- LIPSIA-STRATEGY evaluated whether revascularization guided by angiography-based FFR using CAAS vFFR (vessel Fractional Flow Reserve), delivers clinical outcomes comparable to guidance by pressure wire-based FFR.
- Conclusive trial results provide further randomized clinical evidence validating CAAS vFFR as a safe and effective alternative for wire-based physiology-guided revascularization.
- Results independently confirm the findings of FAST III, demonstrating comparable clinical outcomes while enabling a faster, less invasive workflow with lower radiation exposure, ultimately benefiting both caregivers and patients.
MAASTRICHT, Netherlands, Nov. 3, 2026 /PRNewswire/ -- Pie Medical Imaging, a global leader in cardiovascular image analysis solutions, announces the results of the LIPSIA-STRATEGY trial, presented during the Late-Breaking Clinical Trials session at the Transcatheter Cardiovascular Therapeutics (TCT) 2026 congress and simultaneously published in the Journal of the American College of Cardiology (JACC). The trial demonstrated non-inferiority of revascularization guided by angiography-derived CAAS vFFR compared with revascularization guided by conventional pressure wire-based FFR.
LIPSIA-STRATEGY is an investigator-initiated, multicenter, randomized clinical trial involving 1,053 patients with intermediate coronary artery stenoses. The study was designed to evaluate whether coronary revascularization guided by angiography-derived CAAS vFFR could deliver clinical outcomes comparable to those achieved with conventional pressure wire-based FFR. Patients were randomized to either a vFFR-guided or FFR-guided treatment strategy, with 1-year major adverse cardiovascular events (MACE) serving as the primary endpoint.
Under the leadership of Prof. Dr. med. Holger Thiele, Heart Center Leipzig at Leipzig University, together with the investigators and participating study centers, the trial successfully met its primary endpoint, demonstrating non-inferior clinical outcomes for the CAAS vFFR-guided treatment strategy.
"Angiography-based FFR measurement is easier than wire-based FFR with similar clinical outcome. Thus, this should become the new standard for intermediate coronary artery stenoses." Said Prof. Dr. med. Holger Thiele.
Bas Kuppens, CEO of Pie Medical Imaging, added "LIPSIA-STRATEGY reinforces the findings of FAST III, adding to the clinical evidence for CAAS vFFR and further strengthening confidence in our angiography-based physiology solution. Together with a less invasive workflow, shorter procedure time and shorter fluoroscopy time, these results bring us another step closer to making physiology-guided decision-making more accessible across the PCI pathway, from diagnostic assessment and treatment planning to post-procedural evaluation. "
About Pie Medical Imaging
Pie Medical Imaging is a global leader in advanced cardiovascular image analysis, quantification and visualization. Based in Maastricht, The Netherlands, the company oversees worldwide innovation and commercialization of the CAAS and 3mensio product lines. With decades of expertise and deep commitment to innovation, Pie Medical Imaging delivers software solutions that empower clinicians, researchers, and industry partners to enhance diagnosis, procedure planning, and image‑guided interventions.
The company complies with international quality and regulatory standards, ensuring high reliability and clinical confidence.
Pie Medical Imaging is part of the Esaote Group, a leader in the biomedical equipment sector.
More information about Pie Medical Imaging is available at www.piemedicalimaging.com.
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LIPSIA-STRATEGY trial demonstrates non-inferiority of CAAS vFFR guided revascularization against pressure wire-based FFR revascularization
Latest RECMA Diagnostics Report sees OM agency OMD scoring its 12th consecutive #1 ranking, with PHD and Initiative ranked in the top five
NEW YORK, Nov. 3, 2026 /PRNewswire/ -- In the latest edition of the Network Diagnostics report from RECMA (Research Company Evaluating the Media Agency Industry), Omnicom Media, an Omnicom (NYSE: OMC) Connected Capability, has again been named the best performing global media group, topping both the global ranking as well as the regional rankings across North America, EMEA, APAC and LATAM. This marks the second consecutive report in which Omnicom Media has topped the Network Diagnostics report's global and regional rankings.
As RECMA notes in its report, Omnicom Media "is emerging as the new industry powerhouse." The leader in Activity Volume/Billings with approximately 30% industry share, Omnicom Media also leads this Diagnostic Report with just under 35% of quali-share.
Widely considered the most comprehensive report for analyzing media agency performance, the bi-annual RECMA Diagnostics report is based on the evaluation of approximately 700 agencies in 45 markets. Utilizing 19 KPIs to evaluate vitality and structure, the report offers an assessment index that goes beyond typical quantitative metrics such as new business wins or billings volume alone to also consider criteria such as client portfolio and relationship stability; digital, data & content resources; and homogeneity across geographies. Participating agencies are ranked both numerically by "quali-points" and by the following profiles: Dominant, High Profile, Very Good Profile, Good Profile, and Average Profile.
The Dominant profile is awarded in a market where an agency significantly outperforms its competitors across multiple Diagnostic criteria. In the current report, Omnicom Media agency brands were dominant in 19 markets - more than any other media group – encompassing all four regions.
"These results are a powerful validation that our Growth by Design strategy - built on the simple premise of bringing together our singular advantages in scale, data, identity, commerce, and talent to create a competitive advantage for our clients – is working," says Omnicom Media CEO Florian Adamski. "Leading RECMA's global and all four regional rankings for the second consecutive time since the integration of Omnicom and IPG's media groups, and with three agencies among the global top five, demonstrates the strength of our connected capabilities and our ability to consistent translate them into outsize growth for the world's leading brands."
The RECMA ranking lands amidst a winning streak for Omnicom Media, which in October alone won the media business for The Coca-Cola Company in North America; grocery retailer Lidl across Europe; the global assignment for Lavazza coffee; The British Council; and the L'Oréal business in the DACH region. Adding this 30-day sprint to a 2026 global and regional win record that already included Adidas, Aviva, CVS, Delta, Dyson, IBM, Novo Nordisk, Uber, and Xiaomi brings Omnicom Media's YTD total to approximately US$10 billion in billings won or retained through competitive pitches, more than any other holding company.
Omnicom Media Agencies Dominant the Top Five
Three Omnicom Media agencies - OMD, PHD and Initiative - were among the top five best performing global media agencies, with OMD topping the ranking for the 12th consecutive report.
OMD also stood out as the most balanced agency in terms of performance across the 45 countries studied, ranked as Dominant or High Profile in 29 markets (65% of those evaluated); and was ranked #1 globally for both Digiday Data & Content Experts and its Client Portfolio Profile, which shows very good relationship stability across a roster that includes both major international accounts and a strong local client base.
Hearts United - OM's newly launched agency that brought together Hearts & Science and Mediahub – and PHD were both among the agencies that showed the greatest increase in quali-share scores since the last report as well as over a three-year window, with Hearts United topping this ranking and PHD close behind at #3.
Noting the positive impact that Omnicom's acquisition of IPG has had on the OM agency portfolio, RECMA notes, "all of the group's agencies are benefiting from the advantages in this evaluation, particularly the integration of data and digital specialist units."
Says Adamski, "RECMA's findings underscore the value of what we are building together. The integration of our data and digital specialists, combined with the depth of talent and expertise across our agency portfolio, is creating capabilities that are greater than the sum of their parts. We have the scale to shape the marketplace, the intelligence to make better decisions and the talent to turn those advantages into results. That positions Omnicom Media not simply to lead today's industry, but to help define what the next generation of media looks like."
"Ultimately, the value of our combined capabilities is measured by what they make possible for our clients," says Adamski. By connecting data, identity, commerce, technology, and talent across our business, we can give clients a more complete view of their opportunities, make better investment decisions and turn those decisions into stronger business outcomes. The advantage is not simply the scale of what we bring together, but how we put it to work to help our clients grow, compete, and stay ahead in an increasingly complex marketplace."
CONTACT: isabelle.gauvry@omc.com
ABOUT OMNICOM MEDIA
Omnicom Media, an Omnicom (NYSE: OMC) Connected Capability, is the world's largest global media management network. Powered by the Omni Intelligence Platform, Omnicom Media agencies leverage $75.6 billion in billings, 47,000 specialists across 70+ markets, and the industry's most powerful portfolio identity, commerce, and intelligence assets to design dynamic Growth Ecosystems that enable the world's most ambitious businesses to grow faster and smarter. The Omnicom Media portfolio includes global media agency brands OMD, PHD, Initiative, Hearts United, and UM; core Omnicom Integrated Media offerings Acxiom, the world's premier identity solution, and the Flywheel end-to-end commerce solution; and specialty services across the cloud consulting, creator, financial, healthcare, and sports & entertainment categories. For more information visit omnicommedia.com
About RECMA
RECMA was founded in June 1991 in Paris and is the only global research company that evaluates and rates media agencies qualitatively and quantitatively. RECMA is the leading research company producing a wide range of rankings and reports dedicated to the media industry professionals. RECMA collects and analyzes data from more than 1000 media agencies in 70 countries. For more information visit recma.com.
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Omnicom Media Again Named Best Performing Global Media Group, Earns #1 Ranking Across All Four Regions
Omnicom Media Again Named Best Performing Global Media Group, Earns #1 Ranking Across All Four Regions
Omnicom Media Again Named Best Performing Global Media Group, Earns #1 Ranking Across All Four Regions
Omnicom Media Again Named Best Performing Global Media Group, Earns #1 Ranking Across All Four Regions
