SHANGHAI, Sept. 19, 2024 /PRNewswire/ -- Abbisko Therapeutics (HKEX: 02256) is excited to announce the receipt of the ESMO 2024 Best Poster Award on September 16, 2024. The award was received for the presentation titled "Updated Safety and Efficacy of Irpagratinib (ABSK011) in advanced hepatocellular carcinoma (aHCC) with FGF19 overexpression from a Phase 1 study". The update data from ABSK-011-101 study showed a tolerable safety profile and promising anti-tumor activity of Irpagratinib monotherapy in aHCC. Of note, in aHCC patients who were pretreated with both immune checkpoint inhibitor (ICI) and Tyrosine Kinase Inhibitor (TKI)—a population with high unmet need in the current treatment paradigm—the observed ORR and DCR was 44.8% and 79.3%, respectively, with a median duration of response (mDoR) of 7.4 months and median progression free survival (mPFS) of 5.5 months.
The poster, #983P, was presented at the Hepatocellular Carcinoma poster session on Sunday, September 16, 2024. The Best Poster Award was given at the conclusion of the Sunday Poster Session, with only one recipient being honored in HCC poster session.
As of September 5, 2024, 122 patients have been enrolled, including 74 in the BID cohort with doses consisting of 160mg BID, 220mg BID, and 300mg BID. 5.4% of patients were BCLC Stage B, and 89.2% BCLC Stage C, 64.9% had a Child-Pugh (CP) Score of 5, 27% CP Score of 6, and 6.8% CP Score of 7. 64.9% of patients received multiple lines of prior therapy, 85.1% of patients had previously been treated with ICIs, and 75.7% of patients had previously been treated with both ICIs and mTKIs.
The efficacy data show that forty pre-treated HCC patients with FGF19 overexpression were treated with irpagratinib 220 mg BID. Among the 38 evaluable patients, the response rate was 36.8% (14/38), and the disease control rate (DCR) was 78.9% (30/38). The response rate from the subset of patients who had previously received ICI and mTKI therapy was 44.8% (13/29). The longest observed DoR was 16.4 months and the mDoR was 7.4 months. DCR was 79.3% (23/29). mPFS was 5.5 months.
Safety data show one dose-limiting toxicity (DLT) was observed in the 300 mg BID cohort. The most common treatment-related adverse effects (TRAEs, >20%) were ALT elevation, diarrhea, AST elevation, hyperphosphatemia, bilirubin elevation, alkaline phosphatase elevation, platelet decrease, and total bile acid elevation. Grade 3-4 treatment-related adverse events (>5%) included AST elevation, ALT elevation, and diarrhea. No grade 5 adverse events occurred.
HCC is the main type of liver cancer, accounting for 85% to 90% of primary liver cancers. HCC is highly malignant, about 30% of which have abnormally high FGFR4 expression and a poor prognosis, and the existing treatment methods still cannot meet the long-term survival benefits. Currently, there is no approved standard of care for HCC patients who have progressed from first-line ICI-based therapies. The FGF19/FGFR4 signaling axis could be a novel therapeutic target for HCC. ABSK-011, a potent FGFR4 inhibitor, demonstrated a tolerable safety profile and promising anti-tumor activity as a single agent. Notably, the irpagratinib 220mg BID regimen exhibited a 44.8% ORR, 7.4 months mDoR and 5.5 months mPFS in heavily pre-treated HCC patients who had received both ICI and mTKI therapy, supporting further late-stage development of irpagratinib in such populations with substantial unmet medical need.
In addition, the design of the phase II study of pimicotinib in combination with chemotherapy and with/without toripalimab as first-line treatment for advanced pancreatic ductal adenocarcinoma (PDAC) has been presented.
About Irpagratinib (ABSK011)
Irpagratinib is a highly selective FGFR4 small molecule inhibitor intended for the treatment of advanced solid tumors that present with abnormalities in the FGF19/FGFR4 signaling pathway (e.g., ligand FGF19 amplification/overexpression, FGFR4 mutation/amplification/fusion), including advanced HCC, cholangiocarcinoma, breast cancer, among others. The FGFR4 signaling pathway is a recognized and promising target for treating HCC. Clinical data with irpagratinib have demonstrated improved potency and anti-tumor efficacy, among other favorable therapeutic properties, compared to competitors.
About Abbisko Therapeutics
Founded in April 2016, Abbisko Therapeutics Co., Ltd., a subsidiary of Abbisko Cayman Limited (Stock Code on the Hong Kong Stock Exchange: 2256.HK), is an oncology-focused biopharmaceutical company founded in Shanghai, dedicated to the discovery and development of innovative medicines that treat unmet medical needs in China and globally. The Company was established by a group of seasoned drug hunters with rich R&D and managerial expertise from top multinational pharmaceutical companies. Since its founding, Abbisko Therapeutics has built an extensive pipeline of 16 innovative small molecule programs focused on precision oncology and immuno-oncology. Please visit www.abbisko.com for more information.
** The press release content is from PR Newswire. Bastille Post is not involved in its creation. **
Best Poster of ESMO 2024! Abbisko Announces Updated Clinical Data of Irpagratinib in HCC
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From immersive alpine experiences to the "12 KuCoin Guardians," the festival presence brings KuCoin's brand philosophy to life by making trust visible for a global music community.
PROVIDENCIALES, Turks and Caicos Islands, March 17, 2026 /PRNewswire/ -- KuCoin, a leading global crypto platform built on trust, today announced the launch of its immersive on-site activations for Tomorrowland Winter 2026, marking the first major festival experience under its global partnership with Tomorrowland.
Tomorrowland Winter will take place March 21-28, 2026 in the renowned alpine resort of Alpe d'Huez, welcoming more than 24,000 visitors on average per day for a week-long celebration of electronic music. The festival will feature internationally acclaimed artists including Steve Aoki, Steve Angello, Lost Frequencies, and Dimitri Vegas. With one week to go before the festival opens, KuCoin will bring its "Guided into the Future" campaign to the French Alps through a series of experiences designed to connect music, culture, and digital innovation.
Building on KuCoin's previously announced 2026-2028 global partnership with Tomorrowland, the upcoming activations reflect a deeper alignment between global music culture and the evolving digital asset ecosystem— both rooted in the principles of community, creativity, and trust.
Reflecting on the collaboration, BC Wong, CEO of KuCoin, emphasized the shared community spirit behind the partnership. "Trust is the foundation of every thriving community," said BC. "Tomorrowland has built one of the most vibrant global communities through music and creativity. At KuCoin, we believe the future of digital finance should be built on the same principles of openness, collaboration, and trust. Our presence at Tomorrowland Winter reflects our commitment to connecting technology with culture and empowering global communities."
As part of its campaign at Tomorrowland Winter, KuCoin will introduce three immersive festival experiences across the mountain, transforming trust into a visible and shared experience for the global Tomorrowland community.
Follow the Green Glow: The 12 KuCoin Guardians
At the heart of KuCoin's festival presence are the 12 KuCoin Guardians, inspired by Tomorrowland's iconic festival guides.
Composed of six performers and six brass-band musicians, the Guardians will move throughout the festival grounds, energizing crowds and guiding attendees toward KuCoin experiences across the mountain.
In the Tomorrowland universe, Guardians are widely recognized as trusted helpers for festivalgoers. By bringing this role to life through KuCoin-inspired performances, KuCoin transforms the abstract idea of trust into a living presence within the festival community.
Sound on the Slopes: Day Time Mountain Sessions
During the daytime, KuCoin will host its primary alpine activation next to the Frozen Lotus stage at La Folie Douce, one of the most vibrant social hubs on the ski slopes.
Running daily from 12:00 PM to 4:30 PM, the space will feature DJ performances and a lively après-ski atmosphere, creating a natural gathering place for the international Tomorrowland community.
Immersive After Dark: Base Point in the Main Festival Area
In the evening, KuCoin will host the KuCoin Base Point in the Main Festival Area, open from 7:00 PM to midnight throughout the festival.
The experience will feature an immersive installation with dynamic green motion-tracking visuals, creating interactive photo and video moments designed to capture the energy of the festival while bringing KuCoin's brand identity to life.
Over the past two decades, Tomorrowland has grown into one of the world's most influential music festivals, bringing together hundreds of thousands of fans each year while reaching millions more through global broadcasts and digital experiences. Its winter edition in the French Alps blends music, travel, and culture into a unique alpine festival environment that attracts an international community of fans.
By collaborating with a globally recognized cultural platform like Tomorrowland, KuCoin continues expanding its presence beyond the crypto industry-connecting digital innovation with global audiences through shared cultural experiences. Through music, culture, and immersive storytelling, KuCoin's presence at Tomorrowland Winter reflects its broader vision of building a global digital ecosystem where trust connects communities across borders and empowers the future of digital finance.
About KuCoin
Founded in 2017, KuCoin is a leading global crypto platform trusted by over 40 million users across 200+ countries and regions. The platform delivers innovative digital-asset services, offering access to 1,000+ listed tokens, spot and futures trading, institutional wealth management, and a Web3 wallet.
Recognized by Forbes and Hurun, KuCoin holds SOC 2 Type II and ISO 27001:2022 certifications, underscoring its commitment to top-tier security. With AUSTRAC registration in Australia and a MiCA license in Austria, KuCoin continues expanding its regulated footprint under CEO BC Wong, building a reliable and trusted digital-asset ecosystem.
Learn more: www.kucoin.com
About Tomorrowland
Tomorrowland was founded 20 years ago by Belgian brothers Manu & Michiel Beers and remains a family-owned business, driven by a creative and passionate team. Over the years, Tomorrowland has evolved into a global entertainment brand. The WEAREONE.world group consists of several business units, including Festival & Events, Music, Experiences, Leisure, Products, and Fiction. Today, over 350 passionate team members create magic from the headquarters in Antwerp (Belgium), as well as from local offices in Brazil, France and Ibiza.
From immersive alpine experiences to the "12 KuCoin Guardians," the festival presence brings KuCoin's brand philosophy to life by making trust visible for a global music community.
PROVIDENCIALES, Turks and Caicos Islands, March 17, 2026 /PRNewswire/ -- KuCoin, a leading global crypto platform built on trust, today announced the launch of its immersive on-site activations for Tomorrowland Winter 2026, marking the first major festival experience under its global partnership with Tomorrowland.
Tomorrowland Winter will take place March 21-28, 2026 in the renowned alpine resort of Alpe d'Huez, welcoming more than 24,000 visitors on average per day for a week-long celebration of electronic music. The festival will feature internationally acclaimed artists including Steve Aoki, Steve Angello, Lost Frequencies, and Dimitri Vegas. With one week to go before the festival opens, KuCoin will bring its "Guided into the Future" campaign to the French Alps through a series of experiences designed to connect music, culture, and digital innovation.
Building on KuCoin's previously announced 2026-2028 global partnership with Tomorrowland, the upcoming activations reflect a deeper alignment between global music culture and the evolving digital asset ecosystem— both rooted in the principles of community, creativity, and trust.
Reflecting on the collaboration, BC Wong, CEO of KuCoin, emphasized the shared community spirit behind the partnership. "Trust is the foundation of every thriving community," said BC. "Tomorrowland has built one of the most vibrant global communities through music and creativity. At KuCoin, we believe the future of digital finance should be built on the same principles of openness, collaboration, and trust. Our presence at Tomorrowland Winter reflects our commitment to connecting technology with culture and empowering global communities."
As part of its campaign at Tomorrowland Winter, KuCoin will introduce three immersive festival experiences across the mountain, transforming trust into a visible and shared experience for the global Tomorrowland community.
Follow the Green Glow: The 12 KuCoin Guardians
At the heart of KuCoin's festival presence are the 12 KuCoin Guardians, inspired by Tomorrowland's iconic festival guides.
Composed of six performers and six brass-band musicians, the Guardians will move throughout the festival grounds, energizing crowds and guiding attendees toward KuCoin experiences across the mountain.
In the Tomorrowland universe, Guardians are widely recognized as trusted helpers for festivalgoers. By bringing this role to life through KuCoin-inspired performances, KuCoin transforms the abstract idea of trust into a living presence within the festival community.
Sound on the Slopes: Day Time Mountain Sessions
During the daytime, KuCoin will host its primary alpine activation next to the Frozen Lotus stage at La Folie Douce, one of the most vibrant social hubs on the ski slopes.
Running daily from 12:00 PM to 4:30 PM, the space will feature DJ performances and a lively après-ski atmosphere, creating a natural gathering place for the international Tomorrowland community.
Immersive After Dark: Base Point in the Main Festival Area
In the evening, KuCoin will host the KuCoin Base Point in the Main Festival Area, open from 7:00 PM to midnight throughout the festival.
The experience will feature an immersive installation with dynamic green motion-tracking visuals, creating interactive photo and video moments designed to capture the energy of the festival while bringing KuCoin's brand identity to life.
Over the past two decades, Tomorrowland has grown into one of the world's most influential music festivals, bringing together hundreds of thousands of fans each year while reaching millions more through global broadcasts and digital experiences. Its winter edition in the French Alps blends music, travel, and culture into a unique alpine festival environment that attracts an international community of fans.
By collaborating with a globally recognized cultural platform like Tomorrowland, KuCoin continues expanding its presence beyond the crypto industry-connecting digital innovation with global audiences through shared cultural experiences. Through music, culture, and immersive storytelling, KuCoin's presence at Tomorrowland Winter reflects its broader vision of building a global digital ecosystem where trust connects communities across borders and empowers the future of digital finance.
About KuCoin
Founded in 2017, KuCoin is a leading global crypto platform trusted by over 40 million users across 200+ countries and regions. The platform delivers innovative digital-asset services, offering access to 1,000+ listed tokens, spot and futures trading, institutional wealth management, and a Web3 wallet.
Recognized by Forbes and Hurun, KuCoin holds SOC 2 Type II and ISO 27001:2022 certifications, underscoring its commitment to top-tier security. With AUSTRAC registration in Australia and a MiCA license in Austria, KuCoin continues expanding its regulated footprint under CEO BC Wong, building a reliable and trusted digital-asset ecosystem.
Learn more: www.kucoin.com
About Tomorrowland
Tomorrowland was founded 20 years ago by Belgian brothers Manu & Michiel Beers and remains a family-owned business, driven by a creative and passionate team. Over the years, Tomorrowland has evolved into a global entertainment brand. The WEAREONE.world group consists of several business units, including Festival & Events, Music, Experiences, Leisure, Products, and Fiction. Today, over 350 passionate team members create magic from the headquarters in Antwerp (Belgium), as well as from local offices in Brazil, France and Ibiza.
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KuCoin Launches First Tomorrowland Winter Activations Under Global Partnership, Bringing "Guided into the Future" to the Alps
