BeFisetin® Announced the Global No.1 All-Natural Fisetin With SA-GRAS Status

NEW YORK--(BUSINESS WIRE)--Apr 14, 2025--

Bonerge Lifescience, a trusted innovator in longevity ingredients, proudly announces a historic milestone: on April 2, 2025, its premium fisetin ingredient, BeFisetin ®, has achieved Self-affirmed Generally Recognized as Safe (SA-GRAS) status in the United States. This landmark accomplishment positions Bonerge as the first company globally to secure GRAS certification for fisetin powder, setting a new global benchmark for safety and reliability in the next-generation anti-aging market.

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BeFisetin: Establishing the Gold Standard to Address Chaos in the Fisetin Market

The current fisetin market is plagued by alarming quality inconsistencies. While vague claims of "Fisetin 98% HPLC" dominate as the mainstream specification, actual fisetin content in these products ranges only between 75%-85%, with significant impurities concealed under this ambiguous standard.

For plant extracts derived from non-edible sources, the removal of harmful components is critical. Fisetin, extracted from inedible Anacardiaceae plants, contains large amounts of toxic lacquer, waxes, and wood debris. Eliminating these impurities is essential to producing safe, high-quality fisetin. Yet, the absence of clear, stringent quality standards has made it impossible to verify purity, allowing low-quality products to flood the market.

Many suppliers exploit rudimentary testing methods to falsely label products as "98% HPLC," misleading consumers and perpetuating a cycle where inferior products overshadow genuine quality. This chaos forces brands to settle for subpar fisetin, stifling innovation in premium formulations.

Establishing a gold standard for fisetin quality has been Bonerge’s mission from the start. Recognizing the challenges—extensive R&D, industry-first breakthroughs, and short-term financial sacrifices—we named our product BeFisetin as a constant reminder: "To be or not to be" hinges on our commitment to redefine excellence in fisetin. BeFisetin is not just a product—it’s a pledge to restore integrity and drive progress in the fisetin industry.

What Defines the Gold Standard for Fisetin?

BeFisetin: The 1st All-Natural Fisetin to be Granted SA-GRAS

BeFisetin ® is the first all-natural fisetin to attain SA-GRAS certification. For all dietary supplement ingredients, SA-GRAS represents a critical milestone, but its significance is unparalleled in advancing fisetin as a premium raw material. This certification sets the gold standard for the industry, requiring adherence to rigorous criteria: well-defined quality specifications, scientifically validated testing protocols, GMP-compliant manufacturing environments, and comprehensive safety assessments —all of which elevate fisetin from an underregulated botanical to a clinically trusted ingredient. By establishing these benchmarks, SA-GRAS not only ensures consumer safety but also paves the way for innovation in longevity-focused formulations.

“Beyond regulatory compliance, this accomplishment reflects our foundational commitment to scientific excellence and consumer safety—principles that drive every stage of our ingredient innovation,” stated Gloria, Product Manager of Bonerge. “SA-GRAS BeFisetin ® provides brands with a scientifically validated ingredient that meets international regulatory requirements, enabling them to develop innovative products with assurance.”

A Vision for Trusted Longevity Foundation

The GRAS certification of BeFisetin ® marks the beginning of Bonerge’s mission to redefine aging. By prioritizing rigorous science and consumer safety, Bonerge aims to foster transparency in the anti-aging market, and we are committed to providing scientifically grounded solutions that empower individuals to age healthily. As global interest in senotherapeutics grows, BeFisetin ® stands at the forefront, offering brands a trusted, scalable ingredient to meet the rising demand for effective and safe longevity products.

BeFisetin®: GRAS certified Fisetin for safe use in dietary supplements and health products.

The Trump administration said Thursday that excavation work will start over the next two weeks on the site where it plans to build a towering, gilded arch, a project that is facing a lawsuit and that critics say will disrupt historic sightlines in Washington, D.C.

The proposed arch is one of several projects the Republican president is pursuing to leave his lasting imprint on Washington, including renaming and renovating the Kennedy Center, building a huge new White House ballroom, refurbishing the Lincoln Memorial Reflecting Pool and rebuilding a golf course in East Potomac Park that could significantly reduce the public’s access to running and biking paths.

“This will be one of the Great Pieces of American Architecture,” Interior Secretary Doug Burgum wrote on X, “befitting the most powerful Capital in the World.”

Along with the announcement on X, Burgum posted artistic mockups of the planned 250-foot-tall (76-meter) memorial arch, which will stand between the Lincoln Memorial and Arlington National Cemetery.

The renderings showed a towering, white arch with gold detail, stamped with “ONE NATION UNDER GOD." On its top is a Lady Liberty-like gold figure with wings and a torch, as well as gold eagles, their wings spread outward.

A National Park Service report released Friday backed the project, though it said there would be adverse effects to the sightlines between a host of iconic landmarks, disrupting the historical significance of dozens of nearby sites.

Many of Washington’s monuments, buildings and sites have been carefully planned over decades to reflect significant moments in the nation’s history and to evoke symbolism through sightlines that connect them to other landmarks.

A lawsuit filed by three veterans and an architectural historian argues “congressional authorization is necessary and lacking for this project,” said Nicolas Sansone, an attorney with Public Citizen Litigation Group representing the plaintiffs.

"We believe that construction cannot and should not proceed apace, and we are prepared to inform the court that it needs to, at this juncture, needs to step in," he said. Sansone did not specify what their next court filing would be, but he added that he's “very confident” that they'll find success.

Burgum, in a series of posts on X, defended the arch's construction on historical grounds, arguing that the idea for a monument had been bouncing around for more than a century, citing old reports of congressional attempts at and discussions of a monument in the circle.

“Despite Congress’s intent, the site became and remains today a barren traffic circle lacking any monumental treatment and significant historic value,” he wrote, adding that over 70 cities worldwide had “beautiful arches” but now the U.S. will have the “most spectacular and beautiful arch of them all!”

The court case is ongoing, with the Department of Justice filing a new document Thursday arguing that the lawsuit should be thrown out.

FILE - Memorial Circle, where President Donald Trump has proposed building an arch to commemorate the United States' 250th anniversary, the Arlington Memorial Bridge and the Lincoln Memorial, are seen from the Washington Monument, Aug. 17, 2026, in Washington. (AP Photo/Julia Demaree Nikhinson, File)

FILE - A mockup of President Donald Trump's proposed triumphal arch stands at the Great American State Fair on the National Mall, June 27, 2026, in Washington. (AP Photo/Jen Golbeck, File)

FILE - Flags placed by workers are pictured in the Memorial Circle, where President Donald Trump has proposed building an arch to commemorate the United States' 250th anniversary, Friday, May 15, 2026, in Washington. (AP Photo/Jacquelyn Martin, File)

FILE - Flags are placed as workers survey the Memorial Circle, where President Donald Trump has proposed building an arch to commemorate the United States' 250th anniversary, May 11, 2026, in Washington. (AP Photo/Alex Brandon, File)