The male Javan warty pig has been dubbed the 'world’s ugliest pig'. But they are in danger now and are in need of equal protection.
Javan warty pigs, a native species to the Indonesian islands, were listed as endangered on the International Union for the Conservation of Nature Red List in 1996. Javan warty pigs didn't receive much attention due to their striking appearance.
They are suffering from the danger of dying out. Deforestation from agriculture and urbanization has fractured their habitat, which leads to the decrease of their numbers. Hunting and cross-breeding are also problems for these pigs.
In the past few years, there were researchers tried to estimate the number of these pigs on Indonesian Island, the result has turned out to be sad: researchers believe that creatures had already gone regionally extinct.
The researchers hope that by better understanding the creatures’ population size the better they can protect them.
WASHINGTON (AP) — The first clinical trial is getting underway to see if transplanting pig kidneys into people might really save lives.
United Therapeutics, a producer of gene-edited pig kidneys, announced Monday that the study’s initial transplant was performed successfully at NYU Langone Health.
It’s the latest step in the quest for animal-to-human transplants. A second U.S. company, eGenesis, is preparing to begin its own pig kidney clinical trial in the coming months. These are the first known clinical trials of what is called xenotransplantation in the world.
To protect the study participant’s identity, researchers aren’t releasing information about when the NYU surgery was performed or further patient information.
NYU's Dr. Robert Montgomery, who led the transplant team, told The Associated Press his hospital has a list of other patients interested in joining the small trial, which will initially include six people. If all goes well, it could be expanded to up to 50 as additional transplant centers join.
The Food and Drug Administration is allowing the rigorous studies after a series of so-called “compassionate use” experiments, with mixed results. The first two gene-edited pig kidney transplants were short-lived.
Then doctors began working with patients who badly needed a kidney but weren't as sick as prior recipients. At NYU, an Alabama woman’s pig kidney lasted 130 days before she had to return to dialysis. The latest record, 271 days, was set by a New Hampshire man transplanted at Massachusetts General Hospital; he also is back on dialysis after the pig organ began declining and was removed last month. Others known to be living with a pig kidney are another Mass General patient and a woman in China.
“This thing is moving in the right direction" as doctors learn from each patient's experience, NYU's Montgomery said. He noted the ability to resume dialysis also gives a safety net.
More than 100,000 people, most needing kidneys, are on the U.S. transplant list, and thousands die waiting. As a potential alternative, scientists are genetically altering pigs so their organs are more humanlike, less likely to be immediately attacked and destroyed by people’s immune system.
United Therapeutics' trial is testing pig kidneys with 10 gene edits, “knocking out” pig genes that trigger early rejection and excessive organ grown and adding some human genes to improve compatibility.
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FILE - Surgeons at NYU Langone Health prepare to transplant a pig's kidney into a brain-dead man in New York on July 14, 2023. (AP Photo/Shelby Lum, File)
