PROVIDENCIALES, Turks & Caicos Islands, Oct. 12, 2026 /PRNewswire/ -- KuCoin, a leading global crypto platform built on trust, today unveiled KuCoin 5.0, a comprehensive platform upgrade designed to make trust tangible across the way users trade, manage assets and interact with the platform.
KuCoin 5.0 is the product expression of the global brand initiative "Trust, Built-in." Introduced under KuCoin's enduring "Trust First. Trade Next." proposition, the upgrade spans six areas—Compliance, Technology, Assets, Experience, AI and Wealth Management—bringing them together around a more unified, efficient and user-centered platform experience rather than centering on a single feature.
Among the most visible changes in KuCoin 5.0 are a redesigned experience that creates clearer paths for different types of users; an AI service layer that extends across the platform; and more flexible ways to trade, manage and put assets to work. Underneath these user-facing changes, KuCoin is also strengthening the technology, compliance and asset foundations that support the platform as it continues to evolve.
A Clearer, More Inclusive Experience
KuCoin 5.0 makes everyday use of the platform clearer and more flexible. Profile Center 2.0 introduces a cleaner visual design and a card-based layout that makes information and frequently used functions easier to find. The upgraded sub-account system streamlines account creation, strengthens security controls and improves sub-account management. Enhanced K-line charts offer more practical tools and real-time data, with settings that sync across devices to help users follow the market more efficiently.
KuCoin 5.0 also introduces a color vision accessibility mode, making charts and other visual information easier to distinguish for users with different color vision needs. An estimated 360 million people worldwide experience some degree of difficulty distinguishing colors. By offering a clearer visual experience, KuCoin aims to make the platform more accessible to more users. The Lite and Pro experiences offer paths suited to different levels of familiarity and trading needs.
For users with more advanced trading needs, KuCoin 5.0 introduces the Unified Trading Account (UTA), now available to eligible KuCoin users at VIP1 and above. UTA brings spot, margin and futures trading into a shared framework for funds, margin and risk management. This reduces the need to transfer funds between separate accounts and supports more efficient use of capital across eligible products.
AI That Extends Across the User Journey
KuCoin 5.0 introduces a major upgrade to AI Assistant 5.0, creating a unified AI entry point that brings together conversations, Q&A and task completion across the platform. Spanning market insights, Earn, trading, customer support and campaigns, the assistant uses page context and user actions to better understand what users need, recommend relevant services and help them complete tasks.
Making Assets Work More Efficiently
KuCoin 5.0 connects earning and trading more closely through exclusive wealth management products and benefits for VIP users, Earn access through sub-accounts, and support for selected wealth assets within the Unified Trading Account framework. Main accounts and sub-accounts can participate in Earn while managing funds separately, while KCUSD can be used as margin within the Unified Trading Account, reducing the need to move funds repeatedly between earning and trading activities.
These user-facing changes are supported by continued development across KuCoin's Compliance, Technology and Assets foundations. Together, the six upgrade areas form a platform designed to remain straightforward where possible and provide greater control where needed.
"Trust should be something users can experience in every interaction—not only in how their assets are protected, but in how clearly, reliably and efficiently the platform works," said BC Wong, CEO of KuCoin. "KuCoin 5.0 is an important step in translating our long-term commitment to trust into the product itself. By bringing our core capabilities into a more connected, intuitive and intelligent platform, we are giving users greater confidence and control today while building the foundation for the next stage of digital finance."
KuCoin 5.0 establishes the foundation for the platform's next phase of development. By connecting trading, asset management and intelligent services through a clearer experience, KuCoin is building a platform designed for how users participate today and how digital finance will continue to evolve.
About KuCoin
Founded in 2017, KuCoin is a leading global crypto platform built on trust and security, serving over 45 million users across 200+ countries and regions. Known for its reliability and user-first approach, the platform builds trust into every layer of the user experience, combining advanced technology, deep liquidity, and strong security safeguards to deliver a seamless trading experience. KuCoin provides access to 1,000+ digital assets through a broad product suite and remains committed to building a compliant and user-centric ecosystem for the future of finance, backed by SOC 2 Type II, ISO/IEC 27001:2022, ISO/IEC 27701:2019, ISO 22301:2019 and ISO/IEC 42001:2023 certifications. In recent years, KuCoin has continued to strengthen its global compliance foundation, marked by key milestones including AUSTRAC registration in Australia, a MiCA license in Europe, and regulatory progress in other markets.
Learn more at www.kucoin.com.
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KuCoin Unveils 5.0, Building Trust into Every Layer of the User Experience
BEIJING, Oct. 12, 2026 /PRNewswire/ -- T-MAXIMUM PHARMACEUTICAL ("T-MAXIMUM") today announced that the U.S. Food and Drug Administration (FDA) has cleared the company to initiate a Phase 2 clinical study of MT027, its internally developed, B7-H3-targeted universal (allogeneic) CAR-T therapy, for the treatment of patients with brain metastases from lung cancer and breast cancer.
This is the second Phase 2 study of MT027 to receive FDA clearance. MT027 was previously cleared by the FDA to proceed with a Phase 2 study in recurrent glioblastoma, and has been granted Orphan Drug Designation (ODD) and Fast Track Designation (FTD). With two FDA-cleared Phase 2 programs, T-MAXIMUM has established a dual-indication portfolio for universal CAR-T therapy covering both primary and metastatic intracranial solid tumors.
Brain Metastases: An Unanswered Clinical Question Despite Advances in Systemic Therapy
Brain metastases commonly arise in patients with lung cancer, breast cancer, melanoma, renal cell carcinoma, and colorectal cancer. International studies estimate that approximately 20% of cancer patients may develop brain metastases over the course of their disease, a proportion that can reach 20% to 40% among patients with advanced solid tumors.[1][2] For patients, this means far more than an additional lesion on imaging: brain metastases may be accompanied by headaches, seizures, and cognitive and motor impairment, directly affecting daily life and subsequent treatment options.
This is a truly global clinical challenge. In 2022, there were nearly 20 million new cancer cases worldwide, including nearly 2.5 million new cases of lung cancer and approximately 2.3 million new cases of female breast cancer – the two leading primary tumor types giving rise to brain metastases.[3] Asia accounts for roughly half of all new cancer cases globally;[4] in the United States, an estimated 200,000 to 300,000 patients are newly diagnosed with brain metastases each year.[2] This large patient population means brain metastasis is not a niche need, but a question that oncology worldwide must continue to answer.
Systemic therapies can help control disease throughout the body, but treatment of intracranial lesions often remains constrained by multiple factors, including the blood-brain barrier, tumor heterogeneity, and the need to preserve neurological function. This is especially true for patients who experience intracranial progression after prior therapy, for whom there remains a need for more treatment options that are validated intracranially while balancing safety and accessibility.
Consecutive Clinical Milestones Built on Long-Term Product and Translational Groundwork
MT027's recent series of regulatory milestones is no coincidence. It reflects an integrated capability across product, manufacturing, clinical development, and regulatory affairs built around intracranial solid tumors – one that is now advancing from early exploration toward more systematic clinical validation.
First, a foundation of clinical data. The company has accumulated sustained clinical experience in local delivery, repeat dosing, and safety monitoring for intracranial solid tumors. Years of clinical experience and data with MT027 have already led to two FDA-cleared Phase 2 programs. Data from an investigator-initiated trial (IIT) of MT026, a program built on the same platform, were published in Nature Communications in 2026: among 5 patients with recurrent high-grade glioma, 1 complete response and 3 partial responses were observed, for an objective response rate (ORR) of 80%, with no treatment-related Grade 3 or higher adverse events.
Early clinical data for MT027 in patients with refractory brain metastases from lung cancer were previously presented at the IASLC 2026 World Conference on Lung Cancer (WCLC 2026). Five heavily pretreated patients with no guideline-recommended subsequent treatment options completed treatment; among the 3 evaluable patients, 2 partial responses were observed. The safety profile was favorable, with no Grade 3 or higher adverse events and no graft-versus-host disease (GvHD). These rigorous exploratory clinical studies provide an important basis for the clinical translation of allogeneic, locally delivered CAR-T therapy in intracranial solid tumors.
Second, a well-defined manufacturing process. MT027 is manufactured using a fully non-viral gene-editing process – a generational departure from the industry's mainstream lentiviral vector approach – offering potential advantages in product safety, batch-to-batch consistency, and cost control. The manufacturing process was established and locked prior to entering Phase 2 clinical development.
Third, leadership measured not only by getting there first, but by advancing systematically. For an innovative cell therapy company, leadership in regulatory progress comes from coordinated advancement across product, manufacturing, clinical development, and regulatory strategy. MT027's consecutive entry into FDA-cleared Phase 2 clinical development demonstrates T-MAXIMUM's ability to translate its prior groundwork into a repeatable and scalable clinical development capability.
Management Commentary
"Receiving FDA clearance for two consecutive Phase 2 studies of MT027 marks a pivotal step built on our sustained work in intracranial solid tumors. From glioma to brain metastases, we have always let the data speak and put clinical value first. Going forward, we will continue to rigorously evaluate the product's safety and potential clinical value through well-designed clinical studies, steadily advancing product supply, clinical execution, and the generation of key data, as we explore new possibilities for patients who lack effective treatment options."
About MT027
MT027 is an investigational, B7-H3-targeted universal (allogeneic) CAR-T cell therapy developed by T-MAXIMUM using a fully non-viral gene-editing process and administered via local intracranial delivery. MT027 has received FDA Orphan Drug Designation and Fast Track Designation and is being evaluated in FDA-cleared Phase 2 studies in recurrent glioblastoma and in brain metastases from lung cancer and breast cancer.
About T-MAXIMUM PHARMACEUTICAL
T-MAXIMUM PHARMACEUTICAL is a clinical-stage cell therapy company focused on developing universal (allogeneic) CAR-T therapies for intracranial solid tumors with high unmet medical need, including recurrent glioblastoma and brain metastases. Through engineered cell therapies, local delivery strategies, and clinical translation capabilities, the Company is advancing more accessible treatment approaches with the potential to support repeat dosing. Its lead program, MT027, is a B7-H3-targeted universal CAR-T therapy that has received FDA clearance to initiate Phase 2 clinical studies in recurrent glioblastoma and brain metastases. MT027 has also received Orphan Drug Designation (ODD) in high-grade glioma and Fast Track Designation (FTD) for recurrent or progressive glioblastoma. T-MAXIMUM is working to translate its accumulated capabilities in product development, manufacturing, and clinical execution into continued innovation across both primary and metastatic intracranial solid tumors, with the goal of creating new possibilities for patients with limited treatment options.
Forward-Looking Statements
This press release contains forward-looking statements, including statements regarding the clinical development, potential therapeutic benefits, manufacturing advantages, and regulatory progress of MT027 and other product candidates. These statements are based on current expectations and are subject to risks and uncertainties, including those inherent in clinical development, regulatory review, and manufacturing, that could cause actual results to differ materially. Early clinical results from small numbers of patients may not be predictive of results in larger studies. MT027 is an investigational product, and its safety and efficacy have not been established. T-MAXIMUM undertakes no obligation to update any forward-looking statement, except as required by law.
References
| [1] Achrol AS, et al. Brain metastases. Nature Reviews Disease Primers. 2019;5:5. DOI: 10.1038/s41572-018-0055-y |
| [2] Moravan MJ, et al. Current multidisciplinary management of brain metastases. Cancer. 2020;126:1390-1406. DOI: 10.1002/cncr.32714 |
| [3] Bray F, et al. Global cancer statistics 2022. CA Cancer J Clin. 2024. DOI: 10.3322/caac.21834; IARC GLOBOCAN 2022 |
| [4] Current and future burden of breast cancer in Asia: A GLOBOCAN data analysis for 2022 and 2050. 2024 |
[1] Achrol AS, et al. Brain metastases. Nature Reviews Disease Primers. 2019;5:5. DOI: 10.1038/s41572-018-0055-y
[2] Moravan MJ, et al. Current multidisciplinary management of brain metastases. Cancer. 2020;126:1390-1406. DOI: 10.1002/cncr.32714
[3] Bray F, et al. Global cancer statistics 2022. CA Cancer J Clin. 2024. DOI: 10.3322/caac.21834; IARC GLOBOCAN 2022
[4] Current and future burden of breast cancer in Asia: A GLOBOCAN data analysis for 2022 and 2050. 2024
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T-MAXIMUM's B7-H3-Targeted Allogeneic CAR-T MT027 Receives FDA Clearance for Phase 2 Study in Brain Metastases from Lung and Breast Cancer
