NEWARK, Del.--(BUSINESS WIRE)--Jun 3, 2026--
Corrixr Therapeutics, a pre-clinical genetic medicine company targeting lung, head & neck, and esophageal squamous cell carcinomas, today announced the appointment of Hilary M. Malone, Ph.D. as Chief Executive Officer. Dr. Malone brings more than 25 years of executive leadership experience across both multinational pharmaceutical companies and venture-backed biotech startups, combining deep expertise in science, regulatory strategy, clinical development, and patient/market access across the full drug development lifecycle. She is joining Corrixr at a pivotal moment as the company advances its lead program, CXR101, toward IND filing and first-in-human proof-of-mechanism trials.
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Dr. Malone succeeds Eric B. Kmiec, Ph.D., Founder of Corrixr and Executive Director of ChristianaCare’s Gene Editing Institute, who will continue to serve in his capacity as Chief Scientific Officer and will remain actively engaged in the company’s scientific direction.
“I'm excited to join Corrixr at this important juncture, to lead the company and drive this ground-breaking science forward into clinical development. Corrixr has built a rigorous preclinical foundation, a differentiated mechanism, and a clear path to the clinic,” Dr. Malone said. “We now have a tremendous opportunity to bring a potentially transformative treatment to thousands of patients suffering from head & neck, lung and esophageal squamous cell cancers - indications where patients and physicians have been waiting a long time for something truly effective. I’m looking forward to working with this great team to advance CXR101 into first-in-human trials and building Corrixr into the defining company in eliminating squamous cell cancers,” Dr. Malone added.
“Hilary’s appointment marks a critical step in our shared mission to bring a fundamentally new approach to patients with squamous cell cancers. Corrixr has built a compelling body of scientific evidence, and we believe Hilary has precisely the experience and vision to translate that science into the clinic and beyond. ChristianaCare is proud to be Corrixr’s founding institutional investor and partner, and we look forward to supporting the next chapter of this work,” said Janice E. Nevin, M.D. MPH, Chair of the Corrixr Board and President & CEO of ChristianaCare.
Corrixr is developing CXR101 to eliminate NRF2, a transcription factor constitutively hyperactive in squamous cell cancers, directly at its genetic source. Unlike small-molecule approaches that attempt to inhibit NRF2 protein activity, CXR101 acts upstream, disrupting the mechanism that sustains squamous cell tumor survival without the toxicity associated with systemic exposure. Using CRISPR-directed gene editing delivered locally via ionizable lipid nanoparticles, the approach collapses tumor survival, proliferation, immune evasion, and metabolic reprogramming in a single intervention.
About Hilary M. Malone, Ph.D.
Dr. Malone is a seasoned biotech CEO and drug development executive with a 25+ year career spanning global regulatory affairs, clinical and CMC development, and early-stage company leadership across small molecules, biologics, vaccines, and cell and gene therapies.
Most recently, she served as CEO of Stylus Medicine and, prior to that, as CEO of Certego Therapeutics. Her earlier career includes senior executive roles in major pharmaceutical companies, including Sanofi, where she served as Chief Regulatory Officer and Head of Global Regulatory Affairs; Reata Pharmaceuticals; Pfizer/Wyeth; AstraZeneca; and GSK. Dr. Malone also served as Chief Operating Officer, Therapeutics, at Valo Health.
Dr. Malone currently serves on the board of Hansa Biopharma and holds a Ph.D. in Neuropharmacology.
For more information, visit corrixr.com.
Hilary M. Malone, Ph.D., CEO, Corrixr Therapeutics, Inc.
LONDON (AP) — Britain’s interior minister accused activists of hijacking a tragedy to stir up violence after police were attacked at a protest over the death of a teenager who was handcuffed as he lay dying while his killer stood nearby.
Police were pelted with chairs, cans, rocks and flares late Tuesday by some of the hundreds who attended a protest in the southern English coast city of Southampton, where Henry Nowak was killed in December. Two people were arrested and 11 officers and a police dog were injured, police said.
Nowak's death has triggered debates about policing and knife crime and has spurred claims by far-right activists and politicians that there is bias against white people in the justice system.
Nowak’s killer, Vickrum Digwa, who is Sikh, falsely claimed he was the victim of a racist assault by 18-year-old Nowak, who was white. When police officers arrived, they initially treated the wounded man as a suspect before noticing his injury and trying to resuscitate him.
Prime Minister Keir Starmer said Wednesday that the case had left “serious questions to answer, including how accusations of racism informed police thinking." But he called the street violence “disgraceful and completely unacceptable.”
Home Secretary Shabana Mahmood said Nowak's family had "made a powerful call to us all yesterday to not let Henry’s death be used to create further division, hatred or tension.
“There can be no justification for hijacking this tragedy to stir up violence and disorder. Those responsible can expect to face the full force of the law,” she said.
Digwa, 23, was convicted of murder and sentenced Monday to life in prison with a minimum term of 21 years. The judge said he didn’t believe Nowak had said anything racist to his attacker.
After the sentencing, police released video showing officers dismissing Nowak when he told them he had been stabbed and repeatedly said he couldn’t breathe.
The Independent Office for Police Conduct, which investigates allegations of police wrongdoing, is probing the actions of the officers from the Hampshire and Isle of Wight Constabulary. The National Police Chiefs’ Council said it will review its anti-racism guidance in the wake of the killing.
After the sentencing hearing, the victim’s father, Mark Nowak, said the case was not about racism or religion, and that he wanted his son’s death to lead to safer streets and not to be used to create “further division, hatred or tension.”
But Nigel Farage, leader of the anti-immigration Reform UK party, said on Tuesday that it was an example of so-called two-tier policing — a popular far-right talking point that claims ethnic minorities are better treated than white people.
Farage urged people to respond to the incident with “pure cold rage,” and said, “white lives matter just as much as Black lives.” X owner Elon Musk and British far-right activist Stephen Yaxley-Lennon, known as Tommy Robinson, have also expressed outrage at the crime.
Some politicians have called for Sikhs to be banned from carrying ceremonial knives, known as kirpans. The judge said Digwa had a small kirpan but also had an 8-inch (21-centimeter) sheathed Sikh dagger that was used as the weapon to kill Nowak.
Hampshire Police chief constable Alexis Boon said he understood the “desire for answers and accountability.”
“But that must be done in the right way and not used as an excuse to threaten and intimidate my officers and bring violence to our streets, causing fear and harm to those living and working in Hampshire and the Isle of Wight,” he said.
People protest outside the police station in Southampton, England, on Tuesday, June 2, 2026, one holding a photo of December 2025 stabbing victim Henry Nowak, 18. (Gareth Fuller/PA via AP)
People gather to protest outside Southampton police station, Southampton, England, Tuesday June 2, 2026, after the fatal stabbing of Henry Nowak, a British teenager who was handcuffed despite claiming he was the crime victim. (Gareth Fuller/PA via AP)
In this image taken from PA Video, police and protestors clash during a protest following the death of Henry Nowak, a 18-year-old student stabbed to death with a Sikh kirpan ceremonial by Vickrum Digwa, in Southampton, England, Tuesday June 2, 2026. (Jamie Lashmar/PA via AP)
In this image taken from PA Video, police and protestors clash during a protest following the death of Henry Nowak, a 18-year-old student stabbed to death with a Sikh kirpan ceremonial by Vickrum Digwa, in Southampton, England, Tuesday June 2, 2026. (Jamie Lashmar/PA via AP)
In this image taken from PA Video, police and protestors clash during a protest following the death of Henry Nowak, a 18-year-old student stabbed to death with a Sikh kirpan ceremonial by Vickrum Digwa, in Southampton, England, Tuesday June 2, 2026. (Jamie Lashmar/PA via AP)
