WILMINGTON, Del.--(BUSINESS WIRE)--Sep 25, 2026--
InSilicoTrials, a cloud-based platform for AI and computational modeling and simulation in healthcare, today announced that it is a subawardee on a team led by Sage BioNetworks, which has received an award from the Advanced Research Projects Agency for Health (ARPA-H) under the Critical Illness Immunological Reprogramming and Control Point Learning Engine (CIRCLE) program.
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Critical illness, including severe infections, traumatic injuries and complications of chronic disease, often turns deadly when the body’s immune and inflammatory response spirals out of control and leads to organ failure. ARPA-H’s CIRCLE program aims to develop AI-driven, patient-specific digital twins that let clinicians track and modulate that response in real time, so they can intervene with greater precision and speed.
Within the TWIN-DECC project, InSilicoTrials will extend its existing in silico trials platform into a secure, regulatory-ready environment where digital twin models developed across the CIRCLE program can be tested, evaluated and combined. InSilicoTrials work will focus on automated credibility assessment of digital twin models (verification, validation and uncertainty quantification), co-simulation of mechanistic, AI and hybrid models, and in silico trials on validated digital cohorts, together with the FDA-ready documentation needed to move these tools toward clinical use.
We team with Sage BioNetworks to bring together expertise in AI and model evaluation, critical care, immunology and regulatory science.
" Years ago, when we set out to build technology capable of making computational models credible enough for real patients, this is exactly the kind of recognition we were working toward, " said Luca Emili, Executive Chairman of InSilicoTrials. " Being selected to bring that platform into ARPA-H's CIRCLE program, alongside Sage Bionetworks and this outstanding team, tells us that verification and validation of digital twins is no longer just an ambition — it is now part of one of the most advanced R&D efforts in the field. I could not be prouder of what our team, together with Sage Bionetworks, has achieved to earn this opportunity. "
“ Critical care is where the promise of digital twins meets its toughest test: decisions are made in hours, and every patient responds differently, ” said Mario Torchia, CEO of InSilicoTrials. “ We’re proud to contribute our platform to Sage BioNetworks’ team and to the CIRCLE program. Our goal is to help make sure these models are credible, rigorously validated and ready for the bedside. ”
“ A digital twin is only useful in the ICU if clinicians and regulators can trust it, ” said Dr. Vincenzo Carbone, Head of Research & Innovation at InSilicoTrials. “ By automating verification, validation and uncertainty quantification, and letting teams run in silico clinical trials on validated digital cohorts, we can speed up how quickly promising models are refined and assessed for real patients. ”
This project is funded, in whole or in part, by the Advanced Research Projects Agency for Health (ARPA-H) under the CIRCLE initiative. The views and conclusions contained herein are those of the authors and should not be interpreted as representing the official policies of ARPA-H or the U.S. Government.
About InSilicoTrials
InSilicoTrials is the simulation company founded by experts in life sciences, cybersecurity and digital innovation. Its platform uses AI and simulation to predict drug and medical device safety and efficacy, speed up R&D, and streamline clinical trials for pharmaceutical, biotech, medical device and research organizations. With a global network of more than 70 scientific partners and hundreds of integrated models, InSilicoTrials helps organizations modernize drug and device development.
Learn more at www.insilicotrials.com.
InSilicoTrials Joins ARPA-H CIRCLE Team
ADDIS ABABA, Ethiopia (AP) — Residents of the largest city in northern Ethiopia said they were living in fear Friday, with many reportedly trying to flee to other provinces to escape renewed fighting between federal troops and rebels opposed to Prime Minister Abiy Ahmed.
Some told The Associated Press that internet service was disrupted across parts of northern Ethiopia, and roads connecting the northernmost region of Tigray with the neighboring region of Afar had been closed to civilian traffic.
“There is an atmosphere of fear,” said Selam Fantay, who sells garlic in the market in the Tigrayan capital of Mekelle. “People are deeply concerned that the suspension of transport services signals the outbreak of renewed conflict.”
The AP could not independently verify the reported closures.
Hailay Meles, a businessman in Mekelle, said he was worried that the disruption of transport links could increase the cost of essential goods. “As long as this conflict persists, it will continue to drive up the prices of basic commodities,” Meles said.
Valerie Browning, a co-founder of the Afar Pastoralist Development Association, a humanitarian group, said many people were fleeing Tigray into Afar. She said explosions were heard overnight.
She said that “too many people are being displaced. Our vehicles, including our ambulances are being taken from us by the government for use (in) the war.”
The renewed fighting has shattered a 2022 peace agreement that ended a devastating two-year war in Tigray, the epicenter of renewed hostilities between federal troops and fighters loyal to the Tigray People’s Liberation Front.
The TPLF is an armed political group based in Tigray, and for years it was the dominant party in a coalition that ruled Ethiopia between 1991 and 2018. It has been outlawed by Abiy's government.
After the November 2022 peace agreement between the TPLF and federal authorities, a caretaker administration reporting to Abiy took charge in Mekelle. But tensions remained, and in May caretaker leader Tadesse Werede was removed and replaced with a TPLF leader who led Tigrayans in the 2020-2022 war.
Both sides accuse each other of violating the peace agreement. In recent months, Ethiopian federal authorities accused the TPLF of seeking to build an alliance with neighboring Eritrea to destabilize Ethiopia. The TPLF accused Ethiopian authorities of conducting drone attacks in Tigray.
Neighboring Eritrea, whose soldiers fought alongside Ethiopian troops in the previous Tigray conflict, said it was alarmed by Abiy’s repeated assertions of his wish for sovereign access to the Red Sea via Eritrea.
Ethiopia’s military said Thursday that dozens of TPLF fighters had been killed in ongoing operations. It said other fighters were detained and that federal forces have seized weapons.
Air travel into the region was suspended this week after fighters loyal to the TPLF seized Mekelle’s airport from federal police. Ethiopian Airlines canceled flights to and from the region.
Fighting erupted days after seven opposition groups said they were banding together in a coalition in a bid to remove the recently reelected Prosperity Party government of Abiy.
Magnus Taylor, an analyst with International Crisis Group, said the new alliance combines political opposition to Abiy with military coordination among armed groups operating in different parts of Ethiopia.
The alliance “is a combination of a political alliance based around mutual antipathy to Abiy Ahmed’s government and also a kind of opportunistic military alliance intended to threaten the Ethiopian military in the areas where the groups operate,” Taylor said.
In addition to the TPLF, the coalition’s other prominent members include the Amhara Fano National Movement and the Oromo Liberation Army.
Taylor pointed out that coordinated campaigns could open several fronts against the federal government.
“I think there is a real risk that the fighting could spread around the country,” he said, adding that the opposition alliance meant different armed groups can coordinate to “develop campaigns against the federal government in parallel to each other.”
People walk in Mekelle, the capital of Ethiopia's Tigray region, as fighting escalates with the central government, Thursday, Sept. 24, 2026. (AP Photo)
People walk in Mekelle, the capital of Ethiopia's Tigray region, as fighting escalates with the central government, Thursday, Sept. 24, 2026. (AP Photo)
