has reached since pitch tracking began in 2008.

Misiorowski threw 40 pitches of 100 mph or higher on Wednesday, his third straight game with 40 or more. He struck out Nick Castellanos with a 103.2-mph fastball on his 93rd and final pitch.

New York Yankees slugger and three-time AL MVP Aaron Judge said that the extension Misiorowski gets with his 6-foot-7 frame makes his fastball particularly difficult to hit.

“He’s almost basically releasing it in the catcher’s glove,” Judge said when the Yankees were in Milwaukee. “You see some guys who throw 103, but you get a little bit more time. A guy like that, where he’s almost dropping it in the catcher’s mitt, it makes for a tough day.”

Misiorowski leads major league pitchers with 80 strikeouts. His performance Wednesday lowered his ERA to 2.12.

“I honestly didn’t feel like I had my best stuff," he said.

He diversified his approach by throwing a slider about 30% of the time Wednesday. He entered this game having used the slider on only 22.6% of his pitches.

“That was just the game plan going in,” Misiorowski said. “They saw something back there that they thought the slider would work better.”

AP MLB: https://apnews.com/hub/MLB

Milwaukee Brewers' Jacob Misiorowski smiles as he walks to the dugout during the fourth inning of a baseball game against the San Diego Padres, Wednesday, May 13, 2026, in Milwaukee. (AP Photo/Aaron Gash)

Milwaukee Brewers' Jacob Misiorowski pitches during the fifth inning of a baseball game against the San Diego Padres, Wednesday, May 13, 2026, in Milwaukee. (AP Photo/Aaron Gash)

Milwaukee Brewers' Jacob Misiorowski reacts after striking out San Diego Padres' Nick Castellanos during the seventh inning of a baseball game, Wednesday, May 13, 2026, in Milwaukee. (AP Photo/Aaron Gash)

Milwaukee Brewers' Jacob Misiorowski talks, right, with Pat Murphy before the eighth inning of a baseball game against the San Diego Padres, Wednesday, May 13, 2026, in Milwaukee. (AP Photo/Aaron Gash)

Milwaukee Brewers' Jacob Misiorowski, right, talks with a trainer before the eighth inning of a baseball game against the San Diego Padres, Wednesday, May 13, 2026, in Milwaukee. (AP Photo/Aaron Gash)

HOUSTON (AP) — Christian Walker homered and Zach Cole hit an RBI single in the 10th inning that lifted the Houston Astros to a 4-3 win over the Seattle Mariners on Wednesday night.

Brice Matthews started the 10th as the automatic runner on second base and moved to third on a wild pitch by Alex Hoppe (0-1). Cole, who tied a career high with three hits, singled on a grounder to right field to send Matthews home.

Bryan Abreu (2-2) walked one in a scoreless 10th.

Jose Altuve added two RBIs to help the Astros snap a four-game skid overall and end a nine-game losing streak against the Mariners.

Houston loaded the bases with no outs in the eighth and took the lead on Altuve's one-out sacrifice fly. Altuve became the fifth Astros player with 900 RBIs.

Julio Rodríguez's bases-loaded walk against Bryan King tied it at 3-3 with two outs in the ninth.

J.P. Crawford and Luke Raley hit solo home runs for the Mariners.

Seattle’s Bryce Miller allowed two runs and eight hits over 5 1/3 innings in his season debut after recovering from a strained left oblique.

Houston starter Lance McCullers also went 5 1/3 innings, permitting two runs and seven hits.

Crawford hit a leadoff homer, and Raley’s home run with one out in the sixth chased McCullers and made it 2-0.

Walker opened the bottom of the inning with his shot to the front row in right field to get the Astros within 1.

There was a delay of about 12 minutes with one out in the inning when home plate umpire Roberto Ortiz left the game after Braden Shewmake fouled a ball off his mask. First base umpire Alex MacKay moved from first base to behind the plate after Ortiz left and he got his gear on.

Altuve’s bases-loaded walk with two outs in the inning tied it, but Yordan Alvarez grounded out to end the inning.

Seattle RHP Luis Castillo (0-4, 6.57 ERA) looks for his first win in the series finale Thursday with RHP Mike Burrows (2-4, 5.04) starting for Houston.

AP MLB: https://apnews.com/hub/mlb

Seattle Mariners' J.P. Crawford (3) celebrates with Josh Naylor (12) after hitting a home run during the first inning of a baseball game against the Houston Astros in Houston, Wednesday, May 13, 2026. (AP Photo/Ashley Landis)

Seattle Mariners starting pitcher Bryce Miller throws during the first inning of a baseball game against the Houston Astros in Houston, Wednesday, May 13, 2026. (AP Photo/Ashley Landis)

Seattle Mariners' Luke Raley (20) celebrates with J.P. Crawford (3) after hitting a home run during the sixth inning of a baseball game against the Houston Astros in Houston, Wednesday, May 13, 2026. (AP Photo/Ashley Landis)

Umpire Roberto Ortiz, center, is checked out for injury before leaving the game during the sixth inning of a baseball game between the Seattle Mariners and the Houston Astros in Houston, Wednesday, May 13, 2026. (AP Photo/Ashley Landis)

Houston Astros' Christian Walker (8) celebrates with Zach Dezenzo after hitting a home run during the fifth inning of a baseball game against the Seattle Mariners in Houston, Wednesday, May 13, 2026. (AP Photo/Ashley Landis)

Houston Astros' Brice Matthews (0) celebrates with Yordan Alvarez after scoring during the eighth inning of a baseball game against the Seattle Mariners in Houston, Wednesday, May 13, 2026. (AP Photo/Ashley Landis)