Mets-Phillies start time moved, MLS game between Vancouver-Chicago ppd. due to wildfire smoke

PHILADELPHIA (AP) — The start time for the MLB game between the New York Mets and the Phillies on Thursday in Philadelphia was moved up an hour due to air quality concerns because of wildfire smoke from Canada and northern Minnesota, and an MLS game in Chicago was postponed.

Heavy, pungent wildfire smoke darkened skies in the U.S. from the Great Lakes to parts of the East Coast, reducing visibility and prompting warnings that breathing the air outside could be dangerous.

Officials in many cities urged residents to stay inside or wear masks outside as air quality reached unhealthy to hazardous levels, meaning it’s unhealthy for anyone, regardless of health conditions. The National Weather Service said a lingering high pressure system has trapped the smoke close to the ground.

The Philadelphia region is experiencing smoky and hazy skies. The game's start was moved to 6:10 p.m. EDT from 7:10 p.m. It is the only game on the big league schedule coming out of this week's All-Star break.

“It’s definitely different,” Phillies first baseman Bryce Harper said on ESPN, which is broadcasting the game. “Not the greatest idea, I guess, to come out here and play in this type of weather, but we’re doing it.”

This is the second time wildfire smoke has affected a game in Philadelphia. In June 2023, a game between Detroit and Philadelphia was postponed due to poor air quality related to smoke from Canadian wildfires.

Poor air quality due to wildfire smoke also forced the Major League Soccer game between the Vancouver Whitecaps and Fire at Chicago's Soldier Field, along with a scheduled postgame concert, to be postponed. The game, which was expected to draw 40,000, will be made up on Oct. 6.

Trinity Rodman, a member of the U.S. women's national team, said the smokey sky was difficult to deal with during Wednesday night's NWSL game between the Washington Spirit and Gotham FC at New York's Citi Field.

Rodman said she wasn't a fan of the hydration breaks every 15 minutes in the game as the temperature reached into the 90s.

“Air quality was rough,” Rodman was quoted as saying by The Athletic. “Not to make excuses at all, but I think on both sides we were all like, ‘another break, another break, another break.’”

A crowd of more than 42,000 attended the rematch of teams in last season's NWSL title game. The crowd was a record for a women’s sporting event in New York City.

“If we have to have a hydration break every 15 minutes, then we shouldn’t be playing the game, and that’s my opinion,” Rodman said. “But at the end of the day, there’s 40,000 people. It’s a whole event, so it’s really tough. It’s just a really hard situation for everyone to work around.”

AP sports: https://apnews.com/sports

People wear masks as they walk on the street during poor air quality due to dense smoke from Canadian wildfires in Evanston, Ill., Thursday, July 16, 2026. (AP Photo/Nam Y. Huh)

A general view of a street in Northbrook, Ill., during poor air quality due to dense smoke from Canadian wildfires in Northbrook, Ill., Thursday, July 16, 2026. (AP Photo/Nam Y. Huh)

A general view of street mall during poor air quality due to dense smoke from Canadian wildfires in Glenview, Ill., Thursday, July 16, 2026. (AP Photo/Nam Y. Huh) CORRECTION: Glenview, not Northbrook

WASHINGTON (AP) — The Food and Drug Administration has approved a first-of-its-kind pill that can drastically reduce cholesterol in a way that's previously only been available with expensive, injectable drugs.

The drug from Merck was OK'd on Thursday for patients with artery-clogging cholesterol that persists even after taking statins, the standard medications for cutting heart attack risk. Merck will market its pill under the brand name Lipfendra.

It's the first noninjectable medication that works by blocking a liver protein called PCSK9. That protein limits the body's ability to clear cholesterol from the blood, and biotech injectables targeting it have been available from Amgen and other drugmakers for more than a decade. But patient access has been stymied for years by high prices, insurance restrictions and limited prescribing by doctors.

Statins block some of the liver’s production of cholesterol and are the cornerstone of treatment. But even at the highest doses, many people need additional help lowering their LDL, or bad, cholesterol enough to meet medical guidelines.

Merck, which has headquarters in Rahway, New Jersey, won approval based on two studies in high-risk patients who added the company's pill to their standard treatment, including statins. In one study of 3,000 patients, those taking Lipfendra saw their levels of LDL cholesterol drop more than 55% after six months. In a second study, patients averaged a reduction of 59% compared with patients who received a dummy pill.

That benefit dropped only slightly over a year, and side effects — including dizziness and diarrhea — were similar between those taking the pill or a placebo, researchers found. One caveat: The pill must be taken on an empty stomach.

The FDA reviewed the drug under its program that promises ultra-fast reviews for promising medications that serve the public interest. The pathway was created by then-FDA chief Dr. Marty Makary, who resigned from the agency in May after months of pressure from drugmakers, patients and other outside groups.

Heart disease is the nation’s leading cause of death, and high LDL cholesterol, which causes plaque to build up in arteries, is a top risk factor for heart attacks and strokes. While an LDL level of 100 is considered fine for healthy people, doctors recommend lowering it to at least 70 once people develop high cholesterol or heart disease — and even lower for those at very high risk.

The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education and the Robert Wood Johnson Foundation. The AP is solely responsible for all content.

FILE - The logo for Merck appears above a trading post on the floor of the New York Stock Exchange, May 1, 2025. (AP Photo/Richard Drew, File)