BeFisetin® Announced the Global No.1 All-Natural Fisetin With SA-GRAS Status

NEW YORK--(BUSINESS WIRE)--Apr 14, 2025--

Bonerge Lifescience, a trusted innovator in longevity ingredients, proudly announces a historic milestone: on April 2, 2025, its premium fisetin ingredient, BeFisetin ®, has achieved Self-affirmed Generally Recognized as Safe (SA-GRAS) status in the United States. This landmark accomplishment positions Bonerge as the first company globally to secure GRAS certification for fisetin powder, setting a new global benchmark for safety and reliability in the next-generation anti-aging market.

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BeFisetin: Establishing the Gold Standard to Address Chaos in the Fisetin Market

The current fisetin market is plagued by alarming quality inconsistencies. While vague claims of "Fisetin 98% HPLC" dominate as the mainstream specification, actual fisetin content in these products ranges only between 75%-85%, with significant impurities concealed under this ambiguous standard.

For plant extracts derived from non-edible sources, the removal of harmful components is critical. Fisetin, extracted from inedible Anacardiaceae plants, contains large amounts of toxic lacquer, waxes, and wood debris. Eliminating these impurities is essential to producing safe, high-quality fisetin. Yet, the absence of clear, stringent quality standards has made it impossible to verify purity, allowing low-quality products to flood the market.

Many suppliers exploit rudimentary testing methods to falsely label products as "98% HPLC," misleading consumers and perpetuating a cycle where inferior products overshadow genuine quality. This chaos forces brands to settle for subpar fisetin, stifling innovation in premium formulations.

Establishing a gold standard for fisetin quality has been Bonerge’s mission from the start. Recognizing the challenges—extensive R&D, industry-first breakthroughs, and short-term financial sacrifices—we named our product BeFisetin as a constant reminder: "To be or not to be" hinges on our commitment to redefine excellence in fisetin. BeFisetin is not just a product—it’s a pledge to restore integrity and drive progress in the fisetin industry.

What Defines the Gold Standard for Fisetin?

BeFisetin: The 1st All-Natural Fisetin to be Granted SA-GRAS

BeFisetin ® is the first all-natural fisetin to attain SA-GRAS certification. For all dietary supplement ingredients, SA-GRAS represents a critical milestone, but its significance is unparalleled in advancing fisetin as a premium raw material. This certification sets the gold standard for the industry, requiring adherence to rigorous criteria: well-defined quality specifications, scientifically validated testing protocols, GMP-compliant manufacturing environments, and comprehensive safety assessments —all of which elevate fisetin from an underregulated botanical to a clinically trusted ingredient. By establishing these benchmarks, SA-GRAS not only ensures consumer safety but also paves the way for innovation in longevity-focused formulations.

“Beyond regulatory compliance, this accomplishment reflects our foundational commitment to scientific excellence and consumer safety—principles that drive every stage of our ingredient innovation,” stated Gloria, Product Manager of Bonerge. “SA-GRAS BeFisetin ® provides brands with a scientifically validated ingredient that meets international regulatory requirements, enabling them to develop innovative products with assurance.”

A Vision for Trusted Longevity Foundation

The GRAS certification of BeFisetin ® marks the beginning of Bonerge’s mission to redefine aging. By prioritizing rigorous science and consumer safety, Bonerge aims to foster transparency in the anti-aging market, and we are committed to providing scientifically grounded solutions that empower individuals to age healthily. As global interest in senotherapeutics grows, BeFisetin ® stands at the forefront, offering brands a trusted, scalable ingredient to meet the rising demand for effective and safe longevity products.

BeFisetin®: GRAS certified Fisetin for safe use in dietary supplements and health products.

WASHINGTON (AP) — President Donald Trump’s motorcade took a different route than usual to the airport as he was departing Florida on Sunday due to a “suspicious object,” according to the White House.

The object, which the White House did not describe, was discovered during security sweeps in advance of Trump’s arrival at Palm Beach International Airport.

“A further investigation was warranted and the presidential motorcade route was adjusted accordingly,” White House press secretary Karoline Leavitt said in a statement Sunday.

The president, when asked about the package by reporters, said, “I know nothing about it.”

Trump left his Palm Beach, Florida, club, Mar-a-Lago, around 6:20 p.m. for the roughly 10-minute drive to the airport, but took a circular route around the city to get there.

During the drive, police officers on motorcycles created a moving blockade for the motorcade, at one point almost colliding with the vans that accompanied Trump.

Air Force One was parked on the opposite side of the airport from where it is usually located and the lights outside the plane were turned off.

Anthony Guglielmi, the spokesman for U.S. Secret Service, said the secondary route was taken just as a precaution and that “that is standard protocol.”

President Donald Trump departs Trump International Golf Club in the presidential limousine, known as The Beast, Sunday, Jan. 11, 2026, in West Palm Beach, Fla. (AP Photo/Julia Demaree Nikhinson)