AstraZeneca pulls its COVID-19 vaccine from the European market

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AstraZeneca pulls its COVID-19 vaccine from the European market

2024-05-09 08:28 Last Updated At：14:16

LONDON (AP) — The pharma giant AstraZeneca has requested that the European authorization for its COVID-19 vaccine be pulled, according to the EU medicines regulator.

In an update on the European Medicines Agency's website Wednesday, the regulator said that the approval for AstraZeneca's Vaxzevria had been withdrawn “at the request of the marketing authorization holder.”

AstraZeneca's COVID-19 vaccine was first given the nod by the EMA in January 2021. Within weeks, however, concerns grew about the vaccine's safety, when dozens of countries suspended the vaccine's use after unusual but rare blood clots were detected in a small number of immunized people. The EU regulator concluded AstraZeneca's shot didn't raise the overall risk of clots, but doubts remained.

Partial results from its first major trial — which Britain used to authorize the vaccine — were clouded by a manufacturing mistake that researchers didn’t immediately acknowledge. Insufficient data about how well the vaccine protected older people led some countries to initially restrict its use to younger populations before reversing course.

Billions of doses of the AstraZeneca vaccine were distributed to poorer countries through a U.N.-coordinated program, as it was cheaper and easier to produce and distribute. But studies later suggested that the pricier messenger RNA vaccines made by Pfizer-BioNTech and Moderna provided better protection against COVID-19 and its many variants, and most countries switched to those shots.

The U.K.'s national coronavirus immunization program in 2021 heavily relied on AstraZeneca's vaccine, which was largely developed by scientists at Oxford University with significant financial government support. But even Britain later resorted to buying the mRNA vaccines for its COVID booster vaccination programs and the AstraZeneca vaccine is now rarely used globally.

The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Science and Educational Media Group. The AP is solely responsible for all content.

John Krasinski’s ‘IF’ hits a box office nerve with $35 million debut

2024-05-20 00:34 Last Updated At：00:51

John Krasinski’s imaginary friends movie “IF” claimed the top spot at the box office this weekend according to studio estimates Sunday. Its $35 million North American debut was also a bit lower than some projections.

Is that a disappointment? An ominous sign of the box office times? Or is the final story on “ IF " yet to be written? It's not just your imagination: In these bumpy early weeks of the 2024 summer box office season, in which nothing has been a runaway hit and every new movie has more and more pressure to succeed, “IF” hit a nerve.

Starring Ryan Reynolds, Cailey Fleming, and an army of A-list voices including Steve Carell, Matt Damon, Emily Blunt, Louis Gossett Jr., Phoebe Waller-Bridge and Maya Rudolph, “IF” was an original idea from Krasinski, who wrote, directed and co-stars.

Paramount debuted the film, which cost a reported $110 million to produce, in 4,041 locations in North America. Internationally, it earned an estimated $20 million from 56 markets, adding up to a $55 million global debut.

“Families came out in force and they loved the film,” said Chris Aronson, who heads Paramount’s domestic distribution.

There are several somewhat contradictory narratives swirling around its performance as well. With its PG-rating, “IF” was the first major family friendly film to open in theaters in weeks. And unlike a front-loaded superhero or horror movie, family pics are often running a marathon not a sprint. Last June, Pixar’s “Elemental” was assumed to be dead on arrival when it opened with $29.5 million domestically. But it continued earning throughout the summer and ultimately made nearly $500 million globally.

“IF” got middling reviews from critics (it's currently sitting at a “rotten” 49% on Rotten Tomatoes), but, as with “Elemental,” audiences gave it a solid A CinemaScore this weekend. The studio considers it a successful debut and is optimistic about its longevity as summer actually begins for school age children.

“I think it bodes well for moviegoing in general as we move into the summer movie season," Aronson said. "Kids are out of school starting this coming week and I couldn’t think of a better film to be in the marketplace than this one: It’s new, it’s fresh, its original, and it’s such a heartwarming film.”

“ Kingdom of the Planet of the Apes ” continues to be a bright spot. In just 10 days, it surpassed $100 million domestically and $237 million globally. It came in second place in its second weekend with $26 million (down 55%).

But there also hasn’t been a major movie moment akin to last year’s “The Super Mario Bros. Movie,” “Barbie” or “Oppenheimer” in quite some time. Last year on this weekend “Fast X” opened to over $60 million.

“This is a very unusual summer. It got off to an unusual start without a Marvel movie," said Paul Dergarabedian, the senior media analyst for Comscore. “The box office has been in a holding pattern 20% down from last year.”

“IF” wasn’t the only new film to open this weekend either. Lionsgate’s horror “The Strangers—Chapter 1” overperformed with a $12 million debut from 2,856 locations. The innovative marketing campaign staged some viral moments by bringing the “strangers” to major events, from the Trump trial to Coachella.

The Amy Winehouse biopic “ Back to Black " opened in North America to an estimated $2.9 million from 2,010 screens.

The filmed-for-IMAX documentary “ The Blue Angels ” also made $1.3 million this weekend from 227 screens. It’s playing on the premium large format screens through May 22 before flying to Prime Video on May 23.

The summer, which for Hollywood begins the first weekend in May, is still getting started and could rev up next weekend with the infusion of “Furiosa: A Mad Max Saga” and “The Garfield Movie."

Dergarabedian noted that Memorial Day weekend is a time when moviegoers play can play catch up with films they've missed and heard about. For a film like “IF," which picked up over the weekend with word of mouth buzz, that could bode well. Still, there is no sugar-coating the reality that the 2024 box office is not going to build on 2023.

"On almost every level this is a non-traditional summer in the lineup of films and the trajectory of the box office," Dergarbedian said. “But collectively these films should have a solid Memorial weekend.”

Estimated ticket sales for Friday through Sunday at U.S. and Canadian theaters, according to Comscore. Final domestic figures will be released Monday.

1. “IF,” $35 million.

2. “Kingdom of hte Planet of the Apes,” $26 million.

3. “The Strangers—Chapter 1,” $12 million.

4. “The Fall Guy,” $8.5 million.

5. “Challengers,” $2.9 million.

6. “Back to Black,” $2.9 million.

7. “Tarot,” 2 million.

8. “Godzilla x Kong: The New Empire,” $1.7 million.

9. “The Blue Angels,” $1.3 million.

10. “Unsung Hero,” $1.1 million.